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Role of the Ku Autoantigen in V(D)J Recombination and Double-Strand Break Repair

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Molecular Analysis of DNA Rearrangements in the Immune System

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 217))

Abstract

All cells have biochemical pathways for repairing DNA double-strand breaks induced by ionizing radiation (X-rays) and oxidative metabolism. Lymphoid cells also have a V(D)J recombination pathway for rearranging B cell immunoglobulin or T cell receptor genes (Lewis 1994a). V(D)J recombination involves the cleavage of chromosomal DNA and subsequent resolution of the double-strand breaks. In the past few years, it has become clear that the two pathways share a number of common factors.

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Author information

Authors and Affiliations

  1. Departments of Medicine and Biochemistry, Stanford University Medical Center, 94305, Stanford, CA, USA

    Gilbert Chu

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  1. Gilbert Chu
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Editors and Affiliations

  1. Institute for Immunology, Grenzacherstr. 487, CH-4005, Basel, Switzerland

    Rolf Jessberger

  2. Division of Molecular Oncology, Department of Pathology, Washington University School of Medicine, Campus Box 8118, 660 So. Euclid Ave., 63110, St. Louis, MO, USA

    Michael R. Lieber

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© 1996 Springer-Verlag Berlin Heidelberg

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Chu, G. (1996). Role of the Ku Autoantigen in V(D)J Recombination and Double-Strand Break Repair. In: Jessberger, R., Lieber, M.R. (eds) Molecular Analysis of DNA Rearrangements in the Immune System. Current Topics in Microbiology and Immunology, vol 217. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-50140-1_8

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  • DOI: https://doi.org/10.1007/978-3-642-50140-1_8

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-50142-5

  • Online ISBN: 978-3-642-50140-1

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