Abstract
Uveal melanomas are among the few cancers that, until recently, could be treated without examining tissue to confirm the clinical diagnosis and establish prognosis. The Collaborative Ocular Melanoma Study demonstrated that in patients with clear ocular media, clinical misdiagnosis of choroidal melanocytic neoplasms is extremely rare, so the need to confirm the diagnosis became less urgent. Also, after the Collaborative Ocular Melanoma Study determined that there was no significant difference in mortality between enucleation and vision-sparing radiation therapy, many patients elected to have their tumors ablated to preserve the affected eye, and in such cases, it was possible to begin treatment without examining any tissue to confirm the diagnosis or establish the prognosis.
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References
Collaborative ocular melanoma study (COMOS) randomized trial of pre-enucleation radiation for large choroidal melanoma – II – initial mortality findings – COMS report no. 10. Am J Ophthalmol. 1998;126:622.
Damato B, Eleuteri A, Taktak AF, Coupland SE. Estimating prognosis for survival after treatment of choroidal melanoma. Prog Retin Eye Res. 2011;30:285–95.
Shammas HF, Blodi FC. Prognostic factors in choroidal and ciliary body melanomas. Arch Ophthalmol. 1977;95:63–9.
Kaiserman I, Anteby I, Chowers I, Blumenthal EZ, Kliers I, Pe’er J. Post-brachytherapy initial tumour regression rate correlates with metastatic spread in posterior uveal melanoma. Br J Ophthalmol. 2004;88:892–5.
Kivela T, Kujala E. Prognostication in eye cancer: the latest tumor, node, metastasis classification and beyond. Eye (Lond). 2013;27:243–52.
Augsburger JJ, Gamel JW. Clinical prognostic factors in patients with posterior uveal malignant melanoma. Cancer. 1990;66:1596–600.
Zloto O, Pe’er J, Frenkel S. Gender differences in clinical presentation and prognosis of uveal melanoma. Invest Ophthalmol Vis Sci. 2013;54:652–6.
Char DH, Kroll S, Phillips TL. Uveal melanoma: growth rate and progression. Arch Ophthalmol. 1997;115:1014–8.
Kaiserman I, Rosner M, Pe’er J. Forecasting the prognosis of choroidal melanoma with an artificial neural network. Ophthalmology. 2005;112:1608–11.
Eleuteri A, Damato B, Coupland SE, Taktak AFG. Enhancing survival prognostication in patients with choroidal melanoma by integrating pathologic, clinical and genetic predictors of metastasis. Int J Biomed Eng Technol. 2012;8:18–35.
Jakobiec FA, Silbert G. Are most iris ‘melanomas’ really nevi? A clinicopathologic study of 189 lesions. Arch Ophthalmol. 1981;99:2117–32.
Folberg R, Salomao D, Grossniklaus HE, Proia AD, Rao NA, Cameron JD. Recommendations for the reporting of tissues removed as part of the surgical treatment of common malignancies of the eye and its adnexa. Am J Surg Pathol. 2003;27:999–1004.
Gamel JW, McLean I, Greenberg RA, Naids RM, Folberg R, Augsburger JJ, Donoso LA, Seddon JM, Albert DM. Objective assessment of the malignant potential of intraocular melanomas with standard microslides stained with hematoxylin-eosin. Hum Pathol. 1985;16:689–92.
McLean IW, Foster WD, Zimmerman LE, Gamel JW. Modifications of Callender’s classification of uveal melanoma at the Armed Forces Institute of Pathology. Am J Ophthalmol. 1983;96:502–9.
Callender GR. Malignant melanotic tumors of the eye: a study of histologic types in 111 cases. Trans Am Acad Ophthalmol Otolaryngol. 1931;36:131–42.
McLean IW, Zimmerman LE, Evans RM. Reappraisal of Callender’s spindle A type of malignant melanoma of choroid and ciliary body. Am J Ophthalmol. 1978;86:557–64.
McLean IW, Sibug ME, Becker RL, McCurdy JB. Uveal melanoma - the importance of large nucleoli in predicting patient outcome - an automated image analysis study. Cancer. 1997;79:982–8.
Folberg R, Rummelt V, Parys-Van Ginderdeuren R, Hwang T, Woolson RF, Pe’er J, Gruman LM. The prognostic value of tumor blood vessel morphology in primary uveal melanoma. Ophthalmology. 1993;100:1389–98.
McLean IW, Foster WD, Zimmerman LE. Prognostic factors in small malignant melanomas of choroid and ciliary body. Arch Ophthalmol. 1977;95:48–58.
Pe’er J, Gnessin H, Shargal Y, Livni N. PC-10 immunostaining of proliferating cell nuclear antigen (PCNA) in posterior uveal melanoma. Ophthalmology. 1994;101:56–62.
de la Cruz Jr PO, Specht CS, McLean IW. Lymphocytic infiltration in uveal malignant melanoma. Cancer. 1990;65:112–5.
Lin AY, Maniotis AJ, Valyi-Nagy K, Majumdar D, Setty S, Kadkol S, Leach L, Pe’er J, Folberg R. Distinguishing fibrovascular septa from vasculogenic mimicry patterns. Arch Pathol Lab Med. 2005;129:884–92.
Maniotis AJ, Folberg R, Hess A, Seftor EA, Gardner LMG, Pe’er J, Trent JM, Meltzer PS, Hendrix MJC. Vascular channel formation by human melanoma cells in vivo and in vitro: vasculogenic mimicry. Am J Pathol. 1999;155:739–52.
Clarijs R, Otte-Holler I, Ruiter DJ, de Waal RM. Presence of a fluid-conducting meshwork in xenografted cutaneous and primary human uveal melanoma. Invest Ophthalmol Vis Sci. 2002;43:912–8.
