Abstract
The use of Synchrotron Radiation for medical imaging has seen impressive growth in the last decades. The availability of highly coherent, tunable monochromatic X-ray beams, over a wide energy range, makes Synchrotron Radiation an incomparable tool of research for a variety of purposes. This chapter highlights the main achievements and the perspectives of medical imaging research carried out at various Synchrotron Light laboratories.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
P. Suortti, W. Thomlinson, Phys. Med. Biol. 48, R1–R35 (2003)
R.A. Lewis, Phys. Med. Biol. 49, 3573–3583 (2004)
S.-A. Zhou, A. Brahme, Phys. Med. 24, 129–148 (2008)
A. Bravin, P. Coan, P. Suortti, Phys. Med. Biol. 58, R1–R35 (2013)
A. Snigirev, I. Snigireva, V. Kohn, S. Kuznetsov, I. Schelokov, Rev. Sci. Instrum. 66, 5486–5492 (1995)
S.W. Wilkins, T.E. Gureyev, D. Gao, A. Pogany, A.W. Stevenson, Nature 384, 335–338 (1996)
P. Cloetens, R. Barratt, J. Baruchel, J.P. Guigay, M.J. Schlenker, Phys. D. Appl. Phys. 29, 133–146 (1996)
K.M. Podurets, V.A. Somenkov, S.S. Shil’shtein, Sov. Phys. Tech. Phys. 654, 34–36 (1989)
V.N. Ingal, E.A. Beliaevskaya, J. Phys. D: Appl. Phys. 28, 2134 (1995)
D. Chapman, W. Thomlinson, R.E. Johnston, D. Washburn, E. Pisano, N. Gmür, Z. Zhong, R. Menk, F. Arfelli, D. Sayers, Phys. Med. Biol. 42, 2015–2025 (1997)
E. Forster, K. Goetz, P. Zaumseil, Krist. Tech. 15, 937–945 (1980)
U. Bonse, M. Hart, Appl. Phys. Lett. 6, 155–161 (1965)
A. Momose, T. Takeda, Y. Itai, K. Hirano, Nat. Med. 2(4), 473–475 (1996)
T. Weitkamp, A. Diaz, C. David, F. Pfeiffer, M. Stampanoni, P. Cloetens, E. Ziegler, Opt. Express 13(16), 6296–6304 (2005)
A. Olivo, R.A. Speller, Appl. Phys. Lett. 074106(1–3) (2007)
W. R. Dix, K. Engelke, W. Graeff, C. Hamm, J. Heuer, B. Kaempf, W. Kupper, M. Lohmann, B. Reime, R. Reumann, Nucl. Instrum. Methods Phys. Res. Section A, 314(2), 307–315 (1992)
T. Dill, W.R. Dix, C.W. Hamm, M. Jung, W. Kupper, M. Lohmann, B. Reine, R. Ventura, Eur. J. Phy. 19(6), 499–511 (1998)
W.R. Dix, W. Kupper, T. Dill, C.W. Hamm, H. Job, M. Lohmann, B. Reine, R. Ventura, J. Synchrotron Radiat. 10(3), 219–227 (2003)
E. Rubenstein, R. Hofstadter, H.D. Zeman, A.C. Thompson, J.N. Otis, G.S. Brown, J.C. Giacomini, H.J. Gordon, R.S. Kernoff, D.C. Harrison, Proc. Nat. Acad. Sci. 83(24), 9724–9728 (1986)
E. Rubenstein, in Synchrotron Radiation in the Biosciences, ed. by B. Chance et al. (Oxford University Press, New York, 1994), pp. 639–645
W. Thomlinson, N. Gmur, D. Chapman, R. Garrett, N. Lazarz, H. Moulin, A.C. Thompson, H.D. Zeman, G.S. Brown, J. Morrison, P. Reiser, V. Padmanabahn, L. Ong, S. Green, J. Giacomini, H. Gordon, E. Rubenstein, Rev. Sci. Instr. 63(1), 625–628 (1992)
