Skip to main content

Pharmaceuticals

  • Chapter
  • First Online:

Abstract

A boy who is born in Germany today has a probable life expectancy of around 77 years, and a girl one of 82 years – twice as long as in the year 1880. This increase is a consequence of both, better living circumstances – working conditions, food, clothing, housing –, and also a result of more comprehensive medical care. Thus, a whole range of infectious diseases has been wiped out, or brought at least under control, and the mortality rate for civilisation- and age-related diseases has dropped. Vaccinations and drugs play a key role in this outcome. The 20th century is characterised especially by the worldwide blossoming of the pharmaceutical industry. More and more, the targeted search for and development of new drugs have replaced serendipitous discoveries.

This is a preview of subscription content, log in via an institution.

Buying options

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   119.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   159.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD   159.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

References : References to Introduction

  1. J. Davis, Scrip Magazine , Jan. 2000, 37

    Google Scholar 

  2. H. J. Quadbeck-Seger, R. Faust, G. Knaus, A. Maelicke, U. Simeling, Chemierekorde, Wiley-VCH, Weinheim, 2nd Edn., 1999, 1.

    Google Scholar 

References to 5.1 ACE Inhibitors

  1. S . H. Ferreira, D . C. Bartelt, L . J. Greene, Biochemistry 9 (1970) 2583; S. Müller, I. Paegelow, S. Reismann, Signal Transduction 6 (2006) 5.

  2. H. Remane, Y. Remane, Pharm. Unserer Zeit 39 (2010) 340; C. Roegler, J. Lehmann, Pharm. Unserer Zeit 39 (2010) 351.

    Google Scholar 

  3. P. Dominiak, Pharm. Unserer Zeit 32 (2003) 24.

    Google Scholar 

  4. D. Voet, J. G. Voet, Biochemie, VCH, Weinheim, 1992, 138.

    Google Scholar 

  5. M. A. Ondetti, N. J. Wiliams, E. F. Sabo, J. Pluscec, E. R. Weaver, O. Kocy, Biochemistry 19 (1971) 4033; D. W. Cushman, M. A. Ondetti, Hypertension 17 (1991) 589.

    Google Scholar 

  6. M. L. Nunes-Mamede, F. G. De Mello, A. R. Martins, J. Neuroscience Methods , 31 (1990) 7.

    Google Scholar 

  7. www.laskerfoundation.org/awards/library/1999remarksgsclin2.shtml.

  8. L. D. Byers, R. Wolfenden, Biochemistry 12 (1973) 2070.

    Google Scholar 

  9. H. Kubinyi, Wirkstoffdesign, Graduiertenkolleg University Heidelberg, Feb. 1999.

    Google Scholar 

  10. R. R. Chirumamilla, R. Marchant, P. Nigam, J. Chem. Technol. Biotechnol. 76 (2001) 123.

    Google Scholar 

  11. A. Kleemann, J. Engel, Pharmaceutical Substances, 3rd Edn., Thieme, Stuttgart, 1999, 310.

    Google Scholar 

  12. M. J. Wyvatt, A. A. Patchett, Med. Res. Rev. 5 (1985) 483.

    Google Scholar 

  13. C. Chevillard, S. Jouquey, F. Bree, M.-N. Mathieu, J. P. Stepniewski, J. P. Tillement, G. Hamon, P. Corvol, J. Cardiovascular Pharm. 23rd Suppl. 4 (1994) S11.

    Google Scholar 

  14. F. Brion, C. Marie, P. Mackiewicz, J. M. Roul, J. Buendia, Tetrahedron Lett. 33 (1992) 4889.

    Google Scholar 

  15. H. G. Eckert, M. J. Badian, D. Gantz, H.-M. Kellner, M. Volz, Arzneim.-Forsch./ Drug Res. 34 (1984) 1435.

    Google Scholar 

  16. R. Natesh, S. L. U. Schwager, E. D. Sturrock, K. R. Acharya, Nature 421 (2003) 551.

    Google Scholar 

  17. R. Natesh, S. L. U. Schwager, H. R. Evans, E. D. Sturrock, K. R. Acharya, Biochemistry 43 (2004) 8718.

    Google Scholar 

  18. http://en.wikipedia.org/wiki/Discovery_and_development_of_angiotensin_receptor_Blockers.

  19. http://en.wikipedia.org/wiki/Renin_inhibitor.

  20. http://en.wikipedia.org/wiki/Pepstatin.

  21. G. Klebe, Wirkstoffdesign, 2nd Edn., Spektrum Verlag, Heidelberg, 2009, 384.

    Google Scholar 

  22. http://en.wikipedia.org/wiki/Aliskiren.

References to 5.2 β-Lactam Antibiotics

  1. G. Greene, The Third Man , Heinemann, London, 1950; reprinted Vintage Books, London, 2001; extracts from Chapter 10, pp. 63–64.

    Google Scholar 

  2. J. Nosek, R. Radzio, U. Kück, Chemie in unserer Zeit 31 (1997) 172.

    Google Scholar 

  3. D. Voet, J. G. Voet, Biochemie, VCH, Weinheim, 1994, 6.

    Google Scholar 

  4. D. Voet, J. G. Voet, Biochemie, VCH, Weinheim, 1994, 258.

    Google Scholar 

  5. E. Mutschler, Arzneimittelwirkungen, Wissenschaftliche Verlagsgesellschaft mbH, Stuttgart, 1991, 577.

    Google Scholar 

  6. C. Friedrich, Pharmazie in unserer Zeit , 35 (2009) 392; Kirk-Othmer, Encyclopedia of Chemical Technology, Wiley, New York, 4th Edn., Vol. 2 (Antibiotics), 893; http://en.wikipedia.org/wiki/Ernest_Duchesne.

  7. H. Remane, K. Begitt, Nachrichten aus der Chemie 51 (2003) 1180.

    Google Scholar 

  8. A. Fleming, Brit. J. Exp. Pathol. 10 (1929) 226.

    Google Scholar 

  9. D. Crawfoot Hodgkin, C. Bunn, B. Rogers-Low, A. Turner-Jones, Chemistry of Penicillin , Princeton University Press, Princeton, NJ, 1949; K. C. Nicolaou, E. J. Sorensen, Classics in Total Synthesis, VCH, Weinheim, 1996, 41.

    Google Scholar 

  10. http://veprints.unica.it/148/1/orru-poster_OnlinePDF.pdf.

  11. D. Crawfoot Hodgkin, E. N. Maslen, Biochem. J. 79 (1961) 393.

    Google Scholar 

  12. R. B. Woodward, Science 153 (1966) 487; R. B. Woodward, Angew. Chem. 78 (1966) 557. R. B. Woodward, K. Heusler, J. Gosteli, P. Naegeli, W. Oppolzer, R. Ramage, S. Ranganathan, H. Vorbrüggen, J. Am. Chem. Soc. 88 (1966) 852.

    Google Scholar 

  13. J. Weil, J. Miramonti, M. R. Ladisch, Enzyme Microbial Techn. 17 (1995) 85.

    Google Scholar 

  14. P. L. Roach, I. J. Clifton, C. M. H. Hensgens, N. Shibata, C. J. Schofield, J. Hajdu, J. E. Baldwin, Nature 387 (1997) 827.

    Google Scholar 

  15. W. A. Schenk, Angew. Chem. Internat. Edn. 39 (2000) 3409.

    Google Scholar 

  16. N. I. Burzlaff, P. J. Rutledge, I. J. Clifton, C. M. H. Hensgens, M. Pickford, R. M. Adlington, P. L. Roach, J. E. Baldwin, Nature 401 (1999) 721.

    Google Scholar 

  17. J. E. Baldwin, K.-C. Goh, M. E. Wood, C. J. Schofield, R. D. G. Cooper, G. W. Huffman, Bioorg. Med. Chem. Lett. 1 (1991) 421.

    Google Scholar 

  18. J. E. Baldwin, E. Abraham, Nat. Prod. Rep. 5 (1988) 129.

    Google Scholar 

  19. T. Fekner, J. E. Baldwin, R. M. Adlington, T. W. Jones, C. K. Prout, C. J. Schofield, Tetrahedron 56 (2000) 6053.

    Google Scholar 

  20. S. Kukolja, J. Am. Chem. Soc. 93 (1971) 6267.

    Google Scholar 

  21. S. Kukolja, J. Am. Chem. Soc. 93 (1971) 6269.

    Google Scholar 

  22. R. B. Morin, B. G. Jackson, R. A. Mueller, E. R. Lavagnino, W. B. Scanlon, S. L. Andrews, J. Am. Chem. Soc. 85 (1963) 1896.

    Google Scholar 

  23. R. B. Morin, B. G. Jackson, R. A. Mueller, E. R. Lavagnino, W. B. Scanlon, S. L. Andrews, J. Am. Chem. Soc. 91 (1969) 1401.

    Google Scholar 

  24. M. A. Wegman, M. H. A. Janssen, F. van Rantwijk, R. A. Sheldon, Adv. Synth. Catal. 343 (2001) 559.

    Google Scholar 

  25. Ullmann’s Encyclopedia of Industrial Chemistry, 5thEdn., Vol. B8, 302.

    Google Scholar 

  26. L. Cao, F. van Rantwijk, R. A. Sheldon, Org.Lett. 2 (2000) 1361; R. A. Sheldon, Adv. Synth. Catal. 349 (2007) 1289.

    Google Scholar 

  27. K. C. Nicolaou, E. J. Sorensen, Classics in Total Synthesis, VCH, Weinheim, 1996, 249.

    Google Scholar 

  28. M. Sunagawa, A. Sasaki, Heterocycles 54 (2001) 497.

    Google Scholar 

  29. I. Kawamoto, Drugs Fut. 23 (1998) 181.

    Google Scholar 

  30. K. C. Nicolaou, E. J. Sorensen, Classics in Total Synthesis, VCH, Weinheim, 1996, 343.

    Google Scholar 

  31. H. Nozaki, S. Moriuta, H. Takaya, R. Noyori, Tetrahedron Lett. 1966 , 5239; H. Nozaki,H. Takaya, S. Moriuta, R. Noyori, Tetrahedron 24 (1968) 3655.

    Google Scholar 

  32. G. Sedelmeier in H. Waldmann, Organic Synthesis Highlights II, VCH, Weinheim, 1995, 277; and references cited therein.

    Google Scholar 

  33. P. J. Reider, E. J. J. Grabowski, Tetrahedron Lett. 23 (1982) 2293.

    Google Scholar 

  34. T. N. Salzmann, R. W. Ratcliffe, B. G. Christensen, F. A. Bouffard, J. Am. Chem. Soc. 102 (1980) 6161.

    Google Scholar 

  35. F. A. Bouffard, T. N. Salzmann, Tetrahedron Lett. 26 (1985) 6285; T. Kametani, S.-C. Chu, T. Honda, J. Chem. Soc. Perkin Trans. 1 (1988) 1593.

    Google Scholar 

  36. J. Prous, J. Castaner, Drugs Fut. 13 (1988) 534.

    Google Scholar 

  37. X. Lu, Z. Xu, G. Yang, R. Fan, Org. Proc. Res. Dev. 5 (2001) 186.

    Google Scholar 

  38. M. Sunagawa, H. Matsumura, T. Inoue, M. Fukasawa, M. Kato, J. Antibiot. 43 (1990) 519.

    Google Scholar 

  39. U. Holzgrabe, Pharmazie in unserer Zeit 35 (2006) 410; M. S. Butler, M. A. Cooper, J. Antibiotics 64 (2011) 413.

    Google Scholar 

  40. L. P. Kotra, D. Golemi, S. Vakulenko, S. Mobashery, Chem. Ind. (London) , 2000 , 341.

    Google Scholar 

  41. C. Walsh, Nature 406 (2000) 775.

    Google Scholar 

  42. D. Voet, J. G. Voet, Biochemie, VCH, Weinheim, 1994, 256.

    Google Scholar 

  43. W. Dürckheimer, J. Blumbach, R. Lattrell, K. H. Scheunemann, Angew. Chem.Internat. Edn. 24 (1985) 180.

    Google Scholar 

References to 5.3 Opiates

  1. S. Shaik, Angew. Chem. Internat. Edn. 42 (2003) 3208 (Endorphins and love).

    Google Scholar 

  2. M. Seefelder, Opium – Eine Kulturgeschichte, Athenäum, Frankfurt, 1987.

    Google Scholar 

  3. E. Pallenbach, Pharmazie in unserer Zeit 31 (2002) 90; http://www.drogenbeauftragte.de/fileadmin/dateiendba/Presse/Downloads/Rauschgifttote_52_Geschlecht_110324_Drogenbeauftragte_OnlinePDF.pdf; http://en.wikipedia.org/wiki/ Papaver_somniferum.

  4. F. I. Carroll, L. L. Howell, M. J. Kuhar, J. Med. Chem. 42 (1999) 2721; http://www.drugabuse.gov/publications/drugfacts/nationwide-trends.

