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Superantigens pp 53–62Cite as

The Human T Cell Response to Mitogenic Microbial Exotoxins

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Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 174))

Abstract

Nearly every infectious pathogen has to cope with the host’s adaptive immune response. Common evasion mechanisms in this complex interaction are antigenic variations, the escape to immunologically privileged sites, or the use of immunosuppressive mechanisms. Many bacteria and other microorganisms elaborate soluble factors or toxins that act suppressively on cells of the immune system, such as pore-forming molecules or proteins that interfere with the function of G proteins. Gram-positive cocci and a mycoplasma have developed an extremely potent mechanism of T cell stimulation by closely mimicking recognition of specific antigen. From the functional similarity to antigen recognition and the multiclonal activation of T cells, the designation “superantigen” has been suggested for these molecules (White et al. 1989). This review will focus on the action of the microbial toxins on human T cells.

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References

  • Alber G, Scheuber PH, Reck B, Sailer-Kramer B, Hartmann A, Hammer DK (1989) Role of substance P in immediate-type skin reactions induced by staphylococcal enterotoxin B in unsensitized monkeys. J Allergy Clin Immunol 84: 880–885

    Article  PubMed  CAS  Google Scholar 

  • Alber G, Hammer DK, Fleischer B (1990) Relationship between enterotoxic and T lymphocyte stimulating activity of staphylococcal enterotoxin B. J Immunol 144: 4501–4506

    PubMed  CAS  Google Scholar 

  • Atkin CL, Cole BC, Sullivan GJ, Washburn LR, Wiley BB (1986) Stimulation of mouse lymphocytes by a mitogen derived from M. arthritidis. V. A small basic protein from culture supernatant is a potent T cell mitogen. J Immunol 137: 1581–1589

    PubMed  CAS  Google Scholar 

  • Bergdoll MS (1983) Enterotoxins. In: Easmon SCF, Adlams C (eds) Staphylococci and staphylococcal infections. Academic, New York, pp 559–598

    Google Scholar 

  • Blanco L, Choi EM, Connolly K, Thompson MR, Bonventre PF (1990) Mutants of staphylococcal toxic shock syndrome toxin-1: mitogenicity and recognition by a neutralizing monoclonal antibody. Infect Immun 58: 3020–3028

    PubMed  CAS  Google Scholar 

  • Braun MA, Gerlach D, Ozegowski JH, Carre S, Köhler W, Fleischer B (1991) Preferential Stimulation of Vβ8+ human T cells by the streptococcal “superantigens” erythrogenic toxins A and C (scarlet fever toxins). (submitted)

    Google Scholar 

  • Chatila T, Wood N, Parsonnet J, Geha RS (1988) Toxic shock syndrome toxin-1 induces inositol phospholipid turnover, protein kinase C translocation and calcium mobilization in human T cells. J Immunol 140: 1250–1255

    PubMed  CAS  Google Scholar 

  • Choi Y, Herman A, DiGiusto D, Wade T, Marrack P, Kappler J (1990) Residues of the variable region of the T cell receptor β-chain that interact with S. aureus toxin superantigens. Nature 346: 471–473

    Article  PubMed  CAS  Google Scholar 

  • Cole BC, Kartchener DC, Wells DJ (1990) Stimulation of mouse T lymphocytes by a mitogen derived from Mycoplasma arthritidis. VIII. Selective activation of T cells expressing distinct Vβ T cell receptors from various strains of mice by the “superantigen” MAM. J Immunol 144: 425–429

    PubMed  CAS  Google Scholar 

  • Couch JL, Soltis MT, Betley MJ (1988) Cloning and nucleotide sequence of the type E staphylococcal enterotoxin gene. J Bacteriol 170: 2954–2960

    PubMed  CAS  Google Scholar 

  • Dellabonna P, Peccoud J, Kappler J, Marrack P, Benoist C, Mathis D (1990) Superantigens interact with MHC molecules outside the binding groove. Cell 62: 1115–1121

    Article  Google Scholar 

  • Fischer H, Dohlsten M, Lindvall M, Sjögren O, Carlsson R (1989) Binding of staphylococcal enterotoxin A to HLA-DR on B cell lines. J Immunol 142: 3151–3157

