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Filaggrin pp 75–81Cite as

In Vitro Models of Filaggrin-Associated Diseases

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Abstract

Reconstructed skin models are new and useful research tools to investigate fundamental processes of the skin homeostasis and the pathophysiology of skin diseases. Although still in its infancy, more research efforts need to be made in the field of filaggrin-deficient skin models to unravel the impact and function of filaggrin for the pathogenesis of atopic dermatitis and ichthyosis vulgaris. As for today, only a limited amount of publications are available. Nevertheless, by the means of reconstructed skin models, very promising and interesting new insights in the role of filaggrin have been obtained that are summarized and discussed in this chapter.

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Author information

Authors and Affiliations

  1. Department of Pharmaceutical Sciences, Pharmacology/Toxicology, Freie Universität Berlin, Königin-Luise-Str. 2-4, Berlin, 14195, Germany

    Sarah Küchler PhD

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  1. Sarah Küchler PhD
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Correspondence to Sarah Küchler PhD .

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Editors and Affiliations

  1. Department of Dermato-Allergology, National Allergy Research Centre, Gentofte Hospital, University of Copenhagen, Hellerup, Denmark

    Jacob P. Thyssen

  2. Department of Dermatology, University of California, San Francisco, California, USA

    Howard I. Maibach

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Küchler, S. (2014). In Vitro Models of Filaggrin-Associated Diseases. In: Thyssen, J., Maibach, H. (eds) Filaggrin. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-54379-1_8

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  • DOI: https://doi.org/10.1007/978-3-642-54379-1_8

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