  5. R. J. Bryant, Chem. Ind.(London) (1988) 146.

    Google Scholar 

  6. E. Mutschler, Arzneimittelwirkung, Wissenschaftliche Verlagsgesellschaft, Stuttgart, 1991, 161.

    Google Scholar 

  7. F.-J. Kuhlen, Pharmazie in unserer Zeit 31 (2002) 13 (Historical, on the theme of pain).

    Google Scholar 

  8. E. Friedrichs, W. Straßburger, Pharmazie in unserer Zeit 31 (2002) 32.

    Google Scholar 

  9. M. Eguchi, Med. Res. Rev. 24 (2004) 182.

    Google Scholar 

  10. W. Straßburger, E. Friedrichs, Pharmazie in unserer Zeit 31 (2002) 52.

    Google Scholar 

  11. W. G. Donner, Pharmazie in unserer Zeit 15 (1986) 33.

    Google Scholar 

  12. M. Hesse, Alkaloide–Fluch oder Segen der Natur?, Wiley-VCH, Weinheim, 2000, 344.

    Google Scholar 

  13. 2011 International Narcotics Control Strategy Report: UN World Drug Report; http://www.incb.org/pdf/technical-reports/narcotic-drugs/2011/Nar_Repor_2011_English/Part_FOUR_Comments_NAR-Report-2011_English_OnlinePDF.pdf; 2012 International Narcotics Control Strategy Report: UN World Drug Report; http://www.unodc.org/documents/data-and-analysis/WDR2012/WDR_2012_web_small_OnlinePDF.pdf; http://www.unodc.org/unodc/secured/wdr/wdr2013/World_Drug_Report_2013_OnlinePDF.pdf.

  14. J. Frackenpohl, Chemie in unserer Zeit 34 (2000) 99; D. H. R. Barton, A. M. Deflorin, O. E. Edwards, Chem. Ind. (1955) 1039.

    Google Scholar 

  15. International Narcotics Control Board, 2012; http://www.nacada.go.ke/drugs/heroin/; CD Römpp Chemie Lexikon, Thieme, Stuttgart, 1995.

  16. M. Hesse, Alkaloide–Fluch oder Segen der Natur?, Wiley-VCH, Weinheim, 2000, 275; J. M. Finefield, D. H. Sherman, M. Kreitman, R. M. Williams, Angew. Chem. 124 (2012) 4886.

    Google Scholar 

  17. G. Bringmann, Naturwissenschaften 66 (1979) 22.

    Google Scholar 

  18. A. G. Millgate, B. J. Pogson, I. W. Wilson, T. M. Kutchan, M. H. Zenk, W. L. Gerlach, A. J. Fist, P. J. Larkin, Nature 431 (2004) 413.

    Google Scholar 

  19. K. Oka, J. D. Kantrowitz, S. Spector, Proc. Natl. Acad. Sci. USA 82 (1985) 1852.

    Google Scholar 

  20. T. Amann, M. H. Zenk, Deut. Apotheker Zeit. 136 (1996) 519.

    Google Scholar 

  21. C. Poeaknapo, J. Schmidt, M. Brandsch, B. Dräger, M. H. Zenk, PNAS 1 01 (2004) 14091.

    Google Scholar 

  22. M. Booth, Opium, A History, St. Martin’s Griffin, New York, 1996.

    Google Scholar 

  23. http://en.wikipedia.org/wiki/MacFarlan_Smith; C. Schuster, Die BASF 21 (1971) 47.

  24. 100 Jahre Chemisch-Wissenschaftliches Laboratorium der Bayer AG, Firmenschrift, 1996, 28.

    Google Scholar 

  25. J. M. Gulland, R. Robinson, Mem. Proc. Manch. Lit. Soc. 69 (1925) 79.

    Google Scholar 

  26. M. Gates, G. Tschudi, J. Am. Chem. Soc. 74 (1952) 1109.

    Google Scholar 

  27. M. Gates, G. Tschudi, J. Am. Chem. Soc. 78 (1956) 1380.

    Google Scholar 

  28. M. Maier, H. Waldmann (Ed.), Organic Synthesis Highlights II, VCH, Weinheim, 1995, 357 (Review of non-enantioselective morphine syntheses).

    Google Scholar 

  29. C. Y. Hong, N. Kado, L. E. Overman, J. Am. Chem. Soc. 115 (1993) 11028.

    Google Scholar 

  30. J. Mulzer, G. Dürner, D. Trauner, Angew. Chem. Internat. Edn. 35 (1996) 2832; D. Trauner, S. Porth, T. Opatz, J. W. Bats, G. Giester, J. Mulzer, Synthesis (1998) 653.

    Google Scholar 

  31. J. D. White, P. Hrnciar, F. Stappenbeck, J. Org. Chem. 62 (1997) 5250.

    Google Scholar 

  32. D. F. Taber, T. D. Neubert, A. L. Rheingold, J. Am. Chem. Soc. 124 (2002) 12416.

    Google Scholar 

  33. B. M. Trost, W. Tang, J. Am. Chem. Soc. 124 (2002) 14542.

    Google Scholar 

  34. Review: J. Zezula, T. Hudlicky, Synlett (2005) 388; K. Uchida, S. Yokoshima, T. Kan, T. Fukuyama, Heterocycles 77 (2009) 1219, and references cited therein.

    Google Scholar 

  35. H. L. Goering, S. S. Kantner, C. C. Tseng, J. Org. Chem. 48 (1983) 715.

    Google Scholar 

  36. I. Iijima, J. Minamikawa, A. E. Jacobson, A. Brossi, K. C. Rice, J. Org. Chem. 43 (1978) 1462.

    Google Scholar 

  37. Ullmann’s Encyclopedia of Industrial Chemistry, 6thEdn., Wiley-VCH, Weinheim, 2000, Electronic Release.

    Google Scholar 

  38. C. H. Boehringer, DE 247180 (1909).

    Google Scholar 

  39. G. Geißlinger, Deut. Apotheker Zeit. 143 (2003) 62.

    Google Scholar 

  40. Review of N -demethylation: S. Thavaneswaran, K. McCamley, P. J. Scammells, Nat. Prod. Commun. 1 (2006) 885; G. B. Kok, P. J. Scammells, Bioorg. Med. Chem. Lett. 20 (2010) 4499.

    Google Scholar 

  41. A. Kleemann, J. Engel, Pharmaceutical Substances, Thieme, Stuttgart, 1999, 1294.

    Google Scholar 

  42. O. Schnider, J. Hellerbach, Helv. Chim. Acta 33 (1950) 1437; O. Schnider, A. Grüssner, Helv. Chim. Acta 34 (1951) 2211; V. J. Harding, W. N. Haworth, W. H. Perkin jun., J. Chem. Soc. 93 (1908) 1944.

    Google Scholar 

  43. H. Buschmann, B. Sundermann, C. Maul, Pharmazie in unserer Zeit 31 (2002) 44.

    Google Scholar 

  44. P. K. Gupta, K. Ganesan, A. Pande, R. C. Malhotra, J. Chem. Res. (2005) 452.

    Google Scholar 

  45. G. Satzinger, W. Herrmann, DE 1923619 (1969); G. Satzinger, W. Herrmann, DE 1923620 (1969); K.-O. Vollmer, F. W. Koss, B. Liedtke, G. Heinzel, Arzneimittelforsch. 20 (1970) 990; GB 1226318 (1969); H. Schinz, M. Hinder, Helv. Chim. Acta 39 (1947) 1349; C. W. Jefford, A. Zaslona, Tetrahedron Lett. 26 (1985) 6035; G. M. Ksander, J. E. McMurry, M. Johnson, J. Org. Chem. 42 (1977) 1180; G. Fogliato, G. Fronza, C. Fuganti, P. Grasselli, S. Servi, J. Org. Chem. 60 (1995) 5693; D. B. G. Williams, M. L. Shaw, T. Hughes, Organometallics 30 (2011) 4968.

    Google Scholar 

  46. L. E. Overman, C. B. Petty, R. J. Doedens, J. Org. Chem. 44 (1979) 4183.

    Google Scholar 

  47. G. R. Evans, P. D. Fernández, J. A. Henshilwood, S. Lloyd, C. Nicklin, Org. Proc. Res. Dev. 6 (2002) 729.

    Google Scholar 

  48. RWTH, Arbeits- und Ergebnisbericht, Transferbereich 11, Stereoselektive Synthese (2001).

    Google Scholar 

  49. A. Boumendjel, G. Sotoing Taiwe, E. Ngo Bum, T. Chabrol, C.l Beney, V. Sinniger, R. Haudecoeur, L. Marcourt, S. Challal, E. Ferreira Queiroz, F. Souard, M. Le Borgne, T. Lomberget, A. Depaulis, C. Lavaud, R. Robins, J.-L. Wolfender, B. Bonaz, M. De Waard, Angew. Chem. 125 (2013) 11996; S. Kusari, S. J. N. Tatsimo, S. Zühlke, F. M. Talontsi, S. F. Kouam, M. Spiteller, Angew. Chem. 126 (2014) 12269.

    Google Scholar 

  50. R. F. Schmidt, Pharmazie in unserer Zeit 31 (2002) 23.

    Google Scholar 

  51. G. Seitz, Pharm. Z. 137 (1992) 87.

    Google Scholar 

References to 5.4 Tetrahydrocannabinol

  1. Bibliographisches Institut & F. A. Brockhaus AG, 2001, Electronic Release, Hanf; E. B. Russo, Chem. Biodivers. 4 (2007) 1614; L. O. Hanus, Med. Res. Rev. 29 (2009) 213.

    Google Scholar 

  2. http://en.wikipedia.org/wiki/Club_des_Hashischins; www.hanf-cannabis-sativa.org/geschichte-kultur.htm.

  3. http://www.unodc.org/documents/data-and-analysis/WDR2012/WDR_2012_web_small_OnlinePDF.pdf; http://www.incb.org/documents/Narcotic-Drugs/Technical-Publications/2012/Narcotic_Drugs_Report_2012_OnlinePDF.pdf.

  4. C. Giroud, Chimia 56 (2002) 80.

    Google Scholar 

  5. E. M. Williamson, F. J. Evans, Drugs 60 (2000) 1303.

    Google Scholar 

  6. Römpp, Electronic Release, Thieme, 2004, Tetrahydrocannabinols.

    Google Scholar 

  7. P. Nuhn, Naturstoffchemie, S. Hirzel Verlag, Stuttgart, Leipzig, 1997, 616.

    Google Scholar 

  8. Y. Gaoni, R. Mechoulam, J. Am. Chem. Soc. 86 (1964) 1646.

    Google Scholar 

  9. R. Mechoulam, S. Ben-Shabat, Nat. Prod. Rep. 16 (1999) 131.

    Google Scholar 

  10. M. Fellermeier, M. H. Zenk, FEBS Letters 427 (1998) 283.

    Google Scholar 

  11. F. Taura, S. Morimoto, Y. Shoyama, J. Am. Chem. Soc. 117 (1995) 9766, F. Taura, S. Sirikantaramas, Y. Shoyama, Y. Shoyama, S. Morimoto, Chem. Biodivers. 4 (2007) 1649.

    Google Scholar 

  12. D. M. Lambert, C. J. Fowler, J. Med. Chem. 48 (2005) 5059.

    Google Scholar 

  13. E. di Tomaso, M. Beltramo, D. Piomelli, Nature , 382 (1996) 677.

    Google Scholar 

  14. J. W. Huffman, J. R. A. Miller, J. Liddle, S. Yu, B. F. Thomas, J. L. Wiley, B. R. Martin, Bioorg. Med. Chem. 11 (2003) 1397; further structure-activity relationships: E. Stern, D. M. Lambert, Chem. Biodivers. 4 (2007) 1707.

    Google Scholar 

  15. S. Kreutz, Pharmazie in unserer Zeit 36 (2007) 389; B. Costa, Chem. Biodivers. 4 (2007) 1664.

    Google Scholar 

  16. R. K. Razdan, The Total Synthesis of Natural Products, Vol. 4, J. ApSimon, Ed., Wiley, New York, 1981, 185 (Review).

    Google Scholar 

  17. A. Focella, S. Teitel, A. Brossi, J. Org. Chem. 42 (1977) 3456.

    Google Scholar 

  18. R. Mechoulam, P. Braun, Y. Gaoni, J. Am. Chem. Soc. 89 (1967) 4552.

    Google Scholar 

  19. R. K. Razdan, G. R. Handrick, H. C. Dalzell, Experientia 31 (1975) 16.

    Google Scholar 

  20. Dronabinol, BIC 3000, Becker Associates 1999–2004, 24/11/2004.

    Google Scholar 

  21. L. Crombie, W. M. L. Crombie, S. V. Jamieson, C. J. Palmer, J. Chem. Soc., Perkin. Trans. 1 1988 , 1243.

    Google Scholar 

  22. P. Stoss, P. Merrath, Synlett 1991 , 553.

    Google Scholar 

  23. Johnson Matthey: WO02/096846 (2001).

    Google Scholar 

  24. Johnson Matthey: WO02/096899 (2001).

    Google Scholar 

  25. D. A. Evans, E. A. Shaughnessy, D. M. Barnes, Tetrahedron Lett. 38 (1997) 3193.

    Google Scholar 

  26. R. A. Archer, DE 2451936 (1973).

    Google Scholar 

  27. S. J. Dominianni, C. W. Ryan, C. W. DeArmitt, J. Org. Chem. 42 (1977) 344.

    Google Scholar 

  28. R. A. Archer, W. B. Blanchard, W. A. Day, D. W. Johnson, E. R. Lavagnino, C. W. Ryan, J. E. Baldwin, J. Org. Chem. 42 (1977) 2277.

