Abstract
The scid mutation occurred in the C.B-17Icr (C.B-17) inbred strain, an immunoglobulin heavy chain (Igh) congenic partner strain of BALB/cAnlcr (BALB/c) . The C.B-17 strain was derived from the 13th backcross generation of the original C.B stock of M. Potter. C.B-17 mice are not known to differ from BALB/c mice except that a portion of their chromosome 12 comes from the C57BL/Ka strain and includes the C57BL/Ka Igh locus and other closely-linked genes.
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References
Allison JP, Lanier LL (1987) The T cell antigen receptor gamma gene: rearrangement and cell lineages. Immunol. Today 8: 293–296.
Alt FW, Rosenberg N, Enea V, Siden E, Baltimore D (1982) Multiple immunoglobulin heavy-chain gene transcripts in Abelson murine leukemia virus-transformed lymphoid cell lines. Molec. Cell. Biol. 2: 386–400.
Bancroft GJ, Bosma MJ, Bosma GC, Unanue ER (1986) Regulation of macrophage la expression in mice with severe combined immunodeficiency: induction of la expression by a T cell-independent mechanism. J. Immunol. 137: 4–9.
Bosma GC, Custer RP, Bosma MJ (1983) A severe combined immunodeficiency mutation in the-mouse. Nature 301: 527–530.
Bosma GC, Fried M, Custer RP, Carroll A, Gibson D, Bosma MJ (1987) Evidence of functional lymphocytes in some (leaky) scid mice. J. Exp. Med. (in press) .
Custer RP, Bosma GC, Bosma MJ (1985) Severe combined immunodeficiency (SCID) in the mouse: pathology, reconstitution, neoplasms. J. Amer. J. Pathol. 120: 464–477.
Czitrom AA, Edwards S, Phillips RA, Bosma MJ, Marrack P, Kappler JW (1985) The function of antigen-presenting cells in mice with severe combined immunodeficiency. J. Immunol. 134: 2276–2280.
Dorshkind K, Keller GM, Phillips RA, Miller RG, Bosma GC, O’Toole M, Bosma MJ (1984) Functional status of cells from lymphoid and myeloid tissues in mice with severe combined immunodeficiency disease. J. Immunol. 132: 1804–1808.
Dorshkind K, Pollack SB, Bosma MJ, Phillips RA (1985) Natural killer (NK) cells are present in mice with severe combined immunodeficiency (scid) . J. Immunol. 134: 3798–3801.
Epstein R, Davisson M, Lehmann K, Akeson EC, Cohn M (1986) Position of Igl-l, md, and Bst loci on chromosome 16 of the mouse. Immunogenetics 23: 78–83.
Grosschedl R, Weaver D, Baltimore D, Constantini F (1984) Introduction of a μ immunoglobulin gene into the mouse germ line: specific expression in lymphoid cells and synthesis of functional antibody. Cell 38: 647–658.
Hackett J, Bosma GC, Bosma MJ, Bennett M, Kumar V (1986) Transplantable progenitors of natural killer cells are distinct from those of T and B lymphocytes. Proc. Natl. Acad. Sci. (USA) 83: 3427–3431.
Kemp DJ, Harris AW, Adams JM (1980) Transcripts of the immunoglobulin Cy gene vary in structure and splicing during lymphoid development. Proc. Natl. Acad. Sci. (USA) 77: 7400–7404.
Kim MG, Schuler W, Bosma MJ, Marcu KB (1988) Aberrant Igh locus rearrangements in A-MuLV pre-B lines of scid mice: evidence for deregulated D-J recombination. Curr. Top. Microbiol, and Immunol, (in press) .
Lennon GC, Perry RP (1985) Cy-containing transcripts initiate heterogeneously within the IgH enhancer region and contain a novel 5’-nontranslatable exon. Nature 318: 475–478.
Rosen FS, Cooper MD, Wedgwood RJ (1984) The primary immunodeficiencies. N. Engl. J. Med. 311: 235–242 and 300–310.
Schuler W, Schüler A, Bosma MJ (1987) Evidence for defective rearrangement of TCRγ genes in a mouse mutant (scid) with severe combined immune deficiency. J. Cell. Biochem. suppl. HD p 216 (Abstract) .
Schuler W, Weiler IJr Schuler A, Phillips RA, Rosenberg N, Mak TW, Kearney JFr Perry RP, Bösma MJ (1986) Rearrangement of antigen receptor genes is defective in mice with severe combined immune deficiency. Cell 46: 963–972.
Storb U, Pinkert C, Arp B, Engler P, Gollahon K, Manz J, Brady W, Brinster RL (1986) Transgenic mice with μ and κ genes encoding antiphosphorylcholine antibodies. J. Exp. Med. 164: 627–641.
Van Ness GG, Weigert M, Coleclough C, Mather EL, Kelley DE, Perry RP (1981) Transcription of the unrearranged mouse Cκ locus. Sequence of the initiation region and comparison of activity with a rearranged Vκ-Cκ gene. Cell 27: 593–602.
Yancopoulos G, Alt FW (1985) Developmentally controlled and tissue-specific expression of unrearranged VH gene segments. Cell 40: 271–281.
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© 1988 Springer-Verlag Berlin · Heidelberg
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Bosma, M., Schuler, W., Bosma, G. (1988). The scid Mouse Mutant. In: Mock, B., Potter, M. (eds) Genetics of Immunological Diseases. Current Topics in Microbiology and Immunology, vol 137. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-50059-6_29
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DOI: https://doi.org/10.1007/978-3-642-50059-6_29
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