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PET and SPECT in Neurology pp 605–617Cite as

SPECT Imaging for Idiopatic M. Parkinson and Parkinsonian Syndromes: Guidelines and Comparison with PET and Recent Developments

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Abstract

According to the limited amount of literature available, there is no real difference in diagnostic accuracy between a DaT-SPECT scan and an 18F-FDOPA PET scan nor between an123I-IBZM SPECT and a 11C-raclopride PET. However, while DaT-SPECT and FDOPA PET have gained a role in the clinical evaluation of the parkinsonian patient, especially in the differential diagnosis with other pathologies such as essential tremor, less evidence has been presented for the use of IBZM SPECT in the differential diagnosis of Morbus Parkinson and parkinsonian syndromes. A promising role could be played by 18F-FDG PET or perfusion SPECT in this regard.

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References

  • Aerts MB, Esselink RA, Post B et al (2012) Improving the diagnostic accuracy in parkinsonism: a three-pronged approach. Pract Neurol 12:77–87

    Google Scholar 

  • Antonini A, Leenders KL, Vontobel P et al (1997) Complementary PET studies of striatal neuronal function in the differential diagnosis between multiple system atrophy and Parkinson’s disease. Brain 120(Pt 12):2187–2195

    Article  PubMed  Google Scholar 

  • Benamer TS, Patterson J, Grosset DG et al (2000) Accurate differentiation of Parkinsonism and essential tremor using visual assessment of [123I]-FP-CIT SPECT imaging: the [123I]-FP-CIT study group. Mov Disord 15:503–510

    Article  CAS  PubMed  Google Scholar 

  • Booij J, Tissingh G, Boer GJ et al (1997) [123I]FP-CIT SPECT shows a pronounced decline of striatal dopamine transporter labelling in early and advanced Parkinson’s disease. J Neurol Neurosurg Psychiatry 62:133–140

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Booij J, Tissingh G, Winogrodzka A, van Royen EA (1999) Imaging of the dopaminergic neurotransmission system using single-photon emission tomography and positron emission tomography in patients with Parkinsonism. Eur J Nucl Med 26:171–182

    Article  CAS  PubMed  Google Scholar 

  • Booij J, Bergmans P, Winogrodzka A et al (2001) Imaging of dopamine transporters with [I-123]FP-CIT SPECT does not suggest a significant effect of age on the symptomatic threshold of disease in Parkinson’s disease. Synapse 101–108

    Google Scholar 

  • Braune S, Reinhardt M, Schnitzer R et al (1999) Cardiac uptake of [123I]MIBG separates Parkinson’s disease from multiple system atrophy. Neurology 53:1020–1025

    Article  CAS  PubMed  Google Scholar 

  • Brucke T, Podreka I, Angelberger P et al (1991) Dopamine D2 receptor imaging with SPECT: studies in different neuropsychiatric disorders. J Cereb Blood Flow Metab 11:220–228

    Article  CAS  PubMed  Google Scholar 

  • Buck A, Westera G, Sutter M et al (1995) Iodine-123-IBF SPECT evaluation of extrapyramidal diseases. J Nucl Med 36:1196–1200

    CAS  PubMed  Google Scholar 

  • Bullich S, Cot A, Gallego J et al (2010) Impact of scatter correction on D2 receptor occupancy measurements using 123I-IBZM SPECT: comparison to 11C-Raclopride PET. Neuroimage 50:1511–1518

    Google Scholar 

  • Catafau AM, Suarez M, Bullich S et al (2009) Within-subject comparison of striatal D2 receptor occupancy measurements using [123I]IBZM SPECT and [11C]Raclopride PET. Neuroimage 46:447–458

    Article  PubMed  Google Scholar 

  • Clarke C, Howard R, Rossor M, Shorvon SD (2011) Neurology: A Queen Square Textbook. Wiley-Blackwell, Chichester

    Google Scholar 

  • Darcourt J, Booij J, Tatsch K et al (2009) EANM procedure guidelines for brain neurotransmission SPECT using 123I-labelled dopamine transporter ligands, version 2. Eur J Nucl Med Mol Imaging 37:2093–2102

    Google Scholar 

  • Druschky A, Hilz MJ, Platsch G et al (2000) Differentiation of Parkinson’s disease and multiple system atrophy in early disease stages by means of I-123-MIBG-SPECT. J Neurol Sci 175:3–12