    Google Scholar 

  29. C. F. Carvalho, M. V. Sargent, J. Chem. Soc., Chem. Commun. (1984) 227.

    Google Scholar 

References to 5.5 Nonsteroidal Anti-Inflammatory Drugs

  1. W. Eisenreich, A. Handel, U. E. Zimmer, Tier- und Pflanzenführer, BLV, München, 14th Edn., 1997, 104.

    Google Scholar 

  2. K. Dombrowski, A. W. Alfermann, Pharmazie in unserer Zeit 22 (1993) 275.

    Google Scholar 

  3. http://www.zm-online.de.

  4. Bibliographisches Institut & F. A. Brockhaus AG, Electronic Release, 2001, Aspirin.

    Google Scholar 

  5. N. Kuhnert, Chemie in unserer Zeit , 33 (1999) 213.

    Google Scholar 

  6. Bayer AG, 100 Jahre Chemisch-Wissenschaftliches Laboratorium der Bayer AG in Wuppertal-Elberfeld, 1996, 28.

    Google Scholar 

  7. H. Henderson, Science 286 (1999) 1090.

    Google Scholar 

  8. A. Eichengrün, Die Pharmazie 4 (1949) 582.

    Google Scholar 

  9. W. Sneader, Brit. Med. J. 321 (2000) 1591.

    Google Scholar 

  10. J. R. Vane, Nat. New. Biol. 25 (1971) 232; P. J. Loll, D. Picot, M. Garavito, Nat. Struct. Biol . 2 (1995) 637; R. S. Sidhu, J. Y. Lee, C. Yuan, W. L. Smith, Biochem. 49 (2010) 7069.

    Google Scholar 

  11. D. L. Simmons, R. M. Botting, T. Hla, Pharm. Rev. 56 (2004) 387; R. M. Garavito, A. M. Mulichak, Annu. Rev. Biophys. Biomol. Struct. 32 (2003) 183.

    Google Scholar 

  12. E. Mutschler, Arzneimittelwirkungen, Wissenschaftliche Verlagsgesellschaft mbH, Stuttgart, 6th Edn., 1991, 177.

    Google Scholar 

  13. D. L. Simmons, W. Xie, J. G. Chipman, G. E. Evett, Plenum Press, New York, 1991, 67.

    Google Scholar 

  14. W. Xie, Proc. Nat. Acad. Sci. USA 88 (1991) 2692.

    Google Scholar 

  15. E. A. Meade, W. L. Smith, D. L. DeWitt, J. Biol. Chem. 268 (1993) 6610.

    Google Scholar 

  16. K. N. Allen, Nature Medicine 1 (1995) 882.

    Google Scholar 

  17. K. Schrör, Pharmazie in unserer Zeit 38 (2009) 306.

    Google Scholar 

  18. F. Zhang, N. K. Altorki, J. R. Mestre, K. Subbaramaiah, A. J. Dannenberg, Carcinogenesis 20 (1999) 445.

    Google Scholar 

  19. A. Goel, C. R. Boland, D. P. Chauhan, Cancer Lett. 172 (2001) 111; T. Esatbeyoglu, P. Huebbe, I. M. A. Ernst, D. Chin, A. E. Wagner, G. Rimbach, Angew. Chem. Int. Ed. 51 (2012) 5308.

    Google Scholar 

  20. http://en.wikipedia.org/wiki/Tripterygium_wilfordii.

  21. Y. Gong, B. Xue, J. Jiao, L. Jing, X. Wang, J. Neurochem. 107 (2008) 779.

    Google Scholar 

  22. R. Ariza-Ariza, M. Mestanza-Peralta, M. H. Cardiel, Semin. Arthritis Rheum. 27 (1998) 366.

    Google Scholar 

  23. C. L. Curtis, C. E. Hughes, C. R. Flannery, C. B. Little, J. L. Harwood, B. Caterson, J. Biol. Chem. 275 (2000) 721.

    Google Scholar 

  24. A. Almada, “Natural COX-2 Inhibitors: The Future of Pain Relief” in http://www.chiro.org/nutrition/FULL/Natural_COX-2_Inhibitors.shtml.

  25. H. N. Morse, Ber. Dtsch. Chem. Ges. 11 (1878) 232.

    Google Scholar 

  26. Wikipedia: Paracetamol.

    Google Scholar 

  27. G. Benz, R. Hahn, C. Reinhardt, 100 Jahre Chemisch Wissenschaftliches Laboratorium der Bayer AG in Wuppertal-Elberfeld, Bayer, 1997, p. 22; G. G. Graham, M. J. Davies, R. O. Day, A. Mohamudally, K. F. Scott , Inflammopharmacology 21 (2013) 201.

  28. R. J, Flower, J. R. Vane, Nature 240 (1972) 410.

    Google Scholar 

  29. G. G. Graham, K. F. Scott, Am. J. Ther. 12 (2005) 46.

    Google Scholar 

  30. B. Kis, J. A. Snipes, S. A. Simandle, D. W. Busija, Am. J. Physiol. Regul. Integr. Comp. Physiol. 288 (2005) R897.

    Google Scholar 

  31. K. Brune, T. Egger, Pharmazie in unserer Zeit 31 (2002) 133.

    Google Scholar 

  32. W. Langenbeck, W. Pritzkow, Lehrbuch der Organischen Chemie, Verlag Theodor Steinkopff, Dresden, 21st Edn., 1969, 187.

    Google Scholar 

  33. Wikipedia: Ibuprofen; S. S. Adams, J. Clin. Pharmacol. 32 (1992) 317; http://www.telegraph.co.uk/health/3351540/Dr-Stewart-Adams-I-tested-ibuprofen-on-my-hangover.html.

  34. V. Lambert, Dr. Stewart Adams: “I tested ibuprofen on my hangover“, The Telegraph Magazine, 8.10.2007.

    Google Scholar 

  35. R. M. Garavito, in A. Messerschmidt, R. Huber, T. Poulos, K. Wieghardt, Wiley, Chichester, 2001, 245.

    Google Scholar 

  36. H. Ulbrich, G. Dannhardt, Pharmazie in unserer Zeit 31 (2002) 146.

    Google Scholar 

  37. Wikipedia: Diclofenac.

    Google Scholar 

  38. G. Dannhardt, L. Hahn, Phamazie in unserer Zeit 29 (2000) 100.

    Google Scholar 

  39. R. G. Kurumbail, A. M. Stevens, J. K. Gierse, J. J. McDonald, R. A. Stegeman, J. Y. Pak, D. Gildehaus, J. M. Miyashiro, T. D. Penning, K. Seibert, P. C. Isakson, W. C. Stallings, Nature 384 (1996) 644.

    Google Scholar 

  40. K. Antoniou, M. Malamas, A. A. Drosos, Expert Opin. Pharmacother. 8 (2007) 1719.

    Google Scholar 

  41. S. Laufer, Pharmazie in unserer Zeit 31 (2002) 164.

    Google Scholar 

  42. S. Chaiamnuay, J. J. Allison, J. R. Curtis, Am. J. Health Syst. Pharm. 63 (2006) 1837; D. H. Solomon, Arthritis & Rheumatism 52 (2005) 1968; G. A. FitzGerald, C. Patrono, N. Engl. J. Med. 345 (2001) 433.

    Google Scholar 

  43. RSC: “Ibuprofen – A Case Study in Green Chemistry” in http://www.rsc.org/Education/Teachers/Resources/green/ibuprofen/ibuprofen_OnlinePDF.pdf.

  44. P. G. M. Wuts, C. L. Bergh, Tetrahedron Lett. 27 (1986) 3995.

    Google Scholar 

  45. K. Kogure, K. Nakagawa, US 3965161 (1976).

    Google Scholar 

  46. B. R. Babu, K. K. Balasubramaniam, Org. Prep. Proc. Int. 26 (1994) 123.

    Google Scholar 

  47. J.-P. Rieu, A. Boucherle, H. Cousse, G. Mouzin, Tetrahedron 42 (1986) 4095.

    Google Scholar 

  48. P. J. Harrington, E. Lodewijk, Org. Proc. Res. Dev. 1 (1997) 72.

    Google Scholar 

  49. H. R. Sonawane, N. S. Bellur, J. R. Ahuja, D. G. Kulkarni, Tetrahedron: Asymmetry 3 (1992) 163.

    Google Scholar 

  50. C. Giordano, G. Castaldi, S. Cavicchioli, M. Villa, Tetrahedron 45 (1989) 4243.

    Google Scholar 

  51. A. S. C. Chan, T. T. Huang, J. H. Wagenknecht, R. E. Miller, J. Org. Chem. 60 (1995) 742.

    Google Scholar 

  52. T. Ohta, H. Takaya, M. Kitamura, K. Nagai, R. Noyori, J. Org. Chem. 52 (1987) 3174.

    Google Scholar 

  53. A. S. C. Chan, US 4994607 (1991).

    Google Scholar 

  54. A. Kleemann, J. Engel, Pharmaceutical Substances, 3rd Edn., Thieme, Stuttgart, 1999, 1156.

    Google Scholar 

  55. A. Kleemann, J. Engel, Pharmaceutical Substances, 3. Edn., Thieme, Stuttgart, 1999, 1549.

    Google Scholar 

  56. Wikipedia: Saccharin.

    Google Scholar 

  57. Wikipedia: Constantin Fahlberg.

    Google Scholar 

  58. Celecoxib, BIC 3000, Becker Associates 1999–2010, 08/12/2010; S. Dadiboyena, A. T. Hamme II, Curr. Org. Chem. 16 (2012) 1390.

    Google Scholar 

  59. Rofecoxib, BIC 3000, Becker Associates 1999–2010, 08/12/2010.

    Google Scholar 

  60. http://en.wikipedia.org/wiki/Rheumatoid_arthritis

  61. http://en.wikipedia.org/wiki/Tocilizumab

  62. http://en.wikipedia.org/wiki/Anakinra

  63. http://en.wikipedia.org/wiki/Infliximab

  64. http://en.wikipedia.org/wiki/Adalimumab

  65. http://en.wikipedia.org/wiki/Golimumab

References to 5.6 Prostaglandins

  1. Encyclopedia Britannica, Electronic Release, 2001, Prostaglandins.

    Google Scholar 

  2. E. Matsui, Y. Naruta, F. Tani, Y. Shimazaki, Angew. Chem. Interrnat. Edn. 42 (2003) 2744.

    Google Scholar 

  3. P. Karlson, Kurzes Lehrbuch der Biochemie, Thieme, Stuttgart, 1970, 32; S. Peng, N. M. Okeley, A.-L. Tsai, G. Wu, R. J. Kulmacz, W. A. van der Donk, J. Am. Chem. Soc. 124 (2002) 10785.

    Google Scholar 

  4. R. M. Garavito, A. M. Mulichak, Annu. Rev. Biophys. Biomol. Struct. 32 (2003) 183; R. M. Garavito, in A. Messerschmidt, R. Huber, T. Poulos, K. Wieghardt, Wiley, Chichester, 2001, 245.

    Google Scholar 

  5. G. Habermehl, P. E. Hammann, H. C. Krebs, Naturstoffchemie, 2nd Edn., Springer, Berlin, 2002, 525.

    Google Scholar 

  6. K. C. Nicolaou, E. J. Sorensen, Classics in Total Synthesis, VCH, Weinheim, 1996, 65.

    Google Scholar 

  7. R. Brückner, Reaktionsmechanismen, Spektrum Akademischer, Heidelberg, 1996, 443.

    Google Scholar 

  8. M. Suzuki, T. Kawagishi, T. Suzuki, R. Noyori, Tetrahedron Lett. 23 (1982) 4057.

    Google Scholar 

  9. K. Laumen, M. P. Schneider, J. Chem. Soc. Chem. Commun. (1986) 1298.

    Google Scholar 

  10. K. Laumen, M. P. Schneider, Tetrahedron Lett. 25 (1984) 5875.

    Google Scholar 

  11. L. A. Arnold, R. Naasz, A. J. Minnaard, B. L. Feringa, J. Am. Chem. Soc. 123 (2001) 5841.

    Google Scholar 

  12. P. W. Collins, E. Z. Dajani, D. R. Driskill, M. S. Bruhn, C. J. Jung, R. Pappo, J. Med. Chem. 20 (1977) 1152.

    Google Scholar 

  13. J. R. Beehling, P. W. Collins, J. S. Ng, Adv. Metal-Org. Chem . 4 (1995) 65.

    Google Scholar 

  14. B. H. Lipshutz, R. S. Wilhelm, D. M. Floyd, J. Am. Chem. Soc. 103 (1981) 7672.

    Google Scholar 

  15. B. H. Lipshutz, J. A. Kozlowski, R. S. Wilhelm, J. Org. Chem. 49 (1984) 3943.

    Google Scholar 

  16. J. H. Dygos, J. P. Adamek, K. A. Babiak, J. R. Behling, J. R. Medich, J. S. Ng, J. J. Wieczorek, J. Org. Chem. 56 (1991) 2549.

    Google Scholar 

  17. L. T. Boulton, D. Brick, M. E. Fox, M. Jackson, I. C. Lennon, R. McCague, N. Parkin, D. Rhodes, G. Ruecroft, Org. Proc. Res. Dev. 6 (2002) 138.

    Google Scholar 

  18. P. A. Grieco, J. Org. Chem. 37 (1972) 2363.

    Google Scholar 

  19. Z. Grudzinski, S. M. Roberts, J. Chem. Soc. Perkin Trans. 1 (1975) 1767.

    Google Scholar 

  20. G. A. Tolstikov, M. S. Miftakhov, N. A. Danilova, F. Z. Galin, J. Org. Chem. USSR (Engl. Trans.) 19 (1983) 1624.

    Google Scholar 

  21. D. R. Swanson, T. Nguyen, Y. Noda, E. Negishi, J. Org. Chem. 56 (1991) 2590.

    Google Scholar 

  22. C. Mioskowski, S. Manna, J. R. Falck, Tetrahedron Lett. 24 (1983) 5521 (with primary, secondary and tertiary lithium dialkylcuprates); I. Prowotorow, J. Wicha, K. Mikami, Synthesis (2001) 145 (with magnesium cuprates); T. Hiyama, Y. Morizawa, H. Yamamoto, H. Nozaki, Bull. Soc. Chem. Jpn. 54 (1981) 2151 (with organoaluminium compounds); E. J. Enholm, Z. J. Jia, J. Org. Chem. 62 (1997) 9159 (with organotin compounds); P. Herrington, M. A. Kerr, Tetrahedron Lett. 38 (1997) 5949 (lanthanoid-catalysed homo-Michael reactions).

    Google Scholar 

  23. P. W. Collins, S. W. Djuric, Chem. Rev. 93 (1993) 1533.

    Google Scholar 

  24. W. Skuballa, H. Vorbrüggen, Angew. Chem. Internat. Edn. 20 (1981) 1046.

    Google Scholar 

References to 5.7 Tetrahydrolipstatin

  1. R. H. Marijnissen, P. Ruyffelaere, Bosch, VCH, 1988, 329; http://www.lucifuge.de/themen/religio/suenden.htm.

  2. H. Wolff, C. Kunte, Pharmazie in unserer Zeit 29 (2000) 153.

    Google Scholar 

  3. M. Henningsen, Chemie in unserer Zeit 34 (2000) 179.

    Google Scholar 

  4. C. Leitzmann, Biologie in unserer Zeit 31 (2001) 408.

    Google Scholar 

  5. I. Vermaak, A. M. Viljoen, J. H. Hamman, Nat. Prod. Rep 28 (2011) 1493.

    Google Scholar 

  6. V. Schusdziarra, J. Erdmann, Pharmazie in unserer Zeit 35 (2006) 500.

    Google Scholar 

  7. http://en.wikipedia.org/wiki/Phentermine.

  8. http://en.wikipedia.org/wiki/Sibutramine.

  9. http://en.wikipedia.org/wiki/Rimonabant.

  10. http://en.wikipedia.org/wiki/Gila_monster ; J. Eng, W. A. Kleinman, L. Singh, G. Singh, J.-P. Raufman, J. Biol. Chem. 267 (1992) 7402.

  11. http://en.wikipedia.org/wiki/Exenatide ; A. Hamann, Diabetes Klinik Bad Nauheim, http://www.dgem.de/material/pdfs/Ernaehrung08_PDFs/Hamann%20J%20med%20BehAdi%20120608_OnlinePDF.pdf.

  12. http://www.medknowledge.de/neu/2003/II-2003-21-exenatide-p.htm ; M. Giraud, A.-S. Droz, S. Varray, E. D. Rekai, M.-H. Brichard, D. Latassa, C. Devijver, P. Gilles, J.-M.Cauvin, F. Albericio, M. P. Bas, US 20110046349 (2011).

  13. E. K. Weibel, P. Hadvary, E. Hochuli, E. Kupfer, H. Lengsfeld, J. Antibiot. 40 (1987) 1081; R.-Y. Wu, M.-H. Chen, Bot. Bull. Acad. Sin. 36 (1995) 201.

    Google Scholar 

  14. C. Wedler, B. Costisella, H. Schick, J. Org. Chem. 64 (1999) 5301.

    Google Scholar 

  15. A. Pommier, J.-M.Pons, Synthesis (1995) 729 (review on natural 2-oxetanones); J. W. Yun, Phytochem. 71 (2010) 1625.

    Google Scholar 

  16. H. Umezawa, T. Aoyagi, T. Hazato, K. Uotani, F. Kojima, M. Hamada, T. Takeuchi, J. Antibiot. 31 (1978) 639.

    Google Scholar 

  17. H. Stalder, G. Oesterhelt, B. Borgström, Helv. Chim. Acta 75 (1992) 1593.

    Google Scholar 

  18. P. Barbier, F. Schneider, Helv. Chim. Acta 70 (1987) 196.

    Google Scholar 

  19. E. Hochuli, E. Kupfer, R. Maurer, W. Meister, Y. Mercadal, K. Schmidt, J. Antibiot. 40 (1987) 1086.

    Google Scholar 

  20. A. Pommier, J.-M. Pons, P. J. Kocienski, L. Wong, Synthesis (1994) 1294; P. Hadvary, W. Sidler, W. Meister, W. Vetter, H. Wolfer, J. Biol. Chem. 266 (1991) 2021.

    Google Scholar 

  21. C. W. Pemble, L. C. Johnson, S. J. Kridel, W. T. Lowther, Nat. Struct. Mol. Biology 14 (2007) 704.

    Google Scholar 

  22. W. Eisenreich, E. Kupfer, W. Weber, A. Bacher, J. Biol. Chem. 272 (1997) 867.

    Google Scholar 

  23. U. Kaulmann, C. Hertweck, Angew. Chem. Internat. Edn. 41 (2002) 1866.

    Google Scholar 

  24. D. H. G. Crout, C. R. McIntyre, N. W. Alcock, J. Chem. Soc., Perkin Trans. 2 (1991) 53.

    Google Scholar 

  25. D. H. G. Crout, D. L. Rathbone, J. Chem. Soc., Chem. Commun. (1987) 290.

    Google Scholar 

  26. Daicel Chemical Industries Ltd., DE 3731290 (1987).

    Google Scholar 

  27. C. A. Schuhr, W. Eisenreich, M. Goese, P. Stohler, W. Weber, E. Kupfer, A. Bacher, J. Org. Chem. 67 (2002) 2257.

    Google Scholar 

  28. H. G. W. Leuenberger, P. K. Matzinger, B. Wirz, Chimia 53 (1999) 536.

    Google Scholar 

  29. A. Bacher, P. Stohler, W. Weber, EP 0803576 (1997).

    Google Scholar 

  30. J.-M. Pons, A. Pommier, J. Lerpiniere, P. Kocienski, J. Chem. Soc., Perkin Trans. 1 (1993) 1549.

    Google Scholar 

  31. F. Bennett, D. W. Knight, G. Fenton, J. Chem. Soc., Perkin Trans. 1 (1991) 519.

    Google Scholar 

  32. F. Bennett, D. W. Knight, G. Fenton, Tetrahedron Lett. 29 (1988) 4865.

    Google Scholar 

  33. J.-M. Pons, P. Kocienski, Tetrahedron Lett. 30 (1989) 1833.

    Google Scholar 

  34. J. Prous, N. Mealy, J. Castaner, Drugs of the Future 19 (1994) 1003.

    Google Scholar 

  35. P. Barbier, F. Schneider, U. Widmer, Helv. Chim. Acta 70 (1987) 1412.

    Google Scholar 

  36. N. K. Chadha, A. D. Batcho, P. C. Tang, L. F. Courtney, C. M. Cook, P. M. Wovkulich, M. R. Uskokovic, J. Org. Chem. 56 (1991) 4714.

    Google Scholar 

  37. J. J. Landi Jr., L. M. Garofalo, K. Ramig, Tetrahedron Lett. 34 (1993) 277.

    Google Scholar 

  38. P. Barbier, F. Schneider, J. Org. Chem. 53 (1988) 1218.

    Google Scholar 

  39. I. Fleming, N. J. Lawrence, Tetrahedron Lett. 31 (1990) 3645.

    Google Scholar 

  40. I. Fleming, N. J. Lawrence, J. Chem. Soc., Perkin Trans. 1 (1998) 2679.

    Google Scholar 

  41. A. W. P. Jarvie, A. Holt, J. Thompson, J. Chem. Soc. (B) (1969) 852.

    Google Scholar 

  42. S. C. Case-Green, S. G. Davies, C. J. R. Hedgecock, Synlett (1991) 781.

    Google Scholar 

  43. H. Brunner, E. Schmidt, J. Organometal. Chem. 36 (1972) C18; S. J. Cook, J. F. Costello, S. G. Davies, H. T. Kruk, J. Chem. Soc. Perkin Trans. 1 (1994) 2369.

    Google Scholar 

  44. N. Aktogu, H. Felkin, S. G. Davies, J. Chem. Soc., Chem. Commun. (1982) 1303.

    Google Scholar 

  45. I. Paterson, V. A. Doughty, Tetrahedron Lett. 40 (1999) 393.,

    Google Scholar 

  46. J. March, Advanced Organic Chemistry, 4th Edn., Wiley, New York, 1992, 1175 (mechanism).

    Google Scholar 

  47. A. K. Ghosh, S. Fidanze, Org. Lett. 2 (2000) 2405; meantime a further and similarly lengthy synthesis has appeared: A. K. Ghosh, K. Shurrush, S. Kulkarni, J. Org. Chem. 74 (2009) 4508.

    Google Scholar 

  48. D. Crich, X.-Y. Jiao, M. Brunko, Tetrahedron Lett. 53 (1997) 7127.

    Google Scholar 

  49. M. Kurihara, N. Miyata, Chem. Lett. (1995) 263.

    Google Scholar 

  50. T. Tsunoda, M. Suzuki, R. Noyori, Tetrahedron Lett. 21 (1980) 1357.

    Google Scholar 

  51. D. A. Evans, K. T. Chapman, E. M. Carreira, J. Org. Chem. 53 (1988) 3560.

    Google Scholar 

  52. J. A. Bodkin, E. J. Humphries, M. D. McLeod, Tetrahedron Lett. 44 (2003) 2869.

    Google Scholar 

  53. J. A. Bodkin, E. J. Humphries, M. D. McLeod, Aust. J. Chem. 56 (2003) 795.

    Google Scholar 

  54. U. Zutter, M. Karpf, EP 443449 (1991).

    Google Scholar 

  55. K. Püntener, “With Asymmetric Hydrogenation Towards a Stereoselective Synthesis of Xenical ® ”, Proceedings of the 11th International Conference & Exhibition, Organic Process Research and Development, 25–28 April 2005, Barcelona, Spain.

    Google Scholar 

References to 5.8 Taxol ®

  1. M. Reitz, Krebs als ständiger Begleiter der Menschheit, Neue Züricher Zeitung , April 2004, 7.

    Google Scholar 

  2. http://www.geschichte-muensingen.ch/fileadmin/user_upload/ortsgeschichte_muensingen/dokumente/1.2_Von_keltischem_Schmuck_OnlinePDF.pdf, page 46.

  3. “Every cell comes from another cell”

    Google Scholar 

  4. http://flexikon.doccheck.com/Krebs

  5. http://www.zeit.de/1966/43/Wie-koennen-Viren-Krebs-ausloesen ; H. zur Hausen, Angew. Chem. Internat. Edn. 48 (2009) 5798; C. de Martel, J. Ferlay, S. Franceschi, J. Vignat, F. Bray, D. Forman, M. Plummer, Lancet Oncology 13 (2012) 607.

  6. http://en.wikipedia.org/wiki/Pap_smear.

  7. http://de.wikipedia.org/wiki/Rosafarbene_Catharanthe ; J. R. Wright, Can. Med. Ass.J. 167 (2002) 1391.

  8. http://zptech.net/media/Platinum%20Salts_OnlinePDF.pdf.