H. Elleaume, S. Fiedler, F. Esteve, B. Bertrand, A.M. Charvet, P. Berkvens, G. Berruyer, T. Brochard, G. Le Duc, C. Nemoz, M. Renier, P. Suortti, W. Thomlinson, J.F. Le Bas, Phys. Med. Biol. 45(9), L39–45 (2000)
T. Takeda, K. Umetani, T. Doi, J. Echigo, H. Ueki, K. Ueda, Y. Itai, Acad. Radiol. 4(6), 438–445 (1997)
S. Ohtsuka, Y. Sugishita, T. Takeda, Y. Itai, J. Tada, K. Hyodo, M. Ando, Brit. J. Radiol. 72(853), 24–28 (1999)
M. Shirai, D.O. Schwenke, H. Tsuchimochi, K. Umetani, N. Yagi, J.T. Pearson, Circ. Res. 112(1), 209–221 (2013)
Y. Guan, Y. Wang, F. Yuan, H. Lu, Y. Ren, T. Xiao, K. Chen, D.A. Greenberg, K. Jin, G.-Y. Yang, Stroke 43(3), 888–891 (2012)
H. Lu, Y. Wang, X. He, F. Yuan, X. Lin, B. Xie, G. Tang, J. Huang, Y. Tang, K. Jin, S. Chen, G.Y. Yang, Stroke 43(3), 838–843 (2012)
V.M. Pai, M. Kozlowski, D. Donahue, E. Miller, X. Xiao, M.Y. Chen, Z.-X. Yu, P. Connelly, K. Jeffries, H. Wen, J. Anat. 220(5), 514–524 (2012)
J.C. Giacomini, H. Gordon, R. O’Neil, A. Van Kessel, B. Cason, D. Chapman, W. Lavendar, N. Gmur, R. Menk, W. Thomlinson, Z. Zhong, E. Rubenstein, Nucl. Instrum. Methods Phys. Res. Section A, 406(3), 473–478 (1998)
S. Bayat, G. Le Duc, L. Porra, G. Berruyer, C. Nemoz, S. Monfraix, S. Fiedler, W. Thomlinson, P. Suortti, C.G. Standertskjöld-Nordenstam, A.R. Sovijärvi, Phys. Med. Biol. 46(12), 3287 (2001)
S. Bayat, L. Porra, H. Suhonen, C. Nemoz, P. Suortti, A.R.J. Sovijärvi, Appl. Physiol. 100(6), 1964–1973 (2006)
S. Bayat, S. Strengell, L. Porra, T.Z. Janosi, F. Petak, H. Suhonen, P. Pekka Suortti, Z. Hantos, A.R.A. Sovijärvi, W. Habre, Am. J. Respir. Crit. Care Med. 180(4), 296–303 (2009)
E.D. Pisano, R.E. Johnston, D. Chapman, J. Geradts, M.V. Iacocca, C.A. Livasy, D.B. Washburn, D.E. Sayers, Z. Zhong, M.Z. Kiss, W.C. Thomlinson, Radiology 214(3), 895–901 (2000)
F. Arfelli, M. Assante, V. Bonvicini, A. Bravin, G. Cantatore, E. Castelli, L. Dalla Palma, M. Di Michiel, R. Longo, A. Olivo, S. Pani, D. Pontoni, P. Poropat, M. Prest, A. Rashevsky, G. Tromba, A. Vacchi, E. Vallazza, F. Zanconati, Phys. Med. Biol. 43(10), 2845–2852 (1998)
J. Keyriläinen, A. Bravin, M. Fernández, M. Tenhunen, P. Virkkunen, P. Suortti, Acta Radiologica 51(8), 866–884 (2010)
P. Coan, A. Bravin, G. Tromba, Accepted for publication in J. Phys. D (2013)
F. Arfelli, V. Bonvicini, A. Bravin, G. Cantatore, E. Castelli, L. Dalla Palma, M. Di Michiel, M. Fabrizioli, R. Longo, R. Menk, A. Olivo, S. Pani, D. Pontoni, P. Poropat, M. Prest, A. Rashevsky, M. Ratti, L. Rigon, G. Tromba, A. Vacchi, E. Vallazza, F. Zanconati, Radiology 215(1), 286–293 (2000)
D. Dreossi, A. Abrami, F. Arfelli, P. Bregant, K. Casarin, V. Chenda, M.A. Cova, R. Longo, R.-H. Menk, E. Quaia, E. Quai, L. Rigon, T. Rokvic, D. Sanabor, M. Tonutti, G. Tromba, A. Vascotto, F. Zanconati, E. Castelli, Eur. J. Radiol. 68(3), S58–S62 (2008)
