Immunoglobulin Formation and Function in Different Tissues

  • Joseph F. Heremans
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 45)


There is no reason to doubt that textbooks of immunology are correct when they teach that the immune response to antigenic stimulation is a reaction in which all the lymphatic tissues of the body have their share. However, work initiated shortly after the turn of the century and gaining increasing momentum in recent years has brought to light that nearly all individual tissues and organs, when confronted with an antigen, display the capacity to set up their own local immune response which is largely independent of the systemic reaction.


Mammary Gland Aqueous Humor Immune Globulin Gamma Globulin Nasal Secretion 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. Adinolfi, M., A.A. Glynn, M. Lindsay, and C. M. Milne: Serological properties of γA antibodies to Escherichia coli present in human colostrum. Immunology 10, 517–526 (1966b).PubMedGoogle Scholar
  2. Adinolfi, M., P.L. Mollison, M. J. Polley, and J.M. Rose: y A-blood group antibodies. J. exp. Med. 123, 951–967 (1966a).PubMedCrossRefGoogle Scholar
  3. Alarcón-Segovia, D., T. Herskovic, K. G. Wakim, P.A. Green, and H.H. Scudamore: Presence of circulating antibodies to gluten and milk fractions in patients with nontropical sprue. Amer. J. Med. 36, 485–499 (1964).PubMedCrossRefGoogle Scholar
  4. Alexander, H. L., K. Shirley, and D. Allen: The route of ingested egg white to the systemic circulation. J. clin. Invest. 15, 163–167 (1936).PubMedCrossRefGoogle Scholar
  5. Alford, R.H., R.D. Rossen, W.T. Butler, and J.A. Kasel: Neutralizing and hemagglutination-inhibiting activity of nasal secretions following experimental human infection with A2 influenza virus. J. Immunol. 98, 724–731 (1967).PubMedGoogle Scholar
  6. Allerhand, J., S. Karelitz, H.D. Isenberg, S. Penbharkkul, and A. Ramos: The lacrimal proteins in Down’s syndrome (Mongolism). J. Pediat. 62, 235–238 (1963).PubMedCrossRefGoogle Scholar
  7. AmmannA. J., and E. R. Stiehm: Immune globulin levels in colostrum and breast milk, and serum from formula-and breast-fed newborns. Proc. Soc. exp. Biol. (N.Y.) 122, 1098–1100 (1966).Google Scholar
  8. Andersen, S.B., J. Glenert, and K. Wallevik: Intestinal degradation of gamma-globulin in the dog. Nature (Lond.) 199, 1096–1097 (1963 a).CrossRefGoogle Scholar
  9. Andersen, S.B., J. Glenert, and K. Wallevik: Gamma globulin turnover and intestinal degradation of gamma globulin in the dog. J. clin. Invest. 42, 1873–1881 (1963 b).CrossRefGoogle Scholar
  10. Anderson, T. O., L. J. M. Riff, and G. G. Jackson: Immunoelectrophoresis of nasal secretions collected during a common cold: observations which suggest a mechanism of seroimmunity in viral respiratory infections. J. Immunol. 89, 691–697 (1962).PubMedGoogle Scholar
  11. Andrew, W.: Lymphocyte transformation into epithelium. J. nat. Cancer Inst. 35, 113–137 (1965).PubMedGoogle Scholar
  12. Andrew, W., and N.V. Andrew: Mitotic division and degeneration of lymphocytes within the cells of intestinal epithelium in the mouse. Anat. Rec. 93, 251–277 (1945).PubMedCrossRefGoogle Scholar
  13. Andrew, W., and N.V. Andrew: Lymphocytes in the normal epidermis of the rat and of man. Anat. Rec. 104, 217–241 (1949).PubMedCrossRefGoogle Scholar
  14. Andrew, W., and M. R. Burns: Leucocytes in the tracheal epithelium of the mouse. J. Morph. 81, 317–341 (1947).PubMedCrossRefGoogle Scholar
  15. Andrew, W., and C. K. Collings: Lymphocytes within the cells of intestinal epithelium in man. Anat. Rec. 96, 445–457 (1946).PubMedCrossRefGoogle Scholar
  16. Anzai, T., J. Ibayashi, H. Aldrich, and C.M. Carpenter: Immunochemical study of vaginal secretion. I. Detection of serum and non-serum protein components in normal vaginal secretions. Proc. Soc. exp. Biol. (N.Y.) 113, 54–58 (1963 a).Google Scholar
  17. Anzai, T., J. Ibayashi, C. M. Carpenter, and L. Hyde: ß2 A-Globulin as a molecular constituent of insoluble bronchial mucus gel. Amer. Rev. resp. Dis. 88, 503–508 (1963 b).PubMedGoogle Scholar
  18. Artenstein, M. S., J.A. Bellanti, and E. L. Buescher: Identification of the antiviral substances in nasal secretions. Clin. Res. 12, 240 (1964).Google Scholar
  19. Askonas, B. A., P.N. Campbell, J.H. Humphrey, and T. S. Work: The source of antibody globulin in rabbit milk and goat colostrum. Biochem. J. 56, 597–601 (1954).PubMedGoogle Scholar
  20. Askonas, B. A., and J. H. Humphrey: Formation of specific antibodies and gamma globulin in vitro A study of the synthetic ability of various tissues from rabbits immunized by different methods. Biochem. J. 68, 252–261 (1958 a).Google Scholar
  21. Askonas, B. A.Formation of antibody by isolated perfused lungs of immunized rabbits. The use of C14-amino acids to study the dynamics of antibody synthesis. Biochem. J. 70, 212–222 (1958b).PubMedGoogle Scholar
  22. Asofsky, R., and P.A. Small: Colostral immunoglobulin-A: Synthesis in vitro of T-chain by rabbit mammary gland. Science 158, 932–933 (1967).PubMedCrossRefGoogle Scholar
  23. Asofsky, R., and G. J. Thorbecke: Sites of formation of immune globulins and of a component of C. II. Production of immunoelectrophoretically identified serum proteins by human and monkey tissues in vitro. J. exp. Med. 114, 471–483 (1961).PubMedCrossRefGoogle Scholar
  24. Aubert, L., P. Détolle, P. Chabert et M. Bruno: Macroglobulinémie et glioblastome occipital. Presse méd. 70, 177–180 (1962).PubMedGoogle Scholar
  25. Axelsson, H., B. G. Johansson, and L. Rymo: Isolation of immunoglobulin A (IgA) from human colostrum. Acta chem. scand. 20, 2339–2348 (1966).PubMedCrossRefGoogle Scholar
  26. Badalamenti, G., R. de Santis, R. Caprili, M. Glacovazzo e A. Ippolito: Laricerca di immunoglobuline nella mucosa del colon e retto-sigma di soggetti normali. Boll. Soc. ital. Biol. sper. 43, 685–688 (1967).Google Scholar
  27. Balâzs, V.: Studies on the antibody content of anacid gastric juices. Experientia (Basel) 18, 72–74 (1962).CrossRefGoogle Scholar
  28. Balâzs,V.: and E. Szöllösy: Studies on the virus neutralizing capacity of anacid gastric juices. Experientia (Basel) 18, 515–517 (1962).CrossRefGoogle Scholar
  29. Ballieux, R.: Structuuranalyse en classificatie van ß2A-paraproteïnen. Utrecht: Schotanus & Jens 1963.Google Scholar
  30. >Barksdale, W. L., and A. Ghoda: Agglutinating antibodies in serum and feces. J. Immunol. 66, 395–401 (1951 a).PubMedGoogle Scholar
  31. Barksdale, W. L., and A. Ghoda: Agglutinins for Escherichia coli in serum and in fecal extracts from human enteritides and from hyperimmunized and epinephrine-stimulated rabbits. J. infect. Dis. 89, 35–46 (1951b).PubMedCrossRefGoogle Scholar
  32. Batty, I., and G. H. Warrack: Local antibody production in the mammary gland, spleen, uterus, vagina and appendix of the rabbit. J. Path. Bact. 70, 355–363 (1955).PubMedCrossRefGoogle Scholar
  33. Bauer, H.: Über die Bedeutung der Papierelektrophorese des Liquors für die klinische Forschung. Dtsch. Z. Nervenheilk. 170, 381–401 (1953).CrossRefGoogle Scholar
  34. Bauer, H.: Papierelektrophoretische Darstellung der proteingebundenen Kohlenhydrate und Lipoide des Liquors. Klin. Wschr. 32, 612 (1954).PubMedCrossRefGoogle Scholar
  35. Bauer, H.: Zur Frage der Identität der Liquorproteine mit den Eiweißkörpern des Blutserums. I. Besonderheiten der Liquorproteine hinsichtlich der Vorfraktion, der γ-Globuline und der proteingebundenen Lipide. Dtsch. Z. Nervenheilk. 175, 354–377 (1956).Google Scholar
  36. Becker, B., H.-H. Unger, S.L. Coleman, and E.U. Keates: Plasma cells and gamma-globulin in trabecular meshwork of eyes with primary open-angle glaucoma. Arch. Ophthal. 70, 38–41 (1963).PubMedCrossRefGoogle Scholar
  37. Belanger, C., F. Laroche, C. Poudrier et J. Martin: Etude sur le liquide céphalo-rachidien par l’électrophorèse sur papier. Laval méd. 33, 797–801 (1962).PubMedGoogle Scholar
  38. Bell, E. B., and B. Wolf: Antibody synthesis in vitro by the rabbit vagina against diphtheria toxoid. Nature (Lond.) 214, 423–424 (1967).CrossRefGoogle Scholar
  39. Bellanti, J.A., M. S. Artenstein, and E.L. Buescher: Characterization of virus neutralizing antibodies in human serum and nasal secretions. J. Immunol. 94, 344–351 (1965).PubMedGoogle Scholar
  40. Bellanti, J.A., M. S. Artenstein, Ataxia-telangiectasia: immunologic and virologic studies of serum and respiratory secretions. Pediatrics 37, 924–933 (1966).Google Scholar
  41. Bellanti, J.A., E. L. Buescher, E. L. Brandt, H. G. Dangerfield, and D. Crozier: Characterization of human serum and nasal hemagglutinating antibody to Francisella tularensis. J. Immunol. 98, 171–178 (1967).PubMedGoogle Scholar
  42. Berdal, P.: Serologic investigations on edema fluid from nasal polyps; preliminary report. J. Allergy 23, 11–14 (1952).PubMedCrossRefGoogle Scholar
  43. Berg, O., and S. J. Dencker: Studies on sera of animals with experimental allergic encephalomyelitis and patients with multiple sclerosis using immune precipitation in agar gel and immuno-electrophoresis. Acta path. microbiol. scand. 54, 434–438 (1962).PubMedCrossRefGoogle Scholar
  44. Berger, R., E. Ainbender, H.L. Hodes, H. D. Zepp, and M. M. Hevizy: Demonstration of IgA polioantibody in saliva, duodenal fluid and urine. Nature (Lond.) 214, 420–422 (1967)CrossRefGoogle Scholar
  45. Berggârd, I., and G.M. Edelman: Normal counterparts to Bence- Jones proteins: free L polypeptide chains of human y-globulin. Proc. nat. Acad. Sci. (Wash.) 49, 330–337 (1963).CrossRefGoogle Scholar
  46. Bergmann, L., O. Gilland, S. Olanders, and L. Svennerholm: Clinical profile and paper-electrophoresis in multiple sclerosis. Acta neurol. scand. 40, Suppl. 10, 33–48 (1964).Google Scholar
  47. Berman, E. R.: A γ-globulin glycoprotein in bovine vitreous body. Biochim. biophys. Acta (Amst.) 83, 27–34 (1964).Google Scholar
  48. Biserte, G., R. Havez et R. Cuvelier: Les glycoprotéides des sécrétions bronchiques. Expos. ann. Biochim. méd. 24, 85–120 (1963).Google Scholar
  49. Blakemore, F., and R. J. Garner: The maternal transference of antibodies in the bovine. J. comp. Path. 66, 287–289 (1956).PubMedGoogle Scholar
  50. Blanc, B.: Les protéines du lactosérum, l’immunité et la physiologie de la lactation. Thèse Faculté des Sciences, Lausanne 1964.Google Scholar
  51. Booij, J.: Electrophoresis in cerebrospinal fluid proteins. The significance of the gamma-globulin fraction in particular. Third communication. Folia psychiat. neerl. 55, 137–149 (1952).PubMedGoogle Scholar
  52. Booij, J.: Aspects of the cerebrospinal fluid in leuco-encephalitis. Protides biol. Fluids 6, 219–222 (1958).Google Scholar
  53. Bradley, S.G., Y.B. Kim, and D.W. Watson: Immune response by the mouse to orally administered actinophage. Proc. Soc. exp. Biol. (N.Y.) 113, 686–688 (1963).Google Scholar
  54. Bradshaw, P.: The relation between clinical activity and the level of gammaglobulin in the cerebrospinal fluid in patients with multiple sclerosis. J. neurol. Sci. 1, 374–379 (1964).CrossRefGoogle Scholar
  55. Brandtzaeg, P.: Immunochemical comparison of proteins in human gingival pocket fluid, serum, and saliva. Arch. oral Biol. 10, 795–803 (1965).CrossRefGoogle Scholar
  56. Brandtzaeg, P.: Local factors of resistance in the gingival area. J. periodont. Res. 1, 19–42 (1966).PubMedCrossRefGoogle Scholar
  57. Brandtzaeg, P., I. Fjellanger, and S.T. Gjeruldsen: Localization of immunoglobins in human nasal mucosa. Immunochemistry 4, 57–60 (1967).PubMedCrossRefGoogle Scholar
  58. Brill, N., and R. Brönnestam: Immunoelectrophoretic study of tissue fluid from gingival pockets. Acta odont. scand. 18, 95–100 (1960).CrossRefGoogle Scholar
  59. Bronsky, D., S. E. Kaplitz, J. Muci, A. Dubin, and E. J. Chesrow: Electrophoretic partition of cerebrospinal fluid and serum proteins in multiple sclerosis. J. Lab. clin. Med. 56, 382–390 (1960).PubMedGoogle Scholar
  60. Brunish, R., J. W. Rowen, and R. S. Irvine: Proteins and hyaluronic acid of beef vitreous humor. Trans. Amer. ophthal. Soc. 52, 369–387 (1954).PubMedGoogle Scholar
  61. Brus, I., H. Siegel, and B. Jerzyglass: Immunoglobulins IgA and IgG in the human gastric mucosa. Fed. Proc. 25, 455 (1966).Google Scholar
  62. Bürger-Girard, N.: Etude immunologique des protéines de la salive normale et de mucoviscidose. Schweiz. med. Wschr. 94, 23–26 (1964).Google Scholar
