Abstract
Nanocrystalline apatite-based biomaterials and stem cells are emerging research fields in orthopaedic surgery and traumatology that have the potential of improving quality of life of the elderly and enhance health-related socio-economic challenges. Nanocrystalline apatite-based biomaterials and especially calcium phosphate nano-biomaterials exploit new physical, chemical and biological properties that have the possibility to increase surface area and improve tissue integration. Stem cells of adult origin decrease inflammation, increase vascularity and are able to replace degenerated tissue cells during the process of regeneration. The bone is the only human tissue that regenerates. Musculoskeletal disorders including osteoporotic fractures and osteoarthritis decrease quality of life in the elderly and cause severe burden on economics. Nanocrystalline calcium phosphate bioceramics have the ability to prevent or treat osteoporotic fractures when combined with stem cells. These biomaterials may also be used for drug delivery purposes to treat bone infections when combined with stem cell as they can assist in treating osteoarthritis. Current research challenges are trying to overcome the toxicity and carcinogenesis with these cells and nanomaterials. Long-term stability of these cells and materials is another challenge for these materials. This chapter deals with nanocrystalline calcium phosphate bioceramics and mesenchymal stem cells.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Amini AR, Laurencin CT, Nukavarapu SP (2012) Bone tissue engineering: recent advances and challenges. Crit Rev Biomed Eng 40(5):363–408
Korkusuz F, Tomin E, Yetkiner DN, Timuçin M, Öztürk A, Korkusuz P (2011) Synthetic bone grafts. TOTBID Dergisi 10:134–142
Korkusuz F, Senköylü A, Korkusuz P (2003) Hard tissue-implant interactions-2: bone-ceramic and bone-polymer interactions. Eklem Hastalik Cerr (formerly J Arthroplast Arthrosc Surg) 14:109–125
Demirkiran H (2012) Bioceramics for osteogenesis, molecular and cellular advances. Adv Exp Med Biol 760:134–147
Beck RT, Illingworth KD, Saleh KJ (2012) Review of periprosthetic osteolysis in total joint arthroplasty: an emphasis on host factors and future directions. J Orthop Res 30(4):541–546
Catledge SA, Fries MD, Vohra YK, Lacefield WR, Lemons JE, Woodard S, Venugopalan R (2002) Nanostructured ceramics for biomedical implants. J Nanosci Nanotechnol 2(3–4):293–312
Cazalbou S, Eichert D, Ranz X, Drouet C, Combes C, Harmand MF, Rey C (2005) Ion exchanges in apatites for biomedical application. J Mater Sci Mater Med 16(5):405–409
Dorozhkin SV (2010) Nanosized and nanocrystalline calcium orthophosphates. Acta Biomater 6(3):715–734
Suchanek W, Yoshimura M (1998) Processing and properties of hydroxyapatite-based biomaterials for use as hard tissue replacement implants. J Mater Res 13(1):97–117
Hayek E, Newesely H (1963) Pentacalcium monohydroxyorthophosphate. Inorg Synth 7:63–65
Tas AC, Korkusuz F, Timucin M, Akkas N (1997) An investigation of the chemical synthesis and high-temperature sintering behaviour of calcium hydroxyapatite (HA) and tricalcium phosphate (TCP) ceramics. J Mater Sci Mater Med 8:91–96
Choi D, Kumta PN (2006) An alternative chemical route for the synthesis and thermal stability of chemically enriched hydroxyapatite. J Am Ceram Soc 89(2):444–449
Morales JG, Burgues JT, Boix T, Fraile J, Clemente RR (2001) Precipitation of stoichiometric hydroxyapatite by a continuous method. Cryst Res Technol 36(1):15–26
Sarig S, Kahana F (2002) Rapid formation of nanocrystalline apatite. J Cryst Growth 237–239:55–59
Layrolle P, Ito A, Tateishi T (1998) Sol-gel synthesis of amorphous calcium phosphate and sintering into microporous hydroxyapatite bioceramics. J Am Ceram Soc 81(6):1421–1428
Varma HK, Babu SS (2005) Synthesis of calcium phosphate bioceramics by citrate gel pyrolysis method. Ceram Int 31:109–114
Agrawal K, Singh G, Puri D, Prakash S (2011) Synthesis and characterization of hydroxyapatite powder by sol-gel method for biomedical application. J Miner Mater Char Eng 10(8):727–734
Akao M, Aoki H, Kato K (1981) Mechanical properties of sintered hydroxyapatite for prosthetic applications. J Mater Sci 16:809–812
Vakıfahmetoglu C, Park J, Korkusuz F, Ozturk A, Timucin M (2009) Production and properties of apatite-wollastonite ceramics for biomedical applications. Interceram 58(2–3):86–90
Gibson IR, Best SM, Bonfield W (1999) Chemical characterisation of silicon substituted hydroxyapatite. J Biomed Mater Res 44(4):422–428
Gibson IR, Best SM, Bonfield W (2002) Effect of silicon substitution on the sintering and microstructure of hydroxyapatite. J Am Ceram Soc 85(11):2771–2777