    Article  CAS  PubMed  Google Scholar 

  • Eckert T, Barnes A, Dhawan V et al (2005) FDG PET in the differential diagnosis of parkinsonian disorders. Neuroimage 26:912–921

    Article  PubMed  Google Scholar 

  • Eidelberg D, Moeller JR, Dhawan V et al (1990) The metabolic anatomy of Parkinson’s disease: complementary [18F]fluorodeoxyglucose and [18F]fluorodopa positron emission tomographic studies. Mov Disord 5:203–213

    Article  CAS  PubMed  Google Scholar 

  • Eidelberg D, Moeller JR, Ishikawa T et al (1995) Early differential diagnosis of Parkinson’s disease with 18F-fluorodeoxyglucose and positron emission tomography. Neurology 45:1995–2004

    Article  CAS  PubMed  Google Scholar 

  • Eshuis SA, Maguire RP, Leenders KL et al (2006) Comparison of FP-CIT SPECT with F-DOPA PET in patients with de novo and advanced Parkinson’s disease. Eur J Nucl Med Mol Imaging 33:200–209

    Article  CAS  PubMed  Google Scholar 

  • Ghaemi M, Hilker R, Rudolf J et al (2002) Differentiating multiple system atrophy from Parkinson’s disease: contribution of striatal and midbrain MRI volumetry and multi-tracer PET imaging. J Neurol Neurosurg Psychiatry 73:517–523

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Haaxma CA, Bloem BR, Borm GF et al (2007) Gender differences in Parkinson’s disease. Gender Med 78:819–824

    Google Scholar 

  • Halldin C, Gulyás B, Langer O, Farde L (2001) Brain radioligands–state of the art and new trends. Q J Nucl Med 45:139–152

    CAS  PubMed  Google Scholar 

  • Hellwig S, Amtage F, Kreft A et al (2012) [18F]FDG-PET is superior to [123I]IBZM-SPECT for the differential diagnosis of Parkinsonism. Neurology 79:1314–1322

    Article  CAS  PubMed  Google Scholar 

  • Hughes A, Daniel S, Kilford L, Lees A (1992) Accuracy of clinical diagnosis of idiopathic Parkinson’s disease: a clinico-pathological study of 100 cases. J Neurol Neurosurg Psychiatry 55:181–184

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Hughes AJ, Daniel SE, Lees AJ (2001) Improved accuracy of clinical diagnosis of Lewy body Parkinson’s disease. Neurology 57:1497–1499

    Google Scholar 

  • Hughes AJ, Daniel SE, Ben-Schlomo Y et al (2002) The accuracy of diagnosis of parkinsonian syndromes in a specialist movement disorder service. Brain 125:861–870

    Google Scholar 

  • Ishikawa T, Dhawan V, Kazumata K et al (1996) Comparative nigrostriatal dopaminergic imaging with iodine-123-beta CIT-FP/SPECT and fluorine-18-FDOPA/PET. J Nucl Med 37:1760–1765

    CAS  PubMed  Google Scholar 

  • Kim YJ, Ichise M, Ballinger JR et al (2002) Combination of dopamine transporter and D2 receptor SPELT in the diagnostic evaluation of PD, MSA, and PSP. Mov Disord 17:303–312

    Google Scholar 

  • Köhler C, Hall H, Ögren S-O, Gawell L (1985) Specific in vitro and in vivo binding of 3H-raclopride a potent substituted benzamide drug with high affinity for dopamine D-2 receptors in the rat brain. Biochem Pharmacol 34:2251–2259

    Article  PubMed  Google Scholar 

  • Konno H, Yamamoto T, Iwasaki Y, Iizuka H (1986) Shy-Drager syndrome and amyotrophic lateral sclerosis. Cytoarchitectonic and morphometric studies of sacral autonomic neurons. J Neurol Sci 73:193–204

    Article  CAS  PubMed  Google Scholar 

  • Lavalaye J, Booij J, Reneman L et al (2000) Effect of age and gender on dopamine transporter imaging with [123I]FP-CIT SPET in healthy volunteers. Eur J Nucl Med 27:867–869

    Article  CAS  PubMed  Google Scholar 

  • Lee CS, Samii A, Sossi V et al (2000) In vivo positron emission tomographic evidence for compensatory changes in presynaptic dopaminergic nerve terminals in Parkinson’s disease. 47:493–503

