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A Simulation Model for In Vitro Kinetics of Normal and Irradiated Cells

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Computer Simulation in Cell Radiobiology

Part of the book series: Lecture Notes in Biomathematics ((LNBM,volume 74))

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Abstract

The model proposed here simulates development in time of a cell population which, depending on a chosen model structure and initial values of the parameters, may correspond to either an exponentially growing or stationary culture of normal or tumour cells, as well as to a stem-cell population from embryonal or somatic definitive renewing tissues. It is designed primarily for studying the effect of radiation on the kinetics of cell populations following a single or fractionated exposure. Radiation effect is assessed from the clonogenic capacity of cells. The computer realization of the model was accomplished with the aid of the GPSS/36O language. The individual blocks of the model will be described and substantiated from the standpoint of present-day radiobiological concepts.

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Authors and Affiliations

  1. Leningrad Polytechnical Institute, Politechnicheskaya ul., 29, 195 251, Leningrad, USSR

    Andrej Yu. Yakovlev

  2. Central Research Institute of Roentgenology & Radiology, Leningradskaya, 70/4, Pesochnij-2, Leningrad, 188 646, USSR

    Aleksandr V. Zorin

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  1. Andrej Yu. Yakovlev
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© 1988 Springer-Verlag Berlin Heidelberg

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Yakovlev, A.Y., Zorin, A.V. (1988). A Simulation Model for In Vitro Kinetics of Normal and Irradiated Cells. In: Computer Simulation in Cell Radiobiology. Lecture Notes in Biomathematics, vol 74. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-51716-7_3

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  • DOI: https://doi.org/10.1007/978-3-642-51716-7_3

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-19457-6

  • Online ISBN: 978-3-642-51716-7

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