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The Analytical Separation of Enantiomers by Gas Chromatography on Chiral Stationary Phases

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Practical Gas Chromatography

Abstract

Enantioselective GC is of widespread use in the enantiomeric analysis of volatile natural products such as pheromones, flavors, fragrances, and essential oils as well as synthetic products obtained from asymmetric syntheses and kinetic resolutions. Whereas enantioseparation of derivatized α-amino acids is performed on chiral stationary phases (CSPs) based on α-amino acid derivatives, alkylated/acylated cyclodextrins are employed as versatile CSPs for a multitude of volatile derivatized and nonderivatized enantiomers. Three main types of CSPs are reviewed and the miniaturization of enantioselective GC, the quantification of enantiomers, and validation issues are described. A list of commercially available fused silica capillary columns coated with various CSPs is compiled.

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    Markus Juza & Volker Schurig

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Juza, M., Schurig, V. (2014). The Analytical Separation of Enantiomers by Gas Chromatography on Chiral Stationary Phases. In: Dettmer-Wilde, K., Engewald, W. (eds) Practical Gas Chromatography. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-54640-2_15

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