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The DNA-Activated Protein Kinase — DNA-PK

  • Chapter
Book cover Molecular Analysis of DNA Rearrangements in the Immune System

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 217))

Abstract

Recently, several mammalian and yeast genes have been identified that have carboxy-terminal domains (CTDs) related to the kinase domains of phosphatidylinositol kinases (PI3Ks) and appear to play roles in cell cycle control, DNA replication, recombination, and repair (Zakian 1995). The genes for this family of “lipid-like” kinases include T0R1 (DRR1) and T0R2 (DRR2) from Saccharomyces cerevisiae (Kunz et al. 1993; Helliwell et al. 1994), their mammalian homologue FRAP and RAFT1 (also called RAPT1) (Brown et al. 1994; Chiu et al. 1994; Sabatini et al. 1994), ATM, the gene defective in patients with ataxia telangiectasia (Savitsky et al. 1995a,b), MEI-41, a Drosophila gene that is functionally similar to ATM (Hari etal. 1995), MEC1 (ESR1) and its S. pombe counterpart rad3 (Seaton et al. 1992; Kato and Ogawa 1994; Weinert et al. 1994), TEL1, a S. cerevisiae gene that controls telomere length (Greenwell et al. 1995; Morrow et al. 1995), and DNA-PKcs (PRKDC), the catalytic subunit of the DNA-activated protein kinase (Carter et al. 1990; Lees-Miller et al.

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Authors and Affiliations

  1. Biology Department, Brookhaven National Laboratory, 11973-5000, Upton, NY, USA

    Carl W. Anderson

  2. Department of Biological Sciences, St. John’s University, 11439, New York, NY, USA

    Timothy H. Carter

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  1. Carl W. Anderson
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  2. Timothy H. Carter
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Editors and Affiliations

  1. Institute for Immunology, Grenzacherstr. 487, CH-4005, Basel, Switzerland

    Rolf Jessberger

  2. Division of Molecular Oncology, Department of Pathology, Washington University School of Medicine, Campus Box 8118, 660 So. Euclid Ave., 63110, St. Louis, MO, USA

    Michael R. Lieber

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© 1996 Springer-Verlag Berlin Heidelberg

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Anderson, C.W., Carter, T.H. (1996). The DNA-Activated Protein Kinase — DNA-PK. In: Jessberger, R., Lieber, M.R. (eds) Molecular Analysis of DNA Rearrangements in the Immune System. Current Topics in Microbiology and Immunology, vol 217. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-50140-1_7

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  • DOI: https://doi.org/10.1007/978-3-642-50140-1_7

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-50142-5

  • Online ISBN: 978-3-642-50140-1

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