Abstract
Alveolar echinococcosis is caused by the larval stage of the fox tapeworm Echinococcus multilocularis who has a sylvatic life cycle in foxes and in arvicolid rodents. Foci of human cases also occur where foxes or domestic dogs are fed on infected rodents and where there is accidental ingestion of E. multilocularis eggs from canine fecal matter. Alveolar hydatid disease is an aggressive and a highly lethal parasitic infection characterized by the appearance of a tumor with extensive character, primarily in the liver of intermediate hosts including humans. The tumor has a pronounced pseudomalignant growth and can induce metastasis to different organs. Cerebral hydatid disease is very rare. The cerebral alveolar echinococcosis has a poor prognosis. The lesions may remain asymptomatic until they are quite large. The long-term chemotherapy may be indicated as a life-saving measure for patients with severe liver dysfunction but is associated with a relatively high risk of proliferation of intraoperatively undetected parasite remnants.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Algros MP, Majo F, Bresson-Hadni S, Koch S, Godard J, Cattin F. Intracerebral alveolar echinococcosis. Infection. 2003;31:63–5.
Altinors N, Bavbek M, Caner HH, Erdogan B. Central nervous system hydatidosis in Turkey: a cooperative study and literature survey analysis of 458 cases. J Neurosurg. 2000;93:1–8.
Ammann RW, Eckert J. Cestodes. Echinococcus. Gastroenterol Clin North Am. 1996;25:655–89.
Asanuma T, Matsumoto Y, Takiguchi M, Inanami O, Nakao M, Nakaya K, Ito A, Hashimoto A, Kuwabara M. Magnetic resonance imaging and immunoblot analyses in rats with experimentally induced cerebral alveolar echinococcosis. Comp Med. 2003;53:649–56.
Aydin Y, Barlas O, Yolaş C, Aydin IH, Ceviz A, Aladağ A, Ören D, Akdemir D. Alveolar hydatid disease of the brain. Report of four cases. J Neurosurg. 1986;65:115–9.
Aydinli B, Aydin U, Yazici P, Oztürk G, Onbaş O, Polat KY. Alveolar echinococcosis of liver presenting with neurological symptoms due to brain metastases with simultaneous lung metastasis: a case report. Turkiye Parazitol Derg. 2008;32:371–4.
Barjhoux P, Gilbertas A, Girona GC, Rochet M. Terminal cerebral localization of hepatic alveolar and pulmonary echinococcosis. Apropos of a case. Arch Fr Mal App Dig. 1970;59:263–4.
Bensaid AH, Dietemann JL, Filippi de la Palavesa MM, Klinkert A, Kastler B, Gangi A. Intracranial alveolar echinococcosis: CT and MRI. Neuroradiology. 1994;36:289–91.
Bresson-Hadni S, Vuitton DA, Bartholomot B, Heyd B, Godart D, Meyer JP, Hrusovsky S, Becker MC, Mantion G. A twenty-year history of alveolar echinococcosis: analysis of a series of 117 patients from eastern France. Eur J Gastroenterol Hepatol. 2000;12:327–36.
Brunetti E, Kern P, Vuitton DA. Expert consensus for the diagnosis and treatment of cystic and alveolar echinococcosis in humans. Acta Trop. 2010;114:1–16.
Bükte Y, Kemanoğlu S, Nazaroğlu H, Özkan Ü, Ceviz A, Şimşek M. Cerebral hydatid disease: CT and MR imaging findings. Swiss Med Wkly. 2004;134:459–67.
Devé F. L’echinococcose alvéolaire secondaire. Paris: Masson; 1946.
Georges S, Villard O, Filisetti D, Mathis A, Marcellin L, Hansmann Y, Candolfi E. Usefulness of PCR analysis for diagnosis of alveolar echinococcosis with unusual localizations: two case studies. J Clin Microbiol. 2004;42:5954–6.
Hakan T, Aker FV. A case report of fatal echinococcosis. Ann Neurosurg. 2001;1:14–9.
Hanstein H. Medical therapy of multilocular echinococcosis. Dtsch Med Wochenschr. 1957;82:316–7.
Isik N, Silav G, Cerçi A, Karabagli P, Elmaci I, Kalelioglu M. Cerebral alveolar echinococcosis. A case report with MRI and review of the literature. Neurosurg Sci. 2007;51:145–51.
Jiang P, McManus DP, Jones M. Liver alveolar echinococcosis in China: clinical aspect with relative basic research. World J Gastroenterol. 2005;11:4611–7.
Kammerer WS. Echinococcosis affecting the central nervous system. Semin Neurol. 1993;13:144–7.
Kern P. Clinical features and treatment of alveolar echinococcosis. Curr Opin Infect Dis. 2010;23:505–12.
Kern P, Bardonnet K, Renner E, Auer H, Pawlowski Z, Ammann RW, Vuitton DA, Kern P. European echinococcosis registry: human alveolar echinococcosis, Europe, 1982–2000. Emerg Infect Dis. 2003;9:343–9.
Li HT, Tuerganaili H, Ayifuhanahan, Shao YM, Zhao JM, Ran B, Wen H. Clinical experiences in the treatment of human multi-organ alveolar echinococcosis by surgery and drugs. Zhonghua Yi Xue Za Zhi. 2010;90:2839–42.
Matsuhisa T, Uchino J, Sato N, Furuya K, Fujioka Y. Which component makes distant metastasis of alveolar echinococcosis, germinal cells or protoscolices? In: Uchino J, Sato N, editors. Strategy for eradication of alveolar echinococcosis of the liver. Sapporo: Fuji Shoin Publishers; 1996. p. 233–7.
