Advertisement

Seronegative Spondarthritiden bei Morbus Crohn — Klinik und HLA-Assoziation

  • J. Purrmann
  • J. Bertrams
Conference paper
  • 9 Downloads
Part of the Advances in Internal Medicine and Pediatrics / Ergebnisse der Inneren Medizin und Kinderheilkunde book series (KINDERHEILK. NF, volume 59)

Zusammenfassung

Gelenkbeschwerden sind häufig bei Patienten mit Morbus Crohn. Die Einordnung der einzelnen Formen dieser Gelenkbeschwerden bereitet oft große Schwierigkeiten. Bevor wir auf die einzelnen Krankheitsbilder genauer eingehen, soll deshalb zuvor eine Erläuterung der verschiedenen Begriffe erfolgen. Nach Moll et al. (42) erfüllt die „intestinale Arthropathie“ in Verbindung mit dem Morbus Crohn (MC) die Kriterien der seronegativen Spondarthritis (Tabelle 1). Der Begriff „Spondarthritis“ in der vorliegenden Arbeit entspricht also der Definition von Moll et al. (42).

Key words

Morbus Crohn Seronegative Spondarthritiden Morbus Bechterew HLA-Assoziation, RFLP, Kreuzreaktionen 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  1. 1.
    Acheson ED (1960) An association between ulcerative colitis and regional enteritis and ankylosing spondylitis. Q J Med 116; 489–499Google Scholar
  2. 2.
    Ansell BM, Wighley RAD (1964) Arthritic manifestations in regional enteritis. Ann Rheum Dis 23: 64–72PubMedCrossRefGoogle Scholar
  3. 3.
    Arvanitakis C, Manier WJ (1973) Crohn‘s disease: clinical study of 75 patients. Am J Gastroenterol 59: 532–540PubMedGoogle Scholar
  4. 4.
    Bennett PH, Burch TA (1968) The epidemiological diagnosis of ankylosing spondylitis. In: Bennett PH, Wood PHN (eds) Population studies of the rheumatic diseases. Excerpta Medica, Amsterdam, pp 305–313Google Scholar
  5. 5.
    Bennett PH, Wood PHN (1968) Recommendations. In: Bennett PH, Wood PHN (eds) Population studies of the rheumatic diseases. Excerpta Medica, Amsterdam, pp 456–457Google Scholar
  6. 6.
    Best WR, Becktel JM, Singleton JW (1979) Rederived values of the eight coefficients of the Crohn‘s Diseases Activity Index ( CDAI ). Gastroenterology 77: 843–846PubMedGoogle Scholar
  7. 7.
    Biemond I, Burnham WR, D‘Amaro J, Langman MJS (1986) HLA-A and -B antigens in inflammatory bowel disease. Gut 27: 934–941PubMedCrossRefGoogle Scholar
  8. 8.
    Breur-Vriesendorp, Huis B, Dekker AJ, Breuning MH, Ivanyi P (1985) Subtypes of antigen HLAB27 (B27W and B27K) defined by cytotoxic T lymphocytes: Identification of a third subtype (B27C) prevalent in oriental population. In: Ziff M, Cohen SB (eds) Advances in Inflammation Research. Raven Press, New York, pp 55–65Google Scholar
  9. 9.
    Burbige EJ, Huang SS, Bayless TM (1975) Clinical manifestations of Crohn‘s disease in children and adolescents. Pediatrics 55: 866–871PubMedGoogle Scholar
  10. 10.
    Clark RL, Dixon CF (1939) Regional enteritis. Surgery 5: 277–304Google Scholar
  11. 11.
    Clark RL, Muhletaler CA, Margulies SI (1971) Colitic Arthritis. Clinical and radiographic manifestations. Radiology 101: 585–594PubMedGoogle Scholar
  12. 12.
    Comes JS, Stecher M (1961) Primary Crohn‘s disease of the colon and rectum. Gut 2: 189–201CrossRefGoogle Scholar