    Google Scholar 

  • Marek K, Innis R, van Dyck C et al (2001) [123I]beta-CIT SPECT imaging assessment of the rate of Parkinson’s disease progression. Neurology 57:2089–2094

    Article  CAS  PubMed  Google Scholar 

  • Oertel WH, Schwarz J, Tatsch K et al (1993) IBZM-SPECT as predictor for dopamimetic responsiveness of patients with de novo parkinsonian syndrome. Adv Neurol 60:519–524

    CAS  PubMed  Google Scholar 

  • Pinborg LH, Videbaek C, Knudsen GM et al (2000) Dopamine D(2) receptor quantification in extrastriatal brain regions using [(123)I]epidepride with bolus/infusion. Synapse 36:322–329

    Article  CAS  PubMed  Google Scholar 

  • Poston KL, Eidelberg D (2010) FDG PET in the evaluation of Parkinson’s disease. PET Clin. 5:55–64

    Google Scholar 

  • Rajput AH, Rozdilsky B, Rajput A (1991) Accuracy of clinical diagnosis in Parkinsonism – a prospective study. Can J Neurol Sci 18:275–278

    Google Scholar 

  • Scherfler C, Schwarz J, Antonini A et al (2007) Role of DAT-SPECT in the diagnostic work up of Parkinsonism. Mov Disord 22:1229–1238

    Article  PubMed  Google Scholar 

  • Schwarz J, Tatsch K, Arnold G et al (1993) 123I-iodobenzamide-SPECT in 83 patients with de novo Parkinsonism. Neurology 43:S17–S20

    CAS  PubMed  Google Scholar 

  • Schwarz J, Antonini A, Tatsch K et al (1994) Comparison of 123I-IBZM SPECT and 11C-raclopride PET findings in patients with Parkinsonism. Nucl Med Commun 15:806–813

    Article  CAS  PubMed  Google Scholar 

  • Shen LH, Liao MH, Tseng YC (2012) Recent advances in imaging of dopaminergic neurons for evaluation of neuropsychiatric disorders. J Biomed Biotechnol 2012:259349

    Google Scholar 

  • Sisson JC, Wieland DM, Sherman P et al (1987) Metaiodobenzylguanidine as an index of the adrenergic nervous system integrity and function. J Nucl Med 28:1620–1624

    CAS  PubMed  Google Scholar 

  • Tatsch K, Schwarz J, Oertel WH, Kirsch CM (1991) SPECT imaging of dopamine D2 receptors with 123I-IBZM: initial experience in controls and patients with Parkinson“s syndrome and Wilson”s disease. Nucl Med Commun 12:699–707

    Article  CAS  PubMed  Google Scholar 

  • Tatsch K, Asenbaum S, Bartenstein P et al (2002) European Association of Nuclear Medicine procedure guidelines for brain neurotransmission SPET using (123)I-labelled dopamine D(2) transporter ligands. Eur J Nucl Med Mol Imaging 29:BP30–BP35

    Article  CAS  PubMed  Google Scholar 

  • Teune LK, Renken RJ, Mudali D et al (2013) Validation of parkinsonian disease-related metabolic brain patterns. Mov Disord 28:547–551

    Article  CAS  PubMed  Google Scholar 

  • van Dyck CH, Schmitt FA, Olin JT, Memantine MEM-MD-02 Study Group (2006) A responder analysis of memantine treatment in patients with Alzheimer disease maintained on donepezil. Am J Geriatr Psychiatry 14:428–437

    Article  PubMed  Google Scholar 

  • Van Laere K, Casteels C, De CeunickL et al (2006) Dual-tracer dopamine transporter and perfusion SPECT in differential diagnosis of Parkinsonism using template-based discriminant analysis. J Nucl Med 47:384–392

    Google Scholar 

  • Van Laere K, Santens P, Bosman T et al (2004) Statistical parametric mapping of Tc-99m-ECD SPECT in idiopathic Parkinson’s disease and multiple system atrophy with predominant parkinsonian features: correlation with clinical parameters. J Nucl Med 45:933–942

    Google Scholar 

  • Van Laere K, Varrone A, Booij J et al (2009) EANM procedure guidelines for brain neurotransmission SPECT/PET using dopamine D2 receptor ligands, version 2. Eur J Nucl Med Mol Imaging 37:434–442