McManus DP, Li Z, Yang S, Gray DJ, Yang YR. Case studies emphasising the difficulties in the diagnosis and management of alveolar echinococcosis in rural China. Parasit Vectors. 2011;4:196.
Oktar N, Karabiyikoğlu M, Demirtaş E, Altintaş N, Korkmaz M, Özdamar N. Cerebral alveolar echinococcosis. Review of the literature and report of a case. Norol Bil D Turkish J Neurological Sci. 1999;16:1.
Ozdol C, Yildirim AE, Daglioglu E, Divanlioglu D, Erdem E, Belen D. Alveolar hydatid cyst mimicking cerebellar metastatic tumor. Surg Neurol Int. 2011;2:13.
Piotin M, Cattin F, Kantelip B, Miralbes S, Godard J, Bonneville JF. Disseminated intracerebral alveolar echinococcosis: CT and MRI. Neuroradiology. 1997;39:431–3.
Qiu M, Hun ZS, Liu SC, Wen Li C, Wang S, Bao LS. Intracranial alveolar echinococcosis in China: discussion of surgical treatment. Acta Neurochir (Wien). 1986;82:123–7.
Reittner P, Szolar DH, Schmid M. Case report. Systemic manifestation of Echinococcus alveolaris infection. J Comput Assist Tomogr. 1996;20:1030–2.
Reuter S, Kratzer W, Kurz S, Wellinghausen N, Kern P. Chemotherapy of alveolar echinococcosis with benzimidazoles. A prospective long-term study. Med Klin (Munich). 1998;93:463–7.
Sato Y, Nakao M, Nakaya K, Ito A. Experimental infection of larval Echinococcus multilocularis in the rodent brain as a model for cerebral alveolar echinococcosis. J Helminthol. 1998;72:59–64.
Schmid M, Pendl G, Samonigg H, Ranner G, Eustacchio S, Reisinger EC. Gamma knife radiosurgery and albendazole for cerebral alveolar hydatid disease. Clin Infect Dis. 1998;26:1379–82.
Senturk S, Oguz KK, Soylemezoglu F, Inci S. Cerebral alveolar echinoccosis mimicking primary brain tumor. AJNR Am J Neuroradiol. 2006;27:420–2.
Sikó BS. Echinococcosis with E. multilocularis in Romania. Aetiology, epidemiology, diagnosis and control of the disease. PhD thesis, USAMV Cluj Napoca; 2011a.
Sikó BS. Alveolar echinococcosis. A paraneoplasic zoonosis recent confirmed in Romania. Internat. Congress of Oncology, Neptun, Romania, Workshop 2; 2011b.
Takci E, Sengul G, Akar A, Uslu H, Alper F, Erdogan F. Alveolar echinococcosis of the brain in five patients. J Clin Neurosci. 2008;15:1105–9.
Tappe D, Weise D, Ziegler U, Müller A, Müllges W, Stich A. Brain and lung metastasis of alveolar echinococcosis in a refugee from a hyperendemic area. J Med Microbiol. 2008;57:1420–3.
Torgerson PR, Keller K, Magnotta M, Ragland N. The global burden of alveolar echinococcosis. PLoS Negl Trop Dis. 2010;4:e722.
Tunaci M, Tunaci A, Engin G, Ozkorkmaz B, Ahishali B, Rozanes I. MRI of cerebral alveolar echinococcosis. Neuroradiology. 1999;41:844–6.
Wada H, Takahashi S, Higano S, Tominaga T, Sakamoto K. CT and MR imaging findings in a case of cerebral alveolar echinococcosis masquerading as brain tumor. Nippon Igaku Hoshasen Gakkai Zasshi. 1996;56:608–9.
Wang J, Cai B, You C. Surgical treatment for cerebral alveolar echinococcosis: experience in six patients. Neurol India. 2009;57:157–61.
Wang J, Xing Y, Ren B, Xie W, Wen H, Liu W. Alveolar echinococcosis: correlation of imaging type with PNM stage and diameter of lesions. Chin Med J. 2011;124:2824–8.
Weber M, Vespignani H, Jacquier P, Gérard A, Claudon P, Bracard S, Floquet J. Neurological manifestations of alveolar echinococcosis. Rev Neurol (Paris). 1988;144:104–12.
WHO Informal Working Group on Echinococcosis. Guidelines for treatment of cystic and alveolar echinococcosis in humans. Bull World Health Organ. 1996;74:231–42.
Yamamoto M. Gamma knife radiosurgery: technology, applications, and future directions. Neurosurg Clin N Am. 1999;10:181–202.
Yang YR, Vuitton DA, Jones MK, Craig PS, McManus DP. Brain metastasis of alveolar echinococcosis in a hyperendemic focus of Echinococcus multilocularis infection. Trans R Soc Trop Med Hyg. 2005;99:937–41.
Zhang W, McManus DP. Recent advances in the immunology and diagnosis of echinococcosis. FEMS Immunol Med Microbiol. 2006;47:24–41.
Zhang W, Li J, McManus DP. Review concepts in immunology and diagnosis of hydatid disease. Clin Microbiol Rev. 2003;16:18–36.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2014 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Sándor, S.B. (2014). Alveolar Hydatidosis of the Central Nervous System. In: Turgut, M. (eds) Hydatidosis of the Central Nervous System: Diagnosis and Treatment. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-54359-3_24
Download citation
DOI: https://doi.org/10.1007/978-3-642-54359-3_24
Published:
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-54358-6
Online ISBN: 978-3-642-54359-3
eBook Packages: MedicineMedicine (R0)