  13. 13.
    Crohn BB, Yamis H (1958) Regional ileitis, 2nd edn. Grune & Stratton, New YorkGoogle Scholar
  14. 14.
    Daffner JE, Brown CH (1958) Regional enteritis: clinical aspects and diagnosis in 100 patients. Ann Intern Med 49: 580–594PubMedGoogle Scholar
  15. 15.
    Davis P, Thomson ABR, Lentle BC (1978) Quantitative sakroiliac scintigraphy in patients with Crohn‘s disease. Arthritis Rheum 21: 234–237PubMedCrossRefGoogle Scholar
  16. 16.
    De Bruyère M, De Deuxchaisnes ChN (1976) Segregation of HL-A27 and ankylosing spondylitis in an informative kindred. Tissue Antigens 7: 15–22PubMedCrossRefGoogle Scholar
  17. 17.
    De Deuxchaisnes NC, Huaux JP, Fiasse P, De Bruyère M (1974) Ankylosing spondylitis, sakroiliitis, regional enteritis and HL-A 27. Lancet I: 1238–1239CrossRefGoogle Scholar
  18. 18.
    Dekker-Saeys BJ, Meuwissen SGM, Van den Berg-Loonen EM, De Haas WHD, Meijers KAF, Tytgat GNJ (1978) III. Clinical characteristics and results of histocompatibility typing (HLA B27) in 50 patients with both ankylosing spondylitis and inflammatory bowel disease. Ann Rheum Dis 37: 36–41PubMedCrossRefGoogle Scholar
  19. 19.
    Dekker-Saeys BJ, Meuwissen GM, Van den Berg-Loonen EM, De Haas WHD, Adenant D, Tytgat GM (1978) Prevalence of peripheral arthritis,sakroiliitis, and ankylosing spondylitis in patients suffering from inflammatory bowel disease. Ann Rheum Dis 37: 33–35PubMedCrossRefGoogle Scholar
  20. 20.
    Delpre G, Kadish U, Gazit E, Joshua H, Zamir R (1980) HLA antigens in ulcerative colitis and Crohn‘s disease in Israel. Gastroenterology 78: 1452–1457PubMedGoogle Scholar
  21. 21.
    Donaldson LB (1978) Crohn‘s disease: „Its gynecologic aspect“. Am J Obstet Gynecol 131: 196–202PubMedGoogle Scholar
  22. 22.
    Dubois RS, Rothschild J, Silverman A, Sabra A (1978) The varied manifestations of Crohn‘s disease in children and adolescents. Am J Gastroenterol 69: 208–211Google Scholar
  23. 23.
    Farmer RG, Hawk WA, Tumbull RB (1975) Clinical patterns in Crohn‘s disease: a statistical study of 615 cases. Gastroenterology 68: 627–635PubMedGoogle Scholar
  24. 24.
    Ferguson RH (1979) Enteropathic arthritis. In: McCarthy DJ (ed) Arthritis and allied conditions. Lea & Febiger, Philadelphia 9: 656–662Google Scholar
  25. 25.
    Fiasse R, De Bruyère M, Latine D, Liénard JC, Willcox R, Dive Ch (1984) Etude des antigènes HLA dans la maladie de Crohn. Acta Gastroenterol Belg 47: 137–138PubMedGoogle Scholar
  26. 26.
    Geczy AF, Van Leeuwen A, Van Rood J, Ivnyi P, Breur BS, Cats A (1986) Blind confirmation in Leiden of Geczy factor on the cells of Dutch patients with ankylosing spondylitis. Hum Immunol 17: 239–245PubMedCrossRefGoogle Scholar
  27. 27.
    Gjone E, Myren J, Opting OM (1966) Crohn‘s disease in Norway–clinical features. Scand J Gastroenterol 1: 101–105PubMedGoogle Scholar
  28. 28.
    Greenstein Ai, Janowitz HD, Sachar DB (1976) The extra-intestinal complications of Crohn‘s disease and ulcerative colitis: a study of 700 patients. Medicine 55: 401–412PubMedCrossRefGoogle Scholar
  29. 29.
    Grumet FC, Colin A, Engleman EG, Fish L, Foung SKH (1985) Studies of HLA-B27 using monoclonal antibodies: ethnic–and disease-associated variants. In: Ziff M, Cohn SB (eds) Advances in inflammation research. Raven Press, New York, pp 41–53Google Scholar
  30. 30.
    Grumet FC, Fish L, Moossazadeh J, Ness D, Duceman BW (1983) An HLA-B locus probe clarifies endonuclease polymorphism of major histocompatibility complex class I genes. Mol Biol Med 1: 501–509PubMedGoogle Scholar
  31. 31.
    Hammer B, Ashurst P, Naish J (1986) Diseases associated with ulcerative colitis and Crohn‘s disease. Gut 9: 17–21CrossRefGoogle Scholar
  32. 32.
    Haslock I, Wright V (1973) The musculo-skeletal complications of Crohn‘s disease. Medicine 52: 217–225PubMedCrossRefGoogle Scholar
  33. 33.
    Hyla JF, Franck WA, Davis JS (1976) Lack of association of HLA-B27 with radiographic sacroiliitis in inflammatory bowel disease. J Rheumatol 3: 196–200PubMedGoogle Scholar
  34. 34.
    Jacoby RK, Jayson MIV (1974) HL-A 27 in Crohn‘s disease. Ann Rheum Dis 33: 422–424PubMedCrossRefGoogle Scholar
  35. 35.
    Lindsley CB, Schaller JG (1974) Arthritis associated with inflammatory bowel disease in children. J Pediatr 84: 16–20PubMedCrossRefGoogle Scholar
  36. 36.
    Malchow H, Ewe K, Brandes JW, Goebel H, Ehms H, Sommer H, Jesdinsky H (1984) European Cooperative Crohn‘s Disease Study (ECCDS): results of drug treatment. Gastroenterology 86: 249–266PubMedGoogle Scholar
  37. 37.
    Mallas EG, Mackintosh P, Asquith P, Cooke WT (1976) Histocompatibility antigens in inflammatory bowel disease. Their clinical significance and their association with arthropathy with special reference to HLA-B27 (W27). Gut 17: 906–910PubMedCrossRefGoogle Scholar
  38. 38.
    McEwen C (1968) Arthritis accompanying ulcerative colitis. CLin Orthop 57: 9–17PubMedGoogle Scholar
  39. 39.
    McGuigan LE, Prendergast JK, Geczy AF, Edmonds JP, Bashir HV (1986) Significance of non-pathogenic cross reactive bowel flora in patients with ankylosing spondylitis. Ann Rheum Dis 45: 566–571PubMedCrossRefGoogle Scholar
  40. 40.
    McLain DA, Luehrmann LK, Rodey GE, Schwartz BD (1980) Detection of patients at risk for spondylarthropathy with an antibody to an HLA public antigen determinant. Clin Res 28: 142AGoogle Scholar
  41. 41.
    Moll JMH (1985) Inflammatory bowel disease. CLin Rheum Dis 11: 87–111PubMedGoogle Scholar
  42. 42.
    Moll JMH, Haslock I, Macrae IF, Wright V (1974) Associations between ankylosing spondylitis, psoriatic arthritis, Reiter‘s disease, the intestinal arthropathies, and Behçet syndrome. Medicine 53: 343–364PubMedCrossRefGoogle Scholar
  43. 43.
    Moller P, Berg K (1983) Family studies in Bechterew‘s syndrome (ankylosing spondylitis) III. Genetics. Clin Genet 24: 73–89PubMedCrossRefGoogle Scholar
  44. 44.
    Monconduit M, Cavelier B, Deshayes P, Hecketsweiler P, Colin R, Geffroy Y, Houdent C, Ropartz C (1977) Rheumatic symptoms in Crohn‘s disease and the HLA system. Biomédicine 27: 41–42PubMedGoogle Scholar
  45. 45.
