Skip to main content

Alveolar Hydatidosis of the Central Nervous System

  • Chapter
  • First Online:
Hydatidosis of the Central Nervous System: Diagnosis and Treatment

Abstract

Alveolar echinococcosis is caused by the larval stage of the fox tapeworm Echinococcus multilocularis who has a sylvatic life cycle in foxes and in arvicolid rodents. Foci of human cases also occur where foxes or domestic dogs are fed on infected rodents and where there is accidental ingestion of E. multilocularis eggs from canine fecal matter. Alveolar hydatid disease is an aggressive and a highly lethal parasitic infection characterized by the appearance of a tumor with extensive character, primarily in the liver of intermediate hosts including humans. The tumor has a pronounced pseudomalignant growth and can induce metastasis to different organs. Cerebral hydatid disease is very rare. The cerebral alveolar echinococcosis has a poor prognosis. The lesions may remain asymptomatic until they are quite large. The long-term chemotherapy may be indicated as a life-saving measure for patients with severe liver dysfunction but is associated with a relatively high risk of proliferation of intraoperatively undetected parasite remnants.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  • Algros MP, Majo F, Bresson-Hadni S, Koch S, Godard J, Cattin F. Intracerebral alveolar echinococcosis. Infection. 2003;31:63–5.

    Article  PubMed  Google Scholar 

  • Altinors N, Bavbek M, Caner HH, Erdogan B. Central nervous system hydatidosis in Turkey: a cooperative study and literature survey analysis of 458 cases. J Neurosurg. 2000;93:1–8.

    Article  CAS  PubMed  Google Scholar 

  • Ammann RW, Eckert J. Cestodes. Echinococcus. Gastroenterol Clin North Am. 1996;25:655–89.

    Article  CAS  PubMed  Google Scholar 

  • Asanuma T, Matsumoto Y, Takiguchi M, Inanami O, Nakao M, Nakaya K, Ito A, Hashimoto A, Kuwabara M. Magnetic resonance imaging and immunoblot analyses in rats with experimentally induced cerebral alveolar echinococcosis. Comp Med. 2003;53:649–56.

    CAS  PubMed  Google Scholar 

  • Aydin Y, Barlas O, Yolaş C, Aydin IH, Ceviz A, Aladağ A, Ören D, Akdemir D. Alveolar hydatid disease of the brain. Report of four cases. J Neurosurg. 1986;65:115–9.

    Article  CAS  PubMed  Google Scholar 

  • Aydinli B, Aydin U, Yazici P, Oztürk G, Onbaş O, Polat KY. Alveolar echinococcosis of liver presenting with neurological symptoms due to brain metastases with simultaneous lung metastasis: a case report. Turkiye Parazitol Derg. 2008;32:371–4.

    PubMed  Google Scholar 

  • Barjhoux P, Gilbertas A, Girona GC, Rochet M. Terminal cerebral localization of hepatic alveolar and pulmonary echinococcosis. Apropos of a case. Arch Fr Mal App Dig. 1970;59:263–4.

    CAS  PubMed  Google Scholar 

  • Bensaid AH, Dietemann JL, Filippi de la Palavesa MM, Klinkert A, Kastler B, Gangi A. Intracranial alveolar echinococcosis: CT and MRI. Neuroradiology. 1994;36:289–91.

    Article  CAS  PubMed  Google Scholar 

  • Bresson-Hadni S, Vuitton DA, Bartholomot B, Heyd B, Godart D, Meyer JP, Hrusovsky S, Becker MC, Mantion G. A twenty-year history of alveolar echinococcosis: analysis of a series of 117 patients from eastern France. Eur J Gastroenterol Hepatol. 2000;12:327–36.

    Article  CAS  PubMed  Google Scholar 

  • Brunetti E, Kern P, Vuitton DA. Expert consensus for the diagnosis and treatment of cystic and alveolar echinococcosis in humans. Acta Trop. 2010;114:1–16.

    Article  PubMed  Google Scholar 

  • Bükte Y, Kemanoğlu S, Nazaroğlu H, Özkan Ü, Ceviz A, Şimşek M. Cerebral hydatid disease: CT and MR imaging findings. Swiss Med Wkly. 2004;134:459–67.

    PubMed  Google Scholar 

  • Devé F. L’echinococcose alvéolaire secondaire. Paris: Masson; 1946.

    Google Scholar 

  • Georges S, Villard O, Filisetti D, Mathis A, Marcellin L, Hansmann Y, Candolfi E. Usefulness of PCR analysis for diagnosis of alveolar echinococcosis with unusual localizations: two case studies. J Clin Microbiol. 2004;42:5954–6.

