Abstract
In this study, aortas of 12 rabbits with experimentally induced atherosclerosis were investigated by duplex sonography. The sonographic features of the aortic vessel wall showed parallel wall contours enclosing a hypoechoic space. In vivo experiments in rabbit aortas document the distance between these contours correlating histologically with high cholesterol diet. This diet caused a broadening of the hypoechoic space in the rabbit aortic vessel wall. A comparable correlation was found between the width of the hypoechoic space and the severity of atherosclerotic changes.
The data demonstrate that duplex sonography is a useful non-invasive approach for detection of very early atherosclerotic changes in arterial vessel walls before plaques can be identified.
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References
Strate M, Thygesen K, Ringsted C, Hansen L. Harvald B: Prognosis in treated hypertension. Acta Med Scand 219: 153 - 159, 1986.
Judy Group, European Atherosclerosis Society, Strategies for the prevention of coronary heart disease: A policy statement of the European Atherosclerosis Society. Eur Heart J 8: 77 - 88, 1987.
Meyer WW, Links J, Yao AC, Kauffmann SL: Early arterial lesions in infancy and childhood and ways of prevention. Paediatrician 11: 136 - 156, 1982.
Ludwig M, Harder T, Tr129bestein G: Der zweidimensionale Ultraschall-eine nichtinvasive Methode in der Diagnostik von arteriosklerotischen Verändergungen im Bereich der supraaortalen Aste, Deutsche Med Wochenschr 109: 1878 - 1890, 1984.
Barzilai B, Saffitz JE, Miller JG, Sobel BE, Quantitative ultrasonic characterisation of the nature of atherosclerotic plaques in human aorta. Circ Res 3: 459 - 576, 1987.
Hennerici M, Reifschneider G, Trockel U, Aulich A: Detection of early atherosclerotic lesions by duplex scanning of the carotid artery. J. Clin Ultrasound 10: 455 - 464, 1984.
Ross R The pathogenesis of atherosclerosis-An update. N Engl J Med 314: 488 - 500, 1986.
Pignoli P, Tremoli E, Poli A, Oreste P, Paoletti R: Intimal plus medial thickness of the arterial wall: A direct measurement with ultrasound imaging. Circulation 74: 1399 - 1406, 1986.
Hennerici M, Rautenberg W, Trockel U, Kladetzky RG: Entwicklung nichtstenosierender extrakranieller Karotis-Plaques-Eine prospektive Verlaufsuntersuchung mit dem Duplexsystem. Ultraschall 6: 68 - 73, 1985.
Ludwig M: Die Bedeutung der hochauflösenden Duplex-sonographie in der Arterioskleroseforschung. Perfusion 2: 56 - 62, 1988.
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© 1990 Springer-Verlag Berlin Heidelberg
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Ludwig, M. (1990). Detection of Very Early Atherosclerosis by Duplex Sonography. In: Liepsch, D.W. (eds) Biofluid Mechanics. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-52338-0_17
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DOI: https://doi.org/10.1007/978-3-642-52338-0_17
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