Advertisement

Folgen eines Magnesium- und Zinkmangels während der Schwangerschaft

  • T. Günther
Conference paper

Zusammenfassung

Vom Mg-Bestand des menschlichen Körpers (1 Mol = 24 g) ist etwa die Hälfte intrazellulär lokalisiert. Die andere Hälfte ist an die Oberfläche von Hydroxyl-apatit-Kristallen des Knochens adsorbiert. Nur 1 % des gesamten Mg ist in der extrazellulären Flüssigkeit gelöst.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  1. Bettger WJ, O’Dell BL (1981) A critical physiological role of zinc in the structure and function of biomembranes. Life Sci 28: 1425–1438CrossRefGoogle Scholar
  2. Breskin MW, Worthington-Roberts BS, Knopp RH, Brown Z, Plovie B, Mottet NK, Mills JL (1983) First trimester serum zinc concentrations in human pregnancy. Am J Clin Nutr 38:943–953PubMedGoogle Scholar
  3. Buamah PK, Russell M, Bates G, Milfordward A (1984) Maternal zinc status: a determination of central nervous system malformation. Br J Obstet Gynecol 91:788–790CrossRefGoogle Scholar
  4. Bunce GE, Wilson GR, Mills CF, Klopper A (1983) Studies on the role of zinc in parturition in the rat. Biochem J 210:761–767PubMedGoogle Scholar
  5. Colussi G, Surian M, De Ferrari ME, Rombola G, Minetti L (1987) The changes in plasma diffusible levels and renal tubular handling of magnesium during pregnancy: a longitudinal study. Bone Mineral 2:311–319Google Scholar
  6. Conradt A, Weidinger H (1982) Die zentrale Stellung von Magnesium bei der Behandlung der fetalen Hypotrophie — Ein Beitrag zum Pathomechanismus der utero-plazentaren Insuffizienz, der Früh- und Mangelgeburt sowie der EPH-Gestose. Magnesium Bull 4:103–124Google Scholar
  7. Cunnane SC, Majid E, Senior J, Mills CF (1983) Uteroplacental dysfunction and prostaglan din metabolism in zinc deficient pregnant rats. Life Sci 32:2471–2478PubMedCrossRefGoogle Scholar
  8. Dura-Trave T, Puig-Abuli M, Monreal I, Villa-Elizaga I (1984) Relation between maternal plasmatic zinc levels and uterine contractility. Gynecol Obstet Invest 17:247–251PubMedCrossRefGoogle Scholar
  9. Ebel H, Günther T (1980) Magnesium metabolism: A review. J Clin Chem Clin Biochem 18: 257–270PubMedGoogle Scholar
  10. Günther T (1985) The possible role of magnesium and zinc deficiency in the development of EPH-gestosis. Magnesium Bull 7:87–90Google Scholar
  11. Günther T (1989a) Magnesium-Stoffwechsel, In: Greiling H, Gressner AM (Hrsg) Lehrbuch der Klinischen Chemie und Pathobiochemie, 2. Aufl. Schattauer, Stuttgart, S 404Google Scholar
  12. Günther T (1989b) Stoffwechsel der Spurenelemente Zink, Kupfer, Selen, Chrom, Mangan und Molybdän. In: Greiling H, Gressner AM (Hrsg) Lehrbuch der Klinischen Chemie und Pathobiochemie, 2. Aufl. Schattauer, Stuttgart, S 409Google Scholar
  13. Günther T (1990a) Functional compartmentation of intracellular magnesium. In: Sigel H, Sigel A (eds) Metal ions in biological systems, Vol 26. Marcel Dekker, New York, p 193Google Scholar
  14. Günther T (1990b) Magnesium deficiency generally enhances cytotoxicity. Magnesium Bull 12:61–64Google Scholar
  15. Günther T, Ebel H (1990) Membrane transport of magnesium. In: Sigel H, Sigel A (eds) Metal ions in biological systems, Vol 26. Marcel Dekker, New York, p 215Google Scholar
  16. Günther T, Ising H, Mohr-Nawroth F, Chahoud I, Merker HJ (1981) Embryotoxic effects of magnesium deficiency and stress on rats and mice. Teratology 24:225–233PubMedCrossRefGoogle Scholar
