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Calcium Phosphate Derived from Foraminifera Structures as Drug Delivery Systems and for Bone Tissue Engineering

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Advances in Calcium Phosphate Biomaterials

Part of the book series: Springer Series in Biomaterials Science and Engineering ((SSBSE,volume 2))

Abstract

Currently there is an urgent need to develop an appropriate slow drug delivery system to sustain the local and targeted release of the drug to increase therapeutic efficacy while reducing side effects. In this study, a novel drug delivery system by means of hydrothermally converting marine exoskeletons to β-tricalcium phosphate was investigated. The in vitro dissolution of key chemical compositional elements and the release of drugs such as simvastatin and antibiotics were measured. Coating of these Foraminifera shells with an apatitic bone cement material reduced the dissolution rate by 50 % compared with control samples. This study shows the potential applications of marine structure-derived calcium phosphates as efficient local drug delivery systems.

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Author information

Authors and Affiliations

  1. Faculty of Pharmacy, Research Institute of Pharmaceutical Science, Musashino University, 1-1-20 Shinmachi, 202-8585, Nishi-Tokyo, Tokyo, Japan

    Joshua Chou & Makoto Otsuka

  2. Faculty of Science, University of Technology, Sydney, NSW, Australia

    Joshua Chou & Bruce Milthorpe

  3. Oral Implantology and Regenerative Dental Medicine, Tokyo Medical and Dental University, Tokyo, Japan

    Jia Hao

  4. School of Chemistry and Forensic Science, Faculty of Science, University of Technology, Broadway, Ultimo, 123, Sydney, NSW, 2007, Australia

    Besim Ben-Nissan

Authors
  1. Joshua Chou
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  2. Jia Hao
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  3. Besim Ben-Nissan
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  4. Bruce Milthorpe
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  5. Makoto Otsuka
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Correspondence to Joshua Chou .

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Editors and Affiliations

  1. Chemistry and Forensic Science, University of Technology, Sydney, New South Wales, Australia

    Besim Ben-Nissan

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Chou, J., Hao, J., Ben-Nissan, B., Milthorpe, B., Otsuka, M. (2014). Calcium Phosphate Derived from Foraminifera Structures as Drug Delivery Systems and for Bone Tissue Engineering. In: Ben-Nissan, B. (eds) Advances in Calcium Phosphate Biomaterials. Springer Series in Biomaterials Science and Engineering, vol 2. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-53980-0_14

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