  63. Bürgin-Wolff, A. M., u. E. Berger: Die Bildung von Antikörpern gegen verschiedene Kuhmilch-Proteine bei Neugeborenen, Kindern, Erwachsenen und Graviden. Experientia (Basel) 19, 22–23 (1963).CrossRefGoogle Scholar
  64. Bürgin-Wolff, A. M., u. M. JusT: Die Bedeutung des Nachweises präzipitierender Antikörper gegen einzelne Proteine der Kuhmilch. Schweiz. med. Wschr. 93, 760–764 (1963).Google Scholar
  65. Bunting, C. H., and J. Huston: Fate of the lymphocyte. J. exp. Med. 33, 593–600 (1921).PubMedCrossRefGoogle Scholar
  66. Burnet, M. F.: The clonal selection theory of acquired immunity. p. 83–86.: Cambridge University Press 1959.Google Scholar
  67. Burrows, W.E., M.E. Elliott, and I. Havens: Studies on immunity to Asiatic cholera. IV. The excretion of coproantibody in experimental enteric cholera in the guinea pig. J. infect. Dis. 81, 261–281 (1947a).PubMedCrossRefGoogle Scholar
  68. Burrows, W.E., and I. Havens: Studies on immunity to Asiatic cholera. V. The absorption of immune globulin from the bowel and its excretion in the urine and feces of experimental animals and human volunteers. J. infect. Dis. 82, 231–250 (1948).Google Scholar
  69. Burrows, W.E., A. N. Mather, M. E. Elliott, and I. Havens: Studies on immunity to Asiatic cholera. III. The mouse protection test. J. infect. Dis. 81, 157–174 (1947b).PubMedCrossRefGoogle Scholar
  70. Burrows, W.E., and L.L. Ware: Studies on immunity to Asiatic cholera. VII. Prophylactic immunity to experimental enteric cholera. J. infect. Dis. 92, 164 174 (1953).Google Scholar
  71. Burtin, P.: Les protéines du liquide céphalo-rachidien. In: Analyse électrophorétique. Applications aux liquides biologiques humains (P. Grabar et P. Burtin), p. 245–252. Paris: Masson & Cie. 1960.Google Scholar
  72. Butler, W.T., R.D. Rossen, and T. A. Waldmann: The mechanism of appearance of immunoglobulin A in nasal secretions in man. J. clin. Invest. 46, 1883–1893 (1967).PubMedCrossRefGoogle Scholar
  73. Campbell, B., R. M. Porter, and W. E. Petersen: Plasmacytosis of the bovine udder during colostrum secretion and experimental cessation of milking Nature (Lond.) 166, 913 (1950).Google Scholar
  74. Carmel, R., and V. Herbert: Intrinsic-factor antibody in the saliva of a patient with pernicious anaemia. Lancet 1967 I, 80–81.Google Scholar
  75. Carroll, E. J.: Whey proteins of drying-off secretions, mastitic milk, and colostrum separated by ion-exchange cellulose. J. Dairy Sci. 44, 2194–2211 (1961).CrossRefGoogle Scholar
  76. Castaigne, P., J. Cambier et E. Schuller: Dosage des protéines totales et de certaines globulines du liquide céphalo-rachidien. II. Dosage des y-globulines du liquide céphalo-rachidien. Rev. franç. Étud. clin. biol. 10, 534–539 (1965).Google Scholar
  77. Cebra, J. J., and J. B. Robbins: y A-immunoglobulin from rabbit colostrum. J. Immunol. 97, 12–24 (1966).PubMedGoogle Scholar
  78. Cebra, J. J., and P. A. Small: Polypeptide chain structure of rabbit immunoglobulins III. Secretory gamma A-Immunoglobulin from colostrum. Biochemistry 6, 503–512 (1967).PubMedCrossRefGoogle Scholar
  79. Cederblad, G., B. G. Johansson, and L. Rymo: Reduction and proteolytic degradation of immunoglobulin A from human colostrum. Acta chem. scand. 20, 2349–2357 (1966).PubMedCrossRefGoogle Scholar
  80. Chauncey, H.H., R.P. Feller, E.R. Halsband, and L.D. Jaskiel: Hemagglutinins of human parotid and submandibular secretions. Proc. Soc. exp. Biol. (N.Y.) 121, 130–133 (1966).Google Scholar
  81. Chevance, L. G., A. Galli, J. Jeanmaire et G. Gérard: Liquide périlymphatique. In: Analyse électrophorétique. Applications aux liquides biologiques humains (P. Grabar et P. Burtin), p. 253–256. Paris: Masson & Cie. 1960.Google Scholar
  82. Chodirker, W.B., and T.B. Tomasi: Gamma-globulins: Quantitative relationships in human serum and nonvascular fluids. Science 142, 1080–1081 (1963).PubMedCrossRefGoogle Scholar
  83. Claman, H. N., D. A. Merrill, and T. F. Hartley: Salivary immunoglobulins: normal adult values and dissociation between serum and salivary levels. J. Allergy 40, 151–159 (1967).PubMedCrossRefGoogle Scholar
  84. Clausen, J.: Proteins and acid mucopolysaccharides in the bile. Protides biol. Fluids 10, 218–226 (1962).Google Scholar
  85. Clausen, J., A.R. Krogsgaard, and F. Quaade: Immunoelectrophoretic studies of the cerebrospinal fluid and serum in acute, mainly infectious diseases of the central nervous system. J. infect. Dis. 111, 128–134 (1962).PubMedCrossRefGoogle Scholar
  86. Cohen, S., and R. Bannister: Immunoglobulin synthesis within the central nervous system in disseminated sclerosis. Lancet 1967 I, 366–367.Google Scholar
  87. Coleman, R.D., and M.D. Appleman: Antibodies of syphilis in saliva and serum. J. dent. Res. 32, 294–297 (1953).PubMedCrossRefGoogle Scholar
  88. Collins-Williams, C.: Cow’s milk allergy in infants and children. Int. Arch. Allergy 20, 38–59 (1962).PubMedCrossRefGoogle Scholar
  89. Collomb, H., et P. Mattern: La bêta-2-macroglobuline du liquide céphalo-rachidien dans la trypanosomiase humaine africaine. Rev. neurol. 107, 41–49 (1962).Google Scholar
  90. Colover, J., J. G. Feinberg, A. Temple, and M. Tooley: A comparison of the measurement of gamma globulin in cerebrospinal fluid by electrophoretic and immunological methods. J. clin. Path. 16, 370–374 (1963).PubMedCrossRefGoogle Scholar
  91. Coombs, R. R. A., and L.L. Fiset: Detection of complete and incomplete antibodies to egg albumin by means of sheep red cell — egg albumin antigen unit. Brit. J. exp. Path. 35, 472–477 (1954).PubMedGoogle Scholar
  92. Coombs, R. R. A., W. E. Jonas, P. J. Lachmann, and A. Feinstein: Detection of IgA antibodies by the red cell linked antigen-antiglobulin reaction: antibodies in the sera of infants to milk proteins. Int. Arch. Allergy 27, 321–337 (1965).PubMedCrossRefGoogle Scholar
  93. Cooper, G. N., and J. A. Pillow: Experimental shigellosis in mice. II. Immunological responses to Shigella dysenteriae type 2 infection. Aust. J. exp. Biol. med. Sci. 37, 201–210 (1959).PubMedCrossRefGoogle Scholar
  94. Cowley, G.C.: Fluorescence studies of crevicular fluid. J. dent. Res. 45, 655–661 (1966).CrossRefGoogle Scholar
  95. Crabbé, P.: Signification du tissu lymphoïde des muqueuses digestives. Bruxelles: Arscia et Paris: Maloine 1967.Google Scholar
  96. Crabbé, P., A. O. Carbonara, and J. F. Heremans: The normal human intestinal mucosa as a major source of plasma cells containing y A-immunoglobulin. Lab. Invest. 14, 235–248 (1965).PubMedGoogle Scholar
  97. Crabbé, P., and J.F. Heremans: Lack of gamma A-immunoglobulin in serum of patients with steatorrhoea. Gut 7, 119–127 (1966a).PubMedCrossRefGoogle Scholar
  98. Crabbé, P., and J.F. Heremans: Etude immunohistochimique des plasmocytes de la muqueuse intestinale humaine normale. Rev. franç. Etud. clin. biol. 11, 484–492 (1966b).PubMedGoogle Scholar
  99. Crabbé, P., and J.F. Heremans: The distribution of immunoglobulin-containing cells along the human gastrointestinal tract. Gastroenterology 51, 305–316 (1966c).PubMedGoogle Scholar
  100. Crabbé, P., and J.F. Heremans: Presence of large numbers of plasma cells containing IgD in the rectal mucosa of a patient with ulcerative colitis. Acta clin. belg. 21, 73–83 (1966d).PubMedGoogle Scholar
  101. Crabbé, P., and J.F. Heremans: Presence of antibodies against egg white antigens in human lymphoid tissues. Int. Arch. Allergy 30, 597–603 (1966e).PubMedCrossRefGoogle Scholar
  102. Crabbé, P., and J.F. Heremans: Selective IgA deficiency with steatorrhea. A new syndrome. Amer. J. Med. 42, 319–326 (1967a).PubMedCrossRefGoogle Scholar
  103. Crabbé, P., and J.F. Heremans: Distribution in human nasopharyngeal tonsils of plasma cells containing different types of immunoglobulin polypeptide chains. Lab. Invest. 16, 112–123 (1967b).PubMedGoogle Scholar
  104. Crabbé, P., and J.F. Heremans: Normal and defective production of immunoglobulins in the intestinal tract. In press.Google Scholar
  105. Crandall, R.B., J. J. Cebra, and C.A. Crandall: The relative proportions of IgG-, IgA- and IgM-containing cells in rabbit tissues during experimental trichinosis. Immunology 12, 147–158 (1967).PubMedGoogle Scholar
  106. Crawford, L. V.: Allergenicity of cow’s milk proteins. I. Effect of heat treatment on the allergenicity of protein fractions of milk as studied by the dual-ingestion passive transfer test. Pediatrics 25, 432–436 (1960).PubMedGoogle Scholar
  107. Cutler, R.W.P., G. V. Watters, J. P. Hammerstad, and E. Merler: Origin of cerebrospinal fluid gamma globulin in subacute sclerosing leukoencephalitis. Arch. Neurol. (Chic.) 17, 620–628 (1967).CrossRefGoogle Scholar
  108. Dalgarno, A., W. Godden, and E.F. Mccarthy: The effect of high-and low-plane feeding on serum protein levels of pregnant ewes, foetuses, and young lambs. Biochem. J. 46, 162–167 (1950).PubMedGoogle Scholar
  109. Darlington, D., and A.W. Rogers: Epithelial lymphocytes in the small intestine of the mouse. J. Anat. (Lond.) 100, 813–830 (1966).Google Scholar
  110. Davidson, L.: Milk proteins in ulcerative colitis. Brit. med. J. 1961 II, 1358.CrossRefGoogle Scholar
  111. Davies, A.: An investigation into the serological properties of dysentery stools. Lancet 1922 11, 1009–1012.CrossRefGoogle Scholar
  112. Deane, H.W.: Some electron microscopic observations on the lamina propria of the gut, with comments on the close association of macrophages, plasma cells, and eosinophils. Anat. Rec. 149, 453–474 (1964).PubMedCrossRefGoogle Scholar
  113. Delank, H.W.: 1_Tber die humorale Antikörperbildung gegen Hirngewebsextraktivstoffe bei Entmarkungsencephalomyelitiden und anderen organischen Hirnerkrankungen. Arch. Psychiat. Nervenkr. 195, 383–392 (1957).PubMedCrossRefGoogle Scholar
  114. Delank, H.W., u. G.W. Schimmelpenning: Klinischer Beitrag zur subakuten Panencephalitis (unter besonderer Berücksichtigung elektrophoretischer Liquoreiweißuntersuchungen). Arch. Psychiat. Nervenkr. 193, 607–615 (1955).PubMedGoogle Scholar
  115. Dencker, S. J.: Immuno-electrophoretic investigation of cerebrospinal fluid gamma-globulins in multiple sclerosis. Acta neurol. scand. 40, Suppl. 10, 57–64 (1964).Google Scholar
  116. Dencker, S. J., and O. Kolak: The cerebrospinal fluid gamma-globulin profile in subacute sclerosing leucoencephalitis. Acta neurol. scand. 41, Suppl. 13, 135–140 (1964).Google Scholar
  117. Dennis, E. G., M.M. Hornbrook, and K. Ishizaka: Serum proteins in sputum of patients with asthma. J. Allergy 35, 464–471 (1964).PubMedCrossRefGoogle Scholar
  118. Desmonts, G.: Definitive serological diagnosis of ocular toxoplasmosis. Arch. Ophthal. 76, 839–851 (1966).PubMedCrossRefGoogle Scholar
  119. Desmonts, G., A. Baron, G. Offret, J. Couvreur et M. Lelong: La production locale d’anticorps au cours des toxoplasmoses oculaires. Arch. Ophtal. (Paris) 20, 137–145 (1960).Google Scholar
  120. Deutsch, H. F.: A study of whey proteins from the milk of various animals. J. biol. Chem. 169, 437–448 (1947).PubMedGoogle Scholar
  121. Dieckhues, B.: Allergie und Auge. Klin. Mbl. Auge.heilk. 48, Suppl., 1–65 (1967).Google Scholar
  122. Dieckhues, B., u. W. Böke: Antikörperbildung im Auge. Ein Beitrag zur Frage der elektiven Gewebsensibilisierung. Klin. Mbl. Augenheilk. 138, 25–30 (1961).Google Scholar
  123. Dieckhues, B., u. W. Böke: Immunoelektrophoretische Untersuchungen über die Antikörperbildung in den verschiedenen Augenabschnitten. Albrecht v. Graefes Arch. Ophthal. 164, 524–532 (1962).Google Scholar
  124. Dixon, F. J., W. O. Weigle, and J. J. Vazquez: Metabolism and mammary secretion of serum proteins in the cow. Lab. Invest. 10, 216–237 (1961).PubMedGoogle Scholar
  125. Dobson, C.: Serum protein changes associated with Oesophagostomum columbianum infections in sheep. Nature (Lond.) 207, 1304–1305 (1965).CrossRefGoogle Scholar
  126. Dobson, C.: Immunofluorescent staining of globule leucocytes in the colon of the sheep. Nature (Lond.) 211, 875 (1966a).CrossRefGoogle Scholar
  127. Dobson, C.: Globule leucocytes, mucin and mucin cells in relation to Oesophagostomum columbianum infections in sheep. Aust. J. Sci. 28, 434 (1966b).Google Scholar
  128. Dobson, C.: The demonstration of antibodies in the intestinal mucus of sheep infected with Oesophagostomum columbianum by means of the percutaneous anaphylaxis test. Aust. J. biol. Sci. 19, 339–340 (1966c).PubMedGoogle Scholar
