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Periphere Peptidhormone, Neuropeptide und Neurotransmitter

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Handbuch Essstörungen und Adipositas

Zusammenfassung

Nach dem bisherigen Erkenntnisstand ist davon auszugehen, dass die meisten bei Essstörungen beschriebenen Veränderungen von appetitregulierenden peripheren Peptidhormonen, Neuropeptiden und Neurotransmittern sekundären physiologischen Anpassungsvorgängen an eine veränderte Nahrungsaufnahme entsprechen (State-Marker). Abhängig von der Art der Essstörung (z. B. Anorexia nervosa versus Bulimia nervosa) sind die Veränderungen häufig in entgegengesetzte Richtungen ausgeprägt. Allerdings weist eine zunehmende Zahl von Studien darauf hin, dass zentrale und periphere Auswirkungen der veränderten Energiezufuhr zur Aufrechterhaltung des pathologischen Essverhaltens beitragen können

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Literatur

  • Ehrlich S, Burghardt R, Schneider N et al (2009) The role of leptin and cortisol in hyperactivity in patients with acute and weight-recovered anorexia nervosa. Prog Neuropsychopharmacol Biol Psychiatry 33(4):658–662

    Article  CAS  PubMed  Google Scholar 

  • Exner C, Hebebrand J, Remschmidt H et al (2000) Leptin suppresses semi-starvation induced hyperactivity in rats: implications for anorexia nervosa. Mol Psychiatry 5(5):476–481

    Article  CAS  PubMed  Google Scholar 

  • Fava M, Copeland PM, Schweiger U, Herzog DB (1989) Neurochemical abnormalities of anorexia nervosa and bulimia nervosa. Am J Psychiatry 146:963–971

    Article  CAS  PubMed  Google Scholar 

  • Glass MJ, Billington CJ, Levine AS (1999) Opioids and food intake: distributed functional neural pathways? Neuropeptides 33:360–368

    Article  CAS  PubMed  Google Scholar 

  • Holtkamp K, Hebebrand J, Mika C et al (2004) High serum leptin levels subsequent to weight gain predict renewed weight loss in patients with anorexia nervosa. Psychoneuroendocrinology 29(6):791–797

    Article  CAS  PubMed  Google Scholar 

  • Holtkamp K, Herpertz-Dahlmann B et al (2006) Physical activity and restlessness correlate with leptin levels in patients with adolescent anorexia nervosa. Biol Psychiatry 1;60(3):311–313

    Article  CAS  PubMed  Google Scholar 

  • Kaye W (2008) Neurobiology of anorexia and bulimia nervosa. Physiol Behav 94:121–135

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Merle JV, Haas V, Burghardt R et al (2011). Agouti-related protein in patients with acute and weight-restored anorexia nervosa. Psychol Med 41(10):2183–2192

    Article  CAS  PubMed  Google Scholar 

  • Misra M, Miller KK, Tsai P (2006) Elevated peptide YY levels in adolescent girls with anorexia nervosa. J Clin Endocrinol Metab 91(3):1027–1033

    Article  CAS  PubMed  Google Scholar 

  • Monteleone P, Martiadis V, Rigamonti AE et al (2005) Investigation of peptide YY and ghrelin responses to a test meal in bulimia nervosa. Biol Psychiatry 57(8):926–931

    Article  CAS  PubMed  Google Scholar 

  • Monteleone P, Maj M (2013) Dysfunctions of leptin, ghrelin, BDNF and endocannabinoids in eating disorders: Beyond the homeostatic control of food intake. Psychoneuroendocrinology 38:312–330

    Article  CAS  PubMed  Google Scholar 

  • Otto B, Tschop M, Fruhauf E et al (2005) Postprandial ghrelin release in anorectic patients before and after weight gain. Psychoneuroendocrinology 30(6):577–581

    Article  CAS  PubMed  Google Scholar 

  • Smitka K, Papezova H, Vondra K et al (2013) The role of „mixed“ orexigenic and anorexigenic signals and autoantibodies reacting with appetite-regulating neuropeptides and peptides of the adipose tissue-gut-brain axis: relevance to food intake and nutritional status in patients with anorexia nervosa and bulimia nervosa. Int J Endocrinology (im Druck). doi: 10.1155/2013/483145

    Google Scholar 

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Correspondence to Stefan Ehrlich .

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Ehrlich, S., Holtkamp, K. (2015). Periphere Peptidhormone, Neuropeptide und Neurotransmitter. In: Herpertz, S., Zwaan, M., Zipfel, S. (eds) Handbuch Essstörungen und Adipositas. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-54573-3_23

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  • DOI: https://doi.org/10.1007/978-3-642-54573-3_23

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