E. Castelli, M. Tonutti, F. Arfelli, R. Longo, E. Quaia, L. Rigon, D. Sanabor, F. Zanconati, D. Dreossi, A. Abrami, E. Quai, P. Bregant, K. Casarin, V. Chenda, R.H. Menk, T. Rokvic, A. Vascotto, G. Tromba, M.A. Cova, Radiology 259(3), 684–694 (2011)
E. Quai, R. Longo, F. Zanconati, G. Jaconelli, M. Tonutti, A. Abrami, F. Arfelli, D. Dreossi, G. Tromba, M.A. Cova, La, Radiologia Medica 118(1), 89–100 (2013)
BIRADS, American College of Radiology Illustrated Breast Imaging Reporting and Data System 2003, 4th edn. Reston (VA), ACR (2003)
R.E. Johnston, D. Washburn, E. Pisano, C. Burns, W.C. Thomlinson, L.D. Chapman, F. Arfelli, N.F. Gmur, Z. Zhong, D. Sayers, Mammographic phantom studies with synchrotron radiation. Radiology 200(3), 659–663 (1996)
W. Thomlinson, D. Chapman, Z. Zhong, R.E. Johnston, D. Sayers, in Medical Applications of Synchrotron Radiation, ed. by M. Ando, C. Uyama (Springer, Tokyo, 1998), pp. 72–76
J. Keyriläinen, M. Fernández, M.L. Karjalainen-Lindsberg, P. Virkkunen, M. Leidenius, K. von Smitten, P. Sipilä, S. Fiedler, H. Suhonen, P. Suortti, A. Bravin, Radiology 249(1), 321–327 (2008)
A. Sztrókay, P.C. Diemoz, T. Schlossbauer, E. Brun, F. Bamberg, D. Mayr, A. Bravin, P. Coan, Phys. Med. Biol. 57(10), 2931–42 (2012)
M. Ando, H. Bando, S. Ichihara, E. Hashimoto, K. Hyodo, T. Kunisada, G. Li, A. Maksimenko, K. Mori, D. Shimao, H. Sugiyama, T. Yuasa, E. Ueno, Eur. J. Radiol. 68(3), S32–S36 (2008)
J. Miao, F. Förster, O. Levi, Phys. Rev. B 72(5), 052103 (2005)
B.P. Fahimian, Y. Mao, P. Cloetens, J. Miao, Phys. Med. Biol. 55(18), 5383–5400 (2010)
Y. Zhao, E. Brun, P. Coan, Z. Huang, A. Sztrókay, P.C. Diemoz, S. Liebhardtd, A. Mittone, S. Gasilov, J. Miao, A. Bravin, Proc. Natl Acad. Sci. USA 109(45), 18290–18294 (2012)
M. Stampanoni, Z. Wang, T. Thüring, C. David, E. Roessl, M. Trippel, R.A. Kubik-Huch, G. Singer, M.K. Hohl, N. Hauser, Invest. Radiol. 46(12), 801–806 (2011)
A. Sztrókay, J. Herzen, S.D. Auweter, S. Liebhardt, D. Mayr, M. Willner, D. Hahn, I. Zanette, T. Weitkamp, K. Hellerhoff, F. Pfeiffer, M.F. Reiser, F. Bamberg, Eur. Radiol. 23(2), 381–387 (2013)
J. Mollenhauer, M.E. Aurich, Z. Zhong, C. Muehleman, A.A. Cole, M. Hasnah, O. Oltulue, K.E. Kuettnera, A. Margulis, L.D. Chapman, Osteoarthr. Cartil. 10(3), 163–171 (2002)
C. Muehleman et al., X-ray detection of structural orientation in human articular cartilage. Osteoarthr. Cartil. 12, 97–105 (2004)
A. Wagner, M. Aurich, N. Sieber, M. Stoessel, W.D. Wetzel, K. Schmuck, M. Lohmann, B. Reimec, J. Metge, P. Coan, A. Bravin, F. Arfelli, L. Rigon, R.-H. Menk, G. Heitner, T.Irvingi, Z. Zhong, C. Muehleman, J.A. Mollenhauer, Nucl. Instrum. Methods Phys. Res. Section A, 548(1), 47–53 (2005)