  129. Dobson, C.: Studies on the immunity of sheep to Oesophagostomum columbianum: proteins and haemagglutinating antibodies in mucous exudates and intestinal tissue extracts. Aust. J. agricult. Res. 17, 779–796 (1966d).CrossRefGoogle Scholar
  130. Douglas jr., R. G., R.D. Rossen, W.T. Butler, and R.B. Couch: Rhinovirus neutralizing antibody in tears, parotid saliva, nasal secretions and serum. J. Immunol. 99, 297–303 (1967).PubMedGoogle Scholar
  131. Douvres, F. W.: The in vitro cultivation of Oesophagostomum radiatum, the nodular worm of cattle. II. The use of this technique to study immune responses of host tissue extracts against the developing nematode. J. Parasit. 48, 852–864 (1962).CrossRefGoogle Scholar
  132. Dubler, H., et J. J. Scheidegger: Recherches immuno-électrophorétiques dans l’humeur aqueuse. Ophthalmologica (Basel) 135, 640–644 (1958).CrossRefGoogle Scholar
  133. Dungern, E. v.: Die Antikörper. Resultat früherer Forschungen und neue Ergebnisse. Jena: Gustav Fischer 1902.Google Scholar
  134. Eidelman, S., S.D. Davis, D. Lagunoff, and C. E. Rubin: The relationship between intestinal plasma cells and serum immunoglobulin A (IgA) in man. J. clin. Invest. 45, 1003 (1966) (Abstract).Google Scholar
  135. Epstein, W.V., M. Tan, and D. Gross: Blocked antigenic sites on the L-chain of human gamma-globulin. Nature (Lond.) 202, 1175–1177 (1964).CrossRefGoogle Scholar
  136. Escherich, T.: Versuche zur Immunisierung gegen Diphtherie auf dem Wege des Verdauungstraktes. Wien. klin. Wschr. 10, 799–801 (1897).Google Scholar
  137. Esser, H.: Die elektrophoretische Untersuchungen der LiquoreiweiBkörper und ihre klinische Bedeutung. Munch. med. Wschr. 94, 2313–2318 (1952).Google Scholar
  138. Evans, R. T., and S. E. Mergenhagen: Occurrence of natural antibacterial antibody in human parotid fluid. Proc. Soc. exp. Biol. (N.Y.) 119, 815–819 (1965).Google Scholar
  139. Ewerbeck, H.: Die elektrophoretische Darstellung normalen menschlichen Liquors. Klin. Wschr. 28, 692–693 (1950).PubMedCrossRefGoogle Scholar
  140. Farr, R. S., W. Dickinson, and K. Smith: Quantitative aspects of oral immunization against bovine serum albumin (BSA) (Abstract). Fed. Proc. 19, 199 (1960).Google Scholar
  141. Fazekas de St. Groth, S.: Influenza: a study in mice. Lancet 1950 I, 1101–1105.Google Scholar
  142. Fazekas de St., and M. Donnelley: Studies in experimental immunology of influenza; antibody response. Aust. J. exp. Biol. med. Sci. 28, 45–60 (1950a).CrossRefGoogle Scholar
  143. Fazekas de St., and M. Donnelley: Studies in experimental immunology of influenza. IV. The protective value of active immunization. Aust. J. exp. Biol. med. Sci. 28, 61–75 (1950b).CrossRefGoogle Scholar
  144. Feinstein, A.: Character and allotypy of an immune globulin in rabbit colostrum. Nature (Lond.) 199, 1197–1199 (1963).CrossRefGoogle Scholar
  145. Feldman, J.D.: Fine structure of the cow’s udder during gestation and lactation. Lab. Invest. 10, 238–255 (1961).PubMedGoogle Scholar
  146. Felsenfeld, O., W.E. Greer, and A.D. Felsenfeld: Cholera toxin neutralization and some cellular sites of immune globulin formation in Cercopithecus aethiops. Nature (Lond.) 213, 1249–1251 (1967).CrossRefGoogle Scholar
  147. Fichtelius, K.E.: The mammalian equivalent to bursa Fabricii of birds. Exp. Cell Res. 46, 231–234 (1967).PubMedCrossRefGoogle Scholar
  148. Field, E.O.: The production of gamma globulin in the central nervous system. J. Neurol. Neurosurg. Psychiat. 17, 228–232 (1954).PubMedCrossRefGoogle Scholar
  149. Filipe da Silva, J.A., et C.C. Monteiro: Etude immunoélectrophorétique du colostrum et du lait de femme. Bull. Soc. Chim. biol. (Paris) 41, 1707–1710 (1959).Google Scholar
  150. Fisher, J.M., C. Rees, and K.B. Taylor: Antibodies in gastric juice. Science 150, 1467–1469 (1965).PubMedCrossRefGoogle Scholar
  151. Fisher, J.M., C. Rees, and K.B. Taylor: Intrinsic-factor antibodies in gastric juice of pernicious-anaemia patients. Lancet 1966 II, 88–89.Google Scholar
  152. Foster, J. B., and D. B. Horn: Multiple sclerosis and spinal-fluid gamma-globulin. Brit. med. J. 1962 I, 1527–1528.Google Scholar
  153. Francois, J., and M. Rabaey: Microelectrophoresis on agar of normal and pathological aqueous humor. Arch. Ophthal. 63, 836–849 (1960).CrossRefGoogle Scholar
  154. Freedman, D.A., and H.H. Merritt: Cerebrospinal fluid in multiple sclerosis. Res. nerv. ment. Dis. Proc. 28, 428–439 (1949).Google Scholar
  155. Fresh, J. W., P.M. Versage, and V. Reyes: Intestinal morphology in human and experimental cholera. Arch. Path. 77, 529–537 (1964).PubMedGoogle Scholar
  156. Freter, R.: Coproantibody and bacterial antagonism as protective factors in experimental enteric cholera. J. exp. Med. 104, 419–426 (1956).PubMedCrossRefGoogle Scholar
  157. Freter, R.: Detection of coproantibody and its formation after parenteral and oral immunization of human volunteers. J. infect. Dis. 111, 37 48 (1962).Google Scholar
  158. Freter, R., and E. J. Gangarosa: Oral immunization and production of coproantibody in human volunteers. J. Immunol. 91, 724–729 (1963).PubMedGoogle Scholar
  159. Frick, E.: Immunoelektrophoretische Untersuchungen am Liquor cerebrospinalis. Klin. Wschr. 37, 645–651 (1959).PubMedCrossRefGoogle Scholar
  160. Frick, E., u. L. Scheid-Seydel: Immunologische Untersuchungen an Liquoreiweißkörpern. Z. ges. exp. Med. 129, 221–246 (1957).CrossRefGoogle Scholar
  161. Frick, E., u. L. Scheid-Seydel: Untersuchungen mit J131-markiertem Gamma-Globulin zur Frage der Abstammung der Liquoreiweißkörper. Klin. Wschr. 36, 857–863 (1958).PubMedCrossRefGoogle Scholar
  162. Furuhata, T., K. Nakamura, H. Nakajima, and M. Suzuki: Studies on the secretor (type v) and non-secretor (type V) of group specific agglutinin and their inheritance. Proc. Jap. Acad. 35, 105–107 (1959).Google Scholar
  163. Gabl, F.: Elektrophoretische und immunologische Untersuchungen spezifischer Speicheleiweißkörper. Protides biol. Fluids 10, 230–233 (1962).Google Scholar
  164. Gabl, F.: Immunreaktionen von Anti-Speichelserum mit Antigenen anderen Körperflüssigkeiten. Protides biol. Fluids 11, 235–238 (1963).Google Scholar
  165. Gabl, F.: Über das Vorkommen von normalen und pathologischen Immunglobulinen im Speichel. Wien. Z. inn. Med. 47, 66–81 (1966).PubMedGoogle Scholar
  166. Gabl, F., u. H. Wachter: Weitere Untersuchungen zur Charakterisierung von Speichelproteinen. III. Mitt. Protides biol. Fluids 9, 336–341 (1961).Google Scholar
  167. Gangarosa, E. J., W. R. Beisel, C. Benyajati, H. Sprinz, and P. Piyaratin: The nature of the gastrointestinal lesion in asiatic cholera and its relation to pathogenesis: a biopsy study. Amer. J. trop. Med. 9, 125–135 (1960).PubMedGoogle Scholar
  168. Garcin, R., et J. Lewin: Protéines anormales du sérum et du liquide céphalorachidien dans un cas de macroglobulinémie; répercussion sur la réaction du benjoin colloïdal. C. R. Soc. Biol. (Paris) 152, 1692–1695 (1958).Google Scholar
  169. Gard, S.: Discussion. In: First Int. Conf. on Live Poliovirus Vaccines, Washington D.C., June 1959. Sci. Publ. No 44, p. 368.Google Scholar
  170. Garner, R. J., and W. Crawley: Further observations on the maternal transference of antibodies in the bovine. J. comp. Path. 68, 112–114 (1958).PubMedGoogle Scholar
  171. Gelzayd, E.A., S. C. Kraft, and F.W. Fitch: Immunoglobulin A: localization in rectal mucosal epithelial cells. Science 157, 930–931 (1967).PubMedCrossRefGoogle Scholar
  172. Gershowitz, H., S. J. Behrman, and J.V. Neel: Hemagglutinins in uterine secretions. Science 128, 719–720 (1958).PubMedCrossRefGoogle Scholar
  173. Gisss, D. D.: The permeation of gastric epithelial cells by leucocytes. Gut 5, 160–165 (1964).CrossRefGoogle Scholar
  174. Glass, G. B. J.: Paper electrophoresis of gastric juice in health and disease. In: Current gastroenterology (G. Mchardy, ed.), chap. 13, p. 90–151. New York: Hoeber & Harper 1962.Google Scholar
  175. Goldman, A. S., D.W. Anderson, W.A. Sellers, S. Saperstein, W.T. Kniker, and S. R. Halpern: Milk allergy. I. Oral challenge with milk and isolated milk proteins in allergic children. Pediatrics 32, 425–443 (1963).PubMedGoogle Scholar
  176. Goldmann, H., u. R. Witmer: Antikörper im Kammerwasser. Ophthalmologica (Basel) 127, 323–330 (1954).CrossRefGoogle Scholar
  177. Gonzalez, L.M., G. Arbona, and J. Fernos: Studies in bacillary dysentery; failure to detect coproantibodies in patients with bacillary dysentery (Flexner). J. infect. Dis. 87, 194–196 (1950).PubMedCrossRefGoogle Scholar
  178. Goodman, M., and M. Vulpe: A quantitative immunochemical method for determining serum and cerebrospinal fluid proteins. Wld Neurol. 2, 589–601 (1961).Google Scholar
  179. Gordon, R. S., I.L. Bennett jr., and L.A. Barnes: Field trial of Shigella flexniri III vaccine; coproantibody studies. J. infect. Dis. 86, 197–201 (1950).PubMedCrossRefGoogle Scholar
  180. Gowans, J.L., and E. J. Knight: The route of re-circulation of lymphocytes in the rat. Proc. roy. Soc. B 159, 257–282 (1964).Google Scholar
  181. Grabar, M.M.P., A. Bourduas et A. Holtzer: Mise en évidence in vitro d’anticorps chez des sujets sensibilisés à l’ovalbumine. Acta allerg. (Kbh.) 5, 30–36 (1952).Google Scholar
  182. Green, G.E.: Inherent defense mechanisms in saliva. J. dent. Res. 45, 624–629 (1966).CrossRefGoogle Scholar
  183. Green, G.E., and R. M. Wilson: Chromatographic comparison of caries-immune and caries-susceptible salivas. J. dent. Res. 42, 1380–1386 (1963).PubMedCrossRefGoogle Scholar
  184. Green, G.E., and R. M. Wilson: Gamma globulin levels in serum and saliva of hyper-and hypogammaglobulinemic patients. J. dent. Res. 43, 714 (1964).PubMedCrossRefGoogle Scholar
  185. Greenbaum, D. S., and L. Miller: Antibody in milk and its role in passive immunization. J. Lab. clin. Med. 55, 229–244 (1960).PubMedGoogle Scholar
  186. Greene, H. S. N.: Transplantation of tumors to brains of heterologous species. Cancer Res. 11, 529–534 (1951).PubMedGoogle Scholar
  187. Greene, H. S. N.: Transplantation of human brain tumors to brains of laboratory animals. Cancer Res. 13, 422–426 (1953).PubMedGoogle Scholar
  188. Greene, H. S. N.: Heterotransplantation of tumors. Ann. N.Y. Acad. Sci. 69, 818–829 (1957).PubMedCrossRefGoogle Scholar
  189. Grimm, R. R., M. Alter, and R. C. Williams: Gm and Inv antigenic character of serum and cerebrospinal fluid IgG in multiple sclerosis. Proc. Soc. exp. Biol. (N.Y.) 122, 554–557 (1966).Google Scholar
  190. Groves, M. L., and W. G. Gordon: Isolation of a new glycoprotein-a and a yGglobulin from individual cow milks. Biochemistry 6, 2388–2394 (1967).PubMedCrossRefGoogle Scholar
  191. Gruskay, F. L., and R. E. Cooke: The gastrointestinal absorption of unaltered protein in normal infants and in infants recovering from diarrhea. Pediatrics 16, 763–769 (1955).PubMedGoogle Scholar
  192. Gsell, O., K. Rehsteiner u. F. Verrey: Iridocyclitis als Spätfolge Von Leptospirosis pomona (Schweinehüterkrankheit).Google Scholar
  193. Gsell, O., Agglutinin-and Lymphozyten-Befund im Kammerwasser. Ophthalmologica (Basel) 112, 320–334 (1946).CrossRefGoogle Scholar
  194. Gugler, E., M. Bein u. G. von Muralt: Über immunoelektrophoretische Untersuchungen an Kuhmilchproteinen. Schweiz. med. Wschr. 89, 1172–1176 (1959).Google Scholar
  195. Gugler, E., G. Bokelmann, A. Dätwyler U. G. von Muralt: Über immunoelektrophoretische Untersuchungen an Frauenmilchproteinen. Schweiz. med. Wschr. 88, 1264–1267 (1958).Google Scholar
  196. Gugler, E., u. G. von Muralt: Über immunoelektrophoretische Untersuchungen an Frauenmilchproteinen. 2. Mitt. Schweiz. med. Wschr. 89, 925–929 (1959).Google Scholar
  197. Gunther, M., E. Cheek, R. H. Matthews, and R. R. A. Coombs: Immune responses in infants to cow’s milk proteins taken by mouth. Int. Arch. Allergy 21, 257–278 (1962).PubMedCrossRefGoogle Scholar
  198. György, P., E. Moro u. E. Witebsky: Eiklarempfindlichkeit bei Eczema infantum. Klin. Wschr. 9, 1012–1017 (1930).CrossRefGoogle Scholar
  199. Haelterman, E. O., and B. E. Hooper: Transmissible gastroenteritis of swine as a model for the study of enteric disease. Gastroenterology 53, 109–113 (1967).Google Scholar
  200. Hanson, L.A.: Immunological analysis of bovine blood serum and milk. Experientia (Basel) 15, 471–472(1959 a).CrossRefGoogle Scholar
  201. Hanson, L.A.: Comparative analysis of human milk and human blood plasma by means of diffusion-in-gel methods. Experientia (Basel) 15, 473–474 (1959b).CrossRefGoogle Scholar