    PubMed  CAS  Google Scholar 

  • Fleischer B, Mittrücker HW (1991) Evidence for T cell receptor-HLA class II molecule interaction in the response to superantigenic bacterial toxins. Eur J Immunol 21: 1331–1333

    Article  PubMed  CAS  Google Scholar 

  • Fleischer B, Schrezenmeier H (1987) Staphylococcal enterotoxins: MHC class II-dependent probes for the T cell antigen receptor. Immunobiology 175: 328–329

    Article  Google Scholar 

  • Fleischer B, Schrezenmeier H (1988) Stimulation by staphylococcal enterotoxins. Clonally variable response and requirement for MHC class II molecules on accessory or target cells. J Exp Med 167: 1697–1708

    Article  PubMed  CAS  Google Scholar 

  • Fleischer B, Schrezenmeier H, Conradt P (1989) T cell stimulation by staphylococcal enterotoxins. Role of class II molecules and T cell surface structures. Cell Immunol 119: 92–101

    Article  Google Scholar 

  • Fleischer B, Gerardy-Schahn R, Metzroth B, Carrel S, Gerlach D, Köhler W (1991) A conserved mechanism of T cell stimulation by microbial toxins. Evidence for different affinities of T cell receptor-toxin interaction. J Immunol 146: 11–17

    PubMed  CAS  Google Scholar 

  • Frazer JD (1989) High affinity binding of staphylococcal enterotoxins A and B to HLA-DR. Nature 339: 221–223

    Article  Google Scholar 

  • Grossman D, Cook RD, Sparrow JT, Mollick JA, Rich RR (1990) Dissociation of the stimulatory activities of staphylococcal enterotoxins for T cells and monocytes. J Exp Med 172: 1831–1841

    Article  PubMed  CAS  Google Scholar 

  • Herman A, Croteau G, Sekaly RP, Kappler J, Marrack P (1990) HLA-DR alleles differ in their ability to present staphylococcal enterotoxins to T cells. J Exp Med 172: 709–717

    Article  PubMed  CAS  Google Scholar 

  • Herrmann T, Acolla RS, MacDonald HR (1989) Different staphylococcal enterotoxins bind preferentially to distinct MHC class II isotypes. Eur J Immunol 19: 2171–2174

    Article  PubMed  CAS  Google Scholar 

  • Janeway CA, Yagi J, Conrad PJ, Katz ME, Jones B, Vroegop S, Buxser S (1989) T cell responses to Mls and to bacterial proteins that mimic its behaviour. Immunol Rev 107: 61–68

    Article  PubMed  CAS  Google Scholar 

  • Kappler J, Kotzin B, Herron L, Gelfand E, Bigler RD, Boylston A, Carrel S, Posneit DN, Choi Y, Marrack P (1989) Vβ-specific stimulation of human T cells by staphylococcal toxins. Science 244: 811–814

    Article  PubMed  CAS  Google Scholar 

  • Kawabe Y, Ochi A (1990) Selective anergy of Vβ + CD4+ T cells in staphylococcus enterotoxin B-primed mice. J Exp Med 172: 1065–1070

    Article  PubMed  CAS  Google Scholar 

  • Marrack P, Kappler J (1990) The staphylococcal enterotoxins and their relatives. Science 248: 705–711

    Article  PubMed  CAS  Google Scholar 

  • Matthes M, Schrezenmeier H, Homfeld J, Fleischer S, Malissen B, Kirchner H, Fleischer B (1988) Clonal analysis of human T cell activation by the Mycoplasma arthritidis mitogen. Eur J Immunol 18: 1733–1737

    Article  PubMed  CAS  Google Scholar 

  • Metzroth B, Linnig M, Fleischer B (1991) Effect of deletions on function and antigenicity of staphylococcal enterotoxin B. (submitted)

    Google Scholar 

  • Misfeldt ML (1990) Microbial “superantigens”. Infect Immunol 58: 2409–2413

    CAS  Google Scholar 

  • Mittrücker H-W, Fleischer B (1991) Stimulator cell-dependent requirement for CD2 or LFA-1 mediated adhesions in the T cell response to superantigenic toxins. (submitted)

