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Guidance Cues in the Developing Brain pp 1–32Cite as

Complex Patterns and Simple Architects: Molecular Guidance Cues for Developing Axonal Pathways in the Telencephalon

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Part of the book series: Progress in Molecular and Subcellular Biology ((PMSB,volume 32))

Abstract

The aim of this review is to discuss the current research on the spatio-temporal distribution and function of the four major classes of axonal guidance cues (netrins, semaphorins, slits, and ephrins) and their receptors in the developing mammalian telencephalon. In the first part, we briefly describe guidance molecules and their receptors. In the second part, we review their overlapping distribution in the specific architectonic zones of the cerebral wall during the embryonic and early postnatal period. In the third part, we describe complementary and/or overlapping functions of these molecules in the development of all major classes of telencephalic axon pathways: subcortical (thalamic and extrathalamic) afferent systems, corticofugal (projection) systems, and cortico-cortical (commissural and ipsilateral) fiber systems. To conclude, we discuss several general themes which emerge from the current research, and point out that most axonal guidance cues have other developmental roles as well, including possible involvement in synaptic plasticity in the adult brain.

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  1. Croatian Institute for Brain Research, School of Medicine, University of Zagreb, Šalata 12, Zagreb, 10000, Croatia

    M. Judaš, N. J. Milošević, M.-R. Rašin, M. Heffer-Lauc & I. Kostović

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  2. N. J. Milošević
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  3. M.-R. Rašin
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    Ivica Kostović

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Judaš, M., Milošević, N.J., Rašin, MR., Heffer-Lauc, M., Kostović, I. (2003). Complex Patterns and Simple Architects: Molecular Guidance Cues for Developing Axonal Pathways in the Telencephalon. In: Kostović, I. (eds) Guidance Cues in the Developing Brain. Progress in Molecular and Subcellular Biology, vol 32. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-55557-2_1

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