Abstract
The search for ways to overcome tumour radioresistance is a major problem of experimental and clinical radiation oncology. The difficulties involved in the attempts to solve this problem are a matter of common knowledge. In many a laboratory extensive studies are underway of factors determining tumour tissue response to irradiation and of methods for exerting directional effect upon those factors. Such studies have revealed that, at least at the cellular level, a considerable number of factors manifest themselves which are responsible for radiation effect [1]. Among those are: spatial heterogeneity of tumour cell population producing radioresistant cell reserves (hypoxic cells of solid tumours); differing radiosensitivities of cell life cycle phases; intrinsic dynamics of the processes of radiation damage and postradiation cell recovery; induction of proliferative processes in response to the death of some cells within the population; the stochastic nature of cell kinetics and complicated interaction between individual cell subpopulations corresponding to different tumour loci.
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References
Barendsen, G.W. Variations in radiation responses among experimental tumors, In: Radiation Biology in Cancer Research, Raven Press, New York, 333–343, 1980.
Tannock, I.F. Cell kinetics and chemotherapy: a critical review, Cancer Treat. Rep., 62, 1117–1133, 1978.
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© 1988 Springer-Verlag Berlin Heidelberg
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Yakovlev, A.Y., Zorin, A.V. (1988). Introduction. In: Computer Simulation in Cell Radiobiology. Lecture Notes in Biomathematics, vol 74. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-51716-7_1
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DOI: https://doi.org/10.1007/978-3-642-51716-7_1
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