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Mammalian Transient Receptor Potential (TRP) Cation Channels pp 359–384Cite as

TRPV6 Channels

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Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 222))

Abstract

TRPV6 (former synonyms ECAC2, CaT1, CaT-like) displays several specific features which makes it unique among the members of the mammalian Trp gene family (1) TRPV6 (and its closest relative, TRPV5) are the only highly Ca2+-selective channels of the entire TRP superfamily (Peng et al. 1999; Wissenbach et al. 2001; Voets et al. 2004). (2) Translation of Trpv6 initiates at a non-AUG codon, at ACG, located upstream of the annotated AUG, which is not used for initiation (Fecher-Trost et al. 2013). The ACG codon is nevertheless decoded by methionine. Not only a very rare event in eukaryotic biology, the full-length TRPV6 protein existing in vivo comprises an amino terminus extended by 40 amino acid residues compared to the annotated truncated TRPV6 protein which has been used in most studies on TRPV6 channel activity so far. (In the following numbering occurs according to this full-length protein, with the numbers of the so far annotated truncated protein in brackets). (3) Only in humans a coupled polymorphism of Trpv6 exists causing three amino acid exchanges and resulting in an ancestral Trpv6 haplotype and a so-called derived Trpv6 haplotype (Wissenbach et al. 2001). The ancestral allele encodes the amino acid residues C197(157), M418(378) and M721(681) and the derived alleles R197(157), V418(378) and T721(681). The ancestral haplotype is found in all species, the derived Trpv6 haplotype has only been identified in humans, and its frequency increases with the distance to the African continent. Apparently the Trpv6 gene has been a strong target for selection in humans, and its derived variant is one of the few examples showing consistently differences to the orthologues genes of other primates (Akey et al. 2004, 2006; Stajich and Hahn 2005; Hughes et al. 2008). (4) The Trpv6 gene expression is significantly upregulated in several human malignancies including the most common cancers, prostate and breast cancer (Wissenbach et al. 2001; Zhuang et al. 2002; Fixemer et al. 2003; Bolanz et al. 2008). (5) Male mice lacking functional TRPV6 channels are hypo-/infertile making TRPV6 one of the very few channels essential for male fertility (Weissgerber et al. 2011, 2012).

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References

  • Ajibade DV, Dhawan P, Fechner AJ, Meyer MB, Pike JW, Christakos S (2010) Evidence for a role of prolactin in calcium homeostasis: regulation of intestinal transient receptor potential vanilloid type 6, intestinal calcium absorption, and the 25-hydroxyvitamin D(3) 1alpha hydroxylase gene by prolactin. Endocrinology 151(7):2974–2984

    PubMed Central  PubMed  Google Scholar 

  • Akey JM, Eberle MA, Rieder MJ, Carlson CS, Shriver MD, Nickerson DA, Kruglyak L (2004) Population history and natural selection shape patterns of genetic variation in 132 genes. PLoS Biol 2(10):e286

    PubMed Central  PubMed  Google Scholar 

  • Akey JM, Swanson WJ, Madeoy J, Eberle M, Shriver MD (2006) TRPV6 exhibits unusual patterns of polymorphism and divergence in worldwide populations. Hum Mol Genet 15(13):2106–2113

    PubMed  CAS  Google Scholar 

  • Al-Ansary D, Bogeski I, Disteldorf BM, Becherer U, Niemeyer BA (2010) ATP modulates Ca2+ uptake by TRPV6 and is counteracted by isoform-specific phosphorylation. FASEB J 24(2):425–435

    PubMed  CAS  Google Scholar 

  • Belkacemi L, Simoneau L, Lafond J (2002) Calcium-binding proteins: distribution and implication in mammalian placenta. Endocrine 19(1):57–64

    PubMed  CAS  Google Scholar 

  • Belkacemi L, Gariepy G, Mounier C, Simoneau L, Lafond J (2003) Expression of calbindin-D28k (CaBP28k) in trophoblasts from human term placenta. Biol Reprod 68(6):1943–1950

    PubMed  CAS  Google Scholar 

  • Belkacemi L, Gariepy G, Mounier C, Simoneau L, Lafond J (2004) Calbindin-D9k (CaBP9k) localization and levels of expression in trophoblast cells from human term placenta. Cell Tissue Res 315(1):107–117

    PubMed  CAS  Google Scholar 

  • Benn BS, Ajibade D, Porta A, Dhawan P, Hediger M, Peng JB, Jiang Y, Oh GT, Jeung EB, Lieben L, Bouillon R, Carmeliet G, Christakos S (2008) Active intestinal calcium transport in the absence of transient receptor potential vanilloid type 6 and calbindin-D9k. Endocrinology 149(6):3196–3205. doi:10.1210/en.2007-1655

    PubMed Central  PubMed  CAS  Google Scholar 

  • Bianco SD, Peng JB, Takanaga H, Suzuki Y, Crescenzi A, Kos CH, Zhuang L, Freeman MR, Gouveia CH, Wu J, Luo H, Mauro T, Brown EM, Hediger MA (2007) Marked disturbance of calcium homeostasis in mice with targeted disruption of the Trpv6 calcium channel gene. J Bone Miner Res 22(2):274–285

    PubMed  CAS  Google Scholar 

  • Boass A, Toverud SU, Pike JW, Haussler MR (1981) Calcium metabolism during lactation: enhanced intestinal calcium absorption in vitamin D-deprived, hypocalcemic rats. Endocrinology 109(3):900–907

    PubMed  CAS  Google Scholar 

  • Bodding M, Fecher-Trost C, Flockerzi V (2003) Store-operated Ca2+ current and TRPV6 channels in lymph node prostate cancer cells. J Biol Chem 278(51):50872–50879

    PubMed  Google Scholar 

  • Bolanz KA, Hediger MA, Landowski CP (2008) The role of TRPV6 in breast carcinogenesis. Mol Cancer Ther 7(2):271–279

    PubMed  CAS  Google Scholar 

  • Bolanz KA, Kovacs GG, Landowski CP, Hediger MA (2009) Tamoxifen inhibits TRPV6 activity via estrogen receptor-independent pathways in TRPV6-expressing MCF-7 breast cancer cells. Mol Cancer Res 7(12):2000–2010