  202. Hanson, L.A.: Immunological analysis of human milk. Int. Arch. Allergy 15, 245–256 (1959c).PubMedCrossRefGoogle Scholar
  203. Hanson, L.A.: The serological relationship between human milk and blood plasma. Int. Arch. Allergy 17, 45–69 (1960).PubMedCrossRefGoogle Scholar
  204. Hanson, L.A.: Comparative immunological studies of the immune globulins of human milk and of blood serum. Int. Arch. Allergy 18 241–267 (1961 a).PubMedCrossRefGoogle Scholar
  205. Hanson, L.A.: Comparison of the antigen mosaic of the immune globulins of human blood serum and milk. Protides biol. Fluids 9, 133–134 (1961 b).Google Scholar
  206. Hanson, L.A.: Antigen mosaic of blood serum and milk immune globulins. Acta path. microbiol. scand. 54, 328–334 (1962).PubMedCrossRefGoogle Scholar
  207. Hanson, L.A.: Aspects of the absence of the IgA system. In: R.A. Good, P. Miescher and R.T. Smith (eds.), The immunologic deficiency diseases in man. Gainesville: Florida University Press (in press).Google Scholar
  208. Hanson, L.A.: and H. J. Andersen: A comparison of the antigenic relationships of human milk and goat’s milk to bovine milk. Acta paediat. (Uppsala) 51, 509–512 (1962).CrossRefGoogle Scholar
  209. Hanson, L.A.: and B. G. Johansson: Studies on secretory IgA. In: J. Killander (ed.), Gamma globulins. Structure and control of biosynthesis, Nobel Symposium 3, June 1967Google Scholar
  210. Hanson, L.A.: and B. G. Johansson: Stockholm. Stockholm: Almqvist & Wiksell 1967, p. 141–151.Google Scholar
  211. Hanson, L.A.: and B. G. Johansson: Immunological studies of milk. In: Milk proteins. Chemistry and biochemistry. New York: Academic Press, Inc. (in press).Google Scholar
  212. Hanson, L.A., and I. Mânsson: Immune electrophoretic studies of bovine milk and milk products. Acta paediat. (Uppsala) 50, 484–490 (1961).CrossRefGoogle Scholar
  213. Hanson, L.A., and E. M. Tan: Characterization of antibodies in human urine. J. clin. Invest. 44, 703–715 (1965).PubMedCrossRefGoogle Scholar
  214. Harrison, P. E., and J. Banvard: Coproantibody excretion during enteric infections. Science 106, 188–189 (1947).PubMedCrossRefGoogle Scholar
  215. Hartley, G.: Local formation of antivaccinial antibodies by skin. J. infect. Dis. 66, 44–52 (1940).CrossRefGoogle Scholar
  216. Hartley, T. F., D.A. Merrill, and H.N. Claman: Quantitation of immunoglobulins in cerebrospinal fluid. Arch. Neurol. (Chic.) 15, 472–479 (1966).CrossRefGoogle Scholar
  217. Havez, R., F. Guerrin, J. P. Muh et G. Biserte: Caractérisation et isolement des immunoglobulines A de la muqueuse gastrique. C.R. Soc. Biol. (Paris) 160, 571–576 (1966a).Google Scholar
  218. Havez, R., J.P. Mull, M. Bonte et G. Biserte: Etude des y A-globulines du colostrum humain. Clin. chim. Acta 15, 7–18 (1967).Google Scholar
  219. Havez, R., J.P. Mull, P. Roussel, P. Degand et C. Carlier: Caractères antigéniques particuliers aux immunoglobulines humaines de sécrétion. C.R. Acad. Sci. (Paris) 262, 1379–1381 (1966b).Google Scholar
  220. Haworth, J. C., and L. Dilling: Concentration of y A-globulin in serum, saliva, and nasopharyngeal secretions of infants and children. J. Lab. clin. Med. 67, 922–933 (1966).PubMedGoogle Scholar
  221. Heinen, G.: Immunoelektrophoretische Untersuchungen der weiblichen Vaginal- und Zervikalsekretion. Protides biol. Fluids 12, 210–212 (1964).Google Scholar
  222. Heiner, D.C., M.E. Lahey, J. F. Wilson, J.W. Gerrard, H. Shwachman, and K.-T. Khaw: Precipitins to antigens of wheat and cow’s milk in celiac disease. J. Pediat. 61, 813–830 (1962).CrossRefGoogle Scholar
  223. Heiner, D.C., M.E. Lahey, J. F. Wilson, and G.A. Peck: Precipitins to wheat in steatorrhea. Amer. J. Dis. Child. 102, 446–449 (1961).Google Scholar
  224. Heiner, D.C., and J. W. Sears: Chronic respiratory disease associated with multiple circulating precipitins to cow’s milk. Amer. J. Dis. Child. 100, 500–502 (1960).Google Scholar
  225. Heremans, J. F.: Les globulines sériques du système gamma. Leur nature et leur pathologie. Paris: Masson et Bruxelles: Arscia 1960.Google Scholar
  226. Heremans, J. F.: Gamma-1 a-globulin in health and disease. In: S.E. Björkman (ed.), Gamma-globulins. Proc. 10th Congr. Int. Soc. Hemat., Stockholm 1964. Copenhagen: Munksgaard 1965, p. 17–27, Ser. 4.Google Scholar
  227. Heremans, J. F., and P.A. Crabbé: Immunohistochemical studies on exocrine IgA. In: J. Killander(ed.), Gamma globulins. Structure and control of biosynthesis, Nobel Symposium 3, June 1967, Stockholm, p. 129–139.Google Scholar
  228. Heremans, J. F., and P.A. Crabbé: IgA deficiency. General considerations and relation to human diseases. In: R.A. Good, P. Miescher and R.T. Smith (eds.), The immunologic deficiency diseases in man. Gainesville: Florida University Press (in press).Google Scholar
  229. Heremans, J. F., and P.A. Crabbé: and P. L. Masson: Biological significance of exocrine gamma-A-immunoglobulin. Acta med. scand. 179, Suppl. 445, 84–88 (1966).Google Scholar
  230. Heremans, J. F., J.-P. Vaerman, and C. Vaerman: Studies on the immune globulins of human serum. II. A study of the distribution of anti-brucella and anti-diphtheria antibody activities among yss-, yi M- and yi A-globulin fractions. J. Immunol. 91, 11–17 (1963)PubMedGoogle Scholar
  231. Hermans, P.E., K.A. Huizenga, H. N. Hoffman, A. L. Brown, and H. Markowitz: Dysgammaglobulinemia associated with nodular lymphoid hyperplasia of the small intestine. Amer. J. Med. 40, 78–89 (1966).PubMedCrossRefGoogle Scholar
  232. Hervé, R., M. Robey et P. Sergent: Analyse immuno-électrophorétique du mucus cervical. Recherches d’un test d’ovulation. Gynéc. et Obstét. 64, 347–356 (1965).Google Scholar
  233. Heusser, H., O. Gsell, U. Kanter u. E. Wiesmann: Die periodische Augenentzündung der Pferde als Leptospirenerkrankung. Schweiz. med. Wschr. 78, 756–758 (1948).Google Scholar
  234. Hirsch-Marie, H., et P. Burtin: Etude électrophorétique et immunochimique des protéines du liquide gastrique normal. Rev. franç. Étud. clin. biol. 8, 145–155 (1963).PubMedGoogle Scholar
  235. Hochwald, G.M., E.B. Jacobson, and G. J. Thorbecke: C14-amino acid incorporation into transferrin and ß2A-globulin by ectodermal glands in vitro. Fed. Proc. 23, 557 (1964) (Abstract).Google Scholar
  236. Hochwald, G.M., and G. J. Thorbecke: Occurrence of myeloma-like gamma-globulin in C.S.F. of a four-month old infant with hydrocephalus. Pediatrics 33, 435–440 (1964).PubMedGoogle Scholar
  237. Hodes, H. L.: Poliomyelitis antibodies in human colostrum and milk. J. Pediat. 65, 319–320 (1964).PubMedCrossRefGoogle Scholar
  238. Hochwald, G.M., R. Berger, E. Ainbender, M.M. Hevizy, H.D. Zepp, and S. Kocuwa: Proof that colostrum polio antibody is different from serum antibody. J. Pediat 65, 1017–1018 (1964).CrossRefGoogle Scholar
  239. Holland, N.H., R. Hong, N.C. Davis, and C.D. West: Significance of precipitating antibodies to milk proteins in the serum of infants and children. J. Pediat. 61, 181–195 (1962).PubMedCrossRefGoogle Scholar
  240. Holman, H.R., W.F. Nickel, and M.H. Sleisenger: Hypoproteinemia antedating intestinal lesions, and possibly due to excessive serum protein loss into the intestine. Amer. J. Med. 27, 963–975 (1959).PubMedCrossRefGoogle Scholar
  241. Hong, R., B. Pollara, and R.A. Good: A model for colostral IgA. Proc. nat. Acad. Sci. (Wash.) 56, 602–607 (1966).CrossRefGoogle Scholar
  242. Hooper, B.E., and E.O. Haelterman: Concepts of pathogenesis and passive immunity in transmissible gastroenteritis of swine. J. Amer. vet. med. Ass. 149, 1580–1586 (1966).Google Scholar
  243. Humble, J. G., W.H.W. Jayne, and R. J. V. Pulvertaft: Biological interaction between lymphocytes and other cells. Brit. J. Haemat. 2 283–294 (1956).PubMedCrossRefGoogle Scholar
  244. Hummel, K., u. J. Schöch: Untersuchungen über die Ausscheidung von anti-Aund anti-B-Hämagglutininen im menschlichen Mundspeichel. Z. Immun. allg. klin. Immun. 133, 80–100 (1967).Google Scholar
  245. Hurlimann, J., et J. J. Scheidegger: Analyse immunoélectrophorétique des sucs gastriques humains. Protides biol. Fluids 10, 227–229 (1962).Google Scholar
  246. Isiuzaka, K., E. G. Dennis, and M. Hornbrook: Presence of reagin and y1A-globulin in saliva. J. Allergy 35, 143–148 (1964).CrossRefGoogle Scholar
  247. Isiuzaka, K., T. Ishizaka, and M. M. Hornbrook: Physico-chemical properties of human reaginic antibody. IV. Presence of a unique immunoglobulin as a carrier of reaginic activity. J. Immunol. 97, 75–85 (1966).Google Scholar
  248. Isiuzaka, K., T. Ishizaka, and M. M. Hornbrook: Allergen-binding activity of y E, y G and y A antibodies in sera from atopic patients. J. Immunol. 98, 490–501 (1967).Google Scholar
  249. Ivers, R.R., B.F. Mckenzie, W.F. Mcguckin, and N.P. Goldstein: Spinal-fluid gamma globulin in multiple sclerosis and other neurologic diseases. Electrophoretic patterns in 606 patients. J. Amer. med. Ass. 176, 515–519 (1961).CrossRefGoogle Scholar
  250. Jankovië, B. D., M. Drakoci, and K. Isakovio: Antibody response in rabbits following injection of sheep erythrocytes into lateral ventricle of brain. Nature (Lond.) 191, 288–289 (1961).CrossRefGoogle Scholar
  251. Jeffries, G.H., and M.H. Sleisenger: Studies of parietal cell antibody in pernicious anemia. J. clin. Invest. 44, 2021–2028 (1965).PubMedCrossRefGoogle Scholar
  252. Jenkin, C. R., and D. Rowley: The importance of antibody in the prevention of experimental cholera in rabbits. Brit. J. exp. Path. 41, 24–30 (1960).PubMedGoogle Scholar
  253. Jerne, N.K., and A.A. Nordin: Plaque formation in agar by single antibody-producing cells. Science 140, 405 (1963).CrossRefGoogle Scholar
  254. Johnson, J. S., and J.H. Vaughan: Canine immunoglobulins. I. Evidence for six immunoglobulin classes. J. Immunol. 98, 923–934 (1967).PubMedGoogle Scholar
  255. Johnson, P., and A. E. Pierce: Ultracentrifugal and electrophoretic studies on neonatal calf sera and maternal colostrum. J. Hyg. (Lond.) 57, 309–320 (1959).CrossRefGoogle Scholar
  256. Josephson, A. S., and D.W. Lockwood: Immunoelectrophoretic studies of the protein components of normal tears. J. Immunol. 93, 532–539 (1964).PubMedGoogle Scholar
  257. Rabat, E. A., D.A. Freedman, J.P. Murray, and V. Knaub: Study of crystalline albumin, gamma globulin, and total protein in the cerebrospinal fluid of 100 cases of multiple sclerosis and in other diseases. Amer. J. med. Sci. 219, 55–64 (1950).CrossRefGoogle Scholar
  258. Kabat, E.A., M. Glusman, and V. Knaub: Quantitative estimation of the albumin and gamma globulin in normal and pathologic cerebrospinal fluid by immunochemical methods. Amer. J. Med. 4, 653–662 (1948).PubMedCrossRefGoogle Scholar
  259. Kabat, E.A., H. Landow, and D.H. Moore: Electrophoretic patterns of concentrated cerebrospinal fluid. Proc. Soc. exp. Biol. (N.Y.) 49, 260–263 (1942b).Google Scholar
  260. Kabat, E.A., D.H. Moore, and H. Landow: Electrophoretic study of protein components in cerebrospinal fluid and their relationship to serum proteins. J. clin. Invest. 21, 571–577 (1942a).PubMedCrossRefGoogle Scholar
  261. Karcher, D., M. van Sande, and A. Lowenthal: Micro-electrophoresis in agar gel of proteins of the cerebrospinal fluid and central nervous system. J. Neurochem. 4, 135–140 (1959).PubMedCrossRefGoogle Scholar
  262. Karlsson, B. W.: Antigenic constituents in porcine milk throughout the cow’s lactation period with special reference to colostrum. Ark. Zool., Ser. II, 18, 33–50 (1966).Google Scholar
  263. Karte, H.: Über das Vorkommen von Serumproteinen in der Frauenmilch. Mschr. Kinderheilk. 107, 265–267 (1959).PubMedGoogle Scholar
  264. Kasai, N.: Studies on mucus antibody of bacillary dysentery. First report. The relationship between the excretion of Shigella organisms and the mucus-and serum-agglutinins. Jap. J. exp. Med. 24, 199–209 (1954).PubMedGoogle Scholar
  265. Kasai, N., and I. Tadokoro: Studies on mucus antibody of bacillary dysentery. III. The excretion of mucus antibody in normal human volunteers and mice immunized with chromic vaccine. Jap. J. exp. Med. 27, 447–429 (1957).Google Scholar
  266. Kaulla, K. N. v., J. K. Aikawa, P. D. Bruns, and W. T. Wikle: Secretory function of the human uterine cervix. Studies with radioisotopes. Fertil. and Steril. 8, 444–454 (1957).Google Scholar
  267. Kawakami, K., H. Tatsumi, M. Tatsumi, and R. Kono: Studies on poliovirus coproantibody. I. Neutralizing antibodies in feces of children following Sabin oral poliovirus vaccination. Amer. J. Epidem. 83, 1–43 (1966).Google Scholar