P. Coan, F. Bamberg, P.C. Diemoz, A. Bravin, K. Timpert, E. Mützel, J.G. Raya, S. Adam-Neumair, M.F. Reiser, C. Glaser, Invest. Radiol. 45(7), 437–444 (2010)
E.C. Ismail, W. Kaabar, D. Garrity, O. Gundogdu, O. Bunk, F. Pfeiffer, M.J. Farquharson, D.A. Bradley, Appl. Rad. Isot. 68(4), 767–771 (2010)
J. Li, Z. Zhong, D. Connor, J. Mollenhauer, C. Muehleman, Osteoarthr. Cartil. 17(9), 1193–1196 (2009)
P. Coan, A. Wagner, A. Bravin, P.C. Diemoz, J. Keyriläinen, J. Mollenhauer, Phys. Med. Biol. 55(24), 7649–7662 (2010)
N. Yagi, Y. Suzuki, K. Umetani, Y. Kohmura, K. Yamasaki, Med. Phys. 26, 2190–2193 (1999)
R.A. Lewis, C.J. Hall, A.P. Hufton, S. Evans, R.H. Menk, F. Arfelli, L. Rigon, G. Tromba, D. Dance, I.O. Ellis, A. Evans, E. Jacobs, S.E. Pinder, K.D. Rogers, J. Brit. Rad. 76(905), 301–308 (2003)
M.J. Kitchen, R.A. Lewis, M.J. Morgan, M.J. Wallace, M.L. Siew, K.K.W. Siu, A. Habib, A. Fouras, N. Yagi, K. Uesugi, S.B. Hooper, Phys. Med. Biol. 53(21), 6065–6077 (2008)
S.B. Hooper, M.J. Kitchen, M.L. Siew, R.A. Lewis, A. Fouras, A.B. te Pas, K.K. Siu, N. Yagi, K. Uesugi, M.J. Wallace, Clin. Exp. Pharm. Phys. 36, 117–125 (2009)
D.W. Parsons, K. Morgan, M. Donnelley, A. Fouras, J. Crosbie, I. Williams, R.C. Boucher, K. Uesugi, N. Yagi, K.K.W. Siu, J. Anat. 213, 217–227 (2008)
M.A. Beltran, D.M. Paganin, K.K.W. Siu, A. Fouras, S.B. Hooper, D.H. Reser, M.J. Kitchen, Phys. Med. Biol. 56(23), 7353–7369 (2011)
K.K. Siu, K.S. Morgan, D.M. Paganin, R. Boucher, K. Uesugi, N. Yagi, D.W. Parsons, Eur. J. Radiol. 68(3), S22–S26 (2008)
T. Sera, H. Yokota, K. Uesugi, N. Yagi, Respir. Phys. Neurobiol. 185, 639–646 (2013)
M. Donnelley, K.K. Siu, R.A. Jamison, D.W. Parsons, Gene Therapy 19(1), 8–14 (2011)
K.S. Morgan, M. Donnelley, D.M. Paganin, A. Fouras, N. Yagi, Y. Suzuki, A. Takeuchi, K. Uesugi, R.C. Boucher, D.W. Parsons, K.K.W. Siu, PLoS ONE 8(1) (2013)
D.M. Connor, Z. Zhong, H.D. Foda, S. Wiebe, C.A. Parham, F.A. Dilmanian, E.B. Cole, E.D. Pisano, Acad. Radiol. 18(12), 1515–1521 (2011)
L. Zhang, S. Luo, Open Med. Inform. J. 5(Suppl. 1), 19–25 (2011)
S. Chang, N. Kwon, B.M. Weon, J. Kim, C.K. Rhee, H.S. Choi, Y. Kohmura, M. Yamamoto, T. Ishikawa, J.H. Je, Scientific Reports 3, (2013)
M.J. Kitchen, D.M. Paganin, K. Uesugi, B.J. Allison, R.A. Lewis, S.B. Hooper, K.M. Pavlov, Opt. Express 18(19), 19994–20012 (2010)
M.J. Kitchen, D.M. Paganin, K. Uesugi, B.J. Allison, R.A. Lewis, S.B. Hooper, K.M. Pavlov, Phys. Med. Biol. 56(3), 515–534 (2011)
F. Arfelli, L. Rigon, R.H. Menk, Phys. Med. Biol. 55(6), 1643–1658 (2000)
Y. Xi et al., Microbubbles as contrast agent for in-line x-ray phase-contrast imaging. Appl. Phys. Lett. 99, 011101 (2011)