    PubMed  CAS  Google Scholar 

  • Bond H, Dilworth MR, Baker B, Cowley E, Requena Jimenez A, Boyd RD, Husain SM, Ward BS, Sibley CP, Glazier JD (2008) Increased maternofetal calcium flux in parathyroid hormone-related protein-null mice. J Physiol 586(7):2015–2025

    PubMed Central  PubMed  CAS  Google Scholar 

  • Borthwick LA, Neal A, Hobson L, Gerke V, Robson L, Muimo R (2008) The annexin 2-S100A10 complex and its association with TRPV6 is regulated by cAMP/PKA/CnA in airway and gut epithelia. Cell Calcium 44(2):147–157

    PubMed  CAS  Google Scholar 

  • Bowen CV, Debay D, Ewart HS, Gallant P, Gormley S, Ilenchuk TT, Iqbal U, Lutes T, Martina M, Mealing G, Merkley N, Sperker S, Moreno MJ, Rice C, Syvitski RT, Stewart JM (2013) In Vivo Detection of Human TRPV6-Rich Tumors with Anti-Cancer Peptides Derived from Soricidin. PLoS One 8(3):e58866

    PubMed Central  PubMed  CAS  Google Scholar 

  • Brommage R, Baxter DC, Gierke LW (1990) Vitamin D-independent intestinal calcium and phosphorus absorption during reproduction. Am J Physiol 259:G631–G638

    PubMed  CAS  Google Scholar 

  • Bronner F (2003) Mechanisms of intestinal calcium absorption. J Cell Biochem 88:387–393

    PubMed  CAS  Google Scholar 

  • Bronner F, Pansu D (1999) Nutritional aspects of calcium absorption. J Nutr 129:9–12

    PubMed  CAS  Google Scholar 

  • Bronner F, Pansu D, Stein WD (1986a) Analysis of calcium transport in rat intestine. Adv Exp Med Biol 208:227–234

    PubMed  CAS  Google Scholar 

  • Bronner F, Pansu D, Stein WD (1986b) An analysis of intestinal calcium transport across the rat intestine. Am J Physiol 250:G561–G569

    PubMed  CAS  Google Scholar 

  • Brown AJ, Krits I, Armbrecht HJ (2005) Effect of age, vitamin D, and calcium on the regulation of rat intestinal epithelial calcium channels. Arch Biochem Biophys 437:51–58

    PubMed  CAS  Google Scholar 

  • Brunette MG (1988) Calcium transport through the placenta. Can J Physiol Pharmacol 66:1261–1269

    PubMed  CAS  Google Scholar 

  • Cao C, Zakharian E, Borbiro I, Rohacs T (2013) Interplay between calmodulin and phosphatidylinositol 4,5-bisphosphate in Ca2+-induced inactivation of transient receptor potential vanilloid 6 channels. J Biol Chem 288:5278–5290

    PubMed Central  PubMed  CAS  Google Scholar 

  • Chang Q, Hoefs S, van der Kemp AW, Topala CN, Bindels RJ, Hoenderop JG (2005) The beta-glucuronidase klotho hydrolyzes and activates the TRPV5 channel. Science 310(5747):490–493

    PubMed  CAS  Google Scholar 

  • Charoenphandhu N, Limlomwongse L, Krishnamra N (2001) Prolactin directly stimulates transcellular active calcium transport in the duodenum of female rats. Can J Physiol Pharmacol 79:430–438

    PubMed  CAS  Google Scholar 

  • Courjaret R, Hubrack S, Daalis A, Dib M, Machaca K (2013) The Xenopus TRPV6 homolog encodes a Mg(2+) -permeant channel that is inhibited by interaction with TRPC1. J Cell Physiol 228:2386–2398

    PubMed  CAS  Google Scholar 

  • Derler I, Hofbauer M, Kahr H, Fritsch R, Muik M, Kepplinger K, Hack ME, Moritz S, Schindl R, Groschner K, Romanin C (2006) Dynamic but not constitutive association of calmodulin with rat TRPV6 channels enables fine tuning of Ca2+-dependent inactivation. J Physiol 577:31–44

    PubMed Central  PubMed  CAS  Google Scholar 

  • Devuyst O, Thakker RV (2010) Dent’s disease. Orphanet J Rare Dis 5:28

    PubMed Central  PubMed  Google Scholar 

  • Erler I, Hirnet D, Wissenbach U, Flockerzi V, Niemeyer BA (2004) Ca2+-selective transient receptor potential V channel architecture and function require a specific ankyrin repeat. J Biol Chem 279:34456–34463

    PubMed  CAS  Google Scholar 

  • Fecher-Trost C, Wissenbach U, Beck A, Schalkowsky P, Stoerger C, Doerr J, Dembek A, Simon-Thomas M, Weber A, Wollenberg P, Ruppert T, Middendorff R, Maurer HH, Flockerzi V (2013) The in vivo TRPV6 protein starts at a non-AUG triplet decoded as methionine upstream the canonical initiation at AUG. J Biol Chem 288:16629–16644

    PubMed  CAS  Google Scholar 

  • Fixemer T, Wissenbach U, Flockerzi V, Bonkhoff H (2003) Expression of the Ca2+-selective cation channel TRPV6 in human prostate cancer: a novel prognostic marker for tumor progression. Oncogene 22:7858–7861

    PubMed  CAS  Google Scholar 

  • Fleet JC, Eksir F, Hance KW, Wood RJ (2002) Vitamin D-inducible calcium transport and gene expression in three Caco-2 cell lines. Am J Physiol Gastrointest Liver Physiol 283:G618–G625

    PubMed  CAS  Google Scholar 

  • Frick KK, Asplin JR, Favus MJ, Culbertson C, Krieger NS, Bushinsky DA (2013) Increased biological response to 1,25(OH)2D3 in genetic hypercalciuric stone-forming rats. Am J Physiol Renal Physiol 304:F718–F726

    PubMed Central  PubMed  CAS  Google Scholar 

  • Hache S, Takser L, LeBellego F, Weiler H, Leduc L, Forest JC, Giguere Y, Masse A, Barbeau B, Lafond J (2011) Alteration of calcium homeostasis in primary preeclamptic syncytiotrophoblasts: effect on calcium exchange in placenta. J Cell Mol Med 15:654–667

