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Gentians Used in South America as Antimalarial Agents

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Book cover The Gentianaceae - Volume 2: Biotechnology and Applications

Abstract

Malaria is endemic to many countries of northern South America . There is a rich traditional use of plants to treat malaria in this region. This review focuses on species of Gentianaceae that are used in South America to treat malaria , fevers, and symptoms related to malaria . Species names used in original works are revised in accordance with contemporary knowledge of botany and distribution of these plants. Gentians from the following neotropical genera are used as antimalarials: Calolisianthus Gilg, Centaurium Hill, Chelonanthus Gilg, Coutoubea Aubl., Curtia Cham. and Schltdl., Deianira Cham. and Schltdl., Eustoma Salisb., Gentiana L., Gentianella Moench, Schultesia Mart., Tachia Aubl. and Voyria Aubl. Several gentian extracts and substances exhibit in vitro and especially in vivo antimalarial activity based on pharmacological and chemical composition studies. Water-ethyl alcohol extracts of the bark and roots of Potalia resinifera Mart., chloroform fractions of the ethyl alcohol extracts of leaves, and the methyl alcohol extracts of roots of Tachia grandiflora Maguire and Weaver inhibited Plasmodium falciparum Welch (a human malaria parasite) in vitro. In vivo antimalarial activity in rodent models has been reported for ethnopharmacologically relevant extracts of Calolisianthus speciosus (Cham. & Schltdl.) Gilg, a Chelonanthus Gilg sp. and Tachia Aubl. spp. [originally cited species: Irlbachia speciosa (Cham. and Schltdl.) Maas, I. alata (Aubl.) Maas, Tachia guianensis Aubl., respectively], and T. grandiflora. The antimalarial potential of only a few gentians from South America has been explored. Active antimalarial gentians need further study to identify their active principles and to confirm their medicinal potential.

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Acknowledgements

Funding was provided by grants from the Brazilian National Council for Scientific and Technological Development (CNPQ, National Malaria Network and Bionorth Program), the Amazonas State Research Support Foundation (FAPEAM, PRONEX). G. F., R. B. S. L. and A. M. P. would like to recognize the following scholarships received from CNPq: DTI, GD (383557/2010-0), (554317/2010-9), and PQ (311.649/2011-4), respectively. The authors thank Alex Popovkin, Bertil Ståhl, Guilhem Mansion, and Vinicius Dittrich for images of gentians and Bobbi Angell for botanical illustrations.

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Authors and Affiliations

  1. Federal University of Amazonas (UFAM), Av. General Rodrigo Octávio Jordão Ramos 3000, Campus Universitário, Coroado I, Manaus-AM, CEP 69077-000, Brazil

    Renata Braga Souza Lima

  2. National Institute for Amazon Research (INPA), Av. André Araújo 2936, Petrópolis, Cx, 2223, Manaus-AM, CEP 69080-971, Brazil

    Renata Braga Souza Lima, Gina Frausin & Adrian Martin Pohlit

  3. Rutgers, the State University of New Jersey, 237 Foran Hall, 59 Dudley Road, New Brunswick, NJ, 08901-8551, USA

    Stacy Brody & Lena Struwe

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  1. Renata Braga Souza Lima
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  2. Gina Frausin
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Correspondence to Adrian Martin Pohlit .

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Editors and Affiliations

  1. Botanical Garden-Center for Biological Diversity Conservation, Polish Academy of Sciences, Warsaw, Poland

    Jan J. Rybczyński

  2. Plant and Crop Sciences Division, University of Nottingham School of Biosciences, Loughborough, United Kingdom

    Michael R. Davey

  3. Botanical Garden-Center for Biological Diversity Conservation, Polish Academy of Sciences, Warsaw, Poland

    Anna Mikuła

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Lima, R.B.S., Frausin, G., Brody, S., Struwe, L., Pohlit, A.M. (2015). Gentians Used in South America as Antimalarial Agents. In: Rybczyński, J., Davey, M., Mikuła, A. (eds) The Gentianaceae - Volume 2: Biotechnology and Applications. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-54102-5_18

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