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Development of DNA-based Radiopharmaceuticals Carrying Auger-Electron Emitters for Anti-gene Radiotherapy

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Molecular Nuclear Medicine

Abstract

Most gene therapy methods currently used to correct gene expression rely on either gene introduction, modification, replacement or antisense approaches. Typically, gene therapy seeks to add-back missing functionality. Antisense therapy is employed to reduce or eliminate expression of specific gene products. A more direct manipulation of gene function at the DNA level may be advantageous in circumstances where gene replacement alone is not sufficient to prevent or treat disease due to continued expression of defective gene products, or for cases in which continuous long-term antisense treatment is impractical or impossible. Consequently, exploration of approaches to change gene function directly at the DNA level may, in some cases, provide an important alternative to current methods of gene therapy. Targeting specific genes unique to cancer cells may also be a way to selectively eliminate such cells via induced cell necrosis or apoptosis; and, perhaps, even a way to genetically “correct” some aspect of neoplastic cell behavior to cause reversion to a non-neoplastic phenotype.

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Authors
  1. Igor G. Panyutin
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  2. Thomas A. Winters
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  3. Ludwig E. Feinendegen
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  4. Ronald D. Neumann
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Editor information

Editors and Affiliations

  1. Heinrich-Heine-University Düsseldorf, Wannental 45, 88131, Lindau, Germany

    Ludwig E. Feinendegen M.D. (Professor Emeritus Nuclear Medicine) (Professor Emeritus Nuclear Medicine)

  2. Radiology and Medicine SUNY, Stonybrook, USA

    Walton W. Shreeve M.D., Ph.D. (Professor Emeritus) (Professor Emeritus)

  3. Medical Department Brookhaven National Laboratory, Upton, NY, 11973, USA

    Walton W. Shreeve M.D., Ph.D. (Professor Emeritus) (Professor Emeritus)

  4. National Institutes of Health/Clinical Center, Bldg. 10, Rm 1C401 10 Center Drive, MSC 1180, Bethesda, MD, 20892-1180, USA

    William C. Eckelman Ph. D. (Chief PET Department) (Chief PET Department)

  5. Department of Nuclear Medicine, Sung-Ae General Hospital, Shingil-1-Dong, Youngdungpo-Gu, Seoul, 121-200, Korea

    Yong-Whee Bahk M.D., Ph.D. (Professor Emeritus (CUK) and Director) (Professor Emeritus (CUK) and Director)

  6. Nuclear Medicine and Radiation Health Sciences, The Johns Hopkins University School of Hygiene and Public Health, 615 North Wolfe Street, Baltimore, MD, 21205-2179, USA

    Henry N. Wagner Jr. M. D.

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Panyutin, I.G., Winters, T.A., Feinendegen, L.E., Neumann, R.D. (2003). Development of DNA-based Radiopharmaceuticals Carrying Auger-Electron Emitters for Anti-gene Radiotherapy. In: Feinendegen, L.E., Shreeve, W.W., Eckelman, W.C., Bahk, YW., Wagner, H.N. (eds) Molecular Nuclear Medicine. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-55539-8_29

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