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Successful Destruction of Human Gastrointestinal Carcinomas in Thymusaplastic Nude Mice After Photodyamic Therapy

  • L. Gossner
  • A. Warzecha
  • H. Wittke
  • H. Ernst
  • R. Sroka
  • E. G. Hahn
  • Ch. Ell
Conference paper

Abstract

Photodynamic therapy (PDT) is a new promising method for the local destruction of tumours. It is based on the following theoretical principle: Dihematoporphyrinether/ester, a photodynamic agent, is retained longer and in higher concentrations in tumours than in their surrounding normal tissue. When activated with light, a local cytotoxic effect is produced that is thought to be mediated via singlet oxygen [1]. The primary target of the PDT is, although the mechanism is still unclear, the vascular endothelium of the neoplastic tissue [2]. Although preliminary reports have been published describing PDT of human gastrointestinal carcinomas [3,4], no tumor-specific experimental data are available on the relationship between the energy density applied and tumor destruction.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1992

Authors and Affiliations

  • L. Gossner
    • 1
  • A. Warzecha
    • 1
  • H. Wittke
    • 1
  • H. Ernst
    • 1
  • R. Sroka
    • 1
  • E. G. Hahn
    • 1
  • Ch. Ell
    • 1
  1. 1.Department of Medicine IUniversity of Erlangen - NurembergErlangenGermany

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