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Clinical Applications

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Practical Gas Chromatography

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Abstract

In clinical diagnostics, a wide variety of methods has gained recognition in recent decades to help identify a patient’s health problem and to guide subsequent therapeutic treatments. Today, hundreds of parameters are quantified in central laboratories. Substances with very low molecular weight (e.g., lithium) to those that are heavy (e.g., albumin) are a focus. Beyond these single molecules, even bigger constructs like auto-antibodies or whole cells are investigated in the laboratory. Analytical systems are employed at the clinical bedside (e.g., ‘bloodgases’) and even at home (e.g., blood glucose). Expensive imaging techniques such as nuclear magnetic resonance (NMR) or positron emission tomography (PET) seem to be the latest high-end tools for microscopic and macroscopic diagnosis and are essential in every clinic claiming status as a leading hospital.

What is the position of gas chromatography (GC) in this garden of diagnostic plants? Is it of any worth at all? Do clinicians know anything about this method—its strengths and weaknesses? Or is it quite the opposite—a daily tool in hospital life and used as a matter of course?

Based on a single table and a top-to-bottom strategy, this chapter tries to illuminate the numerous aspects of GC in clinical surroundings. Single items might be represented only by a single literature citation; others are addressed by own chapter. One paragraph is dedicated to an artificial but still human matrix: operational smoke.

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  1. Department of Anesthesiology, University Hospital Regensburg, Franz-Josef-Strauss-Allee 11, 93053, Regensburg, Germany

    Michael A. Gruber

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  1. Institute of Functional Genomics, University of Regensburg, Regensburg, Germany

    Katja Dettmer-Wilde

  2. Institute for Analytical Chemistry, University of Leipzig, Leipzig, Germany

    Werner Engewald

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Gruber, M.A. (2014). Clinical Applications. In: Dettmer-Wilde, K., Engewald, W. (eds) Practical Gas Chromatography. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-54640-2_19

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