Abstract
Just as the development of B cell hybridization techniques and the availability of B cell monospecific products (monoclonal antibody) have revolutionized basic immunological approaches, recently established techniques for T cell cloning have provided another powerful tool. Experiments utilizing T cell clones have provided information relevant to T cell specificity, function, and the biochemistry of the T cell receptor which had been difficult to obtain with polyclonal T cell populations. In this communication, we describe a “clonological analysis”, i.e. the use of cloned T cells for genetic analysis of the strongly stimulatory, yet serologically undefined, T cell stimulatory determinants of the Mls (minor lymphocyte stimulatory locus) system.
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References
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© 1988 Springer-Verlag Berlin · Heidelberg
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Abe, R., Hodes, R.J. (1988). Genetic Analysis of Serologically Undefined Determinants: A T Cell “Clonological” Analysis of the Mls System. In: Mock, B., Potter, M. (eds) Genetics of Immunological Diseases. Current Topics in Microbiology and Immunology, vol 137. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-50059-6_26
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DOI: https://doi.org/10.1007/978-3-642-50059-6_26
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