  268. Keimowitz, R. I.: Immunoglobulins in normal human tracheobronchial washings. A qualitative and quantitative study. J. Lab. clin. Med. 63, 54–59 (1964).PubMedGoogle Scholar
  269. Kelsall, M. A.: Lymphocytes in the intestinal epithelium and Peyer’s patches of normal and tumor-bearing hamsters. Anat. Rec. 96, 391–409 (1946).PubMedCrossRefGoogle Scholar
  270. Kenny, J. F., M. I. Boesman, and R. H. Michaels: Bacterial and viral coproantibodies in breast-fed infants. Pediatrics 39, 202–213 (1967).PubMedGoogle Scholar
  271. Kent, J. F.: Distribution and fine structure of globule leucocytes in respiratory and digestive tracts of the laboratory rat. Anat. Rec. 156, 439–454 (1966).PubMedCrossRefGoogle Scholar
  272. Kenyon, A. J., R. K. Anderson, and R. Jenness: A macroglobulin (12S) agglutinin for Brucella bovine milk. J. Dairy Sci. 44, 1441–1142 (1961).CrossRefGoogle Scholar
  273. Kerr, W. R.: Vaginal and uterine antibodies in cattle with particular reference to Br. abortus. Brit. vet. J. 111, 169–178 (1955).Google Scholar
  274. Kerr, W. R., and M. Robertson: Active and passive sensitization of the uterus of the cow in vivo against Trichomonas foetus antigen and the evidence for the local production of antibody at that site. J. Hyg. (Loud.) 51, 405–415 (1953).CrossRefGoogle Scholar
  275. Kirkman, H.: A comparative morphological and cytochemical study of globule leucocytes (Schollenleukozyten) of the urinary tract and of possibly related cells. Amer. J. Anat. 86, 91–131 (1950).PubMedCrossRefGoogle Scholar
  276. Komi, J.: Electrophoretic and immunological studies on some body fluids in normal and pathological conditions and a preliminary communication on the separation of the labyrinthine fluids. Protides biol. Fluids 7, 67–70 (1959).Google Scholar
  277. Kolar, O.: Zur Bedeutung der pathologischen Proteinkomponenten im Liquor cerebrospinalis und im Serum von Patienten mit der subakuten Encephalitis nach Dawson-Pette-Döring-van Bogaert. Klin. Wschr. 44, 279–281 (1966).PubMedCrossRefGoogle Scholar
  278. Kolar, O.: Problems of the origin of the anodic part of cerebrospinal fluid gamma-G-globulins in inflammatory affections of the central nervous system. Nature (Lond.) 214, 524–525 (1967).CrossRefGoogle Scholar
  279. Koshland, M. E.: The origin of fecal antibody and its relationship to immunization with adjuvant. J. Immunol. 70, 359–365 (1953).PubMedGoogle Scholar
  280. Koshland, M. E., and W. Burrows: Quantitative studies of the relationship between fecal and serum antibody. J. Immunol. 65, 93–103 (1950).PubMedGoogle Scholar
  281. Kotani, M., A. Yamashita, F. Rai, K. Seiki, and I. Horii: Reutilization of DNA breakdown products from lymphocytes in lumen of intestine. Blood 29, 616–627 (1967).PubMedGoogle Scholar
  282. Kraus, F. W., and J. Konno: Antibodies in saliva. Ann. N.Y. Acad. Sci. 106, 311–329 (1963).PubMedCrossRefGoogle Scholar
  283. Kraus, F. W., and J. Konno: The salivary secretion of antibody. Ala. J. med. Sci. 2, 15–22 (1965).PubMedGoogle Scholar
  284. Kraus, F. W., and S. Sirisinha: Gamma globulin in saliva. Arch. oral Biol. 7, 221–234 (1962).PubMedCrossRefGoogle Scholar
  285. Kunin, C. M.: Antibody distribution against nonenteropathic E. coli. Arch. intern. Med. 110, 676–686 (1962).Google Scholar
  286. Kutt, H., F. Mcdowell, L. Chapman, J. H. Pert, and L. J. Hurwitz: Abnormal protein fractions of cerebrospinal fluid demonstrated by starch gel electrophoresis. Neurology (Minneap.) 10, 1064–1067 (1960).Google Scholar
  287. Kutzim, H., W. Scheid u. J. Vonkennel: Die Verschiebung der Bluteiweißkörper im Blut und Liquor bei Syphilis des Zentralnervensystems. Medizinische 1954, 609–612.Google Scholar
  288. Labhart, H., W. Schweizer U. H. Staub: Mikroelektrophoretische Untersuchung von normalem und pathologischem Liquor cerebrospinalis. Confin. neurol. (Basel) 11, 325–339 (1951).Google Scholar
  289. Laffers, Z., U. S. Bozsoky: Die klinische Bedeutung der Antistreptolysinbestimmung im Kammerwasser. Ophthalmologica (Basel) 137, 322–334 (1959).CrossRefGoogle Scholar
  290. Larose, C., P. J. Delorme, M. Richter, and B. Rose: Immunologic studies on milk and egg allergy. J. Allergy 33, 306–315 (1962).PubMedCrossRefGoogle Scholar
  291. Larson, B. L.: Transfer of specific blood serum proteins to lacteal secretions near parturition. J. Dairy Sci. 41, 1033–1044 (1958).CrossRefGoogle Scholar
  292. Larson, B. L., and D. C. Gillespie: Origin of the major specific proteins in milk. J. biol. Chem. 227, 565–573 (1957).PubMedGoogle Scholar
  293. Larson, B. L., and R. L. Hays: An explanation for bovine parturition edema and treatment with blood protein replacements. J. Dairy Sci. 41, 995–997 (1958).CrossRefGoogle Scholar
  294. Lascelles, A. K.: A review of the literature on some aspects of immune milk. Dairy Sci. Abstr. 25, 359 (1963).Google Scholar
  295. Lascelles, A. K., P. M. Outteridge, and D. D. S. Mackenzie: Local production of antibody by the lactating mammary gland following antigenic stimulation. Aust. J. exp. Biol. med. Sci. 44, 169–179 (1966).PubMedCrossRefGoogle Scholar
  296. Laterre, E. C.: Les protéines du liquide céphalo-rachidien à l’état normal et pathologique. Bruxelles: Arscia et Paris: Maloine 1965.Google Scholar
  297. Laterre, E. C.: Les gammaglobulines du liquide céphalo-rachidien dans la sclérose en plaques. Acta neurol. belg. 66, 305–318 (1966).Google Scholar
  298. Laterre, E. C., J. F. Heremans et G. Demanet: La pathologie des protéines du liquide céphalorachidien. Etude électrophorétique et immuno-électrophorétique (600 observations). Rev. neurol. 107, 500–521 (1962).Google Scholar
  299. Leach, L. B., G. H. Wyshak, and D. Weisberger: Human saliva: its antigenic composition. J. dent. Res. (Baltimore) 42, 568–574 (1963).Google Scholar
  300. Leber, A.: Immunitätsverhältnisse der vorderen Augenkammer. Albrecht v. Graefes Arch. Ophthal. 64, 413–444 (1906).Google Scholar
  301. Lehner, T., J. E. Cardwell, and E. D. Clarry: Immunoglobulin in saliva and serum in dental caries. Lancet 1967 I, 1294–1296.Google Scholar
  302. Leibowitz, H. M. I., and J. J. Parks: The in vitro production of antibody by de- layed phase corneal limbal lymphoid foci. J. exp. Med. 117, 197–211 (1963).PubMedCrossRefGoogle Scholar
  303. Lépine, P., J. A. Thomas et J. Leclerc: Recherches préliminaires sur la prévention de la poliomyélite expérimentale chez le singe par injection de globulines anticorps provenant du lait de vache. C. R. Acad. Sci. (Paris) 254, 3467–3469 (1962).Google Scholar
  304. Lerner, A. M., J. S. Remington, and M. Finland: Neutralizing antibody to polioviruses in normal human urine. J. clin. Invest. 41, 805–815 (1962).PubMedCrossRefGoogle Scholar
  305. Link, H.: Immunoglobulin G and low molecular weight proteins in human cerebrospinal fluid. Acta neurol. scand. 43, Suppl. 28, 1-136 (1967).Google Scholar
  306. Lippard, V. W.: Immunologic response to ingestion of foods by normal and eczematous infants. Amer. J. Dis. Child. 57, 524–540 (1939).Google Scholar
  307. Lipton, M. M., and A. J. Steigman: Human coproantibody against poliovirus. J. infect. Dis. 112, 57–66 (1963).CrossRefGoogle Scholar
  308. Laterre, E. C.: Agar gel electrophoresis in neurology. Amsterdam: Elsevier Publ. Co. 1964.Google Scholar
  309. Laterre, E. C., D. Karcher et M. van Sande: Mobilités relatives des ß-globulines du sérum et du liquide céphalo-rachidien. Rev. franç. Étud. clin. biol. 5, 1015–1017 (1960a).Google Scholar
  310. Laterre, E. C., D. Karcher et O. Petre- Quadens: Intérêt de l’électrophorèse en agar des protéines du liquide céphalo-rachidien pour l’établissement du diagnostic différentiel en neurologie. Rev. franç. Etud. clin. biol. 8, 255–263 (1963).Google Scholar
  311. Laterre, E. C., D. Karcher M. van Sande, and D. Karcher: The differential diagnosis of neurological diseases by fractionating electrophoretically the cerebrospinal gamma-globulins. J. Neurochem. 6, 51–56 (1960b).CrossRefGoogle Scholar
  312. Lumsden, C. E.: The proteins of cerebrospinal fluid in multiple sclerosis, chapt. XI, p. 252–299. In: D. Mcalpine, Ch. E. Lumsden and E. D. Acheson (eds.), Multiple sclerosis. Edinburgh & London: E. & S. Livingstone Ltd. 1965.Google Scholar
  313. Lunsford, L., and H. F. Deutsch: Human milk whey proteins. Proc. Soc. exp. Biol. (N.Y.) 96, 742–744 (1957).Google Scholar
  314. Luz, A. Q., and R. H. Todd: Antigenicity of heated milk proteins. An immunologic approach. Amer. J. Dis. Child. 108, 479–486 (1964).PubMedGoogle Scholar
  315. Mackenzie, D. D. S., P. M. Outteridge, and A. K. Lascelles: Transfer of circulating globulin into milk and efferent mammary lymph during experimental mastitis. Aust. J. exp. Biol. med. Sci. 44, 181–195 (1966).PubMedCrossRefGoogle Scholar
  316. Macpherson, C. F., and J. B. Cosgrove: Immunochemical evidence for a gammaglobulin peculiar to cerebrospinal fluid. Canad. J. Biochem. 39, 1567–1574 (1961).PubMedCrossRefGoogle Scholar
  317. Mallik, K. C. B., and J. C. Roy: Coproantibody in cholera. Indian J med. Sci. 14, 776–779 (1960).Google Scholar
  318. Manuel, Y., C. Lapras et A. Goutelle: Electrophorèse du liquide céphalo-rachidien au cours d’abcès du cerveau. C. R. Soc. Biol. (Paris) 158, 117–119 (1964).Google Scholar
  319. Manuel, Y., et E. C. Laterre: Les protéines du liquide céphalo-rachidien normal. H. Origine des protéines du liquide céphalo-rachidien. Path. et Biol. 14, 1145–1156 (1966).Google Scholar
  320. Marshall, A. H. E., and R. G. White: The immunological reactivity of the thymus. Brit. J. exp. Path. 42, 379–385 (1961).Google Scholar
  321. Mason, J. H., T. Dalling, and W. S. Gordon: Transmission of maternal immunity. J. Path. Bact. 33, 783–797 (1930).CrossRefGoogle Scholar
  322. Masson, P. L., A. O. Carbonara, and J. F. Heremans: Studies on the proteins of human saliva. Biochim. biophys. Acta (Amst.) 107, 485–500 (1965 a).Google Scholar
  323. Masson, P. L., and J. F. Heremans: Molecular size of yA-immunoglobulin from bronchial secretions. Biochim. biophys. Acta (Amst.) 120, 172–173 (1966).CrossRefGoogle Scholar
  324. Masson, P. L., and J. F. Heremans, and C. Dive: Studies of the proteins of secretions from two villous tumours of the rectum. Gastroenterologia (Basel) 105, 270–282 (1966).Google Scholar
  325. Masson, P. L., and J. F. Heremans, and J. Prignot: Studies on the proteins of human bronchial secretions. Biochim. biophys. Acta (Amst.) 111, 466–478 (1956b).Google Scholar
  326. Mattern, P.: A propos de la présence de ß 2 macroglobuline dans le liquide céphalorachidien. C.R. Soc. Biol. (Paris) 156, 158–161 (1962a).Google Scholar
  327. Mattern, P.: ß2 macroglobulinorachie importante chez des malades atteints de trypanosomiase africaine. Ann. Inst. Pasteur 102, 64–68 (1962b).Google Scholar
  328. Mattern, P.: Techniques et intérêt épidémiologique du diagnostic de la trypanosomiase humaine africaine par la recherche de la beta-macroglobuline dans le sang et dans le L.C.-R. Ann. Inst. Pasteur 107, 415–421 (1964).Google Scholar
  329. Mattern, P.: G. Sandor et J. Pillot: Contribution à l’étude des immunoglobulines du liquide céphalo-rachidien au cours de la neurosyphilis humaine par les techniques d’analyse irnmunoélectrophorétique et d’immunofluorescence. Ann. Inst. Pasteur 109, 120–127 (1965).Google Scholar
  330. Mcdougall, E. I.: Proteins of ruminant colostrum. Biochem. J. 94, 99–100 (1965).PubMedGoogle Scholar
  331. Mcdougall, E. I.: Proteins of the succus entericus from the jejunum of the sheep. Biochem. J. 100, 19–26 (1966).PubMedGoogle Scholar
  332. Mcfarlin, D. E., W. Strober, R. D. Wochner, and T. A. Waldmann: Immunoglobulin A procuction in ataxia telangiectasia. Science 150, 1175–1177 (1965).PubMedCrossRefGoogle Scholar
  333. Medawar, P. B.: Immunity to homologous grafted skin: III. Fate of skin homo-grafts transplanted to brain, to subcutaneous tissue, and to anterior chamber of the eye. Brit. J. exp. Path. 29, 58–69 (1948).PubMedGoogle Scholar
  334. Mellors, R. C., A. Nowoslawsxl, and L. Korngold: Rheumatoid arthritis and the cellular origin of rheumatoid factors. Amer. J. Path. 39, 533–546 (1961).PubMedGoogle Scholar
  335. Mendes, E., A. Strauss, R. G. Ferri, and A. B. U. Cintra: Immunochemical studies of the asthmatic sputum. Acta allerg. (Kbh.) 18, 17–25 (1963).Google Scholar
