Abstract
An intact gastrointestinal barrier is essential to host homeostasis, with its dysfunction leading to excess inflammation. One particular gene and protein, filaggrin, seems to play a particularly important role in maintaining the integrity of the epithelial barrier of the gastrointestinal tract. We present data to support the hypotheses that alteration in normal filaggrin expression leads to various gastrointestinal pathologies, including inflammatory bowel disease and eosinophilic esophagitis.
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Thyssen, A.P., Thyssen, E.P. (2014). Filaggrin Dysfunction and Its Association with Inflammatory Conditions of the GI Tract. In: Thyssen, J., Maibach, H. (eds) Filaggrin. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-54379-1_32
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DOI: https://doi.org/10.1007/978-3-642-54379-1_32
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