Foss AJE, Alexander RA, Jefferies LW, Hungerford JL, Harris AL, Lightman S. Microvessel count predicts survival in uveal melanoma. Cancer Res. 1996;56:2900–3.
Chen X, Maniotis AJ, Majumdar D, Pe’er J, Folberg R. Uveal melanoma cell staining for CD34 and assessment of tumor vascularity. Invest Ophthalmol Vis Sci. 2002;43:2533–9.
Coupland SE, Lake SL, Zeschnigk M, Damato BE. Molecular pathology of uveal melanoma. Eye. 2013;27(2):230–42. doi:10.1038/eye.2012.255. Epub 2012 Dec 7.
Augsburger JJ, Shields JA, Folberg R, Lang WR, O’Hara BJ, Claricci JD. Fine needle aspiration biopsy in the diagnosis of intraocular cancer cytologic-histologic correlations. Ophthalmology. 1985;92:39–49.
Char DH, Kroll SM, Stoloff A, Kaleta-Michaels S, Crawford JB, Miller TR, Howes Jr EL, Ljung BM. Cytomorphometry of uveal melanoma Comparison of fine needle aspiration biopsy samples with histologic sections. Anal Quant Cytol Histol. 1991;13:293–9.
Maat W, Jordanova ES, van Zelderen-Bhola SL, Barthen ER, Wessels HW, Schalij-Delfos NE, Jager MJ. The heterogeneous distribution of monosomy 3 in uveal melanomas - Implications for prognostication based on fine-needle aspiration biopsies. Arch Pathol Lab Med. 2007;131:91–6.
Schoenfield L, Pettay J, Tubbs RR, Singh AD. Variation of monosomy 3 status within uveal melanoma. Arch Pathol Lab Med. 2009;133:1219–22.
Onken MD, Worley L, Tuscan MD, Harbour JW. An accurate, clinically feasible multi-gene expression assay for predicting metastasis in uveal melanoma. J Mol Diagn. 2010;12:461–8.
Onken MD, Worley LA, Char DH, Augsburger JJ, Correa ZM, Nudleman E, Aaberg Jr TM, Altaweel MM, Bardenstein DS, Finger PT, Gallie BL, Harocopos GJ, Hovland PG, McGowan HD, Milman T, Mruthyunjaya P, Simpson ER, Smith ME, Wilson DJ, Wirostko WJ, Harbour JW. Collaborative Ocular Oncology Group report number 1: prospective validation of a multi-gene prognostic assay in uveal melanoma. Ophthalmology. 2012;119:1596–603.
Folberg R. The molecular classification of uveal melanocytic lesions an important discovery in context. J Mol Diagn. 2010;12:391–3.
Tschentscher F, Husing J, Holter T, Kruse E, Dresen IG, Jockel KH, Anastassiou G, Schilling H, Bornfeld N, Horsthemke B, Lohmann DR, Zeschnigk M. Tumor classification based on gene expression profiling shows that uveal melanomas with and without monosomy 3 represent two distinct entities. Cancer Res. 2003;63:2578–84.
Onken MD, Worley LA, Ehlers JP, Harbour JW. Gene expression profiling in uveal melanoma reveals two molecular classes and predicts metastatic death. Cancer Res. 2004;64:7205–9.
Kadkol SS, Lin AY, Barak V, Kalickman I, Leach L, Valyi-Nagy K, Majumdar D, Setty S, Maniotis AJ, Folberg R, Pe’er J. Osteopontin expression and serum levels in metastatic uveal melanoma: a pilot study. Invest Ophthalmol Vis Sci. 2006;47:802–6.
Folberg R, Arbieva Z, Moses J, Hayee A, Sandal T, Kadkol S, Lin AY, Valyi-Nagy K, Setty S, Leach L, Chevez-Barrios P, Larsen P, Majumdar D, Pe’er J, Maniotis AJ. Tumor cell plasticity in uveal melanoma: microenvironment directed dampening of the invasive and metastatic genotype and phenotype accompanies the generation of vasculogenic mimicry patterns. Am J Pathol. 2006;169:1376–89.
Prescher G, Bornfeld N, Hirche H, Horsthemke B, J’ckel KH, Becher R. Prognostic impliations of monosomy 3 in uveal melanoma. Lancet. 1996;347:1222–5.
Schaller UC, Bosserhoff AK, Neubauer AS, Buettner R, Kampik A, Mueller AJ. Melanoma inhibitory activity: a novel serum marker for uveal melanoma. Melanoma Res. 2002;12:593–9.
Barak V, Kaiserman I, Frenkel S, Hendler K, Kalickman I, Pe’er J. The dynamics of serum tumor markers in predicting metastatic uveal melanoma (part 1). Anticancer Res. 2011;31:345–9.
Frenkel S, Zloto O, Pe’er J, Barak V. Insulin like Growth Factor-I as a predictive biomarker for metastatic uveal melanoma in humans. Invest Ophthalmol Vis Sci. 2013;54:490–3.
Triozzi PL, Elson P, Aldrich W, Achberger S, Tubbs R, Biscotti CV, Singh AD. Elevated blood beta-2 microglobulin is associated with tumor monosomy-3 in patients with primary uveal melanoma. Melanoma Res. 2013;23:1–7.
Triozzi PL, Singh AD. Blood biomarkers for uveal melanoma. Future Oncol. 2012;8:205–15.
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Folberg, R., Pe’er, J. (2014). Prognostic Factors in Uveal Melanoma. In: Damato, B., Singh, A. (eds) Clinical Ophthalmic Oncology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-54255-8_19
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DOI: https://doi.org/10.1007/978-3-642-54255-8_19
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