  336. Merler, E., J. S. Remington, M. Finland, and D. Gitlin: Characterization of antibodies in normal human urine. J. clin. Invest. 42, 1340–1352 (1963).PubMedCrossRefGoogle Scholar
  337. Michaux, J.-L.: Les immunoglobulines des Bantous à l’état normal et pathologique. Ann. Soc. belge Méd. trop. 46, 483–674 (1966).PubMedGoogle Scholar
  338. Michaux, J.-L., and J. F. Heremans: Thirty cases of monoclonal immunoglobulin disorders other than myeloma or macroglobulinemia. A classification of diseases associated with the production of monoclonal-type immunoglobulin. Amer. J. Med., in press.Google Scholar
  339. Michiels, J.: L’humeur aqueuse et la barrière hémato-camérulaire. Louvain; Ceuterick 1968.Google Scholar
  340. Mietens, C.: Untersuchungen über die Antikörperbildung gegen Gliadin und Milchproteine. II. Der Nachweis von y M durch Ultrazentrifugation und Behandlung mit Mercaptoäthanol. Z. Kinderheilk. 99, 130–139 (1967).PubMedCrossRefGoogle Scholar
  341. Mitchell, C. A., L. F. Guerin, and A. E. Pasieka: Antibody production in milk serum after virus instillation of goat mammary gland. I. Responses to influenza virus, mumps virus, and adenovirus 3. Canad. J. Microbiol. 13, 1069–1078 (1967).Google Scholar
  342. Mitchell, C. A., R. V. L. Walker, and G. L. Bannister: Studies relating to the formation of neutralizing antibody following the propagation of influenza and Newcastle disease virus in the bovine mammary gland. Canad. J. Microbiol. 2, 322–328 (1956).CrossRefGoogle Scholar
  343. Mitchison, N. A.: The passage of antibodies into the intestine in rabbits. Quart. J. exp. Physiol. 38, 139–150 (1953).PubMedGoogle Scholar
  344. Mitrovi, K., M. Drasxoci, and B. D. Jankovi: Antibody production in rabbits following immunization via the lateral ventricle of the brain. Experientia (Basel) 20, 700–701 (4964).Google Scholar
  345. Miyakoshi, H.: The serological constitutions of men in respect to the isoagglutinin in saliva. Nihon hoigaku Zasshi 5, 75, 85, 95 (1954).Google Scholar
  346. Moghissi, K. S., and O. W. Neuhaus: Composition and properties of human cervical mucus. Amer. J. Obstet. Gynec. 83, 149–155 (1962).PubMedGoogle Scholar
  347. Moharram, I.: The group properties in the saliva of the Egyptian population. Lab. Med. Progr. 4, 1–13 (1943).Google Scholar
  348. Montreuil, J., A. Crosson, R. Havez et S. Mullet: Isolement de la ß2A-globuline du lait de femme. C. R. Soc. Biol. (Paris) 154, 732–736 (1960).Google Scholar
  349. Morr, F. W.: Observations on the brains of men and animals infected with various forms of trypanosomes. Preliminary note. Proc. roy. Soc. Ser. B 76, 235–242 (1905).Google Scholar
  350. Muralt, G. DE, E. Gugler et D. L. A. Roulet: Analyse antigénique du colostrum et du lait de femme et du colostrum et du lait de vache. Protides biol. Fluids 8, 166–171 (1960).Google Scholar
  351. Murphy, F. A., O. Aalund, J. W. Osebold, and E. J. Carroll: Gamma globulins of bovine lacteal secretions. Arch. Biochem. 108, 230–239 (1964).PubMedCrossRefGoogle Scholar
  352. Murray, R. G., and P. A. Woods: Studies on the fate of lymphocytes. III. The migration and metamorphosis of in situ labeled thymic lymphocytes. Anat. Rec. 150, 113–128 (1964).PubMedCrossRefGoogle Scholar
  353. Newcomb, R. W., and K. Ishizaka: Human diphtheria antitoxin in immunoglobulin classes IgG and IgA. J. Immunol. 99, 40–48 (1967).PubMedGoogle Scholar
  354. Nordbring, F.: The change in total nitrogen and electrophoretic pattern in human colostrum during the first day of lactation. Acta Soc. Med. upsalien. 62, 113–129 (1957).Google Scholar
  355. Nerredam, K., and J. Clausen: Immuno-electrophoretic studies of blood serum and cerebrospinal fluid in early syphilis. Acta derm.-venerol. (Stockh.) 43, 413–420 (1963).Google Scholar
  356. Oakley, C. L., I. Batty, and G. H. Warrack: Local production of antibodies. J. Path. Bact. 63, 33–44 (1951).PubMedCrossRefGoogle Scholar
  357. Oakley, C. L., I. Batty, Antibody production in rabbit cornea. J. Path. Bact. 70, 349–354 (1955).PubMedCrossRefGoogle Scholar
  358. Oeff, K.: Austauschkinetik der Plasmaproteine zwischen Blut und Körperhöhlen. Protides biol. Fluids 7, 164–170 (1959).Google Scholar
  359. Offret, G., C. Desmonts, J. Couvreur, R. Campinchi et Y. Pouliquen: Examen de l’humeur aqueuse pour le diagnostic de la toxoplasmose oculaire. Bull. Soc. Ophtal. Fr. 62, 71–75 (1962).Google Scholar
  360. Outteridge, P. M., J. D. Rock, and A. K. Lascelles: The immune response of the mammary gland and regional lymph node following antigenic stimulation. Aust. J. exp. Biol. med. Sci. 43, 265–274 (1965).PubMedCrossRefGoogle Scholar
  361. Parish, W. E., J. A. Carron-Brown, and C. B. Richards: The detection of antibodies to spermatozoa and to blood group antigens in cervical mucus. J. Reprod. Fertil. 13, 469–483 (1967).PubMedCrossRefGoogle Scholar
  362. Parks, J. J., H. M. I. Leibowitz, and A. E. Maumenee: A transient stage of suspected delayed sensitivity during the early induction phase of immediate corneal sensitivity. J. exp. Med. 115, 867–880 (1962).PubMedCrossRefGoogle Scholar
  363. Pearsall, N. N., and J. C. Sherris: The demonstration of specific urinary antibodies in urinary tract infections caused by gram-negative bacilli. J. Path. Bact. 91, 589–595 (1966).PubMedCrossRefGoogle Scholar
  364. Peretz, W. L., and T. B. Tomasi: Aqueous humor proteins in uveitis. Arch. Ophthal. 65, 20–23 (1961).PubMedCrossRefGoogle Scholar
  365. Petersen, W. E., and B. Campbell: Use of protective principles in milk and colostrum in prevention of disease in man and animals. J. Lancet 1955, 75, 494–496.PubMedGoogle Scholar
  366. Peterson, R. D. A., M. D. Cooper, and R. A. Good: The pathogenesis of immunologic deficiency diseases. Amer. J. Med. 38, 579–604 (1965).PubMedCrossRefGoogle Scholar
  367. Peterson, R. D. A., and R. A. Good: Antibodies to cow’s milk proteins: their presence and significance. Pediatrics 31, 209–221 (1963).PubMedGoogle Scholar
  368. Pierce, A. E.: Demonstration of an agglutinin to Trichomonas foetus in vaginal mucus. Nature (Lond.) 158, 343 (1946).CrossRefGoogle Scholar
  369. Pierce, A. E.: The demonstration of an agglutinin to Trichomonas foetus in the vaginal discharge of infected heifers. J. comp. Path. 57, 84–97 (1947).Google Scholar
  370. Pierce, A. E.: Specific antibodies of mucous surfaces. Vet. Rev. Annot. 5, 17–36 (1959).Google Scholar
  371. Pierce, A. E.; and A. Feinstein: Biophysical and immunological studies on bovine immune globulins with evidence for selective transport within the mammary gland from maternal plasma to colostrum. Immunology 8, 106–123 (1965).PubMedGoogle Scholar
  372. Pierce, A. E., P. L. Long, and C. Horton-Smith: Immunity to Eimeria tenella in young fowls (Gallus domesticus). Immunology 5, 129–152 (1962).PubMedGoogle Scholar
  373. Pokorna, M., J. Sourek U. J. Svejcar: Die Bedeutung der Präzipitine gegenüber Gliadin im Serum von Kindern mit Cöliakie. Helv. paediat. Acta 18, 393–397 (1964).Google Scholar
  374. Pollaci, G., u. S. Ceraulo: Das Agglutinationsvermögen einiger Körperflüssigkeiten beim Mediterranfieber. Zbl. Bakt., I. Abt. 52, 268–275 (1909).Google Scholar
  375. Posthumus, R. G., u. H. A. Zondag: Papierelektrophoretische Eiweißuntersuchung des Augenkammerwassers. Klin. Mbl. Augenheilk. 136, 380–387 (1960).Google Scholar
  376. Predpechensky, S., and O. Moroz: A method for early and rapid diagnosis of dysentery. Zh. Mikrobiol. (Mosk.) 7, 3–11 (1940).Google Scholar
  377. Press, E. M.: A comparative study of cerebrospinal fluid and serum proteins in multiple sclerosis with special reference to the Lange colloidal-gold reaction. Biochem. J. 63, 367–372 (1956).PubMedGoogle Scholar
  378. Prokop, O.: Bemerkenswertes Überwiegen der Anti-B-Ausscheidung im Speichel von 0- gegenüber Al Trägern. Blut 7, 143–148 (1961).PubMedCrossRefGoogle Scholar
  379. Rao, S. S., M. E. Kulkarni, S. N. Cooper, and M. R. Radhakrishnan: Analysis of proteins of bovine lens, vitreous, and aqueous by electrophoresis and by Oudin’s gel diffusion technique. Brit. J. Ophthal. 39, 163–169 (1955).PubMedCrossRefGoogle Scholar
  380. Rapp, W., S. B. Aronson, P. Burtin, and P. Grabar: Constituents and antigens of normal human gastric mucosa as characterized by electrophoresis and immunoelectrophoresis in agar gel. J. Immunol. 92, 579–595 (1964).PubMedGoogle Scholar
  381. Raskin, N.: Antibrain antibodies in multiple sclerosis; study of antibrain antibodies in blood of multiple sclerosis patients by complement fixation tests. Arch. Neurol. Psychiat. (Chic.) 73, 645–655 (1955).Google Scholar
  382. Ratner, B., and H. L. Gruehl: Passage of native proteins through the normal gastro-intestinal wall. J. clin. Invest. 13, 517–532 (1934).PubMedCrossRefGoogle Scholar
  383. Rawson, A. J.: Human bile proteins. I. Proteins identified by antibody to human serum. Clin. Chem. 8, 310–317 (1961).Google Scholar
  384. Rejnek, J., J. Kostka, and O. Kotynek: Electrophoretic behaviour of H and L chains of human serum and colostrum gamma-globulin. Nature (Lond.) 209, 926–928 (1966).CrossRefGoogle Scholar
  385. Rejnek, J., O. Kotnek, and J. Kostka: Contribution to the structural characterization of gamma globulin from pig colostrum. Folia microbiol. (Praha) 10, 327–334 (19X65).Google Scholar
  386. Rejnek, J., F. Kvaizil a A. Dolezal: Elektroforetické a imunoelektroforetické studie séra matky, novorozence a sérovÿch bflkovin kolostra. Cs. Pediat. 15, 97–104 (1960).Google Scholar
  387. Remington, J. S., E. Merler, A. M. Lerner, D. Gitlin, and M. Finland: Antibodies of low molecular weight in normal human urine. Nature (Lond.) 194, 407–408 (1962).CrossRefGoogle Scholar
  388. Remington, J. S., E. Merler, and C. O’nealpage: The demonstration of immune globulins in normal human sweat and their similarity to immune globulins in other body secretions (Abstract). Clin. Res. 13, 126 (1965).Google Scholar
  389. Remington, J. S., E. Merler, and K. L. Vosti: Immunochemical studies of human nasal secretions. Clin. Res. 12, 111 (1964).Google Scholar
  390. Remington, J. S., E. Merler, A. Lietze, and A. L. Zimmerman: Serum proteins and antibody activity in human nasal secretions. J. clin. Invest. 43, 1613–1624 (1964).PubMedCrossRefGoogle Scholar
  391. Remky, H.: Zur Klinik der serologisch diagnostizierten Augentuberkulose. Klin. Mbl. Augenheilk. 133, 518–529 (1958 a).Google Scholar
  392. Remky, H.: L’uvéite streptococcique. Recherches expérimentales et cliniques. Bull. Soc. franç. Ophthal. 71, 461–475 (1958b).Google Scholar
  393. Remky, H.: L’uvéite tuberculeuse. Diagnostic sérologique, formes cliniques et thérapie spécifique. Bull. Soc. franç. Ophtal. 73, 64–79 (1960a).PubMedGoogle Scholar
  394. Remky, H.: Die serologische Diagnose der Streptokokken-Uveitis. Docum. ophth. (Den Haag) 14, 280–285 (1960b).Google Scholar
  395. Remky, H.: Toxoplasmosis. In: Argumenta et Documenta Ophthalmologica. Munich: J. F. Lehmann 1962.Google Scholar
  396. Remky, H.: Etiological diagnosis of endogenous uveitis. In: H. Remky (ed.), The uveal tract and its endogenous inflammations. Int. Ophthalmology Clinics, vol. 5, No 3, p. 789–822, Sept. 1965. Boston: Little, Brown & Co. 1965. Auto-Antikörper bei Uveitis. Docum. ophthal. (Den Haag) 20, 354–363 (1966).Google Scholar
  397. Remky, H., u. H. Kraft: Intraokulare Toxocara-canis-Infestation. Klin. Mbl. Augenheilk. 147, 692–702 (1965).PubMedGoogle Scholar
  398. Rifaat, M. K., O. A. Iseri, and L. S. Gottlieb: An ultrastructural studyof the “extraneous coat” of human colonic mucosa. Gastroenterology 48, 593–601 (1965).PubMedGoogle Scholar
  399. Ritzel, G., R. Wüthrich u. H. P. Rieder: Zur Frage der Antikörper gegen Nervengewebe in Serum und Liquor von Multiple-Sklerose-Kranken. Schweiz. med. Wschr. 93, 1336–1339 (1963).Google Scholar
  400. Rosoz, E., W. C. Hess, and F. M. Forster: Quantitative determination of gamma globulin in cerebrospinal fluid; its application in multiple sclerosis. Neurology (Minneap.) 3, 410–416 (1953).Google Scholar
  401. Rockey, J. H., L. A. Hanson, J. F. Heremans, and H. G. Kunkel: Beta-2 Aaglobulinemia in two healthy men. J. Lab. clin. Med. 63, 205–212 (1964).PubMedGoogle Scholar
  402. Roemer, G. B., A. Schrader u. W. Schild: Ergebnisse serologischer Untersuchungen bei der multiplen Sklerose. Klin. Wschr. 31, 946–948 (1953).PubMedCrossRefGoogle Scholar
  403. Rosenthal, F. D., and J. F. Soothill: An immunochemical study of the proteins in cerebrospinal fluid. J. Neurol. Neurosurg. Psychiat. 25, 177–181 (1962).PubMedCrossRefGoogle Scholar
