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Bisphosphonate-Related Osteonecrosis of the Jaw (BRONJ)

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Complications in Endodontic Surgery

Abstract

Osteonecrosis of the jaw (ONJ) is a rare condition that has been mainly related to the treatment with i.v. bisphosphonates in patients affected by cancer bone disease. The ethiopathology is still unknown and the frequency is between 0.8 and 12 %. It can appear in edentulous patients, but invasive procedures have been demonstrated to increase the risk of developing this complication. Few cases have been described in the endodontic literature. In the next chapter, we will describe ONJ, will analyze the data from literature, and will report expert opinions and guidelines about the best clinical practice in the endodontic field. Finally, since data in this field are limited, we would like to underline that the best treatment plan for cancer patients receiving bisphosphonates and requiring dental procedures is a multidisciplinary, case-by-case approach.

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Authors and Affiliations

  1. Program of Innovative Therapy in Oncology and Hematology, University of Modena and Reggio Emilia, Modena, Italy

    Samantha Pozzi MD & Alessia Bari MD

  2. Dipartimento di Medicina Diagnostica, Clinica e di Sanità Pubblica, Centro Oncologico Modenese, Policlinico di Modena, Università di Modena e Reggio Emilia, Largo del Pozzo 71, stanza #4.20, Modena, 41122, Italy

    Samantha Pozzi MD & Alessia Bari MD

  3. Unit of Cranio-Maxillofacial Surgery, University of Modena and Reggio Emilia, Modena, Italy

    Alexandre Anesi MD & Luigi Chiarini MD

  4. Dipartimento di Scienze Mediche e Chirurgiche Materno-Infantili e dell’Adulto, Chirurgia Maxillofacciale, Policlinico di Modena, Largo del Pozzo 71, Modena, 41122, Italy

    Alexandre Anesi MD & Luigi Chiarini MD

  5. Unit of Dentistry and Oral-Maxillofacial Surgery, University of Modena and Reggio Emilia, Modena, Italy

    Luigi Generali MD & Ugo Consolo MD

  6. Dipartimento Chirurgico, Medico, Odontoiatrico e di Scienze Morfologiche con interesse Trapiantologico, Oncologico e di Medicina Rigenerativa, Odontoiatria, Policlinico di Modena, Università di Modena e Reggio Emilia, Largo del Pozzo 71, Modena, 41122, Italy

    Luigi Generali MD & Ugo Consolo MD

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  1. Samantha Pozzi MD
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  2. Alexandre Anesi MD
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  3. Luigi Generali MD
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  4. Alessia Bari MD
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  5. Ugo Consolo MD
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  6. Luigi Chiarini MD
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Correspondence to Samantha Pozzi MD .

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Editors and Affiliations

  1. Dept. of Endodontology, Maurice and Gabriela Goldschleger, School of Dental Medicine, Tel Aviv University, Tel Aviv, Israel

    Igor Tsesis

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Pozzi, S., Anesi, A., Generali, L., Bari, A., Consolo, U., Chiarini, L. (2014). Bisphosphonate-Related Osteonecrosis of the Jaw (BRONJ). In: Tsesis, I. (eds) Complications in Endodontic Surgery. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-54218-3_14

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  • DOI: https://doi.org/10.1007/978-3-642-54218-3_14

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