Skip to main content
SpringerLink
Log in
Book cover

Angiotensin II AT1-Rezeptorantagonisten pp 101–119Cite as

Angiotensin II AT1-Rezeptorantagonisten und Niere

  • Conference paper

  • 19 Accesses

Zusammenfassung

AT1-Rezeptorantagonisten können die verschiedenen Funktionen der Niere von Nierengesunden und -kranken beeinflußen (13, 20). Positive und negative renale Wirkungen der AT1-Rezeptorantagonisten sind denkbar. Beim Einsatz der AT1-Rezeptorantagonisten in der Therapie z. B. von Patienten mit arterieller Hypertonie sollte der behandelnde Arzt diese renalen Wirkungen kennen, um erwünschte Effekte zu erzielen und unerwünschte möglichst zu vermeiden.

This is a preview of subscription content, log in via an institution.

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   54.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  1. Baboolal K, Meyer TW (1994) The effect of acute angiotensin II blockade on renal function in rats with reduced renal mass. Kidney Int. 46: 980–985

    Article  PubMed  CAS  Google Scholar 

  2. Burnier M, Rutschmann B, Nussberger J, Versaggi J, Shahinfar S, Waeber B, Brunner HR (1993) Salt-dependent renal effects of an angiotensin II antagonist in healthy subjects. Hypertension 22: 339–347

    Article  PubMed  CAS  Google Scholar 

  3. Burnier M, Hagman M, Nussberger J, Biollaz J, Armagnac A, Brouard R, Waeber B, Brunner HR (1995) Short-term and sustained renal effects of Angiotensin II receptor blockade in healthy subjects. Hypertension 25: 602–609

    Article  PubMed  CAS  Google Scholar 

  4. Doig JK, MacFadyen RJ, Sweet CS, Reid JL (1995) Haemodynamic and renal responses to oral losartan potassium during salt depletion or salt repletion in normal human volunteers. J Cardiovasc Pharmacol 25: 511–517

    Article  PubMed  CAS  Google Scholar 

  5. Faulhaber et al. in Vorbereitung

    Google Scholar 

  6. Gansevoort RT, de Zeeuw D, de Jong PE (1993) Dissociation between the course of the hemodynamic and antiproteinuric effects of angiotensin I converting enzyme inhibition. Kidney Int 44: 579–584

    Article  PubMed  CAS  Google Scholar 

  7. Gansevoort RT, deZeeuw D, deJong PE (1994) Is the antiproteinuric effect of ACE inhibition mediated by interference in the renin-angiotensin system? Kidney Intern 45: 861–867

    Article  CAS  Google Scholar 

  8. Goldberg AI, Dunlay MC, Sweet CS (1995) Safety and tolerability of losartan, an angiotensin II receptor antagonist, compared with hydrochlorothiazide, atenolol, felodpine ER, and angiotensin converting enzyme inhibitors for the treatment of systemic hypertension. Am J Cardiol 75: 793–795

    Article  PubMed  CAS  Google Scholar 

  9. Gomez RA (1994) Angiotensin receptors: relevance in development and disease states. Exp Nephrol 2: 259–268

    PubMed  CAS  Google Scholar 

  10. Gomez RA, Norwood VF (1995) Developmental consequences of the renin-angiotensin system. Am J Kidney Dis 26: 409–431

    Article  PubMed  CAS  Google Scholar 

  11. Gradman AH, Arcuri KE, Goldberg AI, Ikeda LS, Nelson NS, Snavely DB, Sweet CS (1995) A randomized, placebo-controlled, double-blind, parallel study of various doses of losartan potassium compared with enalapril maleate in patients with essential hypertension. Hypertension 25: 1345–1350

    Article  PubMed  CAS  Google Scholar 

  12. Hutchison FN, Webster SK (1992) Effect of ANG II receptor antagonist on albuminuria and renal function in passive Heymann nephritis. Am J Physiol 32: F311–F318

    Google Scholar 

  13. Ichikawa I (1996) Will angiotensin II receptor antagonists be renoprotective in humans? Kidney Intern 50: 684–692

    Article  CAS  Google Scholar 

  14. Imamura A, Mackenzie HS, Lacy HR, Hutchison FN, Fitzgibbon WR, Ploth DW (1995) Effects of chronic treatment with angiotensin converting enzyme inhibitor or an angiotensin receptor antagonist in two-kidney, one-clip hypertensive rats. Kidney Intern 45: 1394–402

    Article  Google Scholar 

  15. Komers R, Cooper ME (1995) Acute renal hemodynamic effects of ACE inhibition in diabetic hyperfiltration: role of kinins. Am J Physiol 37: F588–F594