    PubMed  CAS  Google Scholar 

  • Halloran BP, DeLuca HF (1980) Calcium transport in small intestine during early development: role of vitamin D. Am J Physiol 239:G473–G479

    PubMed  CAS  Google Scholar 

  • Haverstick DM, Heady TN, Macdonald TL, Gray LS (2000) Inhibition of human prostate cancer proliferation in vitro and in a mouse model by a compound synthesized to block Ca2+ entry. Cancer Res 60:1002–1008

    PubMed  CAS  Google Scholar 

  • Hellwig N, Albrecht N, Harteneck C, Schultz G, Schaefer M (2005) Homo- and heteromeric assembly of TRPV channel subunits. J Cell Sci 118:917–928

    PubMed  CAS  Google Scholar 

  • Hirnet D, Olausson J, Fecher-Trost C, Bodding M, Nastainczyk W, Wissenbach U, Flockerzi V, Freichel M (2003) The TRPV6 gene, cDNA and protein. Cell Calcium 33:509–518

    PubMed  CAS  Google Scholar 

  • Hoenderop JG, van der Kemp AW, Hartog A, van de Graaf SF, van Os CH, Willems PH, Bindels RJ (1999) Molecular identification of the apical Ca2+ channel in 1, 25-dihydroxyvitamin D3-responsive epithelia. J Biol Chem 274:8375–8378

    PubMed  CAS  Google Scholar 

  • Hoenderop JG, Vennekens R, Muller D, Prenen J, Droogmans G, Bindels RJ, Nilius B (2001) Function and expression of the epithelial Ca(2+) channel family: comparison of mammalian ECaC1 and 2. J Physiol 537:747–761

    PubMed Central  PubMed  CAS  Google Scholar 

  • Hoenderop JG, Nilius B, Bindels RJ (2003a) Epithelial calcium channels: from identification to function and regulation. Pflugers Arch 446:304–308

    PubMed  CAS  Google Scholar 

  • Hoenderop JG, Voets T, Hoefs S, Weidema F, Prenen J, Nilius B, Bindels RJ (2003b) Homo- and heterotetrameric architecture of the epithelial Ca2+ channels TRPV5 and TRPV6. EMBO J 17:776–785

    Google Scholar 

  • Hoenderop JG, van Leeuwen JP, van der Eerden BC, Kersten FF, van der Kemp AW, Merillat AM, Waarsing JH, Rossier BC, Vallon V, Hummler E, Bindels RJ (2003c) Renal Ca2+ wasting, hyperabsorption, and reduced bone thickness in mice lacking TRPV5. J Clin Invest 112:1906–1914

    PubMed Central  PubMed  CAS  Google Scholar 

  • Hoenderop JG, Nilius B, Bindels RJ (2005) Calcium absorption across epithelia. Physiol Rev 85:373–422

    PubMed  CAS  Google Scholar 

  • Hughes DA, Tang K, Strotmann R, Schoneberg T, Prenen J, Nilius B, Stoneking M (2008) Parallel selection on TRPV6 in human populations. PLoS One 3(2):e1686

    PubMed Central  PubMed  Google Scholar 

  • Huybers S, Naber TH, Bindels RJ, Hoenderop JG (2007) Prednisolone-induced Ca2+ malabsorption is caused by diminished expression of the epithelial Ca2+ channel TRPV6. Am J Physiol Gastrointest Liver Physiol 292:G92–G97

    PubMed  CAS  Google Scholar 

  • Huybers S, Apostolaki M, van der Eerden BCJ, Kollias G, Naber THJ, Bindels RJM (2008) Hoenderop JGJ (2008) Murine TNFΔARE Crohn’s Disease Model Displays Diminished Expression of Intestinal Ca2+ Transporters. Inflamm Bowel Dis 14:803–811

    PubMed  Google Scholar 

  • Karaplis AC, Luz A, Glowacki J, Bronson RT, Tybulewicz VL, Kronenberg HM, Mulligan RC (1994) Lethal skeletal dysplasia from targeted disruption of the parathyroid hormone-related peptide gene. Genes Dev 8:277–289

    PubMed  CAS  Google Scholar 

  • Kellett GL (2011) Alternative perspective on intestinal calcium absorption: proposed complementary actions of Ca(v)1.3 and TRPV6. Nutr Rev 69:347–370

    PubMed  Google Scholar 

  • Kessler T, Wissenbach U, Grobholz R, Flockerzi V (2009) TRPV6 alleles do not influence prostate cancer progression. BMC Cancer 9:380

    PubMed Central  PubMed  Google Scholar 

  • Kim HJ, Yang DK, So I (2007) PDZ domain-containing protein as a physiological modulator of TRPV6. Biochem Biophys Res Commun 361:433–438

    PubMed  CAS  Google Scholar 

  • Kim MH, Lee GS, Jung EM, Choi KC, Jeung EB (2009a) The negative effect of dexamethasone on calcium-processing gene expressions is associated with a glucocorticoid-induced calcium-absorbing disorder. Life Sci 85:146–152

    PubMed  CAS  Google Scholar 

  • Kim MH, Lee GS, Jung EM, Choi KC, Oh GT, Jeung EB (2009b) Dexamethasone differentially regulates renal and duodenal calcium-processing genes in calbindin-D9k and -D28k knockout mice. Exp Physiol 94:138–151

    PubMed  CAS  Google Scholar 

  • King N, Westbrook MJ, Young SL, Kuo A, Abedin M, Chapman J, Fairclough S, Hellsten U, Isogai Y, Letunic I, Marr M, Pincus D, Putnam N, Rokas A, Wright KJ, Zuzow R, Dirks W, Good M, Goodstein D, Lemons D, Li W, Lyons JB, Morris A, Nichols S, Richter DJ, Salamov A, Sequencing JG, Bork P, Lim WA, Manning G, Miller WT, McGinnis W, Shapiro H, Tjian R, Grigoriev IV, Rokhsar D (2008) The genome of the choanoflagellate Monosiga brevicollis and the origin of metazoans. Nature 451(7180):783–788

    PubMed Central  PubMed  CAS  Google Scholar 

  • Ko SH, Choi KC, Oh GT, Jeung EB (2009) Effect of dietary calcium and 1,25-(OH)2D3 on the expression of calcium transport genes in calbindin-D9k and -D28k double knockout mice. Biochem Biophys Res Commun 379:227–232