    Morlock G, Bataille R, Blothman F, Baumelou H, Sany J, Simon L, Serre H (1976) Manifestations rheumatismales des colonentéropathies. Rev Rhum Mal Osteoartic 43: 669–677PubMedGoogle Scholar
  46. 46.
    Mörl M, Zöberlein HG, Classen M (1978) Morbus Crohn. Verlauf and Prognose bei 169 Kranken. Dtsch Med Wochenschr 103: 1325–1329PubMedCrossRefGoogle Scholar
  47. 47.
    Moms RJ, Metzger AL, Bluestone R, Terasaki PL (1974) HL-A-W27–A useful discriminator in the arthropathies of inflammatory bowel disease. N Engl J Med 290: 1117–1119CrossRefGoogle Scholar
  48. 48.
    Mueller ChE, Seeger JF, Martel W (1974) Ankylosing spondylitis and regional enteritis. Radiology 112: 579–581PubMedGoogle Scholar
  49. 49.
    Munch H, Purrmann J, Reis HE et al. (1986) Clinical features of inflammatory joint and spine manifestations in Crohn‘s disease. Hepatogastroenterology 33: 123–127PubMedGoogle Scholar
  50. 50.
    Ness DB, Grumet FC (1987) New polymorphisms of HLA-B27 and other antigens detected by RFLP using a locus-specific probe. Hum Immunol 18: 65–73PubMedCrossRefGoogle Scholar
  51. 51.
    Palumbo PJ, Ward LE, Sauer WG, Scudamore HH (1973) Musculoskeletal manifestations of inflammatory bowel disease. Ulcerative and granulomatous colitis and ulcerative proctitis. Mayo Clin Proc 48: 411–416PubMedGoogle Scholar
  52. 52.
    Prendergast JK, McGuigan LE, Geczy AF, Kwong TSL, Edmonds JP (1984) Persistence of HLAB27 cross-reactive bacteria in bowel flora of patients with ankylosing spondylitis. Infect Immun 46: 686–689PubMedGoogle Scholar
  53. 53.
    Prendergast JK, Sullivan JS, Geczy AF, Upfold LI, Edmonds JP, Bashir HV, Reiss-Levy E (1983) Possible role of enteric organisms in the pathogenesis of ankylosing spondylitis and other seronegative arthropathies. Infect Immun 41: 935–941PubMedGoogle Scholar
  54. 54.
    Purrmann J (1988) Genetic aspects of inflammatory bowel disease. In: Goebell H, Peskar BM, Malchow H Inflammatory Bowes‘ Diseases–Basic Reserach and Clinical Implications. MTP Press, Lancester New York Den Haag 203–213Google Scholar
  55. 55.
    Purrmann J, Bertrams J, Cleveland S, Gemsa R, Berges W, Strohmeyer G (1988) Association of Crohn‘s disease with HLA B44, Cw5. Z Gastroenterol 26: 658–662PubMedGoogle Scholar
  56. 56.
    Purrmann J, Bertrams J, Munch H, Zeidler H, Juli E, Reis HE, Strohmeyer G (1987) HLA-Assoziation seronegativer Spondarthritiden bei Patienten mit Morbus Crohn. Med Klin 82: 560–563Google Scholar
  57. 57.
    Purrmann J, Bertrams J (1988) Increased frequency of HLA-B27, 44 in patients with Crohn‘s disease and ankylosing spondylitis. In: Goebel H, Peskar BM, Malchow H (eds) Inflammatory bowel diseases–Basic research and clinical implications. MTP Press, Lancaster New York Den Haag, 434–435Google Scholar
  58. 58.
    Rankin GB, Watts HD, Melnyk CS, Kelly jr ML (1979) National Cooperative Crohn‘s Disease Study: Extraintestinal manifestations and perianal complications. Gastroenterology 77: 914–920PubMedGoogle Scholar
  59. 59.
    Russell AS, Percy JS, Schlaut J, Sartor VE, Goodhart JM, Sherbaniuk RW, Kidd EG (1975) Transplantation antigens in Crohn‘s disease. Linkage of associated ankylosing spondylitis with HL-Aw27. Dig Dis Sci 20: 359–361CrossRefGoogle Scholar
