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Molecular Imaging Using Magnetic Resonance Spectroscopy in Neurology: The Past, the Present, and the Future

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PET and SPECT in Neurology

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Abstract

A description of the principles of nuclear magnetic resonance spectroscopy (MRS), with emphasis on biomedical applications, is followed by a brief summary of the scientific landmarks leading to the development of this method. The main neurological applications up to now are presented: cerebrovascular, white matter and neonatal disorders, epilepsy and oncology. The present state of MRS is represented by providing detail on recent developments such as multivoxel and high-field MRS that facilitate the increasing use of MRS in the study of multiple sclerosis and pediatrics. Future perspectives include the increasing use of shorter echo times for detecting additional metabolites and the study of alternative nuclei, such as carbon-13, facilitated by the stronger signals at higher magnetic field.

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Authors and Affiliations

  1. Department of Radiology, University of Groningen, University Medical Center Groningen, Hanzeplein 1, Groningen, 9713 GZ, Netherlands

    Paul E. Sijens

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  1. Paul E. Sijens
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Correspondence to Paul E. Sijens .

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Editors and Affiliations

  1. Dept. of Nuclear Medicine and Molecular Imaging, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands

    Rudi A.J.O. Dierckx

  2. Faculty of Electrical Engineering and Information Technology, University of Applied Sciences Offenburg, Offenburg, Germany

    Andreas Otte

  3. Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, Groningen, The Netherlands

    Erik F.J. de Vries

  4. Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, Groningen, The Netherlands

    Aren van Waarde

  5. Neurology, University Medical Center Groningen, Groningen, The Netherlands

    Klaus L. Leenders

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Sijens, P.E. (2014). Molecular Imaging Using Magnetic Resonance Spectroscopy in Neurology: The Past, the Present, and the Future. In: Dierckx, R., Otte, A., de Vries, E., van Waarde, A., Leenders, K. (eds) PET and SPECT in Neurology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-54307-4_7

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  • DOI: https://doi.org/10.1007/978-3-642-54307-4_7

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