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Augenirritation und Augenverätzungen

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Verbrennungschirurgie
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Zusammenfassung

Augenirritation und Augenverätzung sind Folge von physikalisch-chemischen Expositionen des Auges, welche die biologischen Abwehrkräfte überfordern. Gewebeschädigung bis hin zur Nekrose führt im Weiteren zu einer Krankheit mit Funktionsverlust und schwerer Entzündung. Das Kapitel zeigt die Mechanismen der Gewebeschädigung auf und differenziert die Möglichkeiten von Behandlungen nach therapeutischen Zielen. Die Bedeutung einer optimalen und schnellen Erstversorgung wird erklärt. Die Wirkprinzipien der konservativen und operativen Therapien werden anhand von Skizzen, Beispielen und konkreten Handlungsempfehlungen dargestellt. Insbesondere die Veränderung der chemischen Zusammensetzung des Gewebes, Grenzen der biologischen Überlebensfähigkeit und die Wiederherstellung der physiologischen Gewebeosmolarität, Reaktionsfähigkeit und chemischen Zusammensetzung werden diskutiert.

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Literatur

  • Adriaens E, Barroso J, Eskes C, Hoffmann S, McNamee P, Alépée N, Bessou-Touya S, De Smedt A, De Wever B, Pfannenbecker U, Tailhardat M, Zuang V (2014) Retrospective analysis of the Draize test for serious eye damage/eye irritation: importance of understanding the in vivo endpoints under UN GHS/EU CLP for the development and evaluation of in vitro test methods. Arch Toxicol 88(3):701–723. doi: 10.1007/s00204-013-1156-8. Epub 2013 Dec 28

    Google Scholar 

  • Bagley DM, Casterton PL, Dressler WE, Edelhauser HF, Kruszewski FH, McCulley JP, Nussenblatt RB, Osborne R, Rothenstein A, Stitzel KA, Thomas K, Ward SL (2006) Proposed new classification scheme for chemical injury to the human eye. Regul Toxicol Pharmacol 45(2):206–213. Epub 2006 Jun 9

    Google Scholar 

  • Behar-Cohen F, Baillet G, De Ayguavives T, Garcia PO, Krutmann J, Peña-García P, Reme C, Wolffsohn JS (2014) Ultraviolet damage to the eye revisited: eye-sun protection factor (E-SPF), a new ultraviolet protection label for eyewear. Clin Ophthalmol 8:87–104

    Google Scholar 

  • Bernauer W, Thiel MA, Kurrer M, Heiligenhaus A, Rentsch KM, Schmitt A, Heinz C, Yanar A (2006) Corneal calcification following intensified treatment with sodium hyaluronate artificial tears. Br J Ophthalmol 90(3):285–288

    Google Scholar 

  • Bernauer W, Thiel MA, Rentsch KM (2008) Phosphate concentration in ophthalmic corticoid preparations. Graefes Arch Clin Exp Ophthalmol 246(7):975–978

    Google Scholar 

  • Böhmer JA, Sellhaus B, Schrage NF (2001) Effects of ascorbic acid on retinal pigment epithelial cells. Curr Eye Res 23(3):206–214

    Google Scholar 

  • Burgher F, Blomet J, Mathieu L (1996) Le Risque chimique et la santé au travail: essai de toxicologie réflexif. Valmandois Ed. Prévor

    Google Scholar 

  • Dua HS, King AJ, Joseph A (2001) A new classification of ocular surface burns. Br J Ophthalmol 85(11):1379–1383

    Google Scholar 

  • Eberwein P, Reinhard T (2012) Aktuelle und zukünftige Therapieoptionen bei Erkrankungen der Limbusstammzellen. Klin Monatsbl Augenheilkd 229(12):1178–1184

    Google Scholar 

  • Erdem E, Undar IH, Esen E, Yar K, Yagmur M, Ersoz R (2013) Topical anesthetic eye drops abuse: are we aware of the danger? Cutan Ocul Toxicol 32(3):189–193

