Abstract
A probabilistic model for angiogenesis was developed to investigate the possible role of microvessel endothelial cell (MEC) Chemotaxis in determining microvessel network morphology and growth rate. The model simulates developing microvessels, providing theoretical pictures of the networks. The cell at the tip of a growing capillary is hypothesized to guide the path of the capillary according to a model of single cell migration, using experimentally measured values for MEC speed and persistence time. The simulations demonstrate that random motility alone cannot account for the directional growth of vessels observed in vivo. A moderate chemotactic response, like that we have measured in acidic fibroblast growth factor (Stokes et al., 1990), is necessary to provide directional growth of vessels similar to that observed in vivo.
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© 1990 Springer-Verlag Berlin Heidelberg
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Stokes, C.L., Lauffenburger, D.A., Williams, S.K. (1990). Endothelial Cell Chemotaxis in Angiogenesis. In: Alt, W., Hoffmann, G. (eds) Biological Motion. Lecture Notes in Biomathematics, vol 89. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-51664-1_30
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DOI: https://doi.org/10.1007/978-3-642-51664-1_30
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