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The Dental Pulp pp 35–46Cite as

Pulp Extracellular Matrix

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Abstract

Collagen fibrils and non-collagenous extracellular matrix components may be extracted from the dental pulp. Differences appear between the coronal and radicular pulp after mechanical preparation. Type I, III, V, and IV collagens have been identified. Other structural proteins play a role in the dental pulp, namely, the phosphorylated proteins of the small integrin-binding ligand N-linked glycoprotein family (SIBLING), implicated in pulp mineralization as promotor or inhibitor, and in dentinogenesis imperfecta. Non-phosphorylated ECM proteins were also identified in pulp tissue. Glycosaminoglycans and proteoglycans act as tissue organizers. They influence cell growth and maturation. A series of molecules are influent as transcription or growth factors. They are acting as proteolytic enzymes including collagenases and other proteases.

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Acknowledgment

All of the work carried out in the Veis laboratory on mineralization and tooth behavior has been supported by the National Institutes of Health and National Institute for Dental and Craniofacial Research Grant DE01374. The French Foundation has supported the work in the Goldberg laboratories for dental research and STEM Pole for funding this research. A personal note of appreciation is in order from AV for the privilege of working with Professor Michel Goldberg, a gifted clinician scientist. He has taught me much about dentistry and the real world of clinical science as compared to the strict physical chemistry approach I brought to my studies of dentin 60 years ago. I have not been the best student, but he has been a great teacher.

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Authors and Affiliations

  1. Department of Cell and Molecular Biology, Feinberg School of Medicine, Northwestern University, 303 East Chicago Avenue, Chicago, IL, 60611, USA

    Arthur Veis PhD

  2. Department of Oral Biology, Institut National de la Santé et de la Recherche Médicale, Université Paris Descartes, 45 Rue des Saints Pères, Paris, 75006, France

    Michel Goldberg DDS, PhD

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  1. Arthur Veis PhD
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Correspondence to Michel Goldberg DDS, PhD .

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Editors and Affiliations

  1. Department of Oral Biology, Institut National de la Santé et de la, Recherche Médicale, Université Paris Descartes, Paris, Paris, France

    Michel Goldberg

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Veis, A., Goldberg, M. (2014). Pulp Extracellular Matrix. In: Goldberg, M. (eds) The Dental Pulp. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-55160-4_3

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  • DOI: https://doi.org/10.1007/978-3-642-55160-4_3

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