    PubMed  CAS  Google Scholar 

  • Kovacs G, Montalbetti N, Simonin A, Danko T, Balazs B, Zsembery A, Hediger MA (2012) Inhibition of the human epithelial calcium channel TRPV6 by 2-aminoethoxydiphenyl borate (2-APB). Cell Calcium 52:468–480

    PubMed  CAS  Google Scholar 

  • Kovacs G, Montalbetti N, Franz MC, Graeter S, Simonin A, Hediger MA (2013) Human TRPV5 and TRPV6: key players in cadmium and zinc toxicity. Cell Calcium 54(4):276–286

    PubMed  CAS  Google Scholar 

  • Kovalevskaya NV, Schilderink N, Vuister GW (2011) Expression and purification of the C-terminal fragments of TRPV5/6 channels. Protein Expr Purif 80:28–33

    PubMed  CAS  Google Scholar 

  • Kovalevskaya NV, Bokhovchuk FM, Vuister GW (2012) The TRPV5/6 calcium channels contain multiple calmodulin binding sites with differential binding properties. J Struct Funct Genom 13:91–100

    CAS  Google Scholar 

  • Kuro-o M, Matsumura Y, Aizawa H, Kawaguchi H, Suga T, Utsugi T, Ohyama Y, Kurabayashi M, Kaname T, Kume E, Iwasaki H, Iida A, Shiraki-Iida T, Nishikawa S, Nagai R, Nabeshima YI (1997) Mutation of the mouse klotho gene leads to a syndrome resembling ageing. Nature 390:45–51

    PubMed  CAS  Google Scholar 

  • Kutuzova GD, Sundersingh F, Vaughan J, Tadi BP, Ansay SE, Christakos S, Deluca HF (2008) TRPV6 is not required for 1alpha,25-dihydroxyvitamin D3-induced intestinal calcium absorption in vivo. Proc Natl Acad Sci USA 105(50):19655–19659

    PubMed Central  PubMed  CAS  Google Scholar 

  • Lafond J, Leclerc M, Brunette MG (1991) Characterization of calcium transport by basal plasma membranes from human placental syncytiotrophoblast. J Cell Physiol 148:17–23

    PubMed  CAS  Google Scholar 

  • Lambers TT, Weidema AF, Nilius B, Hoenderop JG, Bindels RJ (2004) Regulation of the mouse epithelial Ca2+ channel TRPV6 by the Ca2+-sensor calmodulin. J Biol Chem 279:28855–28861

    PubMed  CAS  Google Scholar 

  • Lambers TT, Mahieu F, Oancea E, Hoofd L, de Lange F, Mensenkamp AR, Voets T, Nilius B, Clapham DE, Hoenderop JG, Bindels RJ (2006) Calbindin-D28K dynamically controls TRPV5-mediated Ca2+ transport. EMBO J 25:2978–2988

    PubMed Central  PubMed  CAS  Google Scholar 

  • Landowski CP, Bolanz KA, Suzuki Y, Hediger MA (2011) Chemical inhibitors of the calcium entry channel TRPV6. Pharm Res 28:322–330

    PubMed  CAS  Google Scholar 

  • Lee GS, Jeung EB (2007) Uterine TRPV6 expression during the estrous cycle and pregnancy in a mouse model. Am J Physiol Endocrinol Metab 293:E132–E138

    PubMed  CAS  Google Scholar 

  • Lee CT, Shang S, Lai LW, Yong KC, Lien YH (2004) Effect of thiazide on renal gene expression of apical calcium channels and calbindins. Am J Physiol Renal Physiol 287:F1164–F1170

    PubMed  CAS  Google Scholar 

  • Lee GS, Lee KY, Choi KC, Ryu YH, Paik SG, Oh GT, Jeung EB (2007) Phenotype of a calbindin-D9k gene knockout is compensated for by the induction of other calcium transporter genes in a mouse model. J Bone Miner Res 22:1968–1978

    PubMed  CAS  Google Scholar 

  • Lehen'kyi V, Flourakis M, Skryma R, Prevarskaya N (2007) TRPV6 channel controls prostate cancer cell proliferation via Ca2+/NFAT-dependent pathways. Oncogene 26:7380–7385

    PubMed  Google Scholar 

  • Lehen'kyi V, Raphael M, Oulidi A, Flourakis M, Khalimonchyk S, Kondratskyi A, Gordienko DV, Mauroy B, Bonnal JL, Skryma R, Prevarskaya N (2011) TRPV6 determines the effect of vitamin D3 on prostate cancer cell growth. PLoS One 6(2):e16856

    PubMed Central  PubMed  Google Scholar 

  • Lehen'kyi V, Raphael M, Prevarskaya N (2012) The role of the TRPV6 channel in cancer. J Physiol 590:1369–1376

    PubMed Central  PubMed  Google Scholar 

  • Lieben L, Carmeliet G (2012) The involvement of TRP channels in bone homeostasis. Front Endocrinol 3:99

    Google Scholar 

  • Little R, Muimo R, Robson L, Harris K, Grabowski PS (2011) The transient receptor potential ion channel TRPV6 is expressed at low levels in osteoblasts and has little role in osteoblast calcium uptake. PLoS One 6(11):e28166

    PubMed Central  PubMed  CAS  Google Scholar 

  • Lu P, Boros S, Chang Q, Bindels RJ, Hoenderop JG (2008) The beta-glucuronidase klotho exclusively activates the epithelial Ca2+ channels TRPV5 and TRPV6. Nephrol Dial Transplant 23:3397–3402

