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Marine-Derived Fungal Metabolites

  • Chapter
Springer Handbook of Marine Biotechnology

Part of the book series: Springer Handbooks ((SHB))

Abstract

Marine-derived metabolites continue to be a prolific source for bioactive natural products with a high tendency to become drug candidates. Recently, eribulin mesylate (GlossaryTerm

E7389

), a synthetic derivative of halichondrin B, was approved by the US GlossaryTerm

FDA

(Food and Drug Administration) for the treatment of breast cancer metastases, going under the trade name Halaven. Some other marine-derived pharmaceuticals have likewise already been approved and launched onto the market, including Yondelis (trabectedin), Prialt (ziconotide), Retrovir (zidovudine), Cytosar (cytarabine, GlossaryTerm

Ara-C

), and Vira-A (vidarabine, Ara-A). Research interests in marine natural products have increased in the last few decades, in particular with respect to compounds isolated from marine-derived fungi. In this chapter, a historical background of marine-derived pharmaceuticals and fungal metabolites will be presented, including potential classes of bioactive chemical compounds. In addition, a perspective on the sustainability of marine-derived fungi with regard to a continuous supply of bioactive compounds for market needs rather than a pursuit of other strategies such as aquafarming will be discussed.

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Abbreviations

1-D:

one-dimensional

2-D:

two-dimensional

A549:

human lung adenocarcinoma

AChE:

acetylcholinesterase

AIDS:

acquired immunodeficiency syndrome

ALCL:

anaplastic large cell lymphoma

ATCC:

American Type Culture Collection

Ara-A:

arabinofuranosyl adenine or adenine arabinoside

Ara-C:

arebinosyl cytosine

cytarabine

CD:

circular dichroism

CHO:

Chinese hamster ovary

CML:

chronic myeloid leukemia

CNS:

central nervous system (CNS)

Campto:

camptothecin

DMXBA:

3-(2,4-dimethoxybenzylidene)-anabaseine

DNA:

deoxyribonucleic acid

DPPH:

1,1-diphenyl-2-picrylhydrazyl

E7389:

eribulin mesylate

ECD:

electronic circular dichroism

EMEA:

European Medicines Agency

ET-743:

ecteinascidins

EtOAc:

ethyl acetate

FDA:

Food and Drug Administration

HBV:

hepatitis B virus

HCT:

human colorectal tumor

HDAC:

histone deacetylase

HIV:

human immunodeficiency virus

HLE:

human leukocyte elastase

HMT:

histone methyltransferases

HPLC:

high-performance liquid chromatography

HUVEC:

human umbilical vein endothelial cells

HeLa:

human cervix carcinoma cells

Hep3B:

human liver carcinoma

HepG2:

Hepatoma Growth2

IMPDH:

inosine 5 ′ -monophosphate dehydrogenase

K562:

human chronic myeloid leukemia cells

KB:

human epidermoid carcinoma

LPS:

lipopolysaccharide

MA:

maslinic acid

MCF:

Michigan Cancer Foundation-7

MIC:

minimum inhibitory concentration

MMAE:

monomethyl auristatin E

MOLT:

molybdate uptake transporter

MPA:

mycophenolic acid

MRSA:

methicillin-resistant Staphylococcus aureus

MS:

mass spectroscopy

MTT:

microculture tetrazolium assay

M:

mitosis

NCI-H460:

human lung cancer cell line

NMR:

nuclear magnetic resonance

NOESY:

nuclear Overhauser and exchange spectroscopy

NRPS:

nonribosomal peptide synthase

NSCLC:

non-small cell lung cancer

PC:

phycocyanin

PKS:

polyketide synthase

PRRSV:

porcine reproductive and respiratory syndrome virus

PTP1B:

protein tyrosine phosphatase 1B

RAW:

ATCC cell line

RT:

reverse transcriptase

SAHA:

suberoylanilide hydroxamic acid

SAR:

structure-activity relationship

SF-268:

human CNS cancer cell line

SF:

surfactin

SIV:

subintestinal vessel plexus

S:

synthesis

TDDFT:

time-dependent density functional theory

VDA:

vascular disrupting agent

iNOS:

inducible nitric oxide synthase

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Author information

Authors and Affiliations

  1. Faculty of Pharmacy, Department of Pharmacognosy and Phytochemistry, Ain-Shams University, 11566, Cairo, Egypt

    Sherif S. Ebada

  2. Institute of Pharmaceutical Biology and Biotechology, Heinrich-Heine University, Universitätsstr. 1, 40225, Düsseldorf, Germany

    Peter Proksch

Authors
  1. Sherif S. Ebada
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  2. Peter Proksch
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Correspondence to Sherif S. Ebada .

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  1. Department of Marine-Bio. Convergence Science Specialized Graduate School Science & Technology Convergence Marine Bioprocess Research Center, Pukyong National University, Yongdang Campus, 365, Sinseon-ro, Nam-gu, 608-739, Busan, Korea

    Se-Kwon Kim Prof.

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Ebada, S.S., Proksch, P. (2015). Marine-Derived Fungal Metabolites. In: Kim, SK. (eds) Springer Handbook of Marine Biotechnology. Springer Handbooks. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-53971-8_32

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