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Molecular Nuclear Medicine pp 39–66Cite as

Functional Genomics and Proteomics: Basics, Opportunities and Challenges

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Abstract

Genomics and proteomics are changing our understanding of biology. To date, the greatest impact has come from DNA sequencing projects, which recently culminated in the unveiling of the near-complete 3.2-billion base-pair sequence of the human genome (International Human Genome Sequencing Consortium 2001; Venter et al. 2001). We have thus advanced from having only limited information about the genetic details of biology to possessing an immense amount of structural information about individual genes. The complete genome sequences of more than 60 species are now available in databases, and many more are expected to become available in the near future. These information resources alone will have a significant impact on biomedical research. Even more importantly, blueprints of genomes can provide the basis for the integration of complex data sets derived from a wide range of studies in genomics, functional genomics, and proteomics. The resulting increase in genetic and biological information will have an even greater impact on biomedical research and the way medicine is practiced.

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Authors
  1. Nikolai Kley
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  2. Stefan Schmidt Ph.D.
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  3. Vivian Berlin
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  4. Hannes Loferer
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  5. Jeno Gyuris
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Editors and Affiliations

  1. Heinrich-Heine-University Düsseldorf, Wannental 45, 88131, Lindau, Germany

    Ludwig E. Feinendegen M.D. (Professor Emeritus Nuclear Medicine) (Professor Emeritus Nuclear Medicine)

  2. Radiology and Medicine SUNY, Stonybrook, USA

    Walton W. Shreeve M.D., Ph.D. (Professor Emeritus) (Professor Emeritus)

  3. Medical Department Brookhaven National Laboratory, Upton, NY, 11973, USA

    Walton W. Shreeve M.D., Ph.D. (Professor Emeritus) (Professor Emeritus)

  4. National Institutes of Health/Clinical Center, Bldg. 10, Rm 1C401 10 Center Drive, MSC 1180, Bethesda, MD, 20892-1180, USA

    William C. Eckelman Ph. D. (Chief PET Department) (Chief PET Department)

  5. Department of Nuclear Medicine, Sung-Ae General Hospital, Shingil-1-Dong, Youngdungpo-Gu, Seoul, 121-200, Korea

    Yong-Whee Bahk M.D., Ph.D. (Professor Emeritus (CUK) and Director) (Professor Emeritus (CUK) and Director)

  6. Nuclear Medicine and Radiation Health Sciences, The Johns Hopkins University School of Hygiene and Public Health, 615 North Wolfe Street, Baltimore, MD, 21205-2179, USA

    Henry N. Wagner Jr. M. D.

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Kley, N., Schmidt, S., Berlin, V., Loferer, H., Gyuris, J. (2003). Functional Genomics and Proteomics: Basics, Opportunities and Challenges. In: Feinendegen, L.E., Shreeve, W.W., Eckelman, W.C., Bahk, YW., Wagner, H.N. (eds) Molecular Nuclear Medicine. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-55539-8_3

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