    Google Scholar 

  • Green K, Paterson CA, Siddiqui A (1985) Ocular blood flow after experimental alkali burns and prostaglandin administration.Arch Ophthalmol 103(4):569–571

    Google Scholar 

  • Heckelen A, Hermel M, Kondring B, Schrage NF (2004) Ascorbic acid reversibly inhibits proliferation of retinal pigment epithelial cells. Acta Ophthalmol Scand 82(5):564–568

    Google Scholar 

  • Hellmann M (2008) Eye chemical burns caused by various irritating agents from an epidemiological point of view. RWTH Aachen University Hospital Dissertation

    Google Scholar 

  • Hermel M, Heckelen A, Kirchhof B, Schrage NF (2001) Inhibitory effect of ascorbic acid on human retinal pigment epithelial cell proliferation compared to cytostatic drugs – influence of histamine. Inflamm Res 50 Suppl 2:S93–95

    Google Scholar 

  • Iakimenko SA, Buznyk OI, Rymgayllo-Jankowska B (2013) Amniotic membrane transplantation in treatment of persistent corneal ulceration after severe chemical and thermal eye injuries. Eur J Ophthalmol 23(4):496–503. doi: 10.5301/ejo.5000243. Epub 2013 Mar 20

    Google Scholar 

  • Kearney T, Hiatt P, Birdsall E, Smollin C (2014) Pepper spray injury severity: ten-year case experience of a poison control system. Prehosp Emerg Care 18(3):381–386. doi: 10.3109/10903127.2014.891063. Epub 2014 Mar 26

    Google Scholar 

  • Kompa S, Schareck B, Tympner J, Wustemeyer H, Schrage NF (2002) Comparison of emergency eye-wash products in burned porcine eyes. Graefes Arch Clin Exp Ophthalmol 240(4):308–313

    Google Scholar 

  • Kuckelkorn R, Kottek A, Schrage N, Reim M (1995) Poor prognosis of severe chemical and thermal eye burns: the need for adequate emergency care and primary prevention. Int Arch Occup Environ Health 67(4):281–284

    Google Scholar 

  • Kuckelkorn R, Makropoulos W, Kottek A, Reim M (1993) Retrospective study of severe alkali burns of the eyes Klin Monatsbl Augenheilkd 203(6):397–402

    Google Scholar 

  • Kuckelkorn R, Schrage N, Reim M (1995) Treatment of severe eye burns by tenonplasty. Lancet 11;345(8950):657–658

    Google Scholar 

  • Langefeld S, Reim M, Redbrake C, Schrage NF (1997) The corneal stroma: an inhomogeneous structure. Graefes Arch Clin Exp Ophthalmol 235(8):480–485

    Google Scholar 

  • Mathieu L, Nehles J, Blomet J, Hall AH (2001) Efficacy of hexafluorine for emergent decontamination of hydrofluoric acid eye and skin splashes. Vet Hum Toxicol 43(5):263–265

    Google Scholar 

  • Matsumoto H, Koyama Y, Tanioka A (2001) Preparation and Characterization of Novel Weak Amphoteric Charged Membrane Containing Cysteine Residues. J Colloid Interface Sci 15;239(2):467–474

    Google Scholar 

  • Meller D, Pauklin M, Thomasen H, Westekemper H, Steuhl KP (2011) Amniotic membrane transplantation in the human eye. Dtsch Arztebl Int 108(14):243–248

    Google Scholar 

  • Merle H, Gérard M, Schrage N (2008) Brulure oculaire. J Fr Ophtalmol 31(7):723–734

    Google Scholar 

  • Oh JY, Lee HJ, Khwarg SI, Wee WR (2010) Corneal cell viability and structure after transcorneal freezing-thawing in the human cornea. Clin Ophthalmol 25;4:477–480

    Google Scholar 

  • Pauklin M, Steuhl KP, Meller D (2009) Characterization of the corneal surface in limbal stem cell deficiency and after transplantation of cultivated limbal epithelium. Ophthalmology 116(6):1048–1056

    Google Scholar 

  • Pellegrini G, Traverso CE, Franzi AT, Zingirian M, Cancedda R, De Luca M (1997) Long-term restoration of damaged corneal surfaces with autologous cultivated corneal epithelium. Lancet 5;349(9057):990–993

    Google Scholar 

  • Pfister RR, Haddox JL, Sommers CI, Lam KW (1996) A neutrophil chemoattractant is released from cellular and extracellular components of the alkali-degraded cornea and blood. Invest Ophthalmol Vis Sci 37(1):230–237

    Google Scholar 

  • Pfister RR, Haddox JL, Yuille-Barr D (1991) The combined effect of citrate/ascorbate treatment in alkali-injured rabbit eyes. Cornea 10(2):100–104

    Google Scholar 

  • Pospisil H, Holzhuetter HG (2001) A compartment Model to calculate time-dependent concentration profiles of topically applied chemical compounds in the anteriro compartments of the rabbit eye. ATLA 29, 347–365

    Google Scholar 

  • Reim M (1990) Ein neues Behandlungskonzept für schwere Verätzungen. Klin Monatsbl Augenheilk 196:1–5

    Google Scholar 

  • Reim M, Redbrake C, Schrage N (2001) Chemical and thermal injuries of the eyes. Surgical and medical treatment based on clinical and pathophysiological findings. Arch Soc Esp Oftalmol 76(2):79–124

    Google Scholar 

  • Rihawi S, Frentz M, Schrage NF (2005) Emergency treatment of eye burns: which rinsing solution should we choose? Graefes Arch Clin Exp Ophthalmol 20:1–10

    Google Scholar 

  • Rihawi S, Frentz M, Schrage NF (2006) Emergency treatment of eye burns: which rinsing solution should we choose? Graefes Arch Clin Exp Ophthalmol 244(7):845–854

    Google Scholar 

  • Schrage NF, Frentz M, Reim M (2010) Changing the composition of buffered eye-drops prevents undesired side effects. Br J Ophthalmol 94(11):1519–1522

    Google Scholar 

  • Schrage NF, Kompa S, Ballmann B, Reim M, Langefeld S (2005) Relationship of eye burns with calcifications of the cornea? Graefes Arch Clin Exp Ophthalmol 243(8):780–784

    Google Scholar 

  • Schrage NF, Langefeld S, Zschocke J, Kuckelkorn R, Redbrake C, Reim M (2000) Eye burns: an emergency and continuing problem. Burns 26(8):689–699

    Google Scholar 

  • Schrage NF, Schlossmacher B, Aschenbernner W, Langefeld S (2001) Phosphate buffer in alkali eye burns as an inducer of experimental corneal calcification. Burns 27(5):459–464

    Google Scholar 

  • Söderberg PG (2011) Optical radiation and the eyes with special emphasis on children. Prog Biophys Mol Biol 107(3):389–392. doi: 10.1016/j.pbiomolbio.2011.09.009. Epub 2011 Sep 21

    Google Scholar 

  • Spöler F, Först M, Kurz H, Frentz M, Schrage NF (2007) Dynamic analysis of chemical eye burns using high-resolution optical coherence tomography. J Biomed Opt 12(4):041203

    Google Scholar 

  • Spöler F, Frentz M, Först M, Kurz H, Schrage NF (2008) Analysis of hydrofluoric acid penetration and decontamination of the eye by means of time-resolved optical coherence tomography. Burns 34(4):549–555. Epub 2007 Sep 14

    Google Scholar 

  • Szentmáry N, Daas L, Matoula P, Goebels S, Seitz B (1993) Acanthamoebenkeratitis Ophthalmologe 110(12):1203–1210; quiz 1211. doi: 10.1007/s00347-013-2981-2990

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Schrage, N. (2016). Augenirritation und Augenverätzungen. In: Lehnhardt, M., Hartmann, B., Reichert, B. (eds) Verbrennungschirurgie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-54444-6_28

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  • DOI: https://doi.org/10.1007/978-3-642-54444-6_28

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-54443-9

  • Online ISBN: 978-3-642-54444-6

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