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Phototherapy of Uveal Melanoma

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Clinical Ophthalmic Oncology

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Abstract

Phototherapy of uveal melanoma includes various forms of photocoagulation, thermotherapy, and photodynamic therapy (PDT), which can be administered as primary treatment of the tumor or as an adjunct to radiotherapy or local resection. Photocoagulation raises the tissue temperature above 60 ºC to cause coagulation of proteins and immediate cell death. Transpupillary thermotherapy (TTT) causes tumor cell death by raising the temperature to between 45 ºC and 60 ºC for about 60 s. Photodynamic therapy uses light to activate a photosensitizer, thereby releasing toxic free radicals, which destroy adjacent tumor cells and cause vaso-occlusion.

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Author information

Authors and Affiliations

  1. Ocular Oncology Service, Royal Liverpool, University Hospital, Liverpool, L7 8XP, UK

    Heinrich Heimann MD

  2. Ocular Oncology Service, Department of Ophthalmology, University of California San Francisco, San Francisco, CA, 94143, USA

    Michael Seider MD

  3. Ocular Oncology Service, Departments of Ophthalmology and Radiation Oncology, University of California San Francisco, 10 Koret Way, San Francisco, CA, 94143, USA

    Bertil Damato MD, PhD

Authors
  1. Heinrich Heimann MD
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  2. Michael Seider MD
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  3. Bertil Damato MD, PhD
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Corresponding author

Correspondence to Heinrich Heimann MD .

Editor information

Editors and Affiliations

  1. Ocular Oncology Service, Departments of Ophthalmology and Radiation Oncology, University of California, San Francisco, San Francisco, California, USA

    Bertil Damato

  2. Dept. of Ophthalmic Oncology, Cole Eye Institute Cleveland Clinic Foundation, Cleveland, Ohio, USA

    Arun D. Singh

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© 2014 Springer-Verlag Berlin Heidelberg

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Heimann, H., Seider, M., Damato, B. (2014). Phototherapy of Uveal Melanoma. In: Damato, B., Singh, A. (eds) Clinical Ophthalmic Oncology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-54255-8_16

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  • DOI: https://doi.org/10.1007/978-3-642-54255-8_16

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  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-54254-1

  • Online ISBN: 978-3-642-54255-8

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