Pietak AM, Reid JW, Stott MJ, Sayer M (2007) Silicon substitution in the calcium phosphate bioceramics. Biomaterials 28:4023–4032
Izci Y, Seçer HI, Ilica AT, Karaçalioglu O, Onguru O, Timuçin M, Korkusuz F (2012) The efficacy of bioceramics for the closure of burr-holes in craniotomy: case studies on 14 patients. J Appl Biomater Funct Mater 11:e187–e196. doi:10.5301/JABFM.2012.9252
Lin K, Zhai W, Ni S et al (2005) Study of the mechanical property and in vitro biocompatibility of CaSiO3 ceramics. Ceram Int 31:323–326
Arpınar P, Şimsek B, Sezgin OC, Birlik G, Korkusuz F (2005) Correlation between mechanical vibration analysis and dual energy X-ray absorptiometry (DXA) in the measurement of in vivo human tibial bone strength. Technol Health Care 13:107–113
Bediz B, Özgüven HN, Korkusuz F (2010) Vibration measurements predict the mechanical properties of human tibia. Clin Biomech 25:365–371
Atik OS, Gunal I, Korkusuz F (2006) Burden of osteoporosis. Clin Orthop Relat Res 443:19–24
Muratli HH, Korkusuz F, Korkusuz P, Bicimoglu A, Ercan ZS (2007) Bosentan, a non-specific endothelin antagonist, stimulates fracture healing. Biomedical engineering: application. Basis Commun 19:37–46
Chen G, Deng C, Li YP (2012) TGF-β and BMP signaling in osteoblast differentiation and bone formation. Int J Biol Sci 8:272–288
Steinert AF, Rackwitz L, Gilbert F, Nöth U, Tuan RS (2012) Concise review: the clinical application of mesenchymal stem cells for musculoskeletal regeneration: current status and perspectives. Stem Cells Transl Med 1:237–247
Dominici M, Le Blanc K, Mueller I, Slaper-Cortenbach I, Marini FC, Krause DS, Deans RJ, Keating A, Prockop DJ, Horwitz EM (2006) Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement. Cytotherapy 8:315–317
Vandecandelaere N, Rey C, Drouet C (2012) Biomimetic apatite-based biomaterials: on the critical impact of synthesis and post-synthesis parameters. J Mater Sci Mater Med 23:2593–2606
Zhou H, Lee J (2011) Nanoscale hydroxyapatite particles for bone tissue engineering. Acta Biomater 7:2769–2781
McMahon RE, Wang L, Skoracki R, Mathur AB (2013) Development of nanomaterials for bone repair and regeneration. J Biomed Mater Res B Appl Biomater 101:387–397
Chen Y, Chen H, Shi J (2013) In vivo bio-safety evaluations and diagnostic/therapeutic applications of chemically designed mesoporous silica nanoparticles. Adv Mater 25:3144–3176
Park KH, Kim H, Moon S, Na K (2009) Bone morphogenic protein-2 (BMP-2) loaded nanoparticles mixed with human mesenchymal stem cell in fibrin hydrogel for bone tissue engineering. J Biosci Bioeng 108:530–537
Li J, Li Y, Ma S, Gao Y, Zuo Y, Hu J (2010) Enhancement of bone formation by BMP-7 transduced MSCs on biomimetic nano-hydroxyapatite/polyamide composite scaffolds in repair of mandibular defects. J Biomed Mater Res A95:973–981
Lock J, Nguyen TY, Liu H (2012) Nanophase hydroxyapatite and poly(lactide-co-glycolide) composites promote human mesenchymal stem cell adhesion and osteogenic differentiation in vitro. J Mater Sci Mater Med 23:2543–2552
Cheng Z, Guo C, Dong W, He FM, Zhao SF, Yang GL (2012) Effect of thin nano-hydroxyapatite coating on implant osseointegration in ovariectomized rats. Oral Surg Oral Med Oral Pathol Oral Radiol 113:e48–e53
Fox K, Tran PA, Tran N (2012) Recent advances in research applications of nanophase hydroxyapatite. ChemPhysChem 13:2495–2506
Yamada M, Ueno T, Tsukimura N, Ikeda T, Nakagawa K, Hori N, Suzuki T, Ogawa T (2012) Bone integration capability of nanopolymorphic crystalline hydroxyapatite coated on titanium implants. Int J Nanomedicine 7:859–873
Roy M, Bandyopadhyay A, Bose S (2011) Induction plasma sprayed Sr and Mg doped nano hydroxyapatite coatings on Ti for bone implant. J Biomed Mater Res B Appl Biomater 99:258–265
Acknowledgements
Authors thank Duygu Uçkan Çetinkaya MD, PhD, and Sevil Arslan MSc of Hacettepe University Faculty of Medicine, PediSTEM Stem Cell Research Center, for their contribution to MSC studies.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2014 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Korkusuz, F., Timuçin, M., Korkusuz, P. (2014). Nanocrystalline Apatite-Based Biomaterials and Stem Cells in Orthopaedics. In: Ben-Nissan, B. (eds) Advances in Calcium Phosphate Biomaterials. Springer Series in Biomaterials Science and Engineering, vol 2. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-53980-0_12
Download citation
DOI: https://doi.org/10.1007/978-3-642-53980-0_12
Published:
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-53979-4
Online ISBN: 978-3-642-53980-0
eBook Packages: Chemistry and Materials ScienceChemistry and Material Science (R0)