Skip to main content
SpringerLink
Log in

Inhibitory Action of Radiolytic Compounds on Cell Function

  • Conference paper
Quantitative Biology of Metabolism

Abstract

Glyoxal and malondialdehyde are cytotoxic for cells in culture; the primary site of attack is DNA. Its rate of synthesis is inhibited more profoundly than that of protein and RNA. m-RNA synthesis is suppressed almost entirely after a 5-hr treatment with 100 μg/ml dialdehyde. Obviously bifunctional aldehydes inhibit primarily DNA replication, whereas transcription will be stopped later.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Bachrach, U., and G. Eilon: Biochem. Biophys. Acta 145, 418 (1967).

    PubMed  CAS  Google Scholar 

  2. Berry, R. J., P. R. Hills and W. Trillwood: Int. J. Rad. Biol. 9, 559 (1965).

    Article  CAS  Google Scholar 

  3. Brooks, B. R., and O. L. Klamerth: in press.

    Google Scholar 

  4. Crawford, D., R. O. Sinnhuber, F. M. Stout, J. E. Oldfield and J. Kaufmes: Toxicology and Appl. Pharmacol. 7, 826 (1965).

    Article  CAS  Google Scholar 

  5. Crawford, D. L., T. C. Yu and O. R. Sinnhuber: J. of Food Science 32, 332 (1967).

    Article  CAS  Google Scholar 

  6. Doerr, W.: Verh. Deutsch. Ges. Path. 32, 278 (1948).

    Google Scholar 

  7. Gros, F., W. Gilbert, H. H. Hiatt, G. Attardi, P. F. Spahr and J. D. Watson: Cold Spring Harbour Symp. Quant. Biol. 26, 111 (1961).

    Article  CAS  Google Scholar 

  8. Helge, G.: Verh. Deutsch. Ges. Path. 42, 158 (1958).

    Google Scholar 

  9. Klamerth, O. L.: Biochim. Biophys. Acta 155, 271 (1968).

    PubMed  CAS  Google Scholar 

  10. Levinthal, C., A. Keynan u. A. Higa: Proc. Natl. Acad. Sci. US 48, 1631, (1962).

    Article  CAS  Google Scholar 

  11. Sachsenmaier, W., and D. Ives: Bioch. Z. 343, 399 (1965).

    CAS  Google Scholar 

  12. Schaack, M.: Z. ges. exptl. Med. 135, 223 (1961).

    Article  Google Scholar 

Download references

Authors
  1. O. L. Klamerth
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Institut für Strahlenschutz, Reaktorzentrum Seibersdorf (Österr. Studiengesellschaft für Atomenergie GmbH), Lenaugasse 10, A 1082, Wien, Österreich

    A. Locker

Rights and permissions

Reprints and permissions

Copyright information

© 1968 Springer-Verlag Berlin · Heidelberg

About this paper

Cite this paper

Klamerth, O.L. (1968). Inhibitory Action of Radiolytic Compounds on Cell Function. In: Locker, A. (eds) Quantitative Biology of Metabolism. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-51065-6_25

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-51065-6_25

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-04301-0

  • Online ISBN: 978-3-642-51065-6

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation