Zusammenfassung
Der euglykämische Clamp-Test ist in ein Versuchsmodell zur Quantifizierung der insulinabhängigen Glukoseutilisation in vivo. Anwendung des Modells in der Humanpharmakologie:
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Untersuchung der Beeinflussung der Insulinresistenz (qualitative und quantitative Aussage) bereits in einer sehr frühen Medikamentenentwicklungs-phase.
Weiterhin ist das Modell geeignet zur Aufklärung und diagnostischen Abklärung unerwünschter Wirkungen von Substanzen auf den Glukosestoffwechsel (an Patienten und gesunden Freiwilligen).
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© 1993 Springer-Verlag Berlin Heidelberg
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Schmidtke-Schrezenmeier, G. (1993). Euglycaemic Clamping. In: Lange, L., Seifert, W., Jaeger, H., Klingmann, I. (eds) Pharmakodynamische Modelle für die Arzneimittelentwicklung. Konzepte in der Humanpharmakologie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-50229-3_12
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DOI: https://doi.org/10.1007/978-3-642-50229-3_12
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