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Marine Bioactive Compounds from Cnidarians

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Book cover Springer Handbook of Marine Biotechnology

Part of the book series: Springer Handbooks ((SHB))

Abstract

Cnidaria is a large, diverse and ecologically important phylum of marine invertebrates, which includes corals, sea fans, anemones, and jellyfishes. It contains over 11000 species, 7500 of them belonging to the class Anthozoa. Over 3000 marine natural products have been described from this phylum alone, most of them in the twenty-first century. The present work provides an overview of some of the most promising marine bioactive compounds, from a therapeutic point of view, isolated from cnidarians since the year 2000. The order Alcyonacea (class Anthozoa) exhibits the highest number of species yielding promising compounds. Antitumor activity has been the major area of interest in the screening of cnidarian compounds, the most promising ones being terpenoids (monoterpenoids, diterpenoids, and sesquiterpenoids). Future trends and challenges for the bioprospecting of new marine bioactive compounds produced by cnidarians are also discussed, with emphasis on the sustainable production of target cnidarians biomass and the role played by symbiotic microorganisms in the synthesis of important biomolecules.

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Abbreviations

A549:

human alveolar epithelial cells

AA:

arachidonic acid

AGS:

human gastric cancer cell

ATCC:

American Type Culture Collection

BDS:

bunodosine

CCRF-CEM:

human T-cell lymphoblast-like cell line

COX-2:

cyclooxygenase-2

COX:

cyclooxygenase

Ca9-22:

human gingival carcinoma

ChAT:

choline acetyltransferase

DLD:

dihydrolipoamide dehydrogenase

FPT:

farnesyl protein transferase

GERD:

gastroesophageal reflux disease

GFP:

green fluorescent protein

GI 50 :

growth inhibition

GORD:

gastroesophageal reflux disease

HCMV:

human cytomegalovirus

HCT116:

human colorectal carcinoma cell line

HCT:

human colorectal tumor

HIV:

human immunodeficiency virus

HNE:

human neutrophil elastase

HT-29:

human colon adenocarcinoma

HeLa:

human cervix carcinoma cells

Hep3B:

human liver carcinoma

HepG2:

hepatoma cell line

IDO:

indoleamine 2,3-dioxygenase

IMO:

International Maritime Organization

K562:

human chronic myeloid leukemia cells

KB:

human epidermoid carcinoma

LPS:

lipopolysaccharide

MCF:

Michigan Cancer Foundation-7

MDA-MB-231:

human breast carcinoma

MIC:

minimum inhibitory concentration

MNP:

marine natural product

MOLT:

molybdate uptake transporter

NCI:

National Cancer Institute

NO:

nitric oxide

OPF:

orange fluorescent protein

P-388:

mouse lymphocytic leukemia

PAN:

plane polyacrylonitrile

PBMC:

peripheral blood mononuclear cells

PC:

phycocyanin

PKC:

protein kinase C

RAW:

ATCC cell line

ROS:

reactive oxygen species

SCUBA:

self-contained under water breathing apparatus

TBT:

tri-n-butyltin

TNF:

tumor necrosis factor

TPA:

12-O-tetradecanoylphorbol-13-acetate

VEGF:

vascular endothelial growth factor

WoRMS:

World Register of Marine Species

iNOS:

inducible nitric oxide synthase

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  1. Campus Universitário de Santiago Department of Biology, University of Aveiro, 3810-193, Aveiro, Portugal

    Joana Rocha, Ricardo Calado & Miguel Leal

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    Se-Kwon Kim Prof.

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Rocha, J., Calado, R., Leal, M. (2015). Marine Bioactive Compounds from Cnidarians. In: Kim, SK. (eds) Springer Handbook of Marine Biotechnology. Springer Handbooks. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-53971-8_35

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