    Article  PubMed Central  PubMed  Google Scholar 

  • Hakan T, Aker FV. A case report of fatal echinococcosis. Ann Neurosurg. 2001;1:14–9.

    Google Scholar 

  • Hanstein H. Medical therapy of multilocular echinococcosis. Dtsch Med Wochenschr. 1957;82:316–7.

    Article  CAS  PubMed  Google Scholar 

  • Isik N, Silav G, Cerçi A, Karabagli P, Elmaci I, Kalelioglu M. Cerebral alveolar echinococcosis. A case report with MRI and review of the literature. Neurosurg Sci. 2007;51:145–51.

    CAS  Google Scholar 

  • Jiang P, McManus DP, Jones M. Liver alveolar echinococcosis in China: clinical aspect with relative basic research. World J Gastroenterol. 2005;11:4611–7.

    PubMed  Google Scholar 

  • Kammerer WS. Echinococcosis affecting the central nervous system. Semin Neurol. 1993;13:144–7.

    Article  CAS  PubMed  Google Scholar 

  • Kern P. Clinical features and treatment of alveolar echinococcosis. Curr Opin Infect Dis. 2010;23:505–12.

    Article  PubMed  Google Scholar 

  • Kern P, Bardonnet K, Renner E, Auer H, Pawlowski Z, Ammann RW, Vuitton DA, Kern P. European echinococcosis registry: human alveolar echinococcosis, Europe, 1982–2000. Emerg Infect Dis. 2003;9:343–9.

    Article  PubMed Central  PubMed  Google Scholar 

  • Li HT, Tuerganaili H, Ayifuhanahan, Shao YM, Zhao JM, Ran B, Wen H. Clinical experiences in the treatment of human multi-organ alveolar echinococcosis by surgery and drugs. Zhonghua Yi Xue Za Zhi. 2010;90:2839–42.

    PubMed  Google Scholar 

  • Matsuhisa T, Uchino J, Sato N, Furuya K, Fujioka Y. Which component makes distant metastasis of alveolar echinococcosis, germinal cells or protoscolices? In: Uchino J, Sato N, editors. Strategy for eradication of alveolar echinococcosis of the liver. Sapporo: Fuji Shoin Publishers; 1996. p. 233–7.

    Google Scholar 

  • McManus DP, Li Z, Yang S, Gray DJ, Yang YR. Case studies emphasising the difficulties in the diagnosis and management of alveolar echinococcosis in rural China. Parasit Vectors. 2011;4:196.

    Article  PubMed Central  PubMed  Google Scholar 

  • Oktar N, Karabiyikoğlu M, Demirtaş E, Altintaş N, Korkmaz M, Özdamar N. Cerebral alveolar echinococcosis. Review of the literature and report of a case. Norol Bil D Turkish J Neurological Sci. 1999;16:1.

    Google Scholar 

  • Ozdol C, Yildirim AE, Daglioglu E, Divanlioglu D, Erdem E, Belen D. Alveolar hydatid cyst mimicking cerebellar metastatic tumor. Surg Neurol Int. 2011;2:13.

    Article  PubMed Central  PubMed  Google Scholar 

  • Piotin M, Cattin F, Kantelip B, Miralbes S, Godard J, Bonneville JF. Disseminated intracerebral alveolar echinococcosis: CT and MRI. Neuroradiology. 1997;39:431–3.

    Article  CAS  PubMed  Google Scholar 

  • Qiu M, Hun ZS, Liu SC, Wen Li C, Wang S, Bao LS. Intracranial alveolar echinococcosis in China: discussion of surgical treatment. Acta Neurochir (Wien). 1986;82:123–7.

    Article  CAS  Google Scholar 

  • Reittner P, Szolar DH, Schmid M. Case report. Systemic manifestation of Echinococcus alveolaris infection. J Comput Assist Tomogr. 1996;20:1030–2.

    Article  CAS  PubMed  Google Scholar 

  • Reuter S, Kratzer W, Kurz S, Wellinghausen N, Kern P. Chemotherapy of alveolar echinococcosis with benzimidazoles. A prospective long-term study. Med Klin (Munich). 1998;93:463–7.

    Article  CAS  Google Scholar 

  • Sato Y, Nakao M, Nakaya K, Ito A. Experimental infection of larval Echinococcus multilocularis in the rodent brain as a model for cerebral alveolar echinococcosis. J Helminthol. 1998;72:59–64.

    Article  CAS  PubMed  Google Scholar 

  • Schmid M, Pendl G, Samonigg H, Ranner G, Eustacchio S, Reisinger EC. Gamma knife radiosurgery and albendazole for cerebral alveolar hydatid disease. Clin Infect Dis. 1998;26:1379–82.

    Article  CAS  PubMed  Google Scholar 

  • Senturk S, Oguz KK, Soylemezoglu F, Inci S. Cerebral alveolar echinoccosis mimicking primary brain tumor. AJNR Am J Neuroradiol. 2006;27:420–2.

    CAS  PubMed  Google Scholar 

  • Sikó BS. Echinococcosis with E. multilocularis in Romania. Aetiology, epidemiology, diagnosis and control of the disease. PhD thesis, USAMV Cluj Napoca; 2011a.

    Google Scholar 

  • Sikó BS. Alveolar echinococcosis. A paraneoplasic zoonosis recent confirmed in Romania. Internat. Congress of Oncology, Neptun, Romania, Workshop 2; 2011b.

    Google Scholar 

  • Takci E, Sengul G, Akar A, Uslu H, Alper F, Erdogan F. Alveolar echinococcosis of the brain in five patients. J Clin Neurosci. 2008;15:1105–9.

    Article  PubMed  Google Scholar 

  • Tappe D, Weise D, Ziegler U, Müller A, Müllges W, Stich A. Brain and lung metastasis of alveolar echinococcosis in a refugee from a hyperendemic area. J Med Microbiol. 2008;57:1420–3.

    Article  PubMed  Google Scholar 

  • Torgerson PR, Keller K, Magnotta M, Ragland N. The global burden of alveolar echinococcosis. PLoS Negl Trop Dis. 2010;4:e722.

    Article  PubMed Central  PubMed  Google Scholar 

  • Tunaci M, Tunaci A, Engin G, Ozkorkmaz B, Ahishali B, Rozanes I. MRI of cerebral alveolar echinococcosis. Neuroradiology. 1999;41:844–6.

    Article  CAS  PubMed  Google Scholar 

  • Wada H, Takahashi S, Higano S, Tominaga T, Sakamoto K. CT and MR imaging findings in a case of cerebral alveolar echinococcosis masquerading as brain tumor. Nippon Igaku Hoshasen Gakkai Zasshi. 1996;56:608–9.

    CAS  PubMed  Google Scholar 

  • Wang J, Cai B, You C. Surgical treatment for cerebral alveolar echinococcosis: experience in six patients. Neurol India. 2009;57:157–61.

    Article  PubMed  Google Scholar 

  • Wang J, Xing Y, Ren B, Xie W, Wen H, Liu W. Alveolar echinococcosis: correlation of imaging type with PNM stage and diameter of lesions. Chin Med J. 2011;124:2824–8.

    PubMed  Google Scholar 

  • Weber M, Vespignani H, Jacquier P, Gérard A, Claudon P, Bracard S, Floquet J. Neurological manifestations of alveolar echinococcosis. Rev Neurol (Paris). 1988;144:104–12.

    CAS  Google Scholar 

  • WHO Informal Working Group on Echinococcosis. Guidelines for treatment of cystic and alveolar echinococcosis in humans. Bull World Health Organ. 1996;74:231–42.

    Google Scholar 

  • Yamamoto M. Gamma knife radiosurgery: technology, applications, and future directions. Neurosurg Clin N Am. 1999;10:181–202.

    CAS  PubMed  Google Scholar 

  • Yang YR, Vuitton DA, Jones MK, Craig PS, McManus DP. Brain metastasis of alveolar echinococcosis in a hyperendemic focus of Echinococcus multilocularis infection. Trans R Soc Trop Med Hyg. 2005;99:937–41.

    Article  CAS  PubMed  Google Scholar 

  • Zhang W, McManus DP. Recent advances in the immunology and diagnosis of echinococcosis. FEMS Immunol Med Microbiol. 2006;47:24–41.

    Article  CAS  PubMed  Google Scholar 

  • Zhang W, Li J, McManus DP. Review concepts in immunology and diagnosis of hydatid disease. Clin Microbiol Rev. 2003;16:18–36.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Sikó Barabási Sándor DVM, Dr. Univ., MSc, PhD .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2014 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Sándor, S.B. (2014). Alveolar Hydatidosis of the Central Nervous System. In: Turgut, M. (eds) Hydatidosis of the Central Nervous System: Diagnosis and Treatment. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-54359-3_24

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-54359-3_24

  • Published:

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-54358-6

  • Online ISBN: 978-3-642-54359-3

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics