Abstract
A view is offered on how we might collectively and perhaps objectively judge which of a variety of theories of regulation are the best, and thus decide which theories should be adopted as standard models for more detailed work. A new theoretical symmetry relationship is then presented for pairs of anti-sera of the type A anti-B and B anti-A, together with experimental evidence validating the relationship. The evidence includes a new phenomenon relevant to transplantation immunology, that we call “reverse enhancement”.
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References
“Paradoxes in Immunology”, G. W. Hoffmann, J.G. Levy and G.T. Nepom, Editors, CRC Press, Boca Raton, Florida, 1986. (in press).
Jerne, N.K. “Towards a network theory of the immune system”. Ann. Immunol., 125C (1974) 373–389.
Richter, P.H. “A network theory of the immune response”. Eur. J. Immunol. 5, 350–354 (1975).
Ivanov, V.V., Janenko, V.M., Fontalin, L.N. and Nesterenko, V.G. “Modelling of idiotype-anti-idiotypic interactions of immune network with regard to distinctive subpopulations among lymphocytes” in “Mathematical Modelling in Immunology and Medicine”. G.I. Marchuk and L.N. Belykh, Editors, North-Holland Publishing Co., Amsterdam 1983, pp. 141–149.
Herzenberg, L.A., Black, S.J. and Herzenberg, L.A. “Regulatory circuits and antibody responses”. Eur. J. Immunol. 10, 1–11, 1980.
Hoffmann, G.W. “On Network Theory and H-2 Restriction”, in Contemporary Topics in Immunology (N. Warner, Ed.) vol. 11, 1980, pp. 185–226.
Hoffmann, G.W. and Cooper-Willis, A. “Symmetry, complexity and stability in immune system network theory” in “Mathematical Modelling in Immunology and Medicine”, G.I. Marchuk and L.N. Belykh, Editors, North-Holland Publishing Co., Amsterdam, 1983, pp. 31–42.
Günther, N. and Hoffmann, G.W. “Qualitative dynamics of a network model of regulation of the immune system: A rationale for the IgM to IgG switch”. J. Theoret. Biol. 44, 815–855 (1982).
Jerne, N.K. “Clonal selection in a lymphocyte network” in “Cellular Selection and Regulation in the Immune Response”, G.M. Edelman, Ed., Raven Press, New York, 1974 pp. 39–48.
Hoffmann, G.W. “The Application of Stability Criteria in Evaluating Network Regulation Models”, in “Regulation of Immune Response Dynamics”, C. DeLisi and J.R.J. Hiernaux (Eds.), CRC Press, Boca Raton, Florida, 1982 pp. 137–162.
Spouge, J.L. “Increasing stability with complexity in a system composed of unstable subsystems”. J. Math. Analysis and Applications, in press.
Urbain, J., Wailmart, C. and Cazenave, P.A. “Idiotypic regulation in immune networks” In Contemp. Topics in Molecular Immunology, vol. 8, eds. Inwan, F.P. and Mandy, W.J., pp. 113–148, Plenum Press, New York, 1981.
Cooper-Willis, A. and Hoffmann, G.W. “Symmetry of effector function in the immune system network”. Mol. Immunol. 20 (8), 865–870, 1983.
Steinmetz, M., Minard, K., Horvath, S., McNicholas, J., Frelinger, J., Wake C., Mack, B. and Hood, L. “A molecular map of the immune response region from the major histocompatibility complex of the mouse”. Nature (London) 300, 35–42, 1982.
Klein, J. and Nagy, Z.A. “Trouble in the J-land”. Nature (London) 300, 12–13, 1982.
Munro, A. “The I-J paradox remains unsolved”. Nature (London) 306, 537–538, 1983.
Sachs, D.L., Lynch, D.H. and Epstein, S.L. “The I-J dilemma: new developments”. Immunology Today, 5, 94–95, 1984.
Schrader, J.W. “Nature of the T cell receptor. Both T cell receptor and antigen-specific T cell derived factors are coded for by V genes, but express anti-self idiotypes indirectly determined by major histocompatibility genes”. Scand. J. Immunol. 10, 387–393, 1979.
Tada, T. “Are there unique I region-controlled determinants on T cells?” in “Paradoxes in Immunology”, Hoffmann, G.W., Nepom, G.T. and Levy, J.G., eds., CRC Press, Boca Raton, Florida, 1986.
Carpenter, C.B., d’Apice, A.J.F., Abbas, A.K. “The Role of Antibodies in the Rejection and Enhancement of Organ Allografts”. Advances in Immunol. 22, 1, 1976.
Voisin, G.A. “Role of antibody classes in the regulatory facilitation reaction”. Immunol. Reviews, 49, 3, 1980.
Morris, P.J. “Suppression of rejection of organ allografts by alloantibody”. Immunol. Rev., 49., 93, 1980.
Ramseier, H. and Lindenmann, J. “Aliotypic antibodies”. Transpl. Rev. 10, 57–96, 1972.
Binz, H. and Wigzell, H. “Shared idiotypic determinants on B and T lymphocytes reactive against the same antigenic determinants. I. Demonstration of similar or identical idiotypes on IgG molecules and T cell receptors with specificity for the same alloantigens”. J. Exp. Med. 142, 197–211.
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Hoffmann, G.W., Cooper-Willis, A., Chow, M. (1986). On Paradoxes and Progress in Theoretical Immunology, and Evidence for a New Symmetry. In: Hoffmann, G.W., Hraba, T. (eds) Immunology and Epidemiology. Lecture Notes in Biomathematics, vol 65. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-51691-7_3
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DOI: https://doi.org/10.1007/978-3-642-51691-7_3
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