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Tracer Kinetic Modelling

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Abstract

This chapter provides an overview of the basic principles of quantification of cerebral PET studies using compartmental modelling. Both single- and two-tissue compartment models are presented with emphasis on volume of distribution and non-displaceable binding potential as outcome measures. Next, both full and simplified reference tissue models are introduced, obviating the need for arterial cannulation. Finally, a brief overview is given of various parametric methods enabling calculations at a voxel level.

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Author information

Authors and Affiliations

  1. Department of Radiology and Nuclear Medicine, VU University Medical Center, 7057, Amsterdam, 1007MB, The Netherlands

    Adriaan A. Lammertsma

Authors
  1. Adriaan A. Lammertsma
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Corresponding author

Correspondence to Adriaan A. Lammertsma .

Editor information

Editors and Affiliations

  1. Dept. of Nuclear Medicine and Molecular Imaging, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands

    Rudi A.J.O. Dierckx

  2. Faculty of Electrical Engineering and Information Technology, University of Applied Sciences Offenburg, Offenburg, Germany

    Andreas Otte

  3. Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, Groningen, The Netherlands

    Erik F.J. de Vries

  4. Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, Groningen, The Netherlands

    Aren van Waarde

  5. Neurology, University Medical Center Groningen, Groningen, The Netherlands

    Klaus L. Leenders

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© 2014 Springer-Verlag Berlin Heidelberg

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Lammertsma, A.A. (2014). Tracer Kinetic Modelling. In: Dierckx, R., Otte, A., de Vries, E., van Waarde, A., Leenders, K. (eds) PET and SPECT in Neurology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-54307-4_3

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  • DOI: https://doi.org/10.1007/978-3-642-54307-4_3

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  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-54306-7

  • Online ISBN: 978-3-642-54307-4

  • eBook Packages: MedicineMedicine (R0)

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