    PubMed  CAS  Google Scholar 

  • Merchant SS, Prochnik SE, Vallon O, Harris EH, Karpowicz SJ, Witman GB, Terry A, Salamov A, Fritz-Laylin LK, Marechal-Drouard L, Marshall WF, Qu LH, Nelson DR, Sanderfoot AA, Spalding MH, Kapitonov VV, Ren Q, Ferris P, Lindquist E, Shapiro H, Lucas SM, Grimwood J, Schmutz J, Cardol P, Cerutti H, Chanfreau G, Chen CL, Cognat V, Croft MT, Dent R, Dutcher S, Fernandez E, Fukuzawa H, Gonzalez-Ballester D, Gonzalez-Halphen D, Hallmann A, Hanikenne M, Hippler M, Inwood W, Jabbari K, Kalanon M, Kuras R, Lefebvre PA, Lemaire SD, Lobanov AV, Lohr M, Manuell A, Meier I, Mets L, Mittag M, Mittelmeier T, Moroney JV, Moseley J, Napoli C, Nedelcu AM, Niyogi K, Novoselov SV, Paulsen IT, Pazour G, Purton S, Ral JP, Riano-Pachon DM, Riekhof W, Rymarquis L, Schroda M, Stern D, Umen J, Willows R, Wilson N, Zimmer SL, Allmer J, Balk J, Bisova K, Chen CJ, Elias M, Gendler K, Hauser C, Lamb MR, Ledford H, Long JC, Minagawa J, Page MD, Pan J, Pootakham W, Roje S, Rose A, Stahlberg E, Terauchi AM, Yang P, Ball S, Bowler C, Dieckmann CL, Gladyshev VN, Green P, Jorgensen R, Mayfield S, Mueller-Roeber B, Rajamani S, Sayre RT, Brokstein P, Dubchak I, Goodstein D, Hornick L, Huang YW, Jhaveri J, Luo Y, Martinez D, Ngau WC, Otillar B, Poliakov A, Porter A, Szajkowski L, Werner G, Zhou K, Grigoriev IV, Rokhsar DS, Grossman AR (2007) The Chlamydomonas genome reveals the evolution of key animal and plant functions. Science 318(5848):245–250

    PubMed Central  PubMed  CAS  Google Scholar 

  • Moreau R, Daoud G, Bernatchez R, Simoneau L, Masse A, Lafond J (2002) Calcium uptake and calcium transporter expression by trophoblast cells from human term placenta. Biochim Biophys Acta 1564:325–332

    PubMed  CAS  Google Scholar 

  • Muller D, Hoenderop JG, Merkx GF, van Os CH, Bindels RJ (2000) Gene structure and chromosomal mapping of human epithelial calcium channel. Biochem Biophys Res Commun 275:47–52

    PubMed  CAS  Google Scholar 

  • Niemeyer BA, Bergs C, Wissenbach U, Flockerzi V, Trost C (2001) Competitive regulation of CaT-like-mediated Ca2+ entry by protein kinase C and calmodulin. Proc Natl Acad Sci USA 98(6):3600–3605

    PubMed Central  PubMed  CAS  Google Scholar 

  • Nijenhuis T, Hoenderop JG, van der Kemp AW, Bindels RJ (2003) Localization and regulation of the epithelial Ca2+ channel TRPV6 in the kidney. J Am Soc Nephrol 14:2731–2740

    PubMed  CAS  Google Scholar 

  • Nilius B, Vennekens R, Prenen J, Hoenderop JG, Bindels RJ, Droogmans G (2000) Whole-cell and single channel monovalent cation currents through the novel rabbit epithelial Ca2+ channel ECaC. J Physiol 527(Pt 2):239–248

    PubMed Central  PubMed  CAS  Google Scholar 

  • Nilius B, Vennekens R, Prenen J, Hoenderop JG, Droogmans G, Bindels RJ (2001) The single pore residue Asp542 determines Ca2+ permeation and Mg2+ block of the epithelial Ca2+ channel. J Biol Chem 276:1020–1025

    PubMed  CAS  Google Scholar 

  • Nilius B, Prenen J, Hoenderop JG, Vennekens R, Hoefs S, Weidema AF, Droogmans G, Bindels RJ (2002) Fast and slow inactivation kinetics of the Ca2+ channels ECaC1 and ECaC2 (TRPV5 and TRPV6). Role of the intracellular loop located between transmembrane segments 2 and 3. J Biol Chem 277:30852–30858

    PubMed  CAS  Google Scholar 

  • Nilius B, Prenen J, Droogmans G, Voets T, Vennekens R, Freichel M, Wissenbach U, Flockerzi V (2003) Voltage dependence of the Ca2+-activated cation channel TRPM4. J Biol Chem 278:30813–30820

    PubMed  CAS  Google Scholar 

  • Okano T, Tsugawa N, Morishita A, Kato S (2004) Regulation of gene expression of epithelial calcium channels in intestine and kidney of mice by 1alpha,25-dihydroxyvitamin D3. J Steroid Biochem Mol Biol 89–90:335–338

    PubMed  Google Scholar 

  • Owsianik G, Talavera K, Voets T, Nilius B (2006) Permeation and selectivity of TRP channels. Annu Rev Physiol 68:685–717

    PubMed  CAS  Google Scholar 

  • Oz OK, Hajibeigi A, Howard K, Cummins CL, van Abel M, Bindels RJ, Word RA, Kuro-o M, Pak CY, Zerwekh JE (2007) Aromatase deficiency causes altered expression of molecules critical for calcium reabsorption in the kidneys of female mice *. J Bone Miner Res 22:1893–1902

    PubMed  CAS  Google Scholar 

  • Pahuja DN, DeLuca HF (1981) Stimulation of intestinal calcium transport and bone calcium mobilization by prolactin in vitamin D-deficient rats. Science 214(4524):1038–1039

    PubMed  CAS  Google Scholar 

  • Peng JB (2011) TRPV5 and TRPV6 in transcellular Ca2+ transport: regulation, gene duplication, and polymorphisms in African populations. Adv Exp Med Biol 704:239–275

    PubMed  CAS  Google Scholar 

  • Peng JB, Chen XZ, Berger UV, Vassilev PM, Tsukaguchi H, Brown EM, Hediger MA (1999) Molecular cloning and characterization of a channel-like transporter mediating intestinal calcium absorption. J Biol Chem 274:22739–22746

    PubMed  CAS  Google Scholar 

  • Peng JB, Chen XZ, Berger UV, Weremowicz S, Morton CC, Vassilev PM, Brown EM, Hediger MA (2000) Human calcium transport protein CaT1. Biochem Biophys Res Commun 278:326–332

    PubMed  CAS  Google Scholar 

  • Peng JB, Zhuang L, Berger UV, Adam RM, Williams BJ, Brown EM, Hediger MA, Freeman MR (2001) CaT1 expression correlates with tumor grade in prostate cancer. Biochem Biophys Res Commun 282(3):729–734

