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Temsirolimus

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Small Molecules in Oncology

Part of the book series: Recent Results in Cancer Research ((RECENTCANCER,volume 201))

Abstract

Temsirolimus, an ester of sirolimus (rapamycin), selectively inhibits the kinase mammalian target of rapamycin (mTOR) and consequently blocks the translation of cell cycle regulatory proteins and prevents overexpression of angiogenic growth factors. It has been found to have antitumour activity in patients with relapsed or refractory mantle cell lymphoma (MCL). In addition, patients with advanced renal cell carcinoma (RCC) and a poor prognosis who received a once-weekly intravenous (IV) infusion of temsirolimus 25 mg experienced significant survival benefits compared with patients receiving standard interferon-α (IFN-α) therapy in a large phase III clinical study. In this study, median overall survival was 10.9 versus 7.3 months and objective response rates were 8.6 % in temsirolimus recipients versus 4.8 % IFN-α recipient group. Temsirolimus monotherapy recipients experienced significantly fewer grade 3 or 4 adverse events and had fewer withdrawals for adverse events than patients receiving IFN-α. The role of temsirolimus in sequential and combination therapy is yet to be found.

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Authors and Affiliations

  1. Department of Urology SLK-Klinikum Heilbronn, Teaching Hospital of the University of Heidelberg, Am Gesundbrunnen 20, 74074, Heidelberg, Germany

    Michael Schulze & Jens J. Rassweiler

  2. Department of Urology, St. Vincentius Hospital, Speyer, Germany

    Christian Stock

  3. Department of Urology “U. Bracci”, Policlinico Umberto I, University of Rome “La Sapienza”, Rome, Italy

    Massimo Zaccagnini

  4. Department of Urology, University of Heidelberg, Heidelberg, Germany

    Dogu Teber

Authors
  1. Michael Schulze
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  2. Christian Stock
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  3. Massimo Zaccagnini
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  4. Dogu Teber
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  5. Jens J. Rassweiler
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Corresponding author

Correspondence to Jens J. Rassweiler .

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Editors and Affiliations

  1. Cancer Center Heilbronn-Franken, SLK-Kliniken Heilbronn GmbH Medizinische Klinik III, Heilbronn, Germany

    Uwe M. Martens

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Schulze, M., Stock, C., Zaccagnini, M., Teber, D., Rassweiler, J.J. (2014). Temsirolimus. In: Martens, U. (eds) Small Molecules in Oncology. Recent Results in Cancer Research, vol 201. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-54490-3_24

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  • DOI: https://doi.org/10.1007/978-3-642-54490-3_24

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  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-54489-7

  • Online ISBN: 978-3-642-54490-3

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