Abstract
Toxoplasma gondii is a ubiquitous intracellular pathogen that infects all nucleated cells (as reviewed by Wong and Remington 1993). In the immunocompetent individual, a balanced interaction between the immune system and T. gondii allows the pathogen to survive in the intracellular milieu without damaging the host. In the setting of defective cell-mediated immunity, uncontrolled multiplication of T. gondii tachyzoites may take place, leading to toxoplasmic encephalitis (Luft and Remington 1992). Detailed knowledge of the immune response to T. gondii is needed to unravel the subtle pathogenetic mechanisms of toxoplasmic infection. In this chapter, emphasis will be placed on antigen-specific cell-mediated responses to viable T. gondii tachyzoites, as assessed in chronically infected healthy humans. These studies provide a model for a better comprehension of altered T. gondii-specific cellular immunity in severely immunodeficient patients.
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© 1996 Springer-Verlag Berlin Heidelberg
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Pistoia, V., Facchetti, P., Ghiotto, F., Cesbron-Delauw, M.F., Prigione, I. (1996). Characterization of Human T Cell Clones Specific for Toxoplasma gondii . In: Gross, U. (eds) Toxoplasma gondii. Current Topics in Microbiology and Immunology, vol 219. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-51014-4_15
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DOI: https://doi.org/10.1007/978-3-642-51014-4_15
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