    PubMed  CAS  Google Scholar 

  • Peters AA, Simpson PT, Bassett JJ, Lee JM, Da Silva L, Reid LE, Song S, Parat MO, Lakhani SR, Kenny PA, Roberts-Thomson SJ, Monteith GR (2012) Calcium channel TRPV6 as a potential therapeutic target in estrogen receptor-negative breast cancer. Mol Cancer Ther 11:2158–2168

    PubMed  CAS  Google Scholar 

  • Phelps CB, Huang RJ, Lishko PV, Wang RR, Gaudet R (2008) Structural analyses of the ankyrin repeat domain of TRPV6 and related TRPV ion channels. Biochemistry 47:2476–2484

    PubMed Central  PubMed  CAS  Google Scholar 

  • Pike JW, Zella LA, Meyer MB, Fretz JA, Kim S (2007) Molecular actions of 1,25-dihydroxyvitamin D3 on genes involved in calcium homeostasis. J Bone Miner Res 22(Suppl 2):V16–V19

    PubMed  CAS  Google Scholar 

  • Qiu A, Hogstrand C (2004) Functional characterisation and genomic analysis of an epithelial calcium channel (ECaC) from pufferfish, Fugu rubripes. Gene 342(1):113–123

    PubMed  CAS  Google Scholar 

  • Schindl R, Fritsch R, Jardin I, Frischauf I, Kahr H, Muik M, Riedl MC, Groschner K, Romanin C (2012) Canonical transient receptor potential (TRPC) 1 acts as a negative regulator for vanilloid TRPV6-mediated Ca2+ influx. J Biol Chem 287:35612–35620

    PubMed Central  PubMed  CAS  Google Scholar 

  • Schoeber JP, Topala CN, Wang X, Diepens RJ, Lambers TT, Hoenderop JG, Bindels RJ (2006) RGS2 inhibits the epithelial Ca2+ channel TRPV6. J Biol Chem 281:29669–29674

    PubMed  CAS  Google Scholar 

  • Schoeber JP, Topala CN, Lee KP, Lambers TT, Ricard G, van der Kemp AW, Huynen MA, Hoenderop JG, Bindels RJ (2008) Identification of Nipsnap1 as a novel auxiliary protein inhibiting TRPV6 activity. Pflugers Arch 457:91–101

    PubMed  CAS  Google Scholar 

  • Schwarz EC, Wissenbach U, Niemeyer BA, Strauss B, Philipp SE, Flockerzi V, Hoth M (2006) TRPV6 potentiates calcium-dependent cell proliferation. Cell Calcium 39:163–173

    PubMed  CAS  Google Scholar 

  • Semenova SB, Vassilieva IO, Fomina AF, Runov AL, Negulyaev YA (2009) Endogenous expression of TRPV5 and TRPV6 calcium channels in human leukemia K562 cells. Am J Physiol Cell Physiol 296:C1098–C1104

    PubMed  CAS  Google Scholar 

  • Sibai BM (2005) Diagnosis, prevention, and management of eclampsia. Obstet Gynecol 105:402–410

    PubMed  Google Scholar 

  • Sibley CP, Boyd RD (1988) Control of transfer across the mature placenta. Oxf Rev Reprod Biol 10:382–435

    PubMed  CAS  Google Scholar 

  • Soejima M, Tachida H, Koda Y (2009) Sequence analysis of human TRPV6 suggests positive selection outside Africa. Biochem Genet 47:147–153

    PubMed  CAS  Google Scholar 

  • Song Y, Peng X, Porta A, Takanaga H, Peng JB, Hediger MA, Fleet JC, Christakos S (2003) Calcium transporter 1 and epithelial calcium channel messenger ribonucleic acid are differentially regulated by 1,25 dihydroxyvitamin D3 in the intestine and kidney of mice. Endocrinology 144(9):3885–3894

    PubMed  CAS  Google Scholar 

  • Stajich JE, Hahn MW (2005) Disentangling the effects of demography and selection in human history. Mol Biol Evol 22:63–73

    PubMed  CAS  Google Scholar 

  • Sternfeld L, Anderie I, Schmid A, Al-Shaldi H, Krause E, Magg T, Schreiner D, Hofer HW, Schulz I (2007) Identification of tyrosines in the putative regulatory site of the Ca2+ channel TRPV6. Cell Calcium 42:91–102

    PubMed  CAS  Google Scholar 

  • Stumpf T, Zhang Q, Hirnet D, Lewandrowski U, Sickmann A, Wissenbach U, Dorr J, Lohr C, Deitmer JW, Fecher-Trost C (2008) The human TRPV6 channel protein is associated with cyclophilin B in human placenta. J Biol Chem 283:18086–18098

    PubMed  CAS  Google Scholar 

  • Sudo Y, Matsuo K, Tetsuo T, Tsutsumi S, Ohkura M, Nakai J, Uezono Y (2010) Derived (mutated)-types of TRPV6 channels elicit greater Ca2+ influx into the cells than ancestral-types of TRPV6: evidence from Xenopus oocytes and mammalian cell expression system. J Pharmacol Sci 114:281–291

    PubMed  CAS  Google Scholar 

  • Suzuki Y, Kovacs CS, Takanaga H, Peng JB, Landowski CP, Hediger MA (2008a) Calcium channel TRPV6 is involved in murine maternal-fetal calcium transport. J Bone Miner Res 23:1249–1256

    PubMed Central  PubMed  CAS  Google Scholar 

  • Suzuki Y, Pasch A, Bonny O, Mohaupt MG, Hediger MA, Frey FJ (2008b) Gain-of-function haplotype in the epithelial calcium channel TRPV6 is a risk factor for renal calcium stone formation. Hum Mol Genet 17:1613–1618

    PubMed  CAS  Google Scholar 

  • Suzuki Y, Landowski CP, Hediger MA (2008c) Mechanisms and regulation of epithelial Ca2+ absorption in health and disease. Annu Rev Physiol 70:257–271

    PubMed  CAS  Google Scholar 

  • Taira M, Iizasa T, Shimada H, Kudoh J, Shimizu N, Tatibana M (1990) A human testis-specific mRNA for phosphoribosylpyrophosphate synthetase that initiates from a non-AUG codon. J Biol Chem 265:16491–16497