    Article  Google Scholar 

  • Varrone A, Asenbaum S et al (2009) EANM procedure guidelines for PET brain imaging using [18F]FDG, version 2. Eur J Nucl Med Mol Imaging 36:2103–2110

    Article  PubMed  Google Scholar 

  • Varrone A, Dickson JC, Tossici-Bolt L et al (2013) European multicentre database of healthy controls for [123I]FP-CIT SPECT (ENC-DAT): age-related effects, gender differences and evaluation of different methods of analysis. Eur J Nucl Med Mol Imaging 40:213–227

    Article  CAS  PubMed  Google Scholar 

  • Vlaar AMM, van Kroonenburgh MJPG, Kessels AGH, Weber WEJ (2007) Meta-analysis of the literature on diagnostic accuracy of SPECT in parkinsonian syndromes. BMC Neurol 7:27

    Article  PubMed Central  PubMed  Google Scholar 

  • Walker Z, Jaros E, Walker RWH et al (2007) Dementia with Lewy bodies: a comparison of clinical diagnosis, FP-CIT single photon emission computed tomography imaging and autopsy. J Neurol Neurosurg Psychiatry 78:1176–1181

    Article  PubMed Central  PubMed  Google Scholar 

  • Wang L, Zhang Q, Li H, Zhang H (2012) SPECT molecular imaging in Parkinson’s disease. J Biomed Biotechnol 2012:412486

    Google Scholar 

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Author information

Authors and Affiliations

  1. Department of Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, University of Groningens, Hanzeplein 1, Groningen, 9713 GZ, The Netherlands

    Ronald W. J. van Rheenen

  2. Department of Neurology, Medisch Spectrum Twente, Haaksbergerstraat 55, Enschede, 7513 ER, The Netherlands

    Jacoba P. van Amerongen

  3. Department of Nuclear Medicine, Medisch Centrum Leeuwarden, Leeuwarden, The Netherlands

    Sylvia Eshuis & Andre Dobbeleir

  4. Department of Neurology, University Medical Center Groningen, University of Groningen, Hanzeplein 1, Groningen, 9713 GZ, The Netherlands

    Klaus (Nico) L. Leenders MD

  5. Department of Nuclear Medicine, University Hospital Gent, Ghent University, De Pintelaan 185, Ghent, 9000, Belgium

    Andre Dobbeleir

  6. Department of Nuclear Medicine and Molecular Imaging, University of Groningen, University Medical Center Groningen, Hanzeplein 1, Groningen, 9713GZ, The Netherlands

    Rudi A. J. O. Dierckx

  7. Department of Radiology and Nuclear Medicine, Ghent University, De Pintelaan 185 K12, Ghent, 9000, Belgium

    Rudi A. J. O. Dierckx

Authors
  1. Ronald W. J. van Rheenen
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  2. Jacoba P. van Amerongen
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  3. Sylvia Eshuis
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  4. Klaus (Nico) L. Leenders MD
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  5. Andre Dobbeleir
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  6. Rudi A. J. O. Dierckx
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Corresponding author

Correspondence to Ronald W. J. van Rheenen .

Editor information

Editors and Affiliations

  1. Dept. of Nuclear Medicine and Molecular Imaging, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands

    Rudi A.J.O. Dierckx

  2. Faculty of Electrical Engineering and Information Technology, University of Applied Sciences Offenburg, Offenburg, Germany

    Andreas Otte

  3. Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, Groningen, The Netherlands

    Erik F.J. de Vries

  4. Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, Groningen, The Netherlands

    Aren van Waarde

  5. Neurology, University Medical Center Groningen, Groningen, The Netherlands

    Klaus L. Leenders

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van Rheenen, R.W.J., van Amerongen, J.P., Eshuis, S., Leenders, K.(.L., Dobbeleir, A., Dierckx, R.A.J.O. (2014). SPECT Imaging for Idiopatic M. Parkinson and Parkinsonian Syndromes: Guidelines and Comparison with PET and Recent Developments. In: Dierckx, R., Otte, A., de Vries, E., van Waarde, A., Leenders, K. (eds) PET and SPECT in Neurology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-54307-4_27

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  • DOI: https://doi.org/10.1007/978-3-642-54307-4_27

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