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Molecular Nuclear Medicine pp 327–354Cite as

In Vitro Indicators of Metabolism of Natural Compounds

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Abstract

Measurements of the concentrations of radioactive or stable isotopes in body fluids (e.g., blood, plasma), excreta (e.g., urine, breath, feces, saliva) or biopsied tissue after in vivo administration constituted a major part of nuclear medicine in the early years of the specialty (roughly, the third quarter of the 20th Century). This era was mostly research-oriented and pre-dinical. Yet, clinical applications of in vitro tests were developing for the purposes of recognizing problems of gastrointestinal absorption of minerals, vitamins and energy constituents of the diet and the fate of elements or compounds after enterai or parenteral administration. Amounts and kinetics of body constituents were evaluated in ways which were, and in various cases still are, achievable only, or best, with the isotopic tracers. Another important facet of radiotracer use was the development of radioimmunoassay, by which minute concentrations of proteins (especially hormones) in body fluids would be measured with much benefit to clinical medicine. Autoradiography of uptake of weak beta emitters into isolated cells after in vivo or in vitro exposure also developed in this period, as did initial work with in vitro blood cell tagging for volume assays and for imaging.

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  1. Walton W. Shreeve
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Editors and Affiliations

  1. Heinrich-Heine-University Düsseldorf, Wannental 45, 88131, Lindau, Germany

    Ludwig E. Feinendegen M.D. (Professor Emeritus Nuclear Medicine) (Professor Emeritus Nuclear Medicine)

  2. Radiology and Medicine SUNY, Stonybrook, USA

    Walton W. Shreeve M.D., Ph.D. (Professor Emeritus) (Professor Emeritus)

  3. Medical Department Brookhaven National Laboratory, Upton, NY, 11973, USA

    Walton W. Shreeve M.D., Ph.D. (Professor Emeritus) (Professor Emeritus)

  4. National Institutes of Health/Clinical Center, Bldg. 10, Rm 1C401 10 Center Drive, MSC 1180, Bethesda, MD, 20892-1180, USA

    William C. Eckelman Ph. D. (Chief PET Department) (Chief PET Department)

  5. Department of Nuclear Medicine, Sung-Ae General Hospital, Shingil-1-Dong, Youngdungpo-Gu, Seoul, 121-200, Korea

    Yong-Whee Bahk M.D., Ph.D. (Professor Emeritus (CUK) and Director) (Professor Emeritus (CUK) and Director)

  6. Nuclear Medicine and Radiation Health Sciences, The Johns Hopkins University School of Hygiene and Public Health, 615 North Wolfe Street, Baltimore, MD, 21205-2179, USA

    Henry N. Wagner Jr. M. D.

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Shreeve, W.W. (2003). In Vitro Indicators of Metabolism of Natural Compounds. In: Feinendegen, L.E., Shreeve, W.W., Eckelman, W.C., Bahk, YW., Wagner, H.N. (eds) Molecular Nuclear Medicine. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-55539-8_14

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