    PubMed  CAS  Google Scholar 

  • Taparia S, Fleet JC, Peng JB, Wang XD, Wood RJ (2006) 1,25-Dihydroxyvitamin D and 25-hydroxyvitamin D–mediated regulation of TRPV6 (a putative epithelial calcium channel) mRNA expression in Caco-2 cells. Eur J Nutr 45:196–204

    PubMed  CAS  Google Scholar 

  • Thyagarajan B, Lukacs V, Rohacs T (2008) Hydrolysis of phosphatidylinositol 4,5-bisphosphate mediates calcium-induced inactivation of TRPV6 channels. J Biol Chem 283:14980–14987

    PubMed Central  PubMed  CAS  Google Scholar 

  • Tobias JH, Cooper C (2004) PTH/PTHrP activity and the programming of skeletal development in utero. J Bone Miner Res 19:177–182

    PubMed  CAS  Google Scholar 

  • van Abel M, Hoenderop JG, van der Kemp AW, van Leeuwen JP, Bindels RJ (2003) Regulation of the epithelial Ca2+ channels in small intestine as studied by quantitative mRNA detection. Am J Physiol Gastrointest Liver Physiol 285:G78–G85

    PubMed  Google Scholar 

  • van Abel M, Hoenderop JG, Bindels RJ (2005) The epithelial calcium channels TRPV5 and TRPV6: regulation and implications for disease. Naunyn Schmiedebergs Arch Pharmacol 371:295–306

    PubMed  CAS  Google Scholar 

  • Van Cromphaut SJ, Rummens K, Stockmans I, Van Herck E, Dijcks FA, Ederveen AG, Carmeliet P, Verhaeghe J, Bouillon R, Carmeliet G (2003) Intestinal calcium transporter genes are upregulated by estrogens and the reproductive cycle through vitamin D receptor-independent mechanisms. J Bone Miner Res 18:1725–1736

    PubMed  Google Scholar 

  • Van Cromphaut SJ, Stockmans I, Torrekens S, Van Herck E, Carmeliet G, Bouillon R (2007) Duodenal calcium absorption in dexamethasone-treated mice: functional and molecular aspects. Arch Biochem Biophys 460:300–305

    PubMed  Google Scholar 

  • van de Graaf SF, Hoenderop JG, Gkika D, Lamers D, Prenen J, Rescher U, Gerke V, Staub O, Nilius B, Bindels RJ (2003) Functional expression of the epithelial Ca2+ channels (TRPV5 and TRPV6) requires association of the S100A10-annexin 2 complex. EMBO J 22:1478–1487

    PubMed Central  PubMed  Google Scholar 

  • van de Graaf SF, Chang Q, Mensenkamp AR, Hoenderop JG, Bindels RJ (2006a) Direct interaction with Rab11a targets the epithelial Ca2+ channels TRPV5 and TRPV6 to the plasma membrane. Mol Cell Biol 26:303–312

    PubMed Central  PubMed  Google Scholar 

  • van de Graaf SF, Hoenderop JG, Bindels RJ (2006b) Regulation of TRPV5 and TRPV6 by associated proteins. Am J Physiol Renal Physiol 290:F1295–F1302

    PubMed  Google Scholar 

  • van de Graaf SF, van der Kemp AW, van den Berg D, van Oorschot M, Hoenderop JG, Bindels RJ (2006c) Identification of BSPRY as a novel auxiliary protein inhibiting TRPV5 activity. J Am Soc Nephrol 17:26–30

    PubMed  Google Scholar 

  • van der Eerden BC, Hoenderop JG, de Vries TJ, Schoenmaker T, Buurman CJ, Uitterlinden AG, Pols HA, Bindels RJ, van Leeuwen JP (2005) The epithelial Ca2+ channel TRPV5 is essential for proper osteoclastic bone resorption. Proc Natl Acad Sci USA 102:17507–17512

    PubMed Central  PubMed  Google Scholar 

  • van der Eerden BC, Weissgerber P, Fratzl-Zelman N, Olausson J, Hoenderop JG, Schreuders-Koedam M, Eijken M, Roschger P, de Vries TJ, Chiba H, Klaushofer K, Flockerzi V, Bindels RJ, Freichel M, van Leeuwen JP (2012) The transient receptor potential channel TRPV6 is dynamically expressed in bone cells but is not crucial for bone mineralization in mice. J Cell Physiol 227:1951–1959

    PubMed  Google Scholar 

  • Vassilev PM, Peng JB, Johnson J, Hediger MA, Brown EM (2001) Inhibition of CaT1 channel activity by a noncompetitive IP3 antagonist. Biochem Biophys Res Commun 280:145–150

    PubMed  CAS  Google Scholar 

  • Vennekens R, Hoenderop JG, Prenen J, Stuiver M, Willems PH, Droogmans G, Nilius B, Bindels RJ (2000) Permeation and gating properties of the novel epithelial Ca2+channel. J Biol Chem 275:3963–3969

    PubMed  CAS  Google Scholar 

  • Vennekens R, Owsianik G, Nilius B (2008) Vanilloid transient receptor potential cation channels: an overview. Curr Pharm Des 14:18–31

    PubMed  CAS  Google Scholar 

  • Voets T, Prenen J, Fleig A, Vennekens R, Watanabe H, Hoenderop JG, Bindels RJ, Droogmans G, Penner R, Nilius B (2001) CaT1 and the calcium release-activated calcium channel manifest distinct pore properties. J Biol Chem 276:47767–47770

    PubMed  CAS  Google Scholar 

  • Voets T, Janssens A, Prenen J, Droogmans G, Nilius B (2003) Mg2+-dependent gating and strong inward rectification of the cation channel TRPV6. J Gen Physiol 121:245–260

    PubMed Central  PubMed  CAS  Google Scholar 

  • Voets T, Janssens A, Droogmans G, Nilius B (2004) Outer pore architecture of a Ca2+-selective TRP channel. J Biol Chem 279:15223–15230

    PubMed  CAS  Google Scholar 

  • Walker JJ (2000) Pre-eclampsia. Lancet 356:1260–1265

    PubMed  CAS  Google Scholar 

  • Walters JR, Balesaria S, Chavele KM, Taylor V, Berry JL, Khair U, Barley NF, van Heel DA, Field J, Hayat JO, Bhattacharjee A, Jeffery R, Poulsom R (2006) Calcium channel TRPV6 expression in human duodenum: different relationships to the vitamin D system and aging in men and women. J Bone Miner Res 21:1770–1777