    Google Scholar 

  16. Kon V, Fogo A, Ichikawa I, Hellings AE, Bills T (1993) Bradykinin causes selective efferent arteriolar dilation during angiotensin I converting enzyme inhibition. Kidney Intern 44: 545–550

    Article  CAS  Google Scholar 

  17. Lacourcière, Y, Brunner, HR, Irwin, I, Karlberg, BE, Ramsay, LE, Snavely, DB, Dobbins, TW, Faison, ER Nelson, EB and the losartan cough study group (1994) Effects of modulators of the renin-angiotensinaldosterone system on cough. J Hypertension 12: 1387–1393

    Google Scholar 

  18. Lafayette RA, Mayer G, Park SK, Meyer TK (1992) Angiotensin II receptor blockade limits glomerular injury in rats with reduced renal mass. J Clin Invest 90: 766–771

    Article  PubMed  CAS  Google Scholar 

  19. Lewis EJ, Hunsicker LG, Bain RP, Rohde RD (1993) The effect of angiotensin-converting enzyme inhibition on diabetic nephropathy. New Engl J Med 329: 1456–1462

    Article  PubMed  CAS  Google Scholar 

  20. Mann J (1996) Angiotensin II Rezeptor Antagonisten. DMW 121: 568–72

    Article  CAS  Google Scholar 

  21. Maschio G, Alberti D, Janin G, Locatelli F, Mann JFE, Motolese M, Ponticelli C, Ritz E, Zucchelli P (1996) Effect of the angiotensin converting enzyme inhibitor benazepril on the progression of chronic renal insufficiency. New Engl J Med 334: 939–945

    Article  PubMed  CAS  Google Scholar 

  22. Nakamura T, Takahashi T, Fukui M, Ebihara I, Osada S, TominoY, Koide H (1995) Enalapril attenuates increased gene expression of extracellular matrix components in diabetic rats. J Am Soc Nephrol 5: 1492–1497

    PubMed  CAS  Google Scholar 

  23. Nakashima M, Uematsu T, Kosuge K, Kanamura M (1992) Pilot study of the uricosuric effect of DUP 753, a new angiotensin II receptor antagonist, in healthy subiects. Eur J Pharmacol 42: 333–335

    CAS  Google Scholar 

  24. Remuzzi A, Perico N, Amuchastegnui CS, Malanchini B, Mazerska M, Battaglia C, Bertani T, Remuzzi G (1993) Short- and long-term effect of angiotensin II receptor blockade in rats with experimental diabetes. J Am Soc Nephrol 4: 40–49

    PubMed  CAS  Google Scholar 

  25. Tanaka R, Kon V, Yoshioka T, Ichikawa I, Fogo A (1994) Angiotensin converting enzyme inhibitor modulates glomerular function and structure by distinct mechanisms. Kidney Intern 45: 537–543

    Article  CAS  Google Scholar 

  26. Veelken R, Hilgers KF, Stetter A, Siebert HG, Schmieder RE, Mann JFE (1996) Nerve-mediated antidiuresis and antinatriuresis after air-jet stress is modulated by angiotensin II. Hypertension 28: 825–832

    Article  PubMed  CAS  Google Scholar 

  27. Xie MH, Liu FY, Wong PC, Timmermanns PBMWM, Cogan MG (1990) Proximal nephron and renal effects of DUP 753, a non-peptide angiotensin II antagonist. Kidney Intern 38: 473–479

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Städt. Krankenhaus München-Schwabing, Kölner Platz 1, 80804, München, Deutschland

    Prof. Dr. Johannes Mann

Authors
  1. Prof. Dr. Johannes Mann
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. K. F. Hilgers
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. R. Veelken
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Institut für Pharmakologie, Universität zu Lübeck, Ratzeburger Allee 160, D-23538, Lübeck, Deutschland

    P. Dominiak

  2. Institut für Pharmakologie, Klinikum der Christian-Albrechts-Universität zu Kiel, Hospitalstraße 4, D-24105, Kiel, Deutschland

    Thomas Unger

Rights and permissions

Reprints and permissions

Copyright information

© 1997 Springer-Verlag Berlin Heidelberg

About this paper

Cite this paper

Mann, J., Hilgers, K.F., Veelken, R. (1997). Angiotensin II AT1-Rezeptorantagonisten und Niere. In: Dominiak, P., Unger, T. (eds) Angiotensin II AT1-Rezeptorantagonisten. Steinkopff, Heidelberg. https://doi.org/10.1007/978-3-642-53757-8_4

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-53757-8_4

  • Publisher Name: Steinkopff, Heidelberg

  • Print ISBN: 978-3-642-53758-5

  • Online ISBN: 978-3-642-53757-8

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation