Abstract
In chapters II-V we developed the theory of one-stage chemoreception, in which a ligand can only be absorbed by a cell by a direct hit on the binding site of the receptor molecule. In chapter VIII the theory will be extended to incorporate two-stage capture processes in which the ligand is first incorporated in the cell membrane and then diffuses laterally in the plane of the membrane till it hits a binding site. Actually, two-stage chemoreception is only one of a variety of processes which occur at the surface of the living cell and in which the lateral translational - or rotational diffusion of proteins plays an essential role. It is for this reason that the experimental determination of the relevant diffusion coefficients has been pursued vigorously during the last decade [37–44]. Experimental values of the the lateral translational diffusion coefficient (DT’) range from 10-8 to 10-11 cm2 s-1. For the rotational diffusion coefficient (DR’) of proteins embedded in the cell membrane one measures values in the range from 105 to 103 s-1.
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Wiegel, F.W. (1991). Diffusion and Flow in the Cell. In: Physical Principles in Chemoreception. Lecture Notes in Biomathematics, vol 91. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-51673-3_6
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DOI: https://doi.org/10.1007/978-3-642-51673-3_6
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