Abstract
Possible effects of 1,25-dihydoxyvitamin D3(vitamin D) on ionizing radiation-induced cell damage have been unknown until now. The task of the presentstudy was to analyze, in a human keratinocyte cell line (HaCaT), the effectsof a preincubation with vitamin D on the X-ray-induced mRNA expressionof different genes related to apoptosis (gene array). The first results showthat ionizing radiation leads to a down-regulation of various apoptosis-relevantgenes in HaCaT cells pretreated with vitamin D. Therefore it can be speculated that vitamin D could prove to be a promising radioprotective substance.
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Meineke, V. et al. (2003). Modulation of X-ray-Induced Apoptosis in Human Keratinocytes (HaCaT) by 1,25-Dihydroxyvitamin D3 . In: Reichrath, J., Tilgen, W., Friedrich, M. (eds) Vitamin D Analogs in Cancer Prevention and Therapy. Recent Results in Cancer Research, vol 164. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-55580-0_31
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DOI: https://doi.org/10.1007/978-3-642-55580-0_31
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