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Integrating Oxidative Stress and Hormesis into Research on Senescence and Survival Perspectives

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Book cover Oxidative Stress and Hormesis in Evolutionary Ecology and Physiology

Abstract

Progressive deterioration in performance with age is what we refer to as senescence or ageing. It varies greatly among species, but also among conspecific individuals because of the influence of genetic, environmental and stochastic factors. The recent emergence of long-term field studies has provided widespread evidence that animals in nature do senesce, a finding that has opened new horizons for research on causes and consequences of senescence. Empirical evidence is often supportive of the prediction that long-lived species produce less reactive species, have lower oxidative damage levels and antioxidants and have molecules more resistant to oxidative damage. However, full understanding of mechanisms underlying ageing is still elusive. This chapter reviews briefly the main mechanistic and evolutionary theories of senescence that may be linked to oxidative stress, and discusses comparative studies that tested the link between oxidative status parameters and senescence. The chapter ends with an examination of how mild doses of oxidative stress or other forms of stress experienced during sensitive windows of life may increase longevity through hormetic mechanisms.

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    David Costantini

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Costantini, D. (2014). Integrating Oxidative Stress and Hormesis into Research on Senescence and Survival Perspectives. In: Oxidative Stress and Hormesis in Evolutionary Ecology and Physiology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-54663-1_10

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