R. Tang, Y. Xi, W.M. Chai, Y. Wang, Y. Guan, G.Y. Yang, H. Xie, K.M. Chen, Phys. Med. Biol. 56(12), 3503–3512 (2011)
C.M. Laperle, T.J. Hamilton, P. Wintermeyer, E.J. Walker, D. Shi, M.A. Anastasio, Z. Derdak, J.R. Wands, G. Diebold, C. Rose-Petruck, Phys. Med. Biol. 53(23), 6911–6923 (2008)
U. Lundström, D.H. Larsson, A. Burvall, P.A. Takman, L. Scott, H. Brismar, H.M. Hertz, Phys. Med. Biol. 57(9), 2603–2617 (2012)
J.Z. Hu, T.D. Wu, L. Zeng, H.Q. Liu, Y. He, G.H. Du, H.B. Lu, Phys. Med. Biol 57(5), N55–63 (2012)
M. Hoshino, K. Uesugi, N. Yagi, Biol. Open 1(3), 269–274 (2012)
M. Takeda, T. Yamashita, M. Shinohara, N. Sasaki, H. Tawa, K. Nakajima, A. Momose, K.I. Hirata, Int. J. Cardiovasc. Imaging 28(5), 1181–1191 (2012)
T. Takeda, A. Yoneyama, J. Wu, F.A. Momose, K. Hyodo, J. Synchrotron Radiat. 19(2), 252–256 (2012)
Y. Jiang, Y. Tong, T. Xiao, S. Lu, Dermatology 225(1), 75–80 (2012)
F. Pfeiffer, O. Bunk, C. David, M. Bech, G. Le Duc, A. Bravin, P. Cloetens, Phys. Med. Biol. 52(23), 6923–6930 (2007)
S.A. McDonald, F. Marone, C. Hintermuller, G. Mikuljan, C. David, F. Pfeiffer, M.J. Stampanoni, Synchrotron Radiat. 16(4), 562–572 (2009)
G. Schulz, T. Weitkamp, I. Zanette, F. Pfeiffer, F. Beckmann, C. David, S. Rutishauser, E. Reznikova, B. Müller, J. Royal Soc. Interface 7(53), 1665–1676 (2010)
B.R. Pinzer, M. Cacquevel, P. Modregger, S.A. McDonald, J.C. Bensadoun, T. Thuering, P. Aebischer, M. Stampanoni, Neuroimage 61(4), 1336–1346 (2012)
C.J. Hall, E. Schültke, L. Rigon, K. Ataelmannan, S. Rigley, R. Menk, F. Arfelli, G. Tromba, S. Pearson, S. Wilkinson, A. Round, S. Crittell, R. Griebel, B.H.J. Juurlink, Eur. J. Radiol. 68(3), S156–S159 (2008)
R.H. Menk, E. Schültke, C. Hall, F. Arfelli, A. Astolfo, L. Rigon, A. Round, K. Ataelmannan, S. Rigley MacDonald, B.H. Juurlink, Nanotech. Biol. Med. 7(5), 647–654 (2011)
A. Astolfo, E. Schültke, R.H. Menk, R.D. Kirch, B.H. Juurlink, C. Hall, L.-A. Harsan, M. Stebel, D. Barbetta, G. Tromba, F. Arfelli, Nanomed.: Nanotech. Biol. Med. 9(2), 284–292 (2013)
Acknowledgments
I am grateful to A. Bravin (ESRF), F. de Carlo (APS), M. Kitchen (Melbourne Univ.), R.-H. Menk (Elettra), T. Xiao (SSRF), N. Yagi (Spring-8) for their support in the preparation of the manuscript.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2015 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Tromba, G. (2015). Medical Imaging with Synchrotron Radiation. In: Mobilio, S., Boscherini, F., Meneghini, C. (eds) Synchrotron Radiation. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-55315-8_22
Download citation
DOI: https://doi.org/10.1007/978-3-642-55315-8_22
Published:
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-55314-1
Online ISBN: 978-3-642-55315-8
eBook Packages: Physics and AstronomyPhysics and Astronomy (R0)