    Google Scholar 

  • Mollik JA, Cook GR, Rich RG (1989) Class II MHC molecules are specific receptors for staphylococcal enterotoxin A. Science 244: 817

    Article  Google Scholar 

  • Reck B, Scheuber PH, Londong D, Sailer-Kramer B, Bartsch K, Hammer DK (1988) Protection against the staphylococcal enterotoxin-induced intestinal disorder in the monkey by anti-idiopathic antibodies. Proc Natl Acad Sci USA 85: 3170–3174

    Article  PubMed  CAS  Google Scholar 

  • Rellahan BL, Jones LA, Kruisbeck AM, Fry AM, Mathis LA (1990) In vivo induction of anergy in peripheral Vβ8+ T cells by staphylococcal enterotoxin B. J Exp Med 172: 1091–1100

    Article  PubMed  CAS  Google Scholar 

  • Rust CJ, Verreck F, Vietor H, Koning F (1990) Specific recognition of staphylococcal enterotoxin A by human T cells bearing receptors with the Vγ9 region. Nature 346: 572–574

    Article  PubMed  CAS  Google Scholar 

  • Scheuber PH, Golecki JR, Kickhöfen B, Scheel D, Beck G, Hammer DK (1985) Skin reactivity of unsensitized monkeys upon challenge with staphylococcal enterotoxin B: a new approach for investigating the site of toxin action. Infect Immun 50: 869–876

    PubMed  CAS  Google Scholar 

  • Scholl PR, Sekaly RP, Diez A, Glimcher LM, Geha RS (1990) Binding of toxic shock syndrome toxin 1 to murine MHC class II molecules. Eur J Immunol 20: 1911–1916

    Article  PubMed  CAS  Google Scholar 

  • Schrezenmeier H, Fleischer B (1987) Mitogenic activity of staphylococcal protein A is due to contaminating staphylococcal enterotoxins. J Immunol Methods 105: 133–137

    Article  PubMed  CAS  Google Scholar 

  • Tomai M, Kotb M, Majumdjar G, Beachey EH (1990) Superantigenicity of streptococcal M protein. J Exp Med 172: 359–362

    Article  PubMed  CAS  Google Scholar 

  • White J, Herman A, Pullen AM, Kubo R, Kappler JW, Marrack P (1989) The Vβ-specific superantigen staphylococcal enterotoxin B: stimulation of mature T cells and clonal deletion in neonatal mice. Cell 56: 27–35

    Article  PubMed  CAS  Google Scholar 

  • Yu C, Ferretti J (1989) Molecular epidemiologic analysis of the type A streptococcal exotoxin in clinical S. pyogenes strains. Infect Immun 57: 3715–3719

    PubMed  CAS  Google Scholar 

  • Zehavi-Willner (1988) Induction of murine cytolytic T lymphocytes by Pseudomonas aeruginosaexotoxin A. Infect Immunol 56: 213–218

    CAS  Google Scholar 

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Author information

Authors and Affiliations

  1. Pathophysiology Section, First Department of Medicine, University of Mainz, 6500, Mainz, Germany

    B. Fleischer

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  1. B. Fleischer
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Editors and Affiliations

  1. Pathophysiology Section, First Department of Medicine, University of Mainz, 6500, Mainz, Germany

    Bernhard Fleischer

  2. Wallenberg Laboratory, University of Lund, 22007, Lund, Sweden

    Hans Olov Sjögren

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© 1991 Springer-Verlag Berlin · Heidelberg

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Fleischer, B. (1991). The Human T Cell Response to Mitogenic Microbial Exotoxins. In: Fleischer, B., Sjögren, H.O. (eds) Superantigens. Current Topics in Microbiology and Immunology, vol 174. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-50998-8_4

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  • DOI: https://doi.org/10.1007/978-3-642-50998-8_4

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-51000-7

  • Online ISBN: 978-3-642-50998-8

  • eBook Packages: Springer Book Archive

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