  9. H. Gießen, Pharmazie in unserer Zeit 32 (2003) 90.

    Google Scholar 

  10. B. Kutscher, G. A. Curt, C. J. Allegra, R. L. Fine, H. Mujagic, G. C. Yeh, B. A. Chabner, Ullmann’s Encyclopedia of Industrial Chemistry, Weinheim, 2005, Electronic Release, Cancer Chemotherapy.

    Google Scholar 

  11. A. Jordan, J. A. Hatfield, N. J. Laurence, A. T. McGowan, Med. Res. Rev. 18 (1998) 259; R. A. Stanton, K. M. Gernert, J. H. Nettles, R. Aneja, Med. Res. Rev. 31 (2011) 443.

    Google Scholar 

  12. T. Graening, H.-G. Schmalz, Angew. Chem. Internat. Edn. 43 (2004) 3230.

    Google Scholar 

  13. http://de.wikipedia.org/wiki/Eiben ; K. C. Nicolaou, R. K. Guy, Angew. Chem. Internat. Edn. 34 (1995) 2079.

  14. http://de.wikipedia.org/wiki/Europ%C3%A4ische_Eibe.

  15. G. Julius Caesar, Commentarii de Bello Gallico : English translations by, among others, S. A. Handford (“The Conquest of Gaul”) and K. Gilliver (“Caesar’s Gallic Wars, 58–50 BC”); see also online synopses.

    Google Scholar 

  16. K. C. Nicolaou, W.-M. Dai, R. K. Guy, Angew. Chem. Internat. Edn. 33 (1994) 15.

    Google Scholar 

  17. W. C. Shortly, R. Minorca, in S. P. Raychaudhuri, K. Maramorosch, Biotechnology and Plant Protection in Forestry Science, Science Publishers, (place of publication unknown), 1999, 1.

    Google Scholar 

  18. T. Yabuta, Agriculture and Horticulture 10 (1935) 17.

    Google Scholar 

  19. A. Stierle, G. Strobel, D. Stierle, Science 260 (1993) 214; A. Stierle, G. Strobel, D. Stierle, P. Grothaus, G. Bignami, J. Nat. Prod. 58 (1995) 1315.

    Google Scholar 

  20. E. Leistner, Pharmazie in unserer Zeit 34 (2005) 98.

    Google Scholar 

  21. P. K. Ajikumar, W.-H. Xiao, K. E. J. Tyo, Y. Wang, F. Simeon, E. Leonard, O. Mucha, T. H. Phon, B. Pfeifer, G. Stephanopoulos, Science 330 (2010) 70.

    Google Scholar 

  22. R. A. Holton, H.-B. Kim, C. Somoza, F. Liang, R. J. Biediger, P. D. Boatman, M. Shindo, C. C. Smith, S. Kim, H. Nadizadeh, Y. Suzuki, C. Tao, P. Vu, S. Tang, P. Zhang, K. K. Murthi, L. N. Gentile, J. H. Liu, J. Am. Chem. Soc. 116 (1994) 1597.

    Google Scholar 

  23. R. A. Holton, H.-B. Kim, C. Somoza, F. Liang, R. J. Biediger, P. D. Boatman, M. Shindo, C. C. Smith, S. Kim, H. Nadizadeh, Y. Suzuki, C. Tao, P. Vu, S. Tang, P. Zhang, K. K. Murthi, L. N. Gentile, J. H. Liu, J. Am. Chem. Soc. 116 (1994) 1599.

    Google Scholar 

  24. K. C. Nicolaou, Z. Yang, J. J. Liu, H. Ueno, P. G. Nantermet, R. K. Guy, C. F. Claiborne, J. Renaud, E. A. Couladouros, K. Paulvannan, E. J. Sorensen, Nature 367 (1994) 630.

    Google Scholar 

  25. K. C. Nicolaou, E. J. Sorensen, Classics in Total Synthesis: Targets, Strategies, Methods, VCH, Weinheim, 1996, 655.

    Google Scholar 

  26. J. J. Masters, J. T. Link, L. B. Snyder, W. B. Young, S. J. Danishefsky, Angew. Chem. Internat. Edn. 34 (1995) 1723.

    Google Scholar 

  27. S. J. Danishefsky, J. J. Masters, W. B. Young, J. T. Link, L. B. Snyder, T. V. Magee, D. K. Jung, R. C. A. Isaacs, W. G. Bornmann, C. A. Alaimo, C. A. Coburn, M. J. Di Grandi, J. Am. Chem. Soc. 118 (1996) 2843.

    Google Scholar 

  28. Summary: D. G. I. Kingston, P. G. Jagtop, H. Yuan, L. Samala, Prog. Chem. Org. Nat. Prod. 84 (2002) 53; L. Sun, C. Simmerling, I. Ojima, Chem Med Chem 4 (2009) 719.

    Google Scholar 

  29. V. Sénilh, F. Guéritte, D. Guénard, M. Colin, P. Potier, C. R. Acad. Sci. (Paris), Série 2 , 299 (1984) 1039.

    Google Scholar 

  30. P. G. M. Wuts, Curr. Opin. Drug Discov. Dev. 1 (1998) 329.

    Google Scholar 

  31. J. N. Denis, A. E. Greene, D. Guénard, F. Gueritte-Voegelein, L. Mangatal, M. T. Adeline, P. Potier, J. Am. Chem. Soc. 110 (1988) 5917.

    Google Scholar 

  32. http://www.rinr.fsu.edu/fall2002/taxol.html.

  33. M. A. Poss, J. L. Moniot, I. D. Trifunovich, D. J. Kucera, J. K. Thottathil, S.-H. Chen, J. Wei, WO 94/14787 (1994).

    Google Scholar 

  34. R. A. Holton, EP 400971 (1990).

    Google Scholar 

  35. R. A. Holton, US 5274124 (1993); R. A. Holton, US 6683196 (2004).

    Google Scholar 

  36. A. Commerçon, D. Bézard, F. Bernard, J. D. Bourzat, Tetrahedron Lett. 33 (1992) 5185.

    Google Scholar 

  37. F. Gueritte-Voegelein, V. Sénilh, B. David, D. Guénard, P. Potier, Tetrahedron 42 (1986) 4451; alternative synthesis and x ray structure: N. M. Sekhar, P. Vishweshwar, P. V. R. Acharyulu, Y. Anjaneyulu, Synth. Commun. 42 (2012) 3482.

    Google Scholar 

  38. I. Ojima, M. Zucco, O. Duclos, S. D. Kuduk, C. M. Sun, Y. H. Park, Bioorg. Med. Chem. Lett. 3 (1993) 2479.

    Google Scholar 

  39. M. V. Vononkov, A. V. Gontcharov, Z.-M. Wang, Tetrahedron Lett. 44 (2003) 407.

    Google Scholar 

  40. J.-N. Denis, A. Correa, A. E. Greene, J. Org. Chem. 56 (1991) 6939.

    Google Scholar 

  41. R. Croteau, R. E. B. Ketchum, R. M. Long, R. Kaspera, M. R. Wildung, Phytochem. Rev. 5 (2006) 75.

    Google Scholar 

  42. S. C. Roberts, Nature Chemical Biology 3 (2007) 387.

    Google Scholar 

  43. Y. J. Hong, D. J. Tantillo, J. Am. Chem. Soc. 133 (2011) 18249.

    Google Scholar 

  44. http://www.phytonbiotech.com/about_history.htm.

  45. Y. Yukimune, H. Tabata, Y. Higashi, Y. Hara, Nature Biotechnology 14 (1996) 1129.

    Google Scholar 

  46. H. Tabata, Adv. Biochem. Engin./Biotechnol. 7 (2004) 1.

    Google Scholar 

  47. J. A. Yared, K. H. R. Tkaczuk, Drug Design, Development and Therapy 6 (2012) 371.

    Google Scholar 

References to 5.9 Statins

  1. E. Crispino (Ed.), Leonardo, art and science, Giunti Gruppa Editionale, Firenze, 2001, 112.

    Google Scholar 

  2. K. D. Keele, Med. Hist. 17 (1973) 304.

    Google Scholar 

  3. http://www.mayoclinic.com/health/arteriosclerosis-atherosclerosis/DS00525 ; http://surgery.about.com/od/beforesurgery/f/ArteriosclerosisAtherosclerosis.htm.

  4. E. H. Ackerknecht, Gesnerus 32 (1975) 229.

    Google Scholar 

  5. K. Michel, Zeit online 37 (2007) 42; O. Gabel, K. H. Künzel, Exp. Gerontol. 33 (1998) 655; A. R. David, A. Kershaw, A. Heagerty, The Lancet 375 (2010) 718, A. G. Nerlich, I. Wiest, J. Tübel, J. Paleopathology 9 (1997) 83.

    Google Scholar 

  6. Encyclopedia Britannica, Electronic Release, 2001.

    Google Scholar 

  7. Published in 1799 in the paper “Inquiry into the Symptoms and Causes of Syncope Anginosa, commonly called Angina pectoris”

    Google Scholar 

  8. Joseph Hodgson, “On Wounds and Diseases of Arteries and Veins”, printed by J. Moyes, Greville Street, Hatton Garden for T. Black, Edinburgh; J. Smith and Son, Glasgow; and J. Cumming, Dublin, 1815.

    Google Scholar 

  9. I. Metschnikow, Études sur la Nature Humaine: Essai de Philosophie Optimiste, Paris, Masson, 1903.

    Google Scholar 

  10. A. Ignatowski, Virchows Arch. Pathol. Anat. 198 (1909) 248.

    Google Scholar 

  11. A. Windaus, Hoppe-Seyler’s Z. Physiol. Chem. 67 (1910) 174.

    Google Scholar 

  12. http://www.jci.org/articles/view/102881/files/pdf; http://www.nobelprize.org/nobel_prizes/medicine/laureates/1964/bloch-lecture_OnlinePDF.pdf.

  13. N. Anitschkow, Beitr. Pathol. Anat. 56 (1913) 379; N. N. Anitschkow, S. Chalatov, Zentralbl. Allg. Pathol. 24 (1913) 1; I. E. Konstantinov, N. Mejevoi, N. M. Anichkov, Tex. Heart Inst. J. 33 (2006) 417.

    Google Scholar 

  14. D. Steinberg, J. Lipid Res. 45 (2004) 1583.

    Google Scholar 

  15. J. G. Mönckeberg, Zentralbl. Herz Gefäßkrankheiten 7 (1915) 7.

    Google Scholar 

  16. J. G. Mönckeberg, Zentralbl. Herz Gefäßkrankheiten 7 (1915) 336.

    Google Scholar 

  17. P. Lanzer, C. Shanahan, Deutsches Ärzteblatt 97 (2000) A-1746.

    Google Scholar 

  18. W. F. Enos, R. H. Holmes, J. Beyer, JAMA 152 (1953) 1090.

    Google Scholar 

  19. M. A. Macheboeuf, Bull. Soc. Chim. Biol. 11 (1929) 268.

    Google Scholar 

  20. D. Steinberg, J. Lipid Res. 46 (2005) 2037.

    Google Scholar 

  21. R. Ross, J. Glomset, L. Harker, Am. J. Pathol. 86 (1977) 675.

    Google Scholar 

  22. R. M. Roberts, Serendipity, Wiley, New York, 1989, 137.

    Google Scholar 

  23. K. Arnheim, Deutsches Ärzteblatt 103 (2006) A-796; J. R. Schaefer, B. Hufnagel, S. Klumpp, B. Malsch, J. Krieglstein, Diabetologie 2006 , 187.

    Google Scholar 

  24. M. Reinbold, B. Hufnagel, T. Kewitz, S. Klumpp, J. Krieglstein, Mol. Nutr. Food.Res. 52 (2008) 581; J. W. Heinecke, Circulation 127 (2013) 868.

    Google Scholar 

  25. S. Bernschneider-Reif, Pharmazie in unserer Zeit 36 (2007) 88.

    Google Scholar 

  26. G. Hahn, Erfahrungsheilkunde 51 (2002) 384.

    Google Scholar 

  27. R. B. Woodward, F. E. Bader, H. Bickel, A. J. Frey, R. W. Kierstead, J. Am. Chem. Soc. 78 (1956) 2023; R. B. Woodward, F. E. Bader, H. Bickel, A.. J. Frey, R. W. Kierstead, J. Am. Chem. Soc. 78 (1956) 2657.

    Google Scholar 

  28. R. B. Woodward, F. E. Bader, H. Bickel, A. J. Frey, R. W. Kierstead, Tetrahedron 2 (1958) 1.

    Google Scholar 

  29. K. C. Nicolaou, E. J. Sorensen, Classics in Total Synthesis, VCH, Weinheim, 1996, 55.

    Google Scholar 

  30. G. Stork, Pure Appl. Chem. 61 (1989) 439.

    Google Scholar 

  31. http://www.whale.to/a/hoffer5.html.