  404. Ross, J.: Über Autosensibilisierungsvorgänge bei entzündlichen Erkrankungen des Nervensystems. Klin. Wschr. 42, 514–518 (1964).PubMedCrossRefGoogle Scholar
  405. Ross, J., K. Schumacher u. E. Mangete: Nachweis und Identifizierung eines Faktors von Immunoglobulin-M-Natur und Antikörper-Eigenschaft im Serum von Kranken mit Multipler Sklerose. Klin. Wschr. 43, 1324–1331 (1965).PubMedCrossRefGoogle Scholar
  406. Rossen, R. D., W. T. Butler, T. R. Cate, C. F. Szwed, and R. B. Couch: Protein composition of nasal secretion during respiratory virus infection. Proc. Soc. exp. Biol. (N.Y.) 119, 1169–1176 (1965).Google Scholar
  407. Rossen, R. D., W. T. Butler, W. E. Vannier, R. G. Douglas, and A. G. Steinberg: The sedimentation and antigenic properties of proteins in nasal and other external secretions. J. Immunol. 97, 925–938 (1966c).PubMedGoogle Scholar
  408. Rossen, R. D., R. G. Douglas, T. R. Cate, R. B. Couch, and W. T. Butler: The sedimentation behavior of rhinovirus neutralizing activity in nasal secretion and serum following the rhinovirus common cold. J. Immunol. 97, 532–538 (1966b).PubMedGoogle Scholar
  409. Rossen, R. D., C. Morgan, K. C. Hsu, and H. M. Rose: Localization of 11 S external secretory IgA globulin by immunofluorescence. Clin. Res. 15, 298 (1967c) (Abstract).Google Scholar
  410. Rossen, R. D., A. L. Schade, W. T. Butler, and J. A. Kasel: The proteins in nasal secretions: a longitudinal study of the y A-globulin, y G-globulin, albumin, siderophilin, and total protein concentrations in nasal washings from adult male volunteers. J. clin. Invest. 45, 768–776 (1966a).PubMedCrossRefGoogle Scholar
  411. Rossen, R. D., S. M. Wolff, and W. T. Butler: The antibody response in nasal washings and serum to S. T yphosa endotoxin administered intravenously. J. Immunol. 99, 246–254 (1967b).PubMedGoogle Scholar
  412. Rossen, R. D., S. M. Wolff, W. T. Butler and W. E. Vannier: The identification of low molecular weight bentonite flocculating antibodies in the serum of the rabbit, monkey and man. J. Immunol. 98, 764–777 (1967a).Google Scholar
  413. Rossi, G., u. G. Schneider: Elektrophoretische Untersuchung von pathologischem Liquor cerebrospinalis. Klin. Wschr. 31, 969–975 (1953).PubMedCrossRefGoogle Scholar
  414. Rossi, P., et B. Colochine-Erber: Leptospirose et fluxion périodique. Cah. Méd. vét. 21, 129–138 (1952).Google Scholar
  415. Rothberg, R. M., and R. S. Farr: Anti-bovine serum albumin and anti-alpha lactalbumin in the serum of children and adults. Pediatrics 35, 571–588 (1965).PubMedGoogle Scholar
  416. Rubin, W., A. S. Fauci, M. H. Sleisenger, and G. H. Jeffries: Immunofluorescent studies in adult celiac disease. J. clin. Invest. 44, 475–485 (1965).PubMedCrossRefGoogle Scholar
  417. Russell, I. S., and W. Burnett: The proteins of human bile. Gastroenterology 45, 730–739 (1963).PubMedGoogle Scholar
  418. Russell, W.: An address on a characteristic organism of cancer. Brit. med. J. 1890 II, 1356–1360.Google Scholar
  419. Sabin, A. B., and A. H. Fieldsteel: Antipoliomyelitic activity of human and bovine colostrum and milk Pediatrics 29, 105–115 (1962).Google Scholar
  420. Sabin, A. B., R. H. Michaels, S. Krugman, M. E. Eiger, P. H. Berman, and J. Warren: Effect of oral poliovirus vaccine in newborn children. I. Excretion of virus after ingestion of large doses of Type I or of mixture of all three types, in relation to level of placentally transmitted antibody. Pediatrics 31, 623–640 (1963 a).Google Scholar
  421. Sabin, A. B., R. H. Michaels, P. Ziring, S. Krugman, and J. Warren: Effect of oral poliovirus vaccine in newborn children. II. Intestinal resistance and antibody response at 6 months in children fed Type I vaccine at birth. Pediatrics 31, 641–650 (1963 b).Google Scholar
  422. Sachs, H., u. G. Steiner: Serologische Untersuchungen bei multipler Sklerose. Klin. Wschr. 13, 1714–1717 (1934).CrossRefGoogle Scholar
  423. Salkind, A., H. I. Oshrain, and I. D. Mandel: Observations on gingival pocket fluid. Periodontics 1, 196–198 (1963).Google Scholar
  424. Samter, M., and E. L. Becker: Ragweed reagins in nasal secretion. Proc. Soc. exp. Biol. (N.Y.) 65, 140–141 (1947)•Google Scholar
  425. Sand, B., and W. Lewis: Toxoplasmotic versus amebic chorio-retinitis. Report of a case with study of the intraocular fluid antibody levels. Amer. J. Ophthal. 55, 1039–1043 (1963).PubMedGoogle Scholar
  426. Sande, M. van, D. Karcher et A. Lowenthal: Contribution électrophorétique à l’étude des protéines du liquide céphalo-rachidien et du cerveau dans les encéphalites subaiguës. Protides biol. Fluids 6, 223–228 (1958).Google Scholar
  427. Saperstein, S. S., D. W. Anderson, A. S. Goldman, and W. T. Kniker: Milk allergy. III. Immunological studies with sera from allergic and normal children. Pediatrics 32, 580–587 (1963).PubMedGoogle Scholar
  428. Sarwar, M., B. Campbell, and W. E. Petersen: Production of antibody in mammary gland of pregnant, non-lactating and lactating cows, evoked by polyvalent antigen with reference to dosage and frequency of immunization. Canad. J. comp. Med. 28, 183–192 (1957).Google Scholar
  429. Schade, S. G., P. Feick, M. Muckerheide, and R. F. Schilling: Occurrence in gastric juice of antibody to a complex of intrinsic factor and vitamin B12. New Engl. J. Med. 275, 528–531 (1966).Google Scholar
  430. Schapira, K., and D. C. Park: Gammaglobulin studies in multiple sclerosis and their application to the problem of diagnosis. J. Neurol. Neurosurg. Psychiat. 24, 121–124 (1961).PubMedCrossRefGoogle Scholar
  431. Scheinberg, L. C., F. A. Edelman, and W. A. Levy: Is the brain “an immunologically privileged site” ? I. Studies based on intracerebral tumor homotransplantation to sensitized hosts. Arch. Neurol. (Chic.) 11, 248–264 (1964).CrossRefGoogle Scholar
  432. Scheinberg, L. C., D. G. Kotsilimbas, R. Karpf, and N. Mayer: Is the brain “an immunologically privileged site” ? Arch. Neurol. (Chic.) 15, 62–67 (1966).CrossRefGoogle Scholar
  433. Scheinberg, L. C., A. Levy, and F. Edelman: Is the brain an “immunologically privileged site”? II. Studies in induced host resistance to transplantable mouse glioma following irradiation of prior implants. Arch. Neurol. (Chic.) 13, 283–286 (1965).CrossRefGoogle Scholar
  434. Scheurlen, P. G., K. Felgenhauer u. A. Pappas: Hochmolekulares yG-Paraprotein im Liquor cerebrospinalis bei Plasmocytom. Klin. Wschr. 45, 419–422 (1967).PubMedCrossRefGoogle Scholar
  435. Schlaegel, T. F., J. L. Arbogast, and L. A. Estela: The value of the Middlebrook-Dubos hemagglutination test for tuberculosis. Amer. J. Ophthal. 51, 627–634 (1961).PubMedGoogle Scholar
  436. Schmitz V. Hülst, M., u. K. H. Clausnitzer: Über Blutgruppenagglutinine im Speichel. Z. Immun.-Forsch. 119, 317–319 (1960).Google Scholar
  437. Schneider, G., and G. Wallenius: Electrophoretic studies on cerebrospinal fluid proteins. Scand. J. clin. Lab. Invest. 3, 145–150 (1951).PubMedCrossRefGoogle Scholar
  438. Schubert, J., u. A. Grünberg: Zur Frage der Übertragung von Immun-Antikörpern von der Mutter auf das Kind. Schweiz. med. Wschr. 79, 1007–1010 (1949).PubMedGoogle Scholar
  439. Schultze, H. E.: The synthesis of antibodies and proteins. Protides biol. Fluids 7, 1–17 (1959).Google Scholar
  440. Schultze, H. E., and J. F. Heremans: Molecular biology of human proteins with special reference to plasma proteins, vol. 1, Nature and metabolism of extracellular proteins. Amsterdam: Elsevier Publ. Co. 1966.Google Scholar
  441. Scxwick, H. G.: Die Verteilung von Antikörpern in Human-Immunoglobulinen. J. Mal. inf. parasit. (Roma) 12, 1–23 (1966).Google Scholar
  442. Scxwick, H. G., H. O. Esser u. F. Koch: Qualitative und quantitative immunologische Bestimmung von Plasmaproteinen in Frauenmilch. Behringwerk-Mitt. 37, 11–28 (1959).Google Scholar
  443. Seegal, B. C., and D. Seegal: Local organ hypersensitiveness: VII. Demonstration of agglutinins in tissues of rabbit eye following immunization with Eb. typhi vaccine. Proc. Soc. exp. Biol. (N.Y.) 31, 437–441 (1934).Google Scholar
  444. Sell, S.: Isolation and characterization of rabbit colostral IgA. Immunochemistry 4, 49–55 (1967).PubMedCrossRefGoogle Scholar
  445. Selzer, G., F. C. Path, M. H. Luntz, and M. I. Sacks: Experimental uveitis. II. Amer. J. Ophthal. 61, 1396–1400 (1966).PubMedGoogle Scholar
  446. Settipane, G. A., J. T. Connell, and W. B. Sherman: Reagin in tears. J. Allergy 36, 92–96 (1965).PubMedCrossRefGoogle Scholar
  447. Sherman, J. D., M. M. Adner, and W. Dameshek: Direct injection of the thymus with antigenic substances. Proc. Soc. exp. Biol. (N.Y.) 115, 866–870 (1964).Google Scholar
  448. Shirai, Y.: Transplantation of rat sarcoma in adult heterogeneous animals. Jap. Med. Wld 1, 14–15 (1921).Google Scholar
  449. Shulman, S., L. Hubler, and E. Witebsky: Antibody response to immunization by different routes. Science 145, 815–816 (1964).PubMedCrossRefGoogle Scholar
  450. Simons, K., T. Weber, M. Stiel, and R. Grasbeck: Immunoelectrophoresis of human saliva. Acta med. scand. 175, Suppl. 412, 257–264 (1964).Google Scholar
  451. Skochko, C. T.: Fecal agglutination in comparison with bacteriological and serological investigation during dysentery. Zh. Mikrobiol. (Mosk.) 3, 59–62 (1942).Google Scholar
  452. Skvakii., F., u. J. Rejnek: Imunochemické skrovnânf bflkovin kolostra a mléka s bilkovinami krevni plasmy. Cs. Pediat. 13, 793–797 (1958).Google Scholar
  453. Sluis, I. VON Der: Two cases of pyoderma (ecthyma) gangraenosum associated with the presence of an abnormal serumprotein (ß2 A-paraprotein). With a review of the literature. Dermatologica (Basel) 132, 409–424 (1966).CrossRefGoogle Scholar
  454. Smith, C. B., J. A. Bellanti, and R. M. Chanock: Immunoglobulins in serum and nasal secretions following infection with type 1 parainfluenza virus and injection of inactivated vaccines. J. Immunol. 99, 133–141 (1967).PubMedGoogle Scholar
  455. Smith, E. L.: The immune proteins of bovine colostrum and plasma. J. biol. Chem. 164, 345–358 (1946).PubMedGoogle Scholar
  456. Smith, E. L.: Isolation and properties of immune lactoglobulins from bovine whey. J. biol. Chem. 165, 665–676 (1946).PubMedGoogle Scholar
  457. Smith, E. L.: The isolation and properties of the immune proteins of bovine milk and colostrum and their role in immunity: A review. J. Dairy Sci. 31, 127–138 (1948).CrossRefGoogle Scholar
  458. Smorodintsev, A. A.: Problems of pathogenesis and immunology of virus infections [in Russian]. Leningrad: Medgiz 1955.Google Scholar
  459. Solish, G. I., H. Gershowitz, and S. J. Behrman: Occurrence and titer of isohemagglutinins in secretions of the human uterine cervix. Proc. Soc. exp. Biol. (N.Y.) 108, 645–649 (1961).Google Scholar
  460. Sommerville, R. I.: The histology of the ovine abomasum, and the relation of the globule leucocyte to nematode infestations. Aust. vet. J. 32, 237–240 (1956).CrossRefGoogle Scholar
  461. South, M.A., M. D. Cooper, F. A. Wollheim, R. Hong, and R. A. Good: The IgA system. I. Studies of the transport an immunochemistry of IgA in the saliva. J. exp. Med. 123, 615–628 (1966).Google Scholar
  462. South, M.A., W. J. Warwick, F. A. Wollheim, and R. A. Good: The IgA system. III. IgA levels in the serum and saliva of pediatric patients — evidence for a local immunological system. J. Pediat. 71, 645–653 (1967).PubMedCrossRefGoogle Scholar
  463. South, M.A., F. A. Wollheim, W. J. Warwick, M. D. Cooper, and R. A. Good: Local deficiency of immune globulin A in the saliva of patients with chronic sinopulmonary disease. J. Pediat. 67, 940–941 (1965) (Abstract).Google Scholar
  464. Sprinz, H., D. W. Kundel, G. J. Dammin, R. E. Horowitz, H. Schneider, and S. B. Formal: The response of the germ-free guinea-pig to oreal bacterial challenge with Escherichia coli and Shigella flexneri. Amer. J. Path. 39, 681–695 (1961).PubMedGoogle Scholar
  465. Sprinz, H., R. Sribhibhadh, E. J. Gangarosa, C. Benyajati, D. Kundel, and S. Halstead: Biopsy of small bowel of Thai people. With special reference to recovery from Asiatic cholera and to an intestinal malabsorption syndrome. Amer. J. clin. Path. 38, 43–51 (1962).Google Scholar
  466. Stäubli, C.: Experimentelle Untersuchungen über die Ausscheidung der Typhus-agglutinine. Zbl. Bakt., I. Abt. 33, 375–389 (1903).Google Scholar