  17. Günther T, Chahoud I, Bochert G (1988a) Enhanced teratogenicity of salicylate in Mg-deficient rats. Magnesium Bull 10:51–55Google Scholar
  18. Günther T, Vormann J, Höllriegel V (1988b) Effects of amiloride and furosemide on 28Mg transport into fetuses and maternal tissues of rats. Magnesium Bull 10:34–37Google Scholar
  19. Hackman RM, Hurley LS (1983) Interaction of dietary zinc, genetic strain, and acetazolamide in teratogenesis in mice. Teratology 28:355–368PubMedCrossRefGoogle Scholar
  20. Hackman RM, Hurley LS (1984) Interactions of salicylate, dietary zinc, and genetic strain in teratogenesis in rats. Teratology 30:225–236PubMedCrossRefGoogle Scholar
  21. Hambidge KM, Neidner KH, Walravens PA (1975) Zinc, acrodermatitis enteropathica, and congenital malformations. Lancet I:577–578CrossRefGoogle Scholar
  22. Hambidge KM, Krebs NF, Jacobs MA, Favier A, Guyette L, Ikle DN (1983) Zinc nutritional status during pregnancy: a longitudinal study. Am J Clin Nutr 37:429–442PubMedGoogle Scholar
  23. Hurley LS (1981) Magnesium deficiency in pregnancy and its effects on the fetus. Magnesium Bull 3:202–208Google Scholar
  24. Jackson AJ, Schumacher HJ (1979) The teratogenic activity of a thalidomide analogus EM12 in rats on a low-zinc diet. Teratology 19:341–344PubMedCrossRefGoogle Scholar
  25. Martensson L, Wallenburg HCS (1985) Uterine venous concentrations of 6-keto-PGF1a in normal pregnant (NP) and pregnancy-induced hypertensive (PIH) women. In: Schrör K (ed) Prostaglandins and other eicosanoids in the cardiovascular system. Proc 2nd Intern Symp Nürnberg-Fürth, 1984. Karger, Basel, pp 436–440Google Scholar
  26. Nigam S, Averdunk R, Günther T (1986) Alteration of prostanoid metabolism of rats with magnesium deficiency. Prostagland Leuk Med 23:1–10CrossRefGoogle Scholar
  27. Oster O, Prellwitz W (1984) Die Notwendigkeit der Bestimmung von Spurenelementen im klinisch-chemischen Laboratorium. Ärztl Labor 30:119–127Google Scholar
  28. Sato F, Watanabe T, Hoshi E, Endo A (1985) Teratogenic effect of maternal zinc deficiency and its coteratogenic effect with cadmium. Teratology 31:13–18PubMedCrossRefGoogle Scholar
  29. Shaw AJ, Mughal MZ, Mohammed T, Maresh MJA, Sibley CP (1990) Evidence for active maternofetal transfer of magnesium across the in situ perfused rat placenta. Pediat Res 27:622–625PubMedCrossRefGoogle Scholar
  30. Skajaa K, Forman A, Andersson KE (1990) Effects of magnesium on isolated human fetal and maternal uteroplacental vessels. Acta Physiol Scand 139:551–559PubMedCrossRefGoogle Scholar
  31. Van Assche FA, Spitz B, Vermylen J, Deckmijn H (1984) Preliminary observations on treatment of pregnancy-induced hypertension with a thromboxane synthetase inhibitor. Am J Obstet Gynecol 148:216–218PubMedGoogle Scholar
  32. Vormann J, Günther T (1986) Development of fetal mineral and trace element metabolism in rats with normal as well as magnesium- and zinc-deficient diets. Biol Trace Elem Res 9:37–53CrossRefGoogle Scholar
  33. Vormann J, Höllriegl V, Merker HJ, Günther T (1986) Effect of salicylate on zinc metabolism in fetal and maternal rats fed normal and zinc-deficient diets. Biol Trace Elem Res 9:55–64CrossRefGoogle Scholar
  34. Zimmerman AW, Dunham BS, Nochimson DJ, Kaplan BM, Clive JM, Kunkel SL (1984) Zinc transport in pregnancy. Am J Obstet Gynecol 149:523–529PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1991

Authors and Affiliations

  • T. Günther

There are no affiliations available

Personalised recommendations