  60. 60.
    Seagher K, Bashir HV, Geczy AF, Edmonds JP, De Vere Tyndall A (1979) Evidence for a specific B27 associated cell surface marker on lymphocytes of patients with ankylosing spondylitis. Nature 277: 68–70CrossRefGoogle Scholar
  61. 61.
    Smolen JS, Gangl A, Polterauer P, Menzel EJ, Mayr WR (1982) HLA antigens in inflammatory bowel disease. Gastroenterology 82: 34–38PubMedGoogle Scholar
  62. 62.
    Seren A (1981) Joint Inflammations as complications in intestinal inflammations. Z Rheumatol 40: 15Google Scholar
  63. 63.
    Soren A (1966) Joint affections in regional ileitis. Arch Intern Med 117: 78–83PubMedCrossRefGoogle Scholar
  64. 64.
    Suarez-Almazor ME, Russell AS, LeClercq S (1986) Ankylosing spondylitis in families with two distinct B27 haplotypes: A selective association. Arthritis Rheum 29: 1510–1514PubMedCrossRefGoogle Scholar
  65. 65.
    Taurog JD, Miyachi Y, Nicklas JA et al. (1985) Studies of HLA-B27 cytolytic T-cell clones and HLA loss mutants of a B27-positive lymphoblastoid cell line. In: Ziff M, Cohen SB (eds) Advances in inflammation research. Raven Press, New York, pp 67–74Google Scholar
  66. 66.
    Tiwari JL, Terasaki PI (1985) Ankylosing spondylitis. In: Tiwari JL, Terasaki PI (eds) HLA and disease associations. Springer, New York Berlin Heidelberg 85–100CrossRefGoogle Scholar
  67. 67.
    Upfold LI, Sullivan JS, Geczy A (1986) Biochemical studies on a factor isolated from Klebsiella K43–BTS1 that cross-reacts with cells from HLA-B27 positive patients with ankylosing spondylitis. Hum Immunol 17: 224–238PubMedCrossRefGoogle Scholar
  68. 68.
    Van der Linden JMJP, Cats AJJ, Van Rood JJ, Wuisman JHC (1975) HL-A 27 and ankylosing spondylitis. A family study. Ann Rheum Dis 34 [Suppl. 1]: 53Google Scholar
  69. 69.
    Van Patter WN, Bargen JA, Dockerty MB, Feldman WH, Mayo ChW, Waugh JM (1954) Regional enteritis. Gastroenterology 26: 347–447Google Scholar
  70. 70.
    Van Rood JJ (1986) HLA antigens as carrier molecules. Hum Immunol 17: 246–249PubMedCrossRefGoogle Scholar
  71. 71.
    Wagener P, Zeidler H, Eckert G, Deicher H (1984) Increased frequency of HLA-Bw62 and Bw35 CREG antigens in HLA-B27 negative ankylosing spondylitis. Z Rheumatol 43: 253–257PubMedGoogle Scholar
  72. 72.
    Woodrow JC, Lewkonia RM, McConnell RB et al. (1978) HLA antigens in inflammatory bowel disease. Tissue Antigens 11: 147–152PubMedCrossRefGoogle Scholar
  73. 73.
    Woodrow JC, Nichol FE, Whitehouse GH (1983) Genetic studies in ankylosing spondylitis. BR J Rheumatol 22 (suppl): 12–17PubMedGoogle Scholar
  74. 74.
    Wright V, Watkins G (1966) Articular complications of ulcerative colitis. Am J Proctol 17: 107–115PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1989

Authors and Affiliations

  • J. Purrmann
    • 1
  • J. Bertrams
    • 2
  1. 1.Zentrum für Innere Medizin, Abteilung für GastroenterologieUniversität DüsseldorfDüsseldorfGermany
  2. 2.Abteilung für LaboratoriumsmedizinElisabeth-KrankenhausEssenGermany

Personalised recommendations