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Orthologie und Pathologie der Knochenmarkregeneration

  • Chapter
Book cover Entwicklung · Wachstum II

Part of the book series: Handbuch der Allgemeinen Pathologie ((1712,volume 6 / 2))

Zusammenfassung

Für das Thema der Knochenmarkregeneration ergibt sich aus der phylogenetischen Betrachtung, daß sie in gewisser Weise unabhängig von der Frage der Blutzellregeneration bewertet werden muß und kann. Aus der Klinik ist bekannt, daß sich Blutzellen unter pathologischen Bedingungen aus extramedullären Geweben (Milz, Leber, Organe des reticulo-histiocytären Systems) regenerieren können. Eine solche extramedulläre Blutbildung ist bei bestimmten Säugern physiologisch (z.B. Mäuse, Ratten) und kann in der Regenerationsphase nach Ganzkörperbestrahlung sogar verstärkt sein. Weiterhin ist heute sichergestellt, daß die Blutbildung des Knochenmarkes durch im Blut zirkulierende Stammzellen wieder in Gang gesetzt werden kann, falls diese durch Einwirkung cytotoxischer Noxen ausgeschaltet worden war. Andererseits wird unter physiologischen Bedingungen bei höheren Säugern (Hund, Affe, Mensch) das Fließgleichgewicht des Erythro-cyten-, Granulocyten- und Thrombocytenspiegels durch eine ständige Knochenmarkregeneration aufrechterhalten.

Mit Unterstützung des Euratom-Vertrages „Strahlenhämatologie“. Herrn Dr. med. K. D. Meyer-Hamme danken wir für die intensive Mitarbeit an der Vorbereitung des Manuskriptes.

Abteilung für Klinische Physiologie. Zentrum für Klinische Grundlagenforschung der Universität Ulm und Abteilung Biologie der Gemeinsamen Forschungsstelle der Europäischen Atomgemeinschaft (EURATOM).

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    T. M. Fliedner & W. Calvo

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W. Calvo H. Cottier T. M. Fliedner P. A. Grétillat E. Grundmann M. W. Hess W. Oehlert B. Roos R. Schindler H. J. Seidel F. Büchner

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Fliedner, T.M., Calvo, W. (1969). Orthologie und Pathologie der Knochenmarkregeneration. In: Calvo, W., et al. Entwicklung · Wachstum II. Handbuch der Allgemeinen Pathologie, vol 6 / 2. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-51627-6_4

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