  32. Ala n Wise, S . M. Foord, N . J. Fraser, A . A. Barnes, N . Elshourbagy, M . Eilert, D . M. Ignar, P . R. Murdock, K . Steplewski, A . Green, A . J. Brown, S . J. Dowell, P . G. Szekeres, D . G. Hassall, F . H. Marshall, S . Wilson, N . B. Pike, J. Biol. Chem. 278 (2003) 9869; K. Ahmed, S. Offermanns, Pharmazie in unserer Zeit 36 (2007) 120.

  33. V . Guetta, R . O. Cannon III, Circulation 93 (1996) 1928; D. Steinhilber, M. Schubert-Zsilavecz, Pharmazie in unserer Zeit 36 (2007) 108.

  34. W. Schunack, Pharmazie in unserer Zeit 32 (2003) 498.

    Google Scholar 

  35. A. Endo, in “Statins, The HMG-CoA Reductase Inhibitors in Perspective”, 2nd Edn., Martin Dunitz Ltd., London, 1994, 32; Takuji Hara, Innovation in the Pharmaceutical Industry: The Process of Drug Discovery and Development, Edward Elgar Publishing Ltd., Cheltenham, 2003, 132; D. Steinberg, J. Lipid Res. 47 (2006) 1339.

    Google Scholar 

  36. A . G. Brown, T . C. Smale, T . J. King, R . Hasenkamp, R . H. Thompson, J. Chem. Soc. Perkin I. (1976) 1165.

  37. H. Stark, Pharmazie in unserer Zeit 32 (2003) 464.

    Google Scholar 

  38. A. Sutherland, K. Auclair, J. C. Vederas, Curr. Opin. Drug Dev. 4 (2001) 229.

    Google Scholar 

  39. E. S. Istvan, E. S. Deisenhofer, Science 292 (2001) 1160.

    Google Scholar 

  40. D. J. Witter, J. C. Vederas, J. Org. Chem. 61 (1996) 2613.

    Google Scholar 

  41. K. Wagschal, Y. Yoshizawa, D. J. Witter, Y. Liu, J. C. Vederas, J. Chem. Soc. Perkin Trans. 1 , (1996) 2357.

    Google Scholar 

  42. E. M. Stocking, R. M. Williams, Angew. Chem. Internat. Edn. 42 (2003) 3078.

    Google Scholar 

  43. H. Oikawa, Bull. Chem. Soc. Jpn. 78 (2005) 537; A. Minami, H. Oikawa in Biomimetic Org. Synth.Wiley, 2011, 751.

    Google Scholar 

  44. K. Auclair, A. Sutherland, J. Kennedy, D. J. Winter, J. P. Van den Hoever, C. R. Hutchinson, J. C. Vederas, J. Am. Chem. Soc. 122 (2000) 11519.

    Google Scholar 

  45. Not-concerted reaction mechanism: see also G. Pohnert, ChemBioChem 4 (2003) 713.

    Google Scholar 

  46. O. Diels, K. Alder, Liebigs Annalen der Chemie 460 (1928) 98.

    Google Scholar 

  47. H. Hagiwara, T. Nakano, M. Kon-no, H. Uda, J. Chem. Soc. Perkin Trans. 1 (1995) 777.

    Google Scholar 

  48. C. M. Blackwell, A. H. Davidson, S. B. Launchbury, C. N. Lewis, E. M. Morrice, M. M. Reeve, J. A. R. Roffey, A. S. Tipping, R. S. Todd, J. Org. Chem. 57 (1992) 5596.

    Google Scholar 

  49. D. L. J. Clive, K. S. K. Murthy, A. G. H. Wee, J. S. Prasad, G. V. J. Da Silva, M. Majewski, P. C. Anderson, Stud. Nat. Prod. Chem. 11 (1992) 335.

    Google Scholar 

  50. M. Hirama, M. Iwashita, Tetrahedron Lett. 24 (1983) 1811.

    Google Scholar 

  51. P. M. Wovkulich, P. C. Tang, N. K. Chadha, A. D. Batcho, J. C. Barrish, M. R. Uskokovic, J. Am. Chem. Soc. 111 (1989) 2596.

    Google Scholar 

  52. Unfortunately homologation is not further described in the original publication.

    Google Scholar 

  53. A. Kleemann, Cardiovascular Drugs, Ullmann Encyclopaedia, Electronic Release, Wiley-VCH, Weinheim, 2008.

    Google Scholar 

  54. M. Manzoni, M. Rollini, Appl. Microbiol. Biotechnol. 58 (2002) 555; M. Bizjak, S. Kranjc, R. Mencigar, P. Mrak, D. Smodis, G. Stampar, WO2008092950 A1 (2008).

    Google Scholar 

  55. T. R. Verhoeven, D. Askin, US 4820850 (1989).

    Google Scholar 

  56. R. K. Singamsetty, S. K. Vujjini, N. Manne, B. R. M. V. Naga, V. Himabindu, A. Battacharya, M. R. Ghanta, R. Bandichhor, Synth. Commun. 38 (2008) 4452.

    Google Scholar 

  57. B. D. Roth, Prog. Med. Chem. 40 (2002) 1.

    Google Scholar 

  58. R. R. Sagyam, H. Vurimidi, P. R. Padi, M. R. Ghanta, J. Heterocycl. Chem. 44 (2007) 923.

    Google Scholar 

  59. M. Müller, Angew. Chem. Internat. Edn. 44 (2005) 362.

    Google Scholar 

  60. S. C. Davis, J. H. Grate, D. R. Gray, J. M. Gruber, G. W. Huisman, S. K. Ma, L. M. Newman, R. Sheldon, L. A. Wang, WO 2005/018579.

    Google Scholar 

  61. S. Bergeron, D. A. Chaplin, J. H. Edwards, B. S. W. Ellis, C. L. Hill, K. Holt-Tiffin, J. R. Knight, T. Mahoney, A. P. Osborne, G. Ruecroft, Org. Proc. Res. Dev. 10 (2006) 661.

    Google Scholar 

  62. M. Hajkova, B. Kratochvil, S. Radl, Chem. Listy 102 (2008) 3.

    Google Scholar 

  63. M. Sletzinger, T. R. Verhoeven, R. P. Volante, J. M. McNamara, E. G. Corley, T. M. H. Liu, Tetrahedron Lett. 26 (1985) 2951.

    Google Scholar 

  64. K. Bock, I. Lundt, C. Pedersen, Acta Chim. Scand. B 37 (1983) 341.

    Google Scholar 

  65. O. Repic, K. Prasad, G. T. Lee, Org. Proc. Res. Dev. 5 (2001) 519.

    Google Scholar 

  66. Becker Associates, BIC 3000, Rosuvastatin, 2008.

    Google Scholar 

  67. A. Nadin, K. C. Nicolaou, Angew. Chem. Internat. Edn. 35 (1996) 1622.

    Google Scholar 

  68. J. R. Faust, J. L. Goldstein, M. S. Brown, Arch. Biochem. Biophys. 192 (1979) 86; M. S. Brown, J. L. Goldstein, J. Lipid Res. 21 (1980) 505 .

    Google Scholar 

  69. M. H. Davidson, Curr. Athereoscl. Rep. 9 (2007) 78.

    Google Scholar 

  70. R. K. Elsayed, J. D. Evans, Expert Opinion Emerging Drugs , 13 (2008) 309.

    Google Scholar 

References to 5.10 Artemisinin

  1. Friedrich Schiller, letters to Henriette von Wolzogen, Mannheim, Donnerstag 11. September 1783, and Mannheim, Donnerstag, 13. November 1783; http://www.wissen-im-netz.info/literatur/schiller/briefe/1783/178309111.htm; R. Klimm, Dtsch. Ärztebl. 99 (2002) A-420.

  2. http://www.who.int/malaria/publications/world_malaria_report_2013/en/; http://www.ncbi.nlm.nih.gov/books/NBK2624/.

  3. G. Poinar, Systematic Parasitology 61 (2005) 47.

    Google Scholar 

  4. W. Liu, Y. Li, G. H. Learn, R. S. Rudicell, J. D. Robertson, B. F. Keele, J.-B. N. Ndjango, C. M. Sanz, D. B. Morgan, S. Locatelli, M. K. Gonder, P. J. Kranzusch, P. D. Walsh, E. Delaporte, E. Mpoudi-Ngole, A. V. Georgiev, M. N. Muller, G. M. Shaw, M. Peeters, P. M. Sharp, J. C. Rayner, B. H. Hahn, Nature 467 (2010) 420.

    Google Scholar 

  5. R. Sallares, S. Gomzi, Ancient Biomolecules 3 (2001) 196 ; R. Sallares, A. Bouwman, C. Anderung, Med Hist. 48 (2004) 311.

    Google Scholar 

  6. M. J. Gardner, N. Hall, E. Fung, O. White, M. Berriman, R. W. Hyman, J. M. Carlton, A. Pain, K. E. Nelson, S. Bowman, I. T. Paulsen, K. James, J. A. Eisen, K. Rutherford, S. L. Salzberg, A. Craig, S. Kyes, M.-S. Chan, V. Nene, S. J. Shallom, B. Suh, J. Peterson, S. Angiuoli, M. Pertea, J. Allen, J. Selengut, D. Haft, M. W. Mather, A. B. Vaidya, D. M. A. Martin, A. H. Fairlamb, M. J. Fraunholz, D. S. Roos, S. A. Ralph, G. I. McFadden, L. M. Cummings, G. M. Subramanian, C. Mungall, J. C. Venter, D. J. Carucci, S. L. Hoffman, C. Newbold, R. W. Davis, C. M. Fraser, B. Barrell, Nature 419 (2002) 498.

    Google Scholar 

  7. http://de.wikipedia.org/wiki/Malaria#Geschichte; A. G. Nerlich, B. Schraut, S. Dittrich, T. Jelinek, A. R. Zink, Plasmodium falciparum in ancient Egypt, http://wwwnc.cdc.gov/eid/article/14/8/08-0235_article.htm

  8. F. E. G. Cox, Clin. Microbiol. Rev. 15 (2002) 595;

    Google Scholar 

  9. http://www.malariasite.com/malaria/history_literature.htm.

  10. C. R. Garcia, R. P. Markus, L. Madeira, J. Biol. Rhythms. 16 (2001) 436.

    Google Scholar 

  11. http://www.gigers.com/matthias/malaria/history.htm.

  12. C. B. Cunha, B. A. Cunha, J. Vector Borne Dis. 45 (2008) 194.

    Google Scholar 

  13. http://de.wikipedia.org/wiki/Hygiene_im_R%C3%B6mischen_Reich.

  14. S. Winkle, Sonderdruck aus Hamburger Ärzteblatt, issue 6 and 8 (1984).

    Google Scholar 

  15. http://www.malariasite.com/malaria/history_victims.htm.

  16. G. Fornaciari, V. Giuffra, E. Ferroglio, S. Gino, R. Bianucci, Trans. R. Soc. Trop. Med. Hyg. 104 (2010) 583.

    Google Scholar 

  17. M. K. Dalitz, Martin-Luther-Universität Halle-Wittenberg, Dissertation, 2005.

    Google Scholar 

  18. L. F. Haas, J. Neurol. Neurosurg. Psychiatry 67 (1999) 520; http://de.wikipedia.org/wiki/Alphonse_Laveran; http://www.nobelprize.org/nobel_prizes/medicine/laureates/1907/laveran-bio.html.

  19. http://de.wikipedia.org/wiki/Camillo_Golgi.

  20. http://en.wikipedia.org/wiki/Ronald_Ross.

  21. F. E. G. Cox, Parasites Vectors 3 (2010) 5; http://en.wikipedia.org/wiki/History_of_malaria.

  22. http://www.gigers.com/matthias/malaria/circle.htm; http://www.niaid.nih.gov/topics/malaria/pages/lifecycle.aspx; A. Ferreira, I. Marguti, I. Bechmann, V. Jeney, Â. Chora, N. R. Palha, S. Rebelo, A. Henri, Y. Beuzard, M. P. Soares, Cell 145 (2011) 398.

  23. A. P. C. Fiks, Self-Experimenters: Sources for Study, Praeger Publishers, Westport CT, 2003, 196.

    Google Scholar 

  24. R. Virchow, Arch. Pathol. Anatomie Physiol. Klin. Med. 2 (1849) 587.

    Google Scholar 

  25. J. Ziegler, R. Linck, D. W. Wright, Current Medicinal Chemistry 8 (2001) 171.

    Google Scholar 

  26. T. Carbone, Giornale della R Accademia di Medicina di Torino 39 (1891) 901; W. H. Brown, J. Exp. Med. 13 (1911) 290; .

    Google Scholar 

  27. S. Pagola, P. W. Stephens, D. S. Bohle, A. D. Kosar, S. K. Madsen, Nature 404 (2000) 307; D. S. Bohle, R. E Dinnebier, S. K. Madsen, P. W. Stephens, J. Biol. Chem. 272 (1997) 713.