  467. Steger, J.: Blut-und Liquorveränderungen bei der Polyneuritis (mit vorläufigen elektrophoretischen Ergebnissen). Dtsch. Z. Nervenheilk. 170, 106–121 (1953).CrossRefGoogle Scholar
  468. Steigman, A. J., and M. M. Lipton: Poliovirus-neutralising antibody in faeces of poliomyelitic children. Lancet 1959 II, 272–273.CrossRefGoogle Scholar
  469. Stevens, K. M., C. A. Fost, and C. M. Ison: Circulating antibodies to egg albumin in man. Proc. Soc. exp. Biol. (N.Y.) 113, 188–191 (1963).Google Scholar
  470. Stobo, J. D., and T. B. Tomasi: A low molecular weight immunoglobulin antigenically related to IgM: studies in ataxia telangiectasia. Arthr. and Rheum. 9, 543–544 (1966).Google Scholar
  471. Stoffer, H. R., F. W. Kraus, and A. C. Holmes: Immunochemical identification of salivary proteins. Proc. Soc. exp. Biol. (N.Y.) 111, 467–471 (1962).Google Scholar
  472. Straus, E. K.: Occurrence of antibody in human vaginal mucus. Proc. Soc. exp. Biol. (N.Y.) 106, 617–621 (1961).Google Scholar
  473. Straus, E. K.: Sperm immobilization in the human vagina by induced muco-antibody. Fertil. and Steril. 16, 346–355 (1965).Google Scholar
  474. Strobl, A., u. A. Wasitsky: Über das Vorkommen von komplementbindenden Eiund Milchantikörpern im Blutserum. Mschr. Kinderheilk. 52, 95–105 (1932).Google Scholar
  475. Sugg, J. Y., and J. M. Neill: Loss of immune substances from the body. II. Diphtheria antitoxin in human saliva. J. Immunol. 20, 463–481 (1931).Google Scholar
  476. Sullivan, A. J., and T. B. Toiasr: Studies on bovine serum and salivary y-globulins. Clin. Res. 12, 452 (1964) (Abstract).Google Scholar
  477. Sussman, H., A. Davidson, and M. Walzer: Absorption of undigested proteins in human beings. III. The absorption of unaltered egg protein in adults. Arch. intern. Med. 41, 409 414 (1928).Google Scholar
  478. Taliaferro, W. H., and M. P. Sarles: The cellular reactions in the skin, lungs and intestine of normal and immune rats after infection with Nippostrongylus muris. J. infect. Dis. 64, 157–192 (1939).CrossRefGoogle Scholar
  479. Tansley, K.: The development of the rat eye graft. J. exp. Biol. 22, 221–224 (1946).PubMedGoogle Scholar
  480. Taylor, K. B., and S. C. Truelove: Circulating antibodies to milk proteins in ulcerative colitis. Brit. med. J. 1961 II, 924–929.CrossRefGoogle Scholar
  481. Taylor, K. B., and R. Wright: Serologic reactions to gluten and cow’s milk proteins in gastrointestinal disease. Gastroenterology 46, 99–108 (1964).PubMedGoogle Scholar
  482. Tenorova, M., E. Stuchlfxova, and J. Kokinek: Agarophoresis and immunoelectrophoresis of the proteins of gastric juice. Nature (Lond.) 192, 763 (1961).CrossRefGoogle Scholar
  483. Teponga, W. A.: An indirect haemagglutination test for the detection of Vibrio foetus antibodies. Part 3. Preservation of sensitized erythrocytes. N.Z. vet. J. 7, 72–74 (1959).Google Scholar
  484. Thomas, J. A., et J. Leclerc: Recherches préliminaires sur l’obtention d’anticorps du virus de la fièvre aphteuse dans le lait de vache, après injection de virus dans le canal du trayon. C. R. Acad. Sci. (Paris) 252, 1690–1692 (1962).Google Scholar
  485. Thompson, R., and H. Olson: Antibody production in rabbit’s cornea. J. Immunol. 65, 633–651 (1950).PubMedGoogle Scholar
  486. Thompson, R., and H. Olson, V. H. Olson, and L. R. Sibal: Conditions for the demonstration of local peripheral antibody formation and failure to show localization of antibody by antigen. J. Immunol. 79, 508–515 (1957).PubMedGoogle Scholar
  487. Thonard, J. C., and M. H. Dalbow: Local cellular antibodies. I. Plaque formation by sensitized oral mucosal cells from conventional animals. J. Immunol. 95, 209–213 (1965).PubMedGoogle Scholar
  488. Thorbecke, G. J.: Gamma globulin and antibody formation in vitro. I. Gamma globulin formation in tissues from immature and normal adult rabbits. J. exp. Med. 112, 279–292 (1960).Google Scholar
  489. Tomasi, T. B., and D. S. Czerwinski: The secretory IgA system. In: R. A. GOOD, P. Miescher and R. T. Smith (eds.), The immunologic deficiency diseases in man. Gainesville: Florida University Press (in press).Google Scholar
  490. E. M. Tan, A. Solomon, and R. A. Prendergast: Characteristics of an immune system common to certain external secretions. J. exp. Med. 121, 101–124 (1965).PubMedCrossRefGoogle Scholar
  491. E. M. Tan, and S. D. Zigelbaum: The excretion of gamma globulins in human saliva, colostrum and urine. Arthr. and Rheum. 5, 662–663 (1962).Google Scholar
  492. E. M. Tan, and S. D. Zigelbaum: The selective occurrence of yl A-globulin in certain body fluids. J. clin. Invest. 42, 1552–1560 (1963).CrossRefGoogle Scholar
  493. Toner, P. G.: The fine structure of the globule leucocyte in the fowl intestine. Acta anat. (Basel) 61, 321–330 (1965).Google Scholar
  494. Tourtellotte, W. W.: Multiple sclerosis and cerebrospinal fluid. Med. Clin. N. Amer. 47, 1619–1628 (1963).PubMedGoogle Scholar
  495. Tourtellotte, W. W., and J. A. Parker: Distribution and subfractionation of immunoglobulins in patients with multiple sclerosis. Trans. Amer. neurol. Ass. 90, 107–112 (1965).PubMedGoogle Scholar
  496. Tourtellotte, W. W., and J. A. Parker: Multiple sclerosis: correlation between immunoglobulin-G in cerebrospinal fluid and brain. Science 154, 1044–1046 (1966).PubMedCrossRefGoogle Scholar
  497. Tung, F. F., and A. H. Schein: The appearance of administered proteins in saliva. J. dent. Res. 43, 423–432 (1964).PubMedCrossRefGoogle Scholar
  498. Turner, M. W.: Characterization of antibodies in normal human urine by gel- filtration and antigenic analysis. Protides biol. Fluids 12, 453–456 (1964).Google Scholar
  499. Ursing, B.: Clinical and immunoelectrophoretic studies on cerebrospinal fluid in virus meningoencephalitis and bacterial meningitis. Acta med. scand. 177, Suppl. 429, 1–99 (1964).Google Scholar
  500. Vaerman, J.-P., and J. F. Heremans: The immunoglobulins of the dog. I. Identification of canine immunoglobulins homologous to human IgA and IgM. In press.Google Scholar
  501. Vivell, O.: Die Immunologie der Pränatalperiode. Bibl. microbiol. (Basel) 1, 54–72 (1960).Google Scholar
  502. Volk, B. W., A. Saifer, and A. M. Rabiner: Protein fractions in serum and cerebrospinal fluid in multiple sclerosis. Ann. N.Y. Acad. Sci. 58, 541–720 (1954).CrossRefGoogle Scholar
  503. Volk, B. W., and I. Oreskes: “Protein profile” in multiple sclerosis. Arch. Neurol. Psychiat. (Chic.) 73, 66–75 (1955).Google Scholar
  504. Walsh, T. E., and P. R. Cannon: Immunization of the respiratory tract. A comparative study of the antibody content of the respiratory and other tissues following active, passive and regional immunization. J. Immunol. 35, 31–46 (1938).Google Scholar
  505. Weill, P.: Über die leukozytären Elemente der Darmschleimhaut der Säugetiere. Arch. mikr. Anat. 93, 1–80 (1919).Google Scholar
  506. Weise, H. J.: Vergleichende papierelektrophoretische Analysen der Liquor- und Serumeiweißfraktionen bei Dys- und Paraproteinämie und deren Auswirkungen auf die Liquordiagnostik. Verh. Dtsch. Ges. inn. Med. 66, 889–892 (1960).Google Scholar
  507. Weiss, A. H., E. Smith, N. Christoff, and S. Kocxwa: Cerebrospinal fluid paraproteins in multiple myeloma. J. Lab. clin. Med. 66, 280–293 (1965).PubMedGoogle Scholar
  508. Wells, PH. D.: Mast cell, eosinophil and histamine levels in Nippostrongylus brasiliensis infected rats. Exp. Parasit. 12, 82–101 (1962).PubMedCrossRefGoogle Scholar
  509. Wheatcroft, M. G.: Comparative study of human serum and salivary antibody titres in cases of Brucella melitensis infections. J. dent. Res. 36, 112–117 (1957).PubMedCrossRefGoogle Scholar
  510. White, R. G., A. H. Coons, and J. M. Connolly: Studies on antibody production; alum granuloma. J. exp. Med. 102, 73–82 (1955).PubMedCrossRefGoogle Scholar
  511. Whur, P.: Relationship of globule leucocytes to gastrointestinal nematodes in the sheep, and Nippostrongylus brasiliensis and Hymenolepis nana infections in rats. J. comp. Path. 76, 57–65 (1966a).PubMedCrossRefGoogle Scholar
  512. Whur, P.: Mast cell and globule leucocyte response to Nippostrongylus brasiliensis infection and to induced anaphylaxis. Int. Arch. Allergy 30, 351–359 (1966 b).PubMedCrossRefGoogle Scholar
  513. Whur, P., and H. S. Johnston: Ultrastructure of globule leucocytes in immune rats infected with Nippostrongylus brasiliensis and their possible relationship to the Russell body cell. J. Path. Bact. 93, 81–85 (1967).PubMedCrossRefGoogle Scholar
  514. Wieme, R. J.: Studies on agar gel electrophoresis. Techniques — applications. Bruxelles: Arscia 1959.Google Scholar
  515. Wilson, R. M., and G. E. Green: Genetic aspects of salivary secretion of isoagglutinins. Proc. Soc. exp. Biol. (N.Y.) 115, 982–985 (1964).Google Scholar
  516. Wilson, S. J., and M. Walzer: Absorption of undigested proteins in human beings. IV. Absorption of unaltered egg protein in infants and in children. Amer. J. Dis. Child. 50, 49–54 (1935).Google Scholar
  517. Witmer, R.: Elektrophorese des Kammerwassers. Ophthalmologica (Basel) 123, 280–284 (1952).CrossRefGoogle Scholar
  518. Witmer, R.: Zur experimentellen Augentuberkulose des Kaninchens. Elektrophorese und Haemagglutination. Ophthalmologica (Basel) 127, 315–322 (1954 a).PubMedCrossRefGoogle Scholar
  519. Witmer, R.: Periodic ophthalmia in horses. Amer. J. Ophthal. 37, 243–253 (1954b).PubMedGoogle Scholar
  520. Witmer, R.: Experimental leptospiral uveitis in rabbits. Arch. Ophthal. 53, 547–559 (1955 a).CrossRefGoogle Scholar
  521. Witmer, R.: Antibody formation in rabbit eye studied with fluorescein-labeled antibody. Arch. Ophthal. 53, 811–816 (195 5 b).Google Scholar
  522. Witmer, R.: Atiologische Diagnostik der Uveitis. II. Die Hämagglutination nach Middlebrook und Dubos und die Papierelektrophorese bei der experimentellen Kaninchentuberkulose. Albrecht v. Graefes Arch. Ophthal. 156, 337–355 (1955c).CrossRefGoogle Scholar
  523. Witmer, R.: Endogene Entzündungen des Auges. Ophthalmologica (Basel) 147, 217–228 (1964 a).CrossRefGoogle Scholar
  524. Witmer, R.: Zur Frage der Auto-Immunerkrankung des Auges: Die phako-antigene Uveitis. Int. Arch. Allergy 24, 58–64 (1964b).PubMedCrossRefGoogle Scholar
  525. Volf-Heidegger, C.: Zur Frage der Lymphocytenwanderung durch das Darmepithel. Z. mikr.-anat. Forsch. 45, 90–103 (1939).Google Scholar
  526. Wolxowlcz, M. I., J. W. Hallett, and I. H. Leopold: Studies on antibody production in rabbit eyes. I. Antibody formation in vitro after intraocular injection of typhoid bacilli. Amer. J. Ophthal. 50, 126–138 (1960 a).Google Scholar
  527. Wolxowlcz, M. I., J. W. Hallett, and I. H. Leopold: Studies on antibody production in experimental uveitis. I. Antibody formation in vitro after intraocular injection of typhoid bacilli into the rabbit eye. Docum. ophthal. (Den Haag) 14, 50–64 (1960b).Google Scholar
  528. Wright, R., K. B. Taylor, S. C. Truelove, and R. Aschaffenburg: Circulating antibodies to cow’s milk protein and gluten in the newborn. Brit. med. J. 1962 II, 513–515.Google Scholar
  529. Yahr, M. D., S. S. Goldensohn, and E. A. Rabat: Further studies on the gamma globulin content of cerebrospinal fluid in multiple sclerosis and other neurological diseases. Ann. N.Y. Acad. Sci. 58, 613–624 (1954).CrossRefGoogle Scholar
  530. Yampolsky, W. M., D. M. Gorfunkel, and V. B. Aronina: Early diagnosis of dysentery in children. Pediatriya 5, 13–18 (1944).Google Scholar
  531. Yoffey, J. M., and F. C. Courtice: Lymphatics, lymph and lymphoid tissue. London: Arnold 1956.Google Scholar
  532. Yokoyama, M., and E. Roboz-Einstein: Immunochemical analysis of cerebrospinal fluid. Ann. N.Y. Acad. Sci. 122, 439–451 (1965).PubMedCrossRefGoogle Scholar
  533. Yosida, K. I.: Über die gruppenspezifischen Unterschiede der Transsudate, Exsudate, Sekrete, Exkrete, Organextrakte and Organzellen des Menschen and ihre rechtsmedizinischen Anwendungen. Z. exp. Med. 63, 331–339 (1928).Google Scholar
  534. Zimmerman, L. E., and A. M. Silverstein: Experimental ocular hypersensitivity. Histopathologic changes observed in rabbits receiving a single injection of antigen into the vitreous. Amer. J. Ophth. 48, 447–465 (1959).Google Scholar

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© Springer-Verlag Berlin · Heidelberg 1968

Authors and Affiliations

  • Joseph F. Heremans
    • 1
  1. 1.Research Department of Internal PathologyUniversity of LouvainLouvainBelgium

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