    PubMed  CAS  Google Scholar 

  • Wangemann P, Nakaya K, Wu T, Maganti RJ, Itza EM, Sanneman JD, Harbidge DG, Billings S, Marcus DC (2007) Loss of cochlear HCO3 secretion causes deafness via endolymphatic acidification and inhibition of Ca2+ reabsorption in a Pendred syndrome mouse model. Am J Physiol Renal Physiol 292:F1345–F1353

    PubMed Central  PubMed  CAS  Google Scholar 

  • Weissgerber P, Kriebs U, Tsvilovskyy V, Olausson J, Kretz O, Stoerger C, Vennekens R, Wissenbach U, Middendorff R, Flockerzi V, Freichel M (2011) Male fertility depends on Ca2+ absorption by TRPV6 in epididymal epithelia. Sci Signal 4(171):ra2

    Google Scholar 

  • Weissgerber P, Kriebs U, Tsvilovskyy V, Olausson J, Kretz O, Stoerger C, Mannebach S, Wissenbach U, Vennekens R, Middendorff R, Flockerzi V, Freichel M (2012) Excision of the Trpv6 gene leads to severe defects in epididymal Ca2+ absorption and male fertility much alike the single D541A pore mutation. J Biol Chem 287:17930–17941

    PubMed Central  PubMed  CAS  Google Scholar 

  • Wissenbach U (2013) Pathologies of Ca2+ channels. Springer, Berlin

    Google Scholar 

  • Wissenbach U, Niemeyer BA (2007) Trpv6. Handb Exp Pharmacol 179(179):221–234

    PubMed  CAS  Google Scholar 

  • Wissenbach U, Niemeyer BA, Fixemer T, Schneidewind A, Trost C, Cavalie A, Reus K, Meese E, Bonkhoff H, Flockerzi V (2001) Expression of CaT-like, a novel calcium-selective channel, correlates with the malignancy of prostate cancer. J Biol Chem 276:19461–19468

    PubMed  CAS  Google Scholar 

  • Wissenbach U, Niemeyer B, Himmerkus N, Fixemer T, Bonkhoff H, Flockerzi V (2004) TRPV6 and prostate cancer: cancer growth beyond the prostate correlates with increased TRPV6 Ca2+ channel expression. Biochem Biophys Res Commun 322:1359–1363

    PubMed  CAS  Google Scholar 

  • Wood RJ, Tchack L, Taparia S (2001) 1,25-Dihydroxyvitamin D3 increases the expression of the CaT1 epithelial calcium channel in the Caco-2 human intestinal cell line. BMC Physiol 1:11

    PubMed Central  PubMed  CAS  Google Scholar 

  • Woudenberg-Vrenken TE, Lameris AL, Weissgerber P, Olausson J, Flockerzi V, Bindels RJ, Freichel M, Hoenderop JG (2012) Functional TRPV6 channels are crucial for transepithelial Ca2+ absorption. Am J Physiol Gastrointest Liver Physiol 303:G879–G885

    PubMed  CAS  Google Scholar 

  • Wu G, Zhang W, Na T, Jing H, Wu H, Peng JB (2012) Suppression of intestinal calcium entry channel TRPV6 by OCRL, a lipid phosphatase associated with Lowe syndrome and Dent disease. Am J Physiol Cell Physiol 302:C1479–C1491

    PubMed Central  PubMed  CAS  Google Scholar 

  • Yang S-S, Lo Y-F, Yu I-S, Lin S-W, Chang T-H, Hsu Y-J, Chao T-K, Sytwu H-K, Uchida S, Sasaki S, Lin S-H (2010) Generation and analysis of the thiazide-sensitive Na/Cl cotransporter (Ncc/Slc12a3) Ser707X knockin mouse as a model of Gitelman syndrome. Hum Mutat 31:1304–1315

    PubMed  CAS  Google Scholar 

  • Yang H, Kim TH, An BS, Choi KC, Lee HH, Kim JM, Jeung EB (2013) Differential expression of calcium transport channels in placenta primary cells and tissues derived from preeclamptic placenta. Mol Cell Endocrinol 367:21–30

    PubMed  CAS  Google Scholar 

  • Zakharian E, Cao C, Rohacs T (2011) Intracellular ATP supports TRPV6 activity via lipid kinases and the generation of PtdIns(4,5) P. FASEB J 25:3915–3928

    PubMed Central  PubMed  CAS  Google Scholar 

  • Zheng XE, Wang Z, Liao MZ, Lin YS, Shuhart MC, Schuetz EG, Thummel KE (2012) Human PXR-mediated induction of intestinal CYP3A4 attenuates 1alpha,25-dihydroxyvitamin D(3) function in human colon adenocarcinoma LS180 cells. Biochem Pharmacol 84:391–401

    PubMed Central  PubMed  CAS  Google Scholar 

  • Zhuang L, Peng JB, Tou L, Takanaga H, Adam RM, Hediger MA, Freeman MR (2002) Calcium-selective ion channel, CaT1, is apically localized in gastrointestinal tract epithelia and is aberrantly expressed in human malignancies. Lab Invest 82:1755–1764

    PubMed  CAS  Google Scholar 

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  1. Institut für Experimentelle und Klinische Pharmakologie und Toxikologie, Universität des Saarlandes, 66421, Homburg, Germany

    Claudia Fecher-Trost, Petra Weissgerber & Ulrich Wissenbach

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  1. Claudia Fecher-Trost
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  2. Petra Weissgerber
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  3. Ulrich Wissenbach
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  1. Laboratory Ion Channel Research Campus Gasthuisberg, KU Leuven Department Cell Mol Medicin, Leuven, Belgium

    Bernd Nilius

  2. Institut für Experimentelle u. Klinische, Pharmakologie und Toxikologie, Universität des Saarlandes, Homburg, Saarland, Germany

    Veit Flockerzi

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Fecher-Trost, C., Weissgerber, P., Wissenbach, U. (2014). TRPV6 Channels. In: Nilius, B., Flockerzi, V. (eds) Mammalian Transient Receptor Potential (TRP) Cation Channels. Handbook of Experimental Pharmacology, vol 222. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-54215-2_14

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