    Google Scholar 

  28. http://en.wikipedia.org/wiki/Cinchona; I. W. Sherman (Hrsg.), Malaria: Parasite Biology, Pathogenesis, and Protection, ASM Press, Washington, 1998, 341.

  29. http://de.wikipedia.org/wiki/Chinin.

  30. G. Gramiccia, Parassitologia 29 (1987) 207.

    Google Scholar 

  31. S. Streller, K. Roth, Chemie in unserer Zeit 46 (2012) 228; http://www.chemistryviews.org/details/ezine/4701281/From_Pharmacy_to_the_Pub_A_Bark_Conquers_the_World_Part_1.html.

  32. E. Schwab, Römpp Online – Version, Georg Thieme Verlag, Stuttgart, 2013.

    Google Scholar 

  33. G. Stork, D. Niu, A. Fujimoto, E. R. Koft, J. M. Balkovec, J. R. Tata, G. R. Dake, J. Am. Chem. Soc. 123 (2001) 3239.

    Google Scholar 

  34. R. Woodward, W. Doering, J. Am. Chem. Soc. 66 (1944) 849.

    Google Scholar 

  35. Total synthesis: M. R. Uskokovic, J. Gutzwiller, T. Henderson, J. Am. Chem. Soc. 92 (1970) 203; Enantiopure Quinine: J. A. W. Gutzwiller, M. R. Uskokovic, US 3663554 (1972); M. R. Uskokovic, T. Henderson, C. Reese, H. L. Lee, G. Grethe, J. Gutzwiller, J. Am. Chem. Soc. 100 (1978) 571; J. Gutzwiller, M. R. Uskokovic, J. Am. Chem. Soc. 100 (1978) 576.

    Google Scholar 

  36. K. A. de Villiers, J. Gildenhuys, T. le Roex, ACS Chem. Biol. 7 (2012) 666.

    Google Scholar 

  37. J. M. Karle, I. L. Karle, L. Gerena, W. K. Milhous, Antimicrob. Agents Chemother. 36 (1992) 1538.

    Google Scholar 

  38. http://de.wikipedia.org/wiki/Dichlordiphenyltrichlorethan.

  39. E. Tognotti, Emerg. Infect. Dis. 15 (2009) 1460.

    Google Scholar 

  40. R. H. Schirmer, H. Adler, M. Pickhardt, E. Mandelkow, Neurobiol. Aging 32 (2011) 2325.

    Google Scholar 

  41. P. Guttman, P. Ehrlich, Berliner Klinische Wochenschrift 39 (1891) 953.

    Google Scholar 

  42. http://en.wikipedia.org/wiki/Paul_Ehrlich#Methylene_blue; H. Schirmer, B. Coulibaly, A. Stich M. Scheiwein, H. Merkle, J. Eubel, K. Becker, H. Becher, O. Müller, T. Zich, W. Schiek, B. Kouyaté, Redox Rep. 8 (2003) 272; http://www.malariajournal.com/content/pdf/1475-2875-12-127_OnlinePDF.pdf.

  43. K. Krafts, E. Hempelmann, A. Skórska-Stania, Parastol. Res. 111 (2012) 1.

    Google Scholar 

  44. S. Pou, R. W. Winter, A. Nilsen, J. X. Kelly, Y. Li, J. S. Doggett, E. W. Riscoe, K. W. Wegmann, D. J. Hinrichs, M. K. Riscoe, Antimicrobial Agents and Chemotherapy 56 (2012) 3475.

    Google Scholar 

  45. M. A. Biamonte, J. Wanner, K. G. Le Roch, Bioorg. Med. Chem. Lett. 23 (2013) 2829; H. M. Staines, l. Sanjeev Krishna, Treatment and Prevention of Malaria, Springer, Basel, 2012; M. Schlitzer, Arch. Pharm. Chem. Life Sci. 341 (2008) 149.

    Google Scholar 

  46. A. M Croft, J. Royal Soc. Med. 100 (2007) 170; http://en.wikipedia.org/wiki/Mefloquine.

    Google Scholar 

  47. E. Hsu, Br. J. Clin. Pharmacol. 61 (2006) 666.

    Google Scholar 

  48. U. S. Neill, J. Clin. Invest. 121 (2011) 3768.

    Google Scholar 

  49. Y. Tu, Nature Medicine 17 (2011) 1217.

    Google Scholar 

  50. Anonymus, Kexue Tongbao (Chin.) 3 (1977) 142; J.-M. Liu, M.-Y. Ni, J.-F. Fan, Y.-Y. Tu, Z.-H. Wu, Y.-L. Wu, W.-S. Chou, Huaxue Xuebao 37 (1979) 129.

    Google Scholar 

  51. Anonymus, Chin. Med. J. (Engl.) 92 (1979) 811; D. L. Klayman, Science 228 (1985) 1049.

    Google Scholar 

  52. Carl von Linné, Species Plantarum 2, Stockholm, 1753, 847.

    Google Scholar 

  53. L. Olofsson, A. Engström, A. Lundgren, P. E. Brodelius, BMC Plant Biology 11 (2011) 45.

    Google Scholar 

  54. N. Srivastava, A. Akhila, J. Plant Interactions 6 (2011) 265.

    Google Scholar 

  55. C. J. Paddon, P. J. Westfall, D. J. Pitera, K. Benjamin, K. Fisher, D. McPhee, M. D. Leavell, A. Tai, A. Main, D. Eng, D. R. Polichuk, K. H. Teoh, D. W. Reed, T. Treynor, J. Lenihan, M. Fleck, S. Bajad, G. Dang, D. Dengrove, D. Diola, G. Dorin, K. W. Ellens, S. Fickes, J. Galazzo, S. P. Gaucher, T. Geistlinger, R. Henry, M. Hepp, T. Horning, T. Iqbal, H. Jiang, L. Kizer, B. Lieu, D. Melis, N. Moss, R. Regentin, S. Secrest, H. Tsuruta, R. Vazquez, L. F. Westblade, L. Xu, M. Yu, Y. Zhang, L. Zhao, J. Lievense, P. S. Covello, J. D. Keasling, K. K. Reiling, N. S. Renninger, J. D. Newman, Nature 496 (2013) 528.

    Google Scholar 

  56. Z.-X. Yu, J.-X. Li, C.-Q. Yang, W.-L. Hu, L.-J. Wang, X.-Y. Chen, Mol. Plant 5 (2012) 353.

    Google Scholar 

  57. L.-K. Sy, G. D. Brown, Tetrahedron 58 (2002) 897; G. D. Brown, L.-K. Sy, Tetrahedron 63 (2007) 9548; G. D. Brown, Molecules 15 (2010) 7603; J. Kong, Y. Yang, W. Wang, K. Chenga, P. Zhu, RSC Advances 3 (2013) 7622.

    Google Scholar 

  58. http://www.nature.com/srep/2013/130829/srep02513/full/srep02513.html#affil-auth.

  59. P. M. O’Neill, V. E. Barton, S. A. Ward, Molecules 15 (2010) 1705.

    Google Scholar 

  60. R. K. Haynes, K.-W. Cheu, K.-Y. Li, M. M.-K. Tang, H.-N. Wong, M.-J. Chen, Z.-F. Guo, Z.-H. Guo, P. Coghi, D. Monti, Chem Med Chem 6 (2011) 1603.

    Google Scholar 

  61. S. Pulcini, H. M. Staines, J. K. Pittman, K. Slavic, C. Doerig, J. Halbert, R. Tewari, F. Shah, M. A. Avery, R. K. Haynes, S. Krishna, J. Infect. Dis. 208 (2013) 468.

    Google Scholar 

  62. G. Schmid, W. Hofheinz, J. Am. Chem. Soc. 105 (1983) 624.

    Google Scholar 

  63. X. X. Xu, J. Zhu, D. Z. Huang, W. S. Zhou, Tetrahedron 42 (1986) 819; T. Ravindranathan, M. A. Kumar, R. B. Menon, S. V. Hiremath, Tetrahedron Lett. 31 (1990) 755; H. J. Liu, W. L. Yeh, S. Y. Chew, Tetrahedron Lett. 34 (1993) 4435; M. G. Constantino, M. Beltrame, G. V. J. daSilva, Synth. Commun. 26 (1996) 321; H. J. Liu, W. L. Yeh, Heterocycles 42 (1996) 493.

    Google Scholar 

  64. M. A. Avery, C. Jennings-White, W. K. M. Chong, Tetrahedron Lett. 28 (1987) 4629; M. A. Avery, W. K. M. Chong, C. Jennings-White, J. Am. Chem. Soc. 114 (1992) 974.

    Google Scholar 

  65. P. C. Traas, H. Boelens, H. J. Takken, Tetrahedron Lett. (1976) 2287.

    Google Scholar 

  66. G. Büchi, H. Wuest, J. Am. Chem. Soc. 100 (1978) 294.

    Google Scholar 

  67. J. S. Yadav, B. Thirupathaiah, P. Srihari, Tetrahedron 66 (2010) 2005.

    Google Scholar 

  68. S. C. Vonwiller, J. A. Warner, S. T. Mann, R. K. Haynes, J. Am. Chem. Soc. 117 (1995) 11098.

    Google Scholar 

  69. C. Zhu, S. P. Cook, J. Am. Chem. Soc. 134 (2012) 13577; P. Alsters, W. Jary, V. Nardello-Rataj, J.-M.Aubry, Org. Proc. Res. Dev. 14 (2010) 259.

    Google Scholar 

  70. http://de.wikipedia.org/wiki/Artemisinin.

  71. D. K. Ro, E. M. Paradise, M. Ouellet, K. J. Fisher, K. L. Newman, J. M. Ndungu, K. A. Ho, R. A. Eachus, T. S. Ham, J. Kirby, M. C. Y. Chang, S. T. Withers, Y. Shiba, R. Sarpong, J. D. Keasling, Nature 440 (2006) 940.

    Google Scholar 

  72. F. Lévesque, P. H. Seeberger, Angew. Chem. Int. Ed. 51 (2012) 1706.

    Google Scholar 

  73. http://www.rsc.org/chemistryworld/2013/04/sanofi-launches-malaria-drug-production; J. Turconi, F. Griolet, R. Guevel, G. Oddon, R. Villa, A. Geatti, M. Hvala, K. Rossen, R. Göller, A. Burgard, Org. Proc. Res. Dev. 18 (2014) 417.

  74. M. Peplow, Nature 494 (2013) 160.

    Google Scholar 

  75. R. Jambou, E. Legrand, M. Niang, N. Khim, P. Lim, B. Volney, M. T. Ekala, C. Bouchier, P. Esterre, T. Fandeur, O. Mercereau-Puijalon, The Lancet 366 (2005) 1960; http://www.who.int/malaria/publications/atoz/arupdate042012_OnlinePDF.pdf.

  76. H. Noedl, Y. Se, K. Schaecher, B. L. Smith, D. Socheat, M. M. Fukuda, N. Engl. J. Med. 359 (2008) 2619; N. J. White, Science 320 (2008) 330.

    Google Scholar 

  77. A. P. Phyo, S. Nkhoma, K. Stepniewska, E. A. Ashley, S. Nair, R. McGready, C. ler Moo, S. Al-Saai, A. M. Dondorp, K. M. Lwin, P. Singhasivanon, N. P. J. Day, N. J. White, T. J. C. Anderson, F. Nosten, The Lancet 379 (2012) 1960.

    Google Scholar 

  78. http://www.who.int/malaria/publications/atoz/9789241500838/en/.

References to 5.11 Caffeine

  1. http://www.biggone.com/2013/02/08/top-10-most-traded-commodities-in-the-world-2013/; H. G. Maier, Chemie in unserer Zeit 18 (1984) 17.

  2. http://coopcoffees.com/resources/coffee/coffee-timeline; F. Ferré, Kaffee: Eine Kulturgeschichte, Wasmuth, Tübingen, 1991.

  3. B. Sicard, Spektrum der Wissenschaft , June 2003, 65.

    Google Scholar 

  4. H. Steinhart, Chem. Ind. (London) (2002) 26.

    Google Scholar 

  5. E. A. Starbird, National Geographic 159 (1981) 388.

    Google Scholar 

  6. F. F. Runge, Hauswirthschaftliche Briefe, VCH Verlagsgesellschaft, Weinheim, 1988, Thirty-sixth letter: Mein Besuch bei Goethe im Jahre 1819 (My visit to Goethe in the year 1819), 165.

    Google Scholar 

  7. H. H. Lenz, Ullmann’s Encyclopedia of Industrial Chemistry, Sixth Edition, 1998, Electronic Release.

    Google Scholar 

  8. S. Rau, Pharmazie in unserer Zeit 35 (2006) 286.

    Google Scholar 

  9. B. Best, www.benbest.com/health/caffeine.html.

  10. B. B. Friedholm, K. Bättig, J. Holmén, A. Nehlig, E. E. Zvartau, Pharm. Rev . 51 (1999) 83; P. Araque, H. Casanova, C. Ortiz, B. Henao, C. Reláez, J. Agric. Food Chem. 55 (2007) 6918.

