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Pathology of Pediatric Gastrointestinal and Liver Disease pp 477–501Cite as

Hepatitis and Liver Failure in Infancy and Childhood

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Abstract

Hepatitis in intrauterine and early postnatal life usually has different causes and clinical features than hepatitic processes experienced by older children and adults. The histologic features of neonatal hepatitis and hepatitis in early childhood are often significantly different than those observed in older patients. Because these features are by themselves frequently not diagnostic of any one liver disease, the pathologist must be familiar with all the potential causes and be able to suggest additional testing modalities, such as assays of metabolic enzymes, determination of specific metabolite levels, or ultrastructural examination, that may allow for a definitive diagnosis. In older children, the differential diagnosis of hepatitis overlaps to a greater extent with causes of hepatitis in adult patients, and a detailed discussion of those conditions is beyond the scope of this chapter.

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Authors and Affiliations

  1. Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, 34th St. and Civic Center Blvd, Philadelphia, PA, 19104, USA

    Eduardo D. Ruchelli MD

  2. Department of Pathology, The Children’s Hospital of Philadelphia, 34th St. and Civic Center Blvd, Philadelphia, PA, 19104, USA

    Eduardo D. Ruchelli MD

  3. Division of Gastroenterology and Nutrition, Department of Pediatrics, The Children’s Hospital of Philadelphia, 34th St. and Civic Center Blvd, Philadelphia, PA, 19104, USA

    Jessica W. Wen MD

  4. Division of Gastroenterology and Nutrition Department of Pediatrics, The Children’s Hospital of Philadelphia, University of Pennsylvania, 324 South 34th St, Philadelphia, PA, 19104, USA

    Elizabeth B. Rand MD

Authors
  1. Eduardo D. Ruchelli MD
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  2. Jessica W. Wen MD
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  3. Elizabeth B. Rand MD
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Corresponding author

Correspondence to Eduardo D. Ruchelli MD .

Editor information

Editors and Affiliations

  1. Department of Pathology, Division of Anatomic Pathology, The Children’s Hospital of Philadelphia, and the Perelman School of Medicine at The University of Pennsylvania, Philadelphia, Pennsylvania, USA

    Pierre Russo

  2. Department of Pathology, Division of Anatomic Pathology, The Children’s Hospital of Philadelphia, and the Perelman School of Medicine at The University of Pennsylvania, Philadelphia, Pennsylvania, USA

    Eduardo D. Ruchelli

  3. Division of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, The Children’s Hospital of Philadelphia, and the Perelman School of Medicine at The University of Pennsylvania, Philadelphia, Pennsylvania, USA

    David A. Piccoli

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© 2014 Springer-Verlag Berlin Heidelberg

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Ruchelli, E.D., Wen, J.W., Rand, E.B. (2014). Hepatitis and Liver Failure in Infancy and Childhood. In: Russo, P., Ruchelli, E., Piccoli, D. (eds) Pathology of Pediatric Gastrointestinal and Liver Disease. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-54053-0_12

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  • DOI: https://doi.org/10.1007/978-3-642-54053-0_12

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