    Google Scholar 

  11. S. R. Waldvogel, Angew. Chem. Internat. Edn. 42 (2003) 604.

    Google Scholar 

  12. P. Bützer, www.educeth.ch/chemie/diverses/coffein.

  13. J. Oró, Nature 191 (1961) 1193; J. Oró, A. P. Kimball, Arch. Biochem. Biophys. 94 (1961) 217; R. A. Sanchez, J. P. Ferris, L. E. Orgel, J. Mol. Biol. 30 (1967) 223; A. W. Schwartz, C. G. Bakker, Science 245 (1989) 1102.

    Google Scholar 

  14. J. S. Hudson, J. F. Eberle, R. H. Vachhani, L. C. Rogers, J. H. Wade, R. Krishnamurthy, G. Springsteen, Angew. Chem. 124 (2012) 5224.

    Google Scholar 

  15. P. Karlson, Kurzes Lehrbuch der Biochemie, Thieme, Stuttgart, 1970, 103.

    Google Scholar 

  16. D. Voet, J. G. Voet, Biochemie, VCH, Weinheim, 1992, 764.

    Google Scholar 

  17. D. Voet, J. G. Voet, Biochemie, VCH, Weinheim, 1992, 745.

    Google Scholar 

  18. E. Ito, H. Ashihara, J. Plant Physiol. 154 (1999) 145.

    Google Scholar 

  19. H. Rosemeyer, Chem. Biodivers. 1 (2004) 361 (Review on natural purine derivatives).

    Google Scholar 

  20. A. Crozier, T. W. Baumann, H. Ashihara, T. Suzuki, G. R. Waller, Coll. Sc. Int. sur le Café 17 (1997) 106.

    Google Scholar 

  21. T. Suzuki, E. Takahashi, Phytochem. 15 (1976) 1235.

    Google Scholar 

  22. J. E. Prenosil, M. Hegglin, T. W. Baumann, P. M. Frischknecht, A. W. Kappeler, P. Brodelius, D. Haldimann, Enzyme Microb. Technol. 9 (1987) 450.

    Google Scholar 

  23. S. S. Mösli Waldhauser, J. A. Kretschmar, T. W. Baumann, Phytochem. 44 (1997) 853.

    Google Scholar 

  24. M. Kato, T. Kanehara, H. Shimizu, T. Suzuki, F. M. Gillies, A. Crozier, H. Ashihara, Physiol. Plant. 98 (1996) 629.

    Google Scholar 

  25. Anonymous, Chem. Ind. (London) (2006) 556.

    Google Scholar 

  26. M. Kato, K. Mizuno, A. Crozier, T. Fujimura, H. Ashihara, Nature 406 (2000) 956.

    Google Scholar 

  27. S. N. Katz, Spektrum der Wissenschaft , Mai 1999, 157.

    Google Scholar 

  28. K. Zosel, Angew. Chem. 90 (1978) 748.

    Google Scholar 

  29. E. Fischer, L. Ach, Ber. Dtsch. Chem. Ges. 28 (1895) 2473.

    Google Scholar 

  30. E. Fischer, L. Ach, Ber. Dtsch. Chem. Ges. 28 (1895) 3135.

    Google Scholar 

  31. A. Kossel, Z. physiol. Chem. 13 (1889) 298.

    Google Scholar 

  32. R. Behrend, O. Roosen, Liebigs Ann. Chem. 251 (1888) 235 and 248 (the first uric acid synthesis starting from urea).

    Google Scholar 

  33. W. Traube, Ber. Dtsch. Chem. Ges. 33 (1900) 3035.

    Google Scholar 

  34. E. Mutschler, Arzneimittelwirkungen, Wissenschaftliche Verlagsgesellschaft mbH, Stuttgart, 1991, 239.

    Google Scholar 

  35. H. Bredereck, H.-G. von Schuh, A. Martini, Chem. Ber. 83 (1950) 201; H. Bredereck, R. Gompper, H.-G. von Schuh, G. Theilig, Angew. Chem. 71 (1959) 753.

    Google Scholar 

References to 5.12 Nicotine

  1. F. Eiden, Pharmazie in unserer Zeit 5 (1976) 1.

    Google Scholar 

  2. http://en.wikipedia.org/wiki/Rodrigo_de_Jerez.

  3. E. Ritz, Dtsch. Med. Wochenschr. 130 (2005) 2947.

    Google Scholar 

  4. http://www.fmsi.org/mayawriting/codices/madrid.html.

  5. R. Feser, R. Hilschmann, Weltreiche, Band 3, Zweiburgen Verlag, Weinheim, 193.

    Google Scholar 

  6. M. Hesse, Alkaloide, Wiley-VCH, Weinheim, 2000, 365.

    Google Scholar 

  7. A. Pinner, Arch. Pharm. 231 (1893) 378.

    Google Scholar 

  8. A. Pictet, Ber. Dtsch. Chem. Ges. 28 (1895) 1904.

    Google Scholar 

  9. A. Pictet, Ber. Dtsch. Chem. Ges. 37 (1904) 1225.

    Google Scholar 

  10. P. Karrer, R. Widmer, Helvetica Chimica Acta 8 (1925) 364; P. Nuhn, L. Wessjohann, Naturstoffchemie, Hitzel, Stuttgart, 2006, 587.

    Google Scholar 

  11. Nicotin, Roempp Chemie-Lexikon, Thieme, Stuttgart, electronic release.

    Google Scholar 

  12. G. Habermehl, P. E. Hammann, H. C. Krebs, Naturstoffchemie, Springer, Berlin, 2002, 160.

    Google Scholar 

  13. S. V. Koushik, J. A. Moore III, B. Sundararaju, R. S. Phillips, Biochemistry 37 (1998) 1376.

    Google Scholar 

  14. R. S. Phillips, B. Sundararaju, S. V. Koushik, Biochemistry 37 (1998) 8783.

    Google Scholar 

  15. D. R. Dalton, The Alkaloids, Marcel Dekker, New York, 1979, 145; K.-M. Oksman-Caldentey, Phytochemistry 68 (2007) 2773.

    Google Scholar 

  16. I. T. Baldwin, J. Chem. Ecol. 15 (1989) 1661.

    Google Scholar 

  17. I. T. Baldwin, E. A. Schmelz, T. E. Ohnmeiss, J. Chem. Ecol. 20 (1994) 2139.

    Google Scholar 

  18. M. N. Romanelli, P. Gratteri, L. Guandalini, E. Martini, C. Bonaccini, F. Gualtieri, Chem Med Chem (2007) 746.

    Google Scholar 

  19. T. S. Tso, Tobacco, Ullmann Encyclopaedia, Wiley-VCH, Weinheim, 2005, Electronic Release.

    Google Scholar 

  20. F. F. Wagner, D. L. Comins, Tetrahedron 63 (2007) 8065.

    Google Scholar 

  21. H.-J. Eberhardt, Beiträge Tabakforschung Int. 16 (1995) 119.

    Google Scholar 

  22. B. Vickers, M. Fitzgerald, S. Anderson, M. Turnbull, University of Minnesota, 2008, http://umbbd.msi.umn.edu/nic/nic_map.html ; R. Brandsch, Appl. Microbiol. Biotechnol. 69 (2006) 493; C.-B. Chiribau, M. Mihasan, P. Ganas, G. L. Igloi, V. Artenie, R. Brandsch, FEBS 273 (2006) 1528.

  23. R. B. Silverman, Medizinische Chemie, VCH, Weinheim, 1995, 314; N. L. Benowitz, Ann. Rev. Pharmacol. Toxicol. 36 (1996) 597; J. Hukkanen, P. Jacob III, N. L. Benowitz, Pharm. Rev. 57 (2005) 79.

    Google Scholar 

  24. L. F. Stead, J. R. Hughes, Cochrane Database Syst. Rev. 2012;2:CD000124; http://de.wikipedia.org/wiki/Lobelin.

    Google Scholar 

  25. M. R. Lee, J. R. Coll. Physicians Edinburgh 35 (2005) 83.

    Google Scholar 

  26. J. W. Daly, H. M. Garraffo, T. F. Spande, M. W. Decker, J. P. Sullivan, M. Williams, Nat. Prod. Rep. 17 (2000) 131; H. M. Garraffo, T. F. Spande, M. Williams, Heterocycles 79 (2009) 207; D. L. J. Bilbey, H. Salem, M. H. Grossman, Brit. J. Pharmacol. 15 (1960) 540.

    Google Scholar 

  27. T. F. Spande, H. M. Garraffo, M. W. Edwards, H. J. C. Yeh, L. Pannell, J. W. Daly, J. Am. Chem. Soc. 114 (1992) 3475.

    Google Scholar 

  28. B. Badio, J. W. Daly, Mol. Pharmacol. 45 (1994) 563.

    Google Scholar 

  29. G. Bejeuhr, Pharmazie in unserer Zeit 23 (1994) 105.

    Google Scholar 

  30. C. E. Müller, Pharmazie in unserer Zeit 25 (1996) 85.

    Google Scholar 

  31. A. Husemann, W. Marmé, Z. Chem. (1865) 161.

    Google Scholar 

  32. J. P. Devlin, O. E. Edwards, P. R. Gorham, N. R. Hunter, R. K. Pike, B. Stavric, Can. J. Chem. 55 (1977) 1367.

    Google Scholar 

  33. S. Wonnacott, T. Gallapher, Marine Drugs (2006) 228.

    Google Scholar 

  34. C. S. Huber, Acta Cryst. B28 (1972) 2577.

    Google Scholar 

  35. M. G. Weller, Nachrichten aus der Chemie 50 (2002) 700.

    Google Scholar 

  36. G. Francis, Nature (1878) 11; http://www.epa.gov/cyano_habs_symposium/monograph/Ch28_OnlinePDF.pdf.

  37. W. Schunack, Pharmazie in unserer Zeit 37 (2008) 494.

    Google Scholar 

  38. J. W. Coe, P. R. Brooks, M. G. Vetelino, M. C. Wirtz, E. P. Arnold, J. Huang, S. B. Sands, T. I. Davis, L. A. Lebel, C. B. Fox, A. Shrikhande, J. H. Heym, E. Schaeffer, H. Rollema, Y. Lu, R. S. Mansbach, L. K. Chambers, C. C. Rovetti, D. W. Schulz, F. D. Tingley, B. T. O’Neill, J. Med. Chem. 48 (2005) 3474; P. Rucktooa, C. A. Haseler, R. van Elk, A. B. Smit, T. Gallagher, T. K. Sixma, J. Biol. Chem. 287 (2012) 23283; B. Billen, R. Spurny, M. Brams, R. van Elk, S. Valera-Kummer, J. L. Yakel, T. Voets, D. Bertrand, A. B. Smit, C. Ulens, PNAS 109 (2012) 9173; X. Da Silva Tavares, A. P. Blum, D. T. Nakamura, N. L. Puskar, J. A. P. Shanata, H. A. Lester, D. A. Dougherty, J. Am. Chem. Soc. 134 (2012) 11474; J. B. McClure, G. E. Swan, L. Jack, S. L. Catz, S. M. Zbikowski, T. A. McAfee, M. Deprey, J. Richards, H. Javitz, J. Gen. Intern Med. 24 (2009) 563; R. L. Papke, C. Trocmé-Thibierge, D. Guendisch, S. A. A. Al Rubaiy, S. A. Bloom, J. Pharm. Exp. Ther. 337 (2011) 367.

    Google Scholar 

  39. W. B. Edwards III, R. McCuen, J. Org. Chem. 48 (1983) 2484.

    Google Scholar 

  40. S. Girard, R. J. Robins, J. Villiéras, J. Lebreton, Tetrahedron Lett. 41 (2000) 9245.

    Google Scholar 

  41. C. Welter, R. M. Moreno, S. Streiff, G. Helmchen, Org. Biomol. Chem . 3 (2005) 3266.

    Google Scholar 

  42. E. V. Dehmlow, J. prakt. Chem. 337 (1995) 167.

    Google Scholar 

  43. B. M. Trost, G. R. Cook, Tetrahedron Lett. 37 (1996) 7485.

    Google Scholar 

  44. S. C. Clayton, A. C. Regan, Tetrahedron Lett. 34 (1993) 7493.

    Google Scholar 

  45. J. C. Namyslo, D. E. Kaufmann, Synlett (1999) 804.

    Google Scholar 

  46. R. Prasad, H. J. Grubbs, US 5497792 (1996).

    Google Scholar 

  47. J. Wadsworth Coe, P. R. Palmer Brooks, US 7144882 (2006).

    Google Scholar 

  48. J. Wadsworth Coe, P. R. Palmer Brooks, US 6410550 (2002).

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

Copyright information

© 2014 Springer Berlin Heidelberg

About this chapter

Cite this chapter

Schaefer, B. (2014). Pharmaceuticals. In: Natural Products in the Chemical Industry. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-54461-